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Article ; Online: Is It Time for a Requiem for Creatine Supplementation-Induced Kidney Failure? A Narrative Review.

Longobardi, Igor / Gualano, Bruno / Seguro, Antonio Carlos / Roschel, Hamilton

2023 Volume 15, Issue 6

Abstract: Creatine has become one of the most popular dietary supplements among a wide range of healthy and clinical populations. However, its potential adverse effects on kidney health are still a matter of concern. This is a narrative review of the effects of ... ...

Abstract	Creatine has become one of the most popular dietary supplements among a wide range of healthy and clinical populations. However, its potential adverse effects on kidney health are still a matter of concern. This is a narrative review of the effects of creatine supplementation on kidney function. Despite a few case reports and animal studies suggesting that creatine may impair kidney function, clinical trials with controlled designs do not support this claim. Creatine supplementation may increase serum creatinine (Crn) concentration for some individuals, but it does not necessarily indicate kidney dysfunction, as creatine is spontaneously converted into Crn. Based on studies assessing kidney function using reliable methods, creatine supplements have been shown to be safe for human consumption. Further studies with people who have pre-existing kidney disease remain necessary.
MeSH term(s)	Animals ; Humans ; Creatine/adverse effects ; Renal Insufficiency/chemically induced ; Kidney ; Glomerular Filtration Rate ; Dietary Supplements/adverse effects ; Creatinine
Chemical Substances	Creatine (MU72812GK0) ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2023-03-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15061466
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Commentaries on "Effect of blood-flow restricted vs heavy-load strength training on muscle strength: Systematic review and meta-analysis".

Emílio Lixandrão, Manoel / Ugrinowitsch, Carlos / Roschel, Hamilton

Scandinavian journal of medicine & science in sports

2021 Volume 31, Issue 2, Page(s) 489–492

MeSH term(s)	Hemodynamics ; Humans ; Muscle Strength/physiology ; Muscle, Skeletal/physiology ; Resistance Training
Language	English
Publishing date	2021-01-22
Publishing country	Denmark
Document type	Letter ; Comment
ZDB-ID	1077418-x
ISSN	1600-0838 ; 0905-7188
ISSN (online)	1600-0838
ISSN	0905-7188
DOI	10.1111/sms.13875
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exercise Is Key to Sustaining Metabolic Gains After Bariatric Surgery.

Gualano, Bruno / Kirwan, John P / Roschel, Hamilton

Exercise and sport sciences reviews

2021 Volume 49, Issue 3, Page(s) 197–204

Abstract: The extent to which the benefits of bariatric surgery may be maintained by lifestyle changes after surgery is unclear. Our hypothesis is that exercise may sustain some metabolic benefits and counteract some of the adverse effects of surgery. In this ... ...

Abstract	The extent to which the benefits of bariatric surgery may be maintained by lifestyle changes after surgery is unclear. Our hypothesis is that exercise may sustain some metabolic benefits and counteract some of the adverse effects of surgery. In this review, we present findings supporting the proposition that exercise is key to improving overall health in patients after bariatric surgery.
MeSH term(s)	Bariatric Surgery ; Exercise ; Humans ; Life Style ; Obesity, Morbid/surgery ; Weight Loss
Language	English
Publishing date	2021-06-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	187040-3
ISSN	1538-3008 ; 0091-6331
ISSN (online)	1538-3008
ISSN	0091-6331
DOI	10.1249/JES.0000000000000253
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Article ; Online: Use of factor analysis to model relationships between bone mass and physical, dietary, and metabolic factors in frail and pre-frail older adults.

Esteves, Gabriel P / Swinton, Paul / Sale, Craig / Gualano, Bruno / Roschel, Hamilton / Dolan, Eimear

Journal of applied physiology (Bethesda, Md. : 1985)

2023 Volume 135, Issue 1, Page(s) 146–153

Abstract: Bone mass and quality decline with age, and can culminate in osteoporosis and increased fracture risk. This investigation modeled associations between bone and physical, dietary, and metabolic factors in a group of 200 pre-frail/frail older adults using ... ...

Abstract	Bone mass and quality decline with age, and can culminate in osteoporosis and increased fracture risk. This investigation modeled associations between bone and physical, dietary, and metabolic factors in a group of 200 pre-frail/frail older adults using factor analysis and structural equation modeling (SEM). Exploratory (EFA) and confirmatory factor analysis (CFA) were conducted to compose factors and to assess their robustness. SEM was used to quantify associations between bone and the other factors. Factors arising from EFA and CFA were: bone (whole body, lumbar and femur bone mineral density, and trabecular bone score; good fit), body composition - lean (lean mass, body mass, vastus lateralis, and femoral cross-sectional area; good fit), body composition - fat (total fat mass, gynoid, android, and visceral fat; acceptable fit), strength (bench and leg press, handgrip, and knee extension peak torque; good fit), dietary intake (kilocalories, carbohydrate, protein, and fat; acceptable fit), and metabolic status (cortisol, insulin-like growth factor 1 (IGF-1), growth hormone (GH), and free testosterone; poor fit). SEM using isolated factors showed that body composition (lean) (β = 0.66,
MeSH term(s)	Humans ; Aged ; Bone Density ; Frail Elderly ; Hand Strength ; Absorptiometry, Photon ; Body Composition
Language	English
Publishing date	2023-05-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219139-8
ISSN	1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
ISSN (online)	1522-1601
ISSN	0021-8987 ; 0161-7567 ; 8750-7587
DOI	10.1152/japplphysiol.00129.2023
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Article ; Online: Risk of Increased Physical Inactivity During COVID-19 Outbreak in Older People: A Call for Actions.

Roschel, Hamilton / Artioli, Guilherme G / Gualano, Bruno

Journal of the American Geriatrics Society

2020 Volume 68, Issue 6, Page(s) 1126–1128

MeSH term(s)	Aged ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Female ; Humans ; Male ; Muscular Atrophy/psychology ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; Quarantine/psychology ; Risk Factors ; SARS-CoV-2 ; Sedentary Behavior
Keywords	covid19
Language	English
Publishing date	2020-05-14
Publishing country	United States
Document type	Editorial
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.16550
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Article ; Online: Creatine supplementation for older adults: Focus on sarcopenia, osteoporosis, frailty and Cachexia.

Candow, Darren G / Chilibeck, Philip D / Forbes, Scott C / Fairman, Ciaran M / Gualano, Bruno / Roschel, Hamilton

Bone

2022 Volume 162, Page(s) 116467

Abstract: Sarcopenia refers to the age-related reduction in strength, muscle mass and functionality which increases the risk for falls, injuries and fractures. Sarcopenia is associated with other age-related conditions such as osteoporosis, frailty and cachexia. ... ...

Abstract	Sarcopenia refers to the age-related reduction in strength, muscle mass and functionality which increases the risk for falls, injuries and fractures. Sarcopenia is associated with other age-related conditions such as osteoporosis, frailty and cachexia. Identifying treatments to overcome sarcopenia and associated conditions is important from a global health perspective. There is evidence that creatine monohydrate supplementation, primarily when combined with resistance training, has favorable effects on indices of aging muscle and bone. These musculoskeletal benefits provide some rationale for creatine being a potential intervention for treating frailty and cachexia. The purposes of this narrative review are to update the collective body of research pertaining to the effects of creatine supplementation on indices of aging muscle and bone (including bone turnover markers) and present possible justification and rationale for its utilization in the treatment of frailty and cachexia in older adults.
MeSH term(s)	Aged ; Cachexia ; Creatine/therapeutic use ; Dietary Supplements ; Frailty/complications ; Frailty/drug therapy ; Humans ; Muscle Strength/physiology ; Osteoporosis/complications ; Osteoporosis/drug therapy ; Sarcopenia/complications ; Sarcopenia/drug therapy
Chemical Substances	Creatine (MU72812GK0)
Language	English
Publishing date	2022-06-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	632515-4
ISSN	1873-2763 ; 8756-3282
ISSN (online)	1873-2763
ISSN	8756-3282
DOI	10.1016/j.bone.2022.116467
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Zs.A 1571: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 332: Show issues

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Article ; Online: Creatine Supplementation and Brain Health.

Roschel, Hamilton / Gualano, Bruno / Ostojic, Sergej M. / Rawson, Eric S.

Nutrients

2021 Volume 13, Issue 2

Abstract: There is a robust and compelling body of evidence supporting the ergogenic and therapeutic role of creatine supplementation in muscle. Beyond these well-described effects and mechanisms, there is literature to suggest that creatine may also be beneficial ...

Abstract	There is a robust and compelling body of evidence supporting the ergogenic and therapeutic role of creatine supplementation in muscle. Beyond these well-described effects and mechanisms, there is literature to suggest that creatine may also be beneficial to brain health (e.g., cognitive processing, brain function, and recovery from trauma). This is a growing field of research, and the purpose of this short review is to provide an update on the effects of creatine supplementation on brain health in humans. There is a potential for creatine supplementation to improve cognitive processing, especially in conditions characterized by brain creatine deficits, which could be induced by acute stressors (e.g., exercise, sleep deprivation) or chronic, pathologic conditions (e.g., creatine synthesis enzyme deficiencies, mild traumatic brain injury, aging, Alzheimer's disease, depression). Despite this, the optimal creatine protocol able to increase brain creatine levels is still to be determined. Similarly, supplementation studies concomitantly assessing brain creatine and cognitive function are needed. Collectively, data available are promising and future research in the area is warranted.
MeSH term(s)	Aging ; Alzheimer Disease/therapy ; Blood-Brain Barrier/metabolism ; Brain/drug effects ; Brain Concussion/therapy ; Brain Injuries/therapy ; Cognition/drug effects ; Creatine/administration & dosage ; Creatine/metabolism ; Dietary Supplements ; Exercise ; Female ; Health Status ; Humans ; Male ; Muscle, Skeletal/drug effects ; Performance-Enhancing Substances/administration & dosage ; Performance-Enhancing Substances/metabolism
Chemical Substances	Performance-Enhancing Substances ; Creatine (MU72812GK0)
Language	English
Publishing date	2021-02-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13020586
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Article ; Online: Response to Letter to the Editor: "Exercise Mitigates Bone Loss in Women With Severe Obesity After Roux-en-Y Gastric Bypass: A Randomized Controlled Trial".

Murai, Igor Hisashi / Roschel, Hamilton / Gualano, Bruno

The Journal of clinical endocrinology and metabolism

2019 Volume 105, Issue 3

Language	English
Publishing date	2019-10-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgz109
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Article ; Online: Physiology of sedentary behavior.

Pinto, Ana J / Bergouignan, Audrey / Dempsey, Paddy C / Roschel, Hamilton / Owen, Neville / Gualano, Bruno / Dunstan, David W

Physiological reviews

2023 Volume 103, Issue 4, Page(s) 2561–2622

Abstract: Sedentary behaviors (SB) are characterized by low energy expenditure while in a sitting or reclining posture. Evidence relevant to understanding the physiology of SB can be derived from studies employing several experimental models: bed rest, ... ...

Abstract	Sedentary behaviors (SB) are characterized by low energy expenditure while in a sitting or reclining posture. Evidence relevant to understanding the physiology of SB can be derived from studies employing several experimental models: bed rest, immobilization, reduced step count, and reducing/interrupting prolonged SB. We examine the relevant physiological evidence relating to body weight and energy balance, intermediary metabolism, cardiovascular and respiratory systems, the musculoskeletal system, the central nervous system, and immunity and inflammatory responses. Excessive and prolonged SB can lead to insulin resistance, vascular dysfunction, shift in substrate use toward carbohydrate oxidation, shift in muscle fiber from oxidative to glycolytic type, reduced cardiorespiratory fitness, loss of muscle mass and strength and bone mass, and increased total body fat mass and visceral fat depot, blood lipid concentrations, and inflammation. Despite marked differences across individual studies, longer term interventions aimed at reducing/interrupting SB have resulted in small, albeit marginally clinically meaningful, benefits on body weight, waist circumference, percent body fat, fasting glucose, insulin, HbA1c and HDL concentrations, systolic blood pressure, and vascular function in adults and older adults. There is more limited evidence for other health-related outcomes and physiological systems and for children and adolescents. Future research should focus on the investigation of molecular and cellular mechanisms underpinning adaptations to increasing and reducing/interrupting SB and the necessary changes in SB and physical activity to impact physiological systems and overall health in diverse population groups.
MeSH term(s)	Child ; Adolescent ; Humans ; Aged ; Sedentary Behavior ; Exercise/physiology ; Cardiovascular System ; Body Weight ; Insulins
Chemical Substances	Insulins
Language	English
Publishing date	2023-06-16
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209902-0
ISSN	1522-1210 ; 0031-9333
ISSN (online)	1522-1210
ISSN	0031-9333
DOI	10.1152/physrev.00022.2022
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Article ; Online: Association between ultra-processed food and flavonoid intakes in a nationally representative sample of the US population.

Leitão, Alice Erwig / Roschel, Hamilton / Oliveira-Júnior, Gersiel / Genario, Rafael / Franco, Tathiane / Monteiro, Carlos Augusto / Martinez-Steele, Euridice

The British journal of nutrition

2023 Volume 131, Issue 6, Page(s) 1074–1083

Abstract: Consumption of ultra-processed food (UPF) has been associated with several chronic diseases and poor diet quality. It is reasonable to speculate that the consumption of UPF negatively associates with flavonoid dietary intake; however, this assumption has ...

Abstract	Consumption of ultra-processed food (UPF) has been associated with several chronic diseases and poor diet quality. It is reasonable to speculate that the consumption of UPF negatively associates with flavonoid dietary intake; however, this assumption has not been previously examined. The present study aims to assess association between the dietary contribution of UPF and flavonoid intake in the US population aged 0 years and above. We performed a cross-sectional analysis of dietary data collected by 24-h recalls from 7640 participants participating in the National Health and Nutrition Examination Survey 2017-2018. Foods were classified according to the Nova classification system. The updated US Department of Agriculture (USDA) Database for the Flavonoid Content of Selected Foods (Release 3.3) database was used to estimate total and six classes of flavonoid intakes. Flavonoid intakes were compared across quintiles of dietary contribution of UPF (% of total energy intake) using linear regression models. The total and five out of six class flavonoid intakes decreased between 50 and 70 % across extreme quintiles of the dietary contribution of UPF (
MeSH term(s)	Humans ; Nutrition Surveys ; Food, Processed ; Flavonoids ; Cross-Sectional Studies ; Food Handling ; Fast Foods ; Diet ; Energy Intake ; Isoflavones
Chemical Substances	Flavonoids ; Isoflavones
Language	English
Publishing date	2023-11-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114523002568
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