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Article ; Online: T

Captur, Gabriella / Bhandari, Abhiyan / Brühl, Rüdiger / Ittermann, Bernd / Keenan, Kathryn E / Yang, Ye / Eames, Richard J / Benedetti, Giulia / Torlasco, Camilla / Ricketts, Lewis / Boubertakh, Redha / Fatih, Nasri / Greenwood, John P / Paulis, Leonie E M / Lawton, Chris B / Bucciarelli-Ducci, Chiara / Lamb, Hildo J / Steeds, Richard / Leung, Steve W /

Berry, Colin / Valentin, Sinitsyn / Flett, Andrew / de Lange, Charlotte / DeCobelli, Francesco / Viallon, Magalie / Croisille, Pierre / Higgins, David M / Greiser, Andreas / Pang, Wenjie / Hamilton-Craig, Christian / Strugnell, Wendy E / Dresselaers, Tom / Barison, Andrea / Dawson, Dana / Taylor, Andrew J / Mongeon, François-Pierre / Plein, Sven / Messroghli, Daniel / Al-Mallah, Mouaz / Grieve, Stuart M / Lombardi, Massimo / Jang, Jihye / Salerno, Michael / Chaturvedi, Nish / Kellman, Peter / Bluemke, David A / Nezafat, Reza / Gatehouse, Peter / Moon, James C

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

2020 Volume 22, Issue 1, Page(s) 31

Abstract: Background: The T: Methods: Phantoms batch-manufactured in August 2015 underwent 2 years ... setting, T ...

Abstract	Background: The T Methods: Phantoms batch-manufactured in August 2015 underwent 2 years of structural imaging, B Results: Over 2 years, phantom gel integrity remained intact (no rips/tears), B Conclusion: The T1MES CE/FDA approved phantom is a robust quality assurance device. In a multi-center setting, T
MeSH term(s)	Consensus ; Humans ; Magnetic Resonance Imaging/instrumentation ; Magnetic Resonance Imaging/standards ; Observer Variation ; Phantoms, Imaging/standards ; Predictive Value of Tests ; Reproducibility of Results
Language	English
Publishing date	2020-05-07
Publishing country	England
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	1458034-2
ISSN	1532-429X ; 1097-6647
ISSN (online)	1532-429X
ISSN	1097-6647
DOI	10.1186/s12968-020-00613-3
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Book ; Online: Unravelling T. cruzi Biology

Yoshida, Nobuko / Craig Taylor, Martin / Lander, Noelia

2020

Keywords	Science: general issues ; Infectious & contagious diseases ; Trypanosoma cruzi ; Chagas disease ; parasite-host interaction ; gene function ; CRISPR/Cas9 technique
Size	1 electronic resource (236 pages)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021230419
ISBN	9782889660131 ; 2889660133
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: True-T

Makhlouf, Yasmine / Singh, Vivek Kumar / Craig, Stephanie / McArdle, Aoife / French, Dominique / Loughrey, Maurice B / Oliver, Nicola / Acevedo, Juvenal Baena / O'Reilly, Paul / James, Jacqueline A / Maxwell, Perry / Salto-Tellez, Manuel

Computational and structural biotechnology journal

2023 Volume 23, Page(s) 174–185

Abstract: ... interventions has dominated the field of cancer research over the last decade. T-cell lymphocytes ... in the tumor microenvironment are a crucial aspect of cancer's adaptive immunity, and the quantification of T-cells in specific ...

Abstract	The immune response associated with oncogenesis and potential oncological ther- apeutic interventions has dominated the field of cancer research over the last decade. T-cell lymphocytes in the tumor microenvironment are a crucial aspect of cancer's adaptive immunity, and the quantification of T-cells in specific can- cer types has been suggested as a potential diagnostic aid. However, this is cur- rently not part of routine diagnostics. To address this challenge, we present a new method called
Language	English
Publishing date	2023-12-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2694435-2
ISSN	2001-0370
ISSN	2001-0370
DOI	10.1016/j.csbj.2023.11.048
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Article: T

Hamilton-Craig, Christian R / Strudwick, Mark W / Galloway, Graham J

Frontiers in cardiovascular medicine

2017 Volume 3, Page(s) 49

Abstract: Cardiac magnetic resonance (CMR) imaging has been widely used to assess myocardial perfusion and scar and is the non-invasive gold standard for identification of focal myocardial fibrosis. However, the late gadolinium enhancement technique is limited in ... ...

Abstract	Cardiac magnetic resonance (CMR) imaging has been widely used to assess myocardial perfusion and scar and is the non-invasive gold standard for identification of focal myocardial fibrosis. However, the late gadolinium enhancement technique is limited in its accuracy for absolute quantification and assessment of diffuse myocardial fibrosis by technical and pathophysiological features. CMR relaxometry, incorporating
Language	English
Publishing date	2017-03-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2016.00049
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Article ; Online: Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity.

Hamid, Megat H B A / Cespedes, Pablo F / Jin, Chen / Chen, Ji-Li / Gileadi, Uzi / Antoun, Elie / Liang, Zhu / Gao, Fei / Teague, Renuka / Manoharan, Nikita / Maldonado-Perez, David / Khalid-Alham, Nasullah / Cerundolo, Lucia / Ciaoca, Raul / Hester, Svenja S / Pinto-Fernández, Adán / Draganov, Simeon D / Vendrell, Iolanda / Liu, Guihai /

Yao, Xuan / Kvalvaag, Audun / Dominey-Foy, Delaney C C / Nanayakkara, Charunya / Kanellakis, Nikolaos / Chen, Yi-Ling / Waugh, Craig / Clark, Sally-Ann / Clark, Kevin / Sopp, Paul / Rahman, Najib M / Verrill, Clare / Kessler, Benedikt M / Ogg, Graham / Fernandes, Ricardo A / Fisher, Roman / Peng, Yanchun / Dustin, Michael L / Dong, Tao

Nature immunology

2024 Volume 25, Issue 5, Page(s) 834–846

Abstract: Cancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer treatments. In the past decade, ... ...

Abstract	Cancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer treatments. In the past decade, CD103
MeSH term(s)	Humans ; Antigens, CD/metabolism ; Antigens, CD/immunology ; Integrin alpha Chains/metabolism ; Signal Transduction/immunology ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Antigen, T-Cell/immunology ; Animals ; Mice ; Cytotoxicity, Immunologic ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Cell Line, Tumor ; T-Lymphocytes, Cytotoxic/immunology ; Neoplasms/immunology ; Neoplasms/therapy ; Apyrase
Chemical Substances	alpha E integrins ; Antigens, CD ; Integrin alpha Chains ; Receptors, Antigen, T-Cell ; ENTPD1 protein, human (EC 3.6.1.5) ; Apyrase (EC 3.6.1.5)
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-024-01802-3
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Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

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Article: Les guides d'activité physique du Canada : leur publication a t-elle eu un effet?

Cameron, Christine / Craig, Cora L / Bull, Fiona C / Bauman, Adrian

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

2007 Volume 32 Suppl 2F, Page(s) S179–88

Abstract: The purpose of this paper is to examine the reach of different versions of Canada's physical activity guide (CPAG) and their impacts, including immediate effects (awareness, knowledge, beliefs, future intention to be active, first steps towards ... ...

Title translation	Physical Activity guidelines in Canada: has publication had an effect?.
Abstract	The purpose of this paper is to examine the reach of different versions of Canada's physical activity guide (CPAG) and their impacts, including immediate effects (awareness, knowledge, beliefs, future intention to be active, first steps towards behavioural change) and population levels of physical activity. The analysis is based on eligible adults aged 18 years and older (n = 8892) included in the 2003 Physical Activity Monitor (PAM) survey. The 2003 PAM was a cross-sectional, telephone interview of a representative population sample. Secular trends of Canadians aged 12 years and older were examined, using representative samples from the National Population Health and Canadian Community Health Surveys. Unprompted recall of any guidelines for physical activity was very low (4%), whereas prompted recall of the CPAG was higher (37%). Unprompted and prompted recall were higher among women and high-income earners, and increased with level of education. Behaviours associated with "seeking information" and "initiating action" were associated with unprompted and prompted recall. Beliefs about the benefits of physical activity and intention to be active were also associated with prompted recall. Unprompted CPAG recall, knowledge about the amount of activity required to meet the CPAG, intention to be active, "seeking information", and "initiating action" were associated with being "sufficiently active". The CPAG is an appropriate set of public health guidelines or recommendations around physical activity. The low unprompted recall rate points to the need for a coordinated, well-funded approach to communication of these guidelines, involving governmental and non-governmental partners and intermediaries in municipalities, schools, workplaces, and the recreational, public health, and health-care systems.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Canada ; Education ; Exercise/physiology ; Female ; Guidelines as Topic ; Health Education/statistics & numerical data ; Health Surveys ; Humans ; Male ; Middle Aged ; Motor Activity/physiology ; Population ; Sex Factors ; Socioeconomic Factors ; Young Adult
Language	French
Publishing date	2007
Publishing country	Canada
Document type	English Abstract ; Journal Article
ZDB-ID	2236708-1
ISSN	1715-5320 ; 1715-5312
ISSN (online)	1715-5320
ISSN	1715-5312
DOI	10.1139/H07-160
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Article ; Online: Humanization of T cell-mediated immunity in mice.

Moore, Michael J / Zhong, Maggie / Hansen, Johanna / Gartner, Hans / Grant, Craig / Huang, Mei / Harris, Faith M / Tu, Naxin / Bowerman, Natalie A / Edelmann, Kurt H / Barry, Thomas / Herbin, Olivier / Tay, Chin-Siean / DiLillo, David J / Decker, Corinne E / Levenkova, Natasha / Shevchuk, James / Dhanik, Ankur / Meagher, Karoline A /

Science immunology

2021 Volume 6, Issue 66, Page(s) eabj4026

Abstract: Despite the enormous promise of T cell therapies, the isolation and study of human T cell receptors ... mice with a genetically humanized system of T cell immunity. We used VelociGene technology to replace ... peripheral αβ T cell subsets comparable with wild-type mice. VelociT mice expressed a diverse TCR repertoire ...

Abstract	Despite the enormous promise of T cell therapies, the isolation and study of human T cell receptors (TCRs) of dedicated specificity remains a major challenge. To overcome this limitation, we generated mice with a genetically humanized system of T cell immunity. We used VelociGene technology to replace the murine TCRαβ variable regions, along with regions encoding the extracellular domains of co-receptors CD4 and CD8, and major histocompatibility complex (MHC) class I and II, with corresponding human sequences. The resulting “VelociT” mice have normal myeloid and lymphoid immune cell populations, including thymic and peripheral αβ T cell subsets comparable with wild-type mice. VelociT mice expressed a diverse TCR repertoire, mounted functional T cell responses to lymphocytic choriomeningitis virus infection, and could develop experimental autoimmune encephalomyelitis. Immunization of VelociT mice with human tumor-associated peptide antigens generated robust, antigen-specific responses and led to identification of a TCR against tumor antigen New York esophageal squamous cell carcinoma-1 with potent antitumor activity. These studies demonstrate that VelociT mice mount clinically relevant T cell responses to both MHC-I– and MHC-II–restricted antigens, providing a powerful new model for analyzing T cell function in human disease. Moreover, VelociT mice are a new platform for de novo discovery of therapeutic human TCRs.
MeSH term(s)	Animals ; Humans ; Mice ; Mice, Inbred C57BL ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; T-Lymphocytes/immunology
Chemical Substances	Receptors, Antigen, T-Cell, alpha-beta
Language	English
Publishing date	2021-12-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.abj4026
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Article ; Online: Post-infusion CAR T

Good, Zinaida / Spiegel, Jay Y / Sahaf, Bita / Malipatlolla, Meena B / Ehlinger, Zach J / Kurra, Sreevidya / Desai, Moksha H / Reynolds, Warren D / Wong Lin, Anita / Vandris, Panayiotis / Wu, Fang / Prabhu, Snehit / Hamilton, Mark P / Tamaresis, John S / Hanson, Paul J / Patel, Shabnum / Feldman, Steven A / Frank, Matthew J / Baird, John H /

Muffly, Lori / Claire, Gursharan K / Craig, Juliana / Kong, Katherine A / Wagh, Dhananjay / Coller, John / Bendall, Sean C / Tibshirani, Robert J / Plevritis, Sylvia K / Miklos, David B / Mackall, Crystal L

Nature medicine

2022 Volume 28, Issue 9, Page(s) 1860–1871

Abstract: ... CAR) T cell therapies targeting CD19 experience disease progression, and neurotoxicity remains ... proteomic profiling of circulating CAR T cells in 32 patients treated with CD19-CAR identified that CD4 ...

Abstract	Approximately 60% of patients with large B cell lymphoma treated with chimeric antigen receptor (CAR) T cell therapies targeting CD19 experience disease progression, and neurotoxicity remains a challenge. Biomarkers associated with resistance and toxicity are limited. In this study, single-cell proteomic profiling of circulating CAR T cells in 32 patients treated with CD19-CAR identified that CD4
MeSH term(s)	Antigens, CD19 ; Humans ; Immunotherapy, Adoptive/adverse effects ; Immunotherapy, Adoptive/methods ; Lactate Dehydrogenases ; Neurotoxicity Syndromes/etiology ; Proteomics ; Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen
Chemical Substances	Antigens, CD19 ; Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen ; Lactate Dehydrogenases (EC 1.1.-)
Language	English
Publishing date	2022-09-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-022-01960-7
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Zs.A 4212: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function.

Nitz, Katrin / Lacy, Michael / Bianchini, Mariaelvy / Wichapong, Kanin / Kücükgöze, Irem Avcilar / Bonfiglio, Cecilia A / Migheli, Roberta / Wu, Yuting / Burger, Carina / Li, Yuanfang / Forné, Ignasi / Ammar, Constantin / Janjic, Aleksandar / Mohanta, Sarajo / Duchene, Johan / Heemskerk, Johan W M / Megens, Remco T A / Schwedhelm, Edzard / Huveneers, Stephan /

Lygate, Craig A / Santovito, Donato / Zimmer, Ralf / Imhof, Axel / Weber, Christian / Lutgens, Esther / Atzler, Dorothee

Circulation research

2022 Volume 131, Issue 8, Page(s) 701–712

Abstract: ... immunological phenotyping. T cells were characterized using mass spectrometry-based proteomics, by functional ... by which the amino acid homoarginine reduces atherosclerosis, establishing that homoarginine modulates the T-cell ... cytoskeleton and thereby mitigates T-cell functions important during atherogenesis. These findings provide ...

Abstract	Background: Amino acid metabolism is crucial for inflammatory processes during atherogenesis. The endogenous amino acid homoarginine is a robust biomarker for cardiovascular outcome and mortality with high levels being protective. However, the underlying mechanisms remain elusive. We investigated the effect of homoarginine supplementation on atherosclerotic plaque development with a particular focus on inflammation. Methods: Female ApoE-deficient mice were supplemented with homoarginine (14 mg/L) in drinking water starting 2 weeks before and continuing throughout a 6-week period of Western-type diet feeding. Control mice received normal drinking water. Immunohistochemistry and flow cytometry were used for plaque- and immunological phenotyping. T cells were characterized using mass spectrometry-based proteomics, by functional in vitro approaches, for example, proliferation and migration/chemotaxis assays as well as by super-resolution microscopy. Results: Homoarginine supplementation led to a 2-fold increase in circulating homoarginine concentrations. Homoarginine-treated mice exhibited reduced atherosclerosis in the aortic root and brachiocephalic trunk. A substantial decrease in CD3 Conclusions: Our study unravels a novel mechanism by which the amino acid homoarginine reduces atherosclerosis, establishing that homoarginine modulates the T-cell cytoskeleton and thereby mitigates T-cell functions important during atherogenesis. These findings provide a molecular explanation for the beneficial effects of homoarginine in atherosclerotic cardiovascular disease.
MeSH term(s)	Amino Acids ; Animals ; Apolipoproteins E ; Atherosclerosis/drug therapy ; Atherosclerosis/metabolism ; Atherosclerosis/prevention & control ; Drinking Water ; Female ; Homoarginine/pharmacology ; Mice ; Myosin Heavy Chains ; Plaque, Atherosclerotic ; T-Lymphocytes/metabolism
Chemical Substances	Amino Acids ; Apolipoproteins E ; Drinking Water ; Homoarginine (156-86-5) ; Myosin Heavy Chains (EC 3.6.4.1)
Language	English
Publishing date	2022-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.122.321094
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Ui IV Zs.70: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Temporary increase in circulating replication-competent latent HIV-infected resting CD4+ T cells after switch to an integrase inhibitor based antiretroviral regimen.

Ferreira, Roux-Cil / Reynolds, Steven J / Capoferri, Adam A / Baker, Owen R / Brown, Erin E / Klock, Ethan / Miller, Jernelle / Lai, Jun / Saraf, Sharada / Kirby, Charles / Lynch, Briana / Hackman, Jada / Gowanlock, Sarah N / Tomusange, Stephen / Jamiru, Samiri / Anok, Aggrey / Kityamuweesi, Taddeo / Buule, Paul / Bruno, Daniel /

Martens, Craig / Rose, Rebecca / Lamers, Susanna L / Galiwango, Ronald M / Poon, Art F Y / Quinn, Thomas C / Prodger, Jessica L / Redd, Andrew D

EBioMedicine

2024 Volume 102, Page(s) 105040

Abstract: Background: The principal barrier to an HIV cure is the presence of the latent viral reservoir (LVR), which has been understudied in African populations. From 2018 to 2019, Uganda instituted a nationwide rollout of ART consisting of Dolutegravir (DTG) ... ...

Abstract	Background: The principal barrier to an HIV cure is the presence of the latent viral reservoir (LVR), which has been understudied in African populations. From 2018 to 2019, Uganda instituted a nationwide rollout of ART consisting of Dolutegravir (DTG) with two NRTI, which replaced the previous regimen of one NNRTI and the same two NRTI. Methods: Changes in the inducible replication-competent LVR (RC-LVR) of ART-suppressed Ugandans with HIV (n = 88) from 2015 to 2020 were examined using the quantitative viral outgrowth assay. Outgrowth viruses were examined for viral evolution. Changes in the RC-LVR were analyzed using three versions of a Bayesian model that estimated the decay rate over time as a single, linear rate (model A), or allowing for a change at time of DTG initiation (model B&C). Findings: Model A estimated the slope of RC-LVR change as a non-significant positive increase, which was due to a temporary spike in the RC-LVR that occurred 0-12 months post-DTG initiation (p < 0.005). This was confirmed with models B and C; for instance, model B estimated a significant decay pre-DTG initiation with a half-life of 6.9 years, and an ∼1.7-fold increase in the size of the RC-LVR post-DTG initiation. There was no evidence of viral failure or consistent evolution in the cohort. Interpretation: These data suggest that the change from NNRTI- to DTG-based ART is associated with a significant temporary increase in the circulating RC-LVR. Funding: Supported by the NIH (grant 1-UM1AI164565); Gilead HIV Cure Grants Program (90072171); Canadian Institutes of Health Research (PJT-155990); and Ontario Genomics-Canadian Statistical Sciences Institute.
MeSH term(s)	Humans ; CD4-Positive T-Lymphocytes ; HIV Infections/drug therapy ; Bayes Theorem ; HIV-1 ; Virus Latency ; Anti-Retroviral Agents/therapeutic use ; HIV Integrase Inhibitors/pharmacology ; HIV Integrase Inhibitors/therapeutic use ; Ontario ; Viral Load ; East African People
Chemical Substances	Anti-Retroviral Agents ; HIV Integrase Inhibitors
Language	English
Publishing date	2024-03-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2024.105040
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