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Article ; Online: Altered Microbial Transcription in Long-term Proton Pump Inhibitor Use: Findings From a United States Cohort Study.

Kim, Hanseul / Nzabarushimana, Etienne / Huttenhower, Curtis / Chan, Andrew T / Nguyen, Long H

2024

Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2024.03.026
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Article: Sargramostim for Prophylactic Management of Gastrointestinal Immune-Related Adverse Events of Immune Checkpoint Inhibitor Therapy for Cancer.

Dougan, Michael / Nguyen, Long H / Buchbinder, Elizabeth I / Lazarus, Hillard M

Cancers

2024 Volume 16, Issue 3

Abstract: Immune checkpoint inhibitor (ICI) therapy improves outcomes in several cancers. Unfortunately, many patients experience grade 3-4 treatment-related adverse events, including gastrointestinal (GI) toxicities which are common. These GI immune-related ... ...

Abstract	Immune checkpoint inhibitor (ICI) therapy improves outcomes in several cancers. Unfortunately, many patients experience grade 3-4 treatment-related adverse events, including gastrointestinal (GI) toxicities which are common. These GI immune-related adverse events (irAEs) induced by ICIs present significant clinical challenges, require prompt intervention, and result in treatment delays or discontinuations. The treatment for these potentially severe and even fatal GI irAEs which include enterocolitis, severe diarrhea, and hepatitis may interfere with the anti-cancer approach. Sargramostim (glycosylated, yeast-derived, recombinant human GM-CSF) is an agent that has been used in clinical practice for more than 30 years with a well-recognized safety profile and has been studied in many therapeutic areas. The mechanism of action of sargramostim may treat moderate-to-severe GI irAEs without impairing the anti-cancer therapy. Some early data also suggest a potential survival benefit. Through the differentiation/maturation of monocytes, macrophages, and neutrophils and induction of anti-inflammatory T cell responses, GM-CSF aids in GI homeostasis, mucosal healing, and mucosal immunity. GM-CSF knockout mice are susceptible to severe colitis which was prevented with murine GM-CSF administration. For some patients with GI mucosa and immune cell function impairment, e.g., Crohn's disease, sargramostim reduces disease severity. In a prospective, randomized study (ECOG 1608), advanced melanoma patients had a reduction in grade 3-5 GI irAEs and less frequent colonic perforation in the sargramostim plus ipilimumab arm compared to ipilimumab alone. Sargramostim continues to be studied with ICIs for the prophylactic management of irAEs while also potentially providing a survival benefit.
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16030501
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Article ; Online: The Adaptation of the Buddhist Death Acceptance Scale for Vietnamese Persons with Cancer.

Long, Nguyen H / Thanasilp, Sureeporn

Asian nursing research

2021 Volume 15, Issue 2, Page(s) 144–149

Abstract: Purpose: This study reports on selected psychometric properties of the adapted Buddhist Death Acceptance Scale (BDAS) for Vietnamese persons with cancer.: Methods: The original 13-item BDAS was developed based on Buddhist perspectives toward death ... ...

Abstract	Purpose: This study reports on selected psychometric properties of the adapted Buddhist Death Acceptance Scale (BDAS) for Vietnamese persons with cancer. Methods: The original 13-item BDAS was developed based on Buddhist perspectives toward death and life and was translated from Thai into Vietnamese. Item content checking with five Vietnamese local experts suggested three items of the original BDAS were irrelevant in Vietnamese culture and hence should be excluded. Psychometric properties of the 10-item BDAS Vietnamese version were tested using a convenience sample of 193 Vietnamese Buddhists with cancer. Results: The internal consistency coefficient of the scale was found to be 0.73. Exploratory factor analysis showed that the 10 items of the BDAS Vietnamese version constituted 2 factors, explaining 51.1% of the variance of death acceptance. The first factor was "acceptance of natural process of death" and the second was "preparing for death." Both factors reflected explicitly Buddhist viewpoints toward death acceptance and were consistent with the original Thai BDAS. However, although similar factors were found, some items in the Vietnamese BDAS did not load to same factors as in the Thai BDAS. Conclusions: The BDAS Vietnamese version provides an initial suitable measurement for death acceptance among Vietnamese Buddhists. Its availability will enable cross-cultural research to investigate death acceptance among Buddhist patients with cancer in Vietnam. However, the differences in item loadings between the Thai and Vietnamese scales suggest that further conceptual and empirical works to refine the measurement are needed.
MeSH term(s)	Asian Continental Ancestry Group ; Factor Analysis, Statistical ; Humans ; Neoplasms ; Psychometrics ; Reproducibility of Results
Language	English
Publishing date	2021-02-10
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2481635-8
ISSN	2093-7482 ; 2093-7482
ISSN (online)	2093-7482
ISSN	2093-7482
DOI	10.1016/j.anr.2021.02.002
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Article ; Online: Cellulose nanocrystals extracted from rice husk using the formic/peroxyformic acid process: isolation and structural characterization.

Vu, An Nang / Nguyen, Long Hoang / Tran, Ha-Chi V / Yoshimura, Kimio / Tran, Tap Duy / Van Le, Hieu / Nguyen, Ngoc-Uyen T

RSC advances

2024 Volume 14, Issue 3, Page(s) 2048–2060

Abstract: ... was subsequently acid hydrolyzed by H ...

Abstract	Cellulose derived from biomass is a renewable resource with numerous applications. Using formic/peroxyformic acid at atmospheric pressure, cellulose nanocrystals (CNC) were isolated from rice husk (RH) in this study. This method was an excellent way to get rid of lignin and hemicelluloses from RH. The cellulose was subsequently acid hydrolyzed by H
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra06724f
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Article ; Online: Symptom clusters: Revisiting the concept in nursing care for cancer patients.

Nguyen, Long H / Nguyen, Huyen T H

Nursing forum

2021 Volume 57, Issue 3, Page(s) 469–472

Abstract: Background: Studies on symptom clusters among cancer patients have been conducted intensively. However, the concept seems not to be well defined, hindering its utilization in clinical practice.: Aim: The aim of this paper is to reconceptualize ... ...

Abstract	Background: Studies on symptom clusters among cancer patients have been conducted intensively. However, the concept seems not to be well defined, hindering its utilization in clinical practice. Aim: The aim of this paper is to reconceptualize symptom cluster and discuss areas of future research. Results: A cluster of symptoms should not be viewed as simply as a group of symptoms appearing together. It should be clinically relevant, and symptom members should be interactive or have a mutual etiology. A cluster is declared as stable if its "quality" or "nature" is remained instead of merely having the same number of symptoms. Importantly, each symptom cluster should have a sentinel symptom. The sentinel symptom could be the one that predicts the presence of the cluster or could be the one that significantly interacts with other symptoms. The search for symptom clusters, which are common among various patient groups, might be helpful in some aspects. However, to better understand them, symptom clusters should be examined in specific populations. Conclusion: The nature of the relationship between symptom members, clinical relevance, sentinel symptom, stability, and prevalence are important features of a symptom cluster. More explorations into these properties by future studies are suggested.
MeSH term(s)	Humans ; Neoplasms/complications ; Nursing Care ; Syndrome
Language	English
Publishing date	2021-12-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	412336-0
ISSN	1744-6198 ; 0029-6473
ISSN (online)	1744-6198
ISSN	0029-6473
DOI	10.1111/nuf.12684
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Article ; Online: Gut Microbiome of Patients With Breast Cancer in Vietnam.

Nguyen, Sang M / Tran, Huong T T / Long, Jirong / Shrubsole, Martha J / Cai, Hui / Yang, Yaohua / Nguyen, Lan M / Nguyen, Giang H / Nguyen, Chu V / Ta, To V / Wu, Jie / Cai, Qiuyin / Zheng, Wei / Tran, Thuan V / Shu, Xiao-Ou

JCO global oncology

2024 Volume 10, Page(s) e2300234

Abstract: Purpose: Gut microbiota play an important role in human health, including cancer. Cancer and its treatment, in turn, may alter the gut microbiome. To understand this complex relationship, we profiled the gut microbiome of 356 Vietnamese patients with ... ...

Abstract	Purpose: Gut microbiota play an important role in human health, including cancer. Cancer and its treatment, in turn, may alter the gut microbiome. To understand this complex relationship, we profiled the gut microbiome of 356 Vietnamese patients with breast cancer. Materials and methods: Stool samples were collected before chemotherapy, with 162 pre- and 194 postsurgery. The gut microbiome was measured by shotgun metagenomic sequencing. Associations of gut microbial diversity, taxa abundance, and gut microbiome health index (GMHI) with sociodemographic, clinical factors, and tumor characteristics were evaluated. Results: Postsurgery samples were associated with significantly lower α- and β-diversities ( Conclusion: Our study revealed that diagnosis delay, high fiber intake, and breast cancer surgery, which is always followed by antibiotic prophylaxis in Vietnam, led to a less diverse and unhealthy gut microbiome among patients with breast cancer.
MeSH term(s)	Humans ; Female ; Gastrointestinal Microbiome ; Vietnam/epidemiology ; Breast Neoplasms ; Feces/microbiology ; Metagenome
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article
ISSN	2687-8941
ISSN (online)	2687-8941
DOI	10.1200/GO.23.00234
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Article ; Online: Gaps in Access to Reconstruction Compared with Audiologic Care among Children with Microtia.

Long, Aaron S / Junn, Adam H / Shah, Hemali P / Almeida, Mariana N / Rivera, Jean Carlo / Nguyen, Hang P / Persing, John A / Alperovich, Michael

The Journal of pediatrics

2023 Volume 262, Page(s) 113340

Abstract: Reconstruction for microtia decreased psychosocial morbidity; timely referral for surgery is crucial. We evaluated specialist referrals for microtia at a major academic medical center. Only one-half of patients were evaluated at any point by a ... ...

Abstract	Reconstruction for microtia decreased psychosocial morbidity; timely referral for surgery is crucial. We evaluated specialist referrals for microtia at a major academic medical center. Only one-half of patients were evaluated at any point by a reconstructive craniofacial surgeon. Patients followed early for audiologic concerns may not be receiving timely referred for reconstruction.
MeSH term(s)	Humans ; Child ; Congenital Microtia/surgery ; Plastic Surgery Procedures
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2023.01.014
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Article ; Online: Microbiome epidemiology and association studies in human health.

VanEvery, Hannah / Franzosa, Eric A / Nguyen, Long H / Huttenhower, Curtis

Nature reviews. Genetics

2022 Volume 24, Issue 2, Page(s) 109–124

Abstract: Studies of the human microbiome share both technical and conceptual similarities with genome-wide association studies and genetic epidemiology. However, the microbiome has many features that differ from genomes, such as its temporal and spatial ... ...

Abstract	Studies of the human microbiome share both technical and conceptual similarities with genome-wide association studies and genetic epidemiology. However, the microbiome has many features that differ from genomes, such as its temporal and spatial variability, highly distinct genetic architecture and person-to-person variation. Moreover, there are various potential mechanisms by which distinct aspects of the human microbiome can relate to health outcomes. Recent advances, including next-generation sequencing and the proliferation of multi-omic data types, have enabled the exploration of the mechanisms that connect microbial communities to human health. Here, we review the ways in which features of the microbiome at various body sites can influence health outcomes, and we describe emerging opportunities and future directions for advanced microbiome epidemiology.
MeSH term(s)	Humans ; Genome-Wide Association Study ; Microbiota/genetics ; High-Throughput Nucleotide Sequencing
Language	English
Publishing date	2022-10-05
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2035157-4
ISSN	1471-0064 ; 1471-0056
ISSN (online)	1471-0064
ISSN	1471-0056
DOI	10.1038/s41576-022-00529-x
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Article ; Online: Deep learning for computational structural optimization.

Nguyen, Long C / Nguyen-Xuan, H

ISA transactions

2020 Volume 103, Page(s) 177–191

Abstract: We investigate a novel computational approach to computational structural optimization based on deep learning. After employing algorithms to solve the stiffness formulation of structures, we used their improvement to optimize the structural computation. ... ...

Abstract	We investigate a novel computational approach to computational structural optimization based on deep learning. After employing algorithms to solve the stiffness formulation of structures, we used their improvement to optimize the structural computation. A standard illustration of 10 bar-truss was revisited to illustrate the mechanism of neural networks and deep learning. Several benchmark problems of 2D and 3D truss structures were used to verify the reliability of the present approach, and its extension to other engineering structures is straightforward. To enhance computational efficiency, a constant sum technique was proposed to generate data for the input of multi-similar variables. Both displacement and stress enforcements were the constraints of the optimized problem. The optimization data for cross sections with the objective function of total weight were then employed in the context of deep learning. The stochastic gradient descent (SGD) with Nesterov's accelerated gradient (NAG), root mean square propagation (RMSProp) and adaptive moment estimation (Adam) optimizers were compared in terms of convergence. In addition, this paper devised Chebyshev polynomials for a new approach to activation functions in single-layer neural networks. As expected, its convergence was quicker than the popular learning functions, especially in a short training with a small number of epochs for tested problems. Finally, a split data technique for linear regression was proposed to deal with some sensitive data.
MeSH term(s)	Algorithms ; Deep Learning ; Image Interpretation, Computer-Assisted ; Least-Squares Analysis ; Neural Networks, Computer ; Reproducibility of Results ; Stochastic Processes ; Stress, Mechanical
Language	English
Publishing date	2020-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012746-7
ISSN	1879-2022 ; 0019-0578
ISSN (online)	1879-2022
ISSN	0019-0578
DOI	10.1016/j.isatra.2020.03.033
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Article: Preferences for childbirth delivery and pain relief methods among pregnant women in Vietnam.

Nguyen, Tham Thi / Nguyen, Long Hoang / Nguyen, Ha Thu Thi / Dam, Vu Anh Trong / Vu, Thuc Minh Thi / Latkin, Carl A / Zhang, Melvyn W B / Ho, Roger C M / Ho, Cyrus S H

Frontiers in medicine

2024 Volume 11, Page(s) 1290232

Abstract: Background: Understanding childbirth delivery and pain relief method preferences is important as a part of the shared decision-making process between pregnant women and health professionals. This study aimed to examine the preferences for childbirth ... ...

Abstract	Background: Understanding childbirth delivery and pain relief method preferences is important as a part of the shared decision-making process between pregnant women and health professionals. This study aimed to examine the preferences for childbirth delivery modes and pain relief methods and factors related to these preferences among pregnant women in Vietnam. Methods: A cross-sectional survey on pregnant women was conducted in two obstetrics hospitals in Vietnam. Face-to-face interviews using a structured questionnaire were performed to collect information about sociodemographic characteristics, pregnancy characteristics, preferences for different childbirth delivery modes, and pain relief methods. Multivariate logistic regression was employed for determining associated factors with the preferences. Results: Of 576 pregnant women, 34% of participants preferred cesarean section. Most of the sample did not have any preferences for specific pharmacological pain relief methods (70.1%), while support from partner/relatives was the most preferable non-pharmacological method (61.3%), following by water birth (11.1%) and acupuncture (9.9%). Desire to have another baby, relatives' experience, selection date of birth, and instrumental social support were major drivers of the cesarean section selection. This preference was an important factor in the preference for pharmacological pain relief. Meanwhile, high levels of informational and emotional support were associated with non-pharmacological method preference. Conclusion: This study highlighted a high preference rate for cesarean section in urban pregnant women in Vietnam. Holistic approaches from family, health facility, and policy should be performed to diminish the cesarean rate preference and promote the use of non-pharmacological pain relief methods during birth.
Language	English
Publishing date	2024-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1290232
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