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Article ; Online: Association of a coronavirus disease 2019 (COVID-19) vaccine booster with control of a COVID-19 outbreak in a long-term care facility in Switzerland, November to December 2021.

Leiblein, Thomas W / Winistörfer, Annemarie / Seiler, Kurt / Hauri, Rudolf / Sommerstein, Rami

Infection control and hospital epidemiology

2023 Volume 45, Issue 4, Page(s) 543–545

Abstract: Coronavirus disease 2019 (COVID-19) outbreaks in long-term care facilities are often correlated with high case fatality rates. We describe the association of administration of an mRNA booster with the control of an outbreak. Our findings highlight the ... ...

Abstract	Coronavirus disease 2019 (COVID-19) outbreaks in long-term care facilities are often correlated with high case fatality rates. We describe the association of administration of an mRNA booster with the control of an outbreak. Our findings highlight the possibility of vaccine booster early in an outbreak as a promising method to mitigate the spread of infection.
MeSH term(s)	Humans ; COVID-19 Vaccines ; COVID-19/prevention & control ; Switzerland/epidemiology ; Long-Term Care ; Nursing Homes ; Disease Outbreaks/prevention & control
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-12-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2023.240
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Zs.A 1714: Show issues

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Article ; Online: Invasive Mycobacterium chimaera Infections and Heater-Cooler Devices in Cardiac Surgery.

Sommerstein, Rami / Hasse, Barbara / Widmer, Andreas F

Emerging infectious diseases

2020 Volume 26, Issue 3, Page(s) 632–633

MeSH term(s)	Cardiac Surgical Procedures ; Chimera ; Global Health ; Humans ; Mycobacterium ; Mycobacterium Infections
Language	English
Publishing date	2020-02-24
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2603.191818
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Zs.A 4778: Show issues

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Article: OP-Design reduziert Spitalinfektionen

Sommerstein, Rami

Hygiene + Medizin: Zeitschrift für angewandte Hygiene in Krankenhäusern und Praxis

2016 Volume 42, Issue 11, Page(s) 293

Abstract: Nach grossen Herzoperationen kann es in seltenen Fällen zu Infektionen mit M.chimaera kommen. Ein Gerät zur Regulation der Körperwärme ist dafür verantwortlich. Seit der Entdeckung erarbeitet das Berner Inselspital Richtlinien zur Infektionsprävention. ...

Abstract	Nach grossen Herzoperationen kann es in seltenen Fällen zu Infektionen mit M.chimaera kommen. Ein Gerät zur Regulation der Körperwärme ist dafür verantwortlich. Seit der Entdeckung erarbeitet das Berner Inselspital Richtlinien zur Infektionsprävention.
Language	German
Document type	Article
ZDB-ID	518696-1
ISSN	0172-3790
ISSN	0172-3790
Database	bibnet.org

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Zs.B 1725: Show issues

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Article ; Online: Meticillin-resistant

Bächli, Magi / Sommerstein, Rami / Casanova, Carlo / Droz, Sara / Küffer, Marianne / Marschall, Jonas

Infection prevention in practice

2022 Volume 4, Issue 2, Page(s) 100211

Abstract: Background: The optimal screening strategy in hospitals to identify secondary cases after contact with a meticillin-resistant : Method: Single center, retrospective, nested case-control study. We evaluated the screening strategy in our 950 bed ... ...

Abstract	Background: The optimal screening strategy in hospitals to identify secondary cases after contact with a meticillin-resistant Method: Single center, retrospective, nested case-control study. We evaluated the screening strategy in our 950 bed tertiary care hospital from 2008 - 2014. Room and ward contacts of MRSA index patients present at time of MRSA identification were screened. We compared characteristics of Results: Among 270,000 inpatients from 2008 - 2014, 215 MRSA screenings yielded 3013 contact patients, and 6 (0.2%) spa-type matched pairs. We included 225 controls for the nested case-control study. The contact type for the cases was more frequently "same room" and less frequently "same ward" compared with the controls ( Conclusion: The extensive MRSA screening strategy revealed only few index/contact matches based on spa-typing. Prolonged exposure time and a shared room were significantly associated with MRSA transmission. A targeted screening strategy may be more useful in a low prevalence setting than screening entire wards.
Language	English
Publishing date	2022-02-25
Publishing country	England
Document type	Journal Article
ISSN	2590-0889
ISSN (online)	2590-0889
DOI	10.1016/j.infpip.2022.100211
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Article: Infections postchirurgie artérielle des membres inférieurs : peut-on mieux faire?

Catho, Gaud / Moulin, Estelle / Sommerstein, Rami / Deslarzes, Céline / Arts, Laure / Danzer, Daniel / Haller, Claude / Berthod, Delphine

Revue medicale suisse

2023 Volume 19, Issue 845, Page(s) 1824–1829

Abstract: Infections associated with arterial reconstructions of the lower limbs are associated with high morbidity. This article reviews the risk factors for infection associated with this surgery and the preventive measures. These include smoking cessation and ... ...

Title translation	Surgical site infection after lower limb arterial reconstruction: can we improve prevention?
Abstract	Infections associated with arterial reconstructions of the lower limbs are associated with high morbidity. This article reviews the risk factors for infection associated with this surgery and the preventive measures. These include smoking cessation and glycemic control preoperatively; avoiding unnecessary exposure to antibiotics or corticosteroids; optimal peripheral wound care; rigorous antisepsis and antibiotic prophylaxis in the operating theatre and finally, meticulous post-operative wound monitoring. The benefit of Staphylococcus aureus decolonization in vascular surgery is less clearly established than in cardiac and thoracic surgery, but it is still recommended in cases of implant placement or where there is a high risk of S. aureus infection, depending on the planned approach and type of surgery.
MeSH term(s)	Humans ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/prevention & control ; Surgical Wound Infection/drug therapy ; Staphylococcus aureus ; Anti-Bacterial Agents/therapeutic use ; Staphylococcal Infections/drug therapy ; Antibiotic Prophylaxis/adverse effects ; Vascular Surgical Procedures/adverse effects
Chemical Substances	Anti-Bacterial Agents
Language	French
Publishing date	2023-10-11
Publishing country	Switzerland
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2023.19.845.1824
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Article ; Online: Invasive Mycobacterium chimaera Infections and Heater-Cooler Devices in Cardiac Surgery

Rami Sommerstein / Barbara Hasse / Andreas F. Widmer

Emerging Infectious Diseases, Vol 26, Iss 3, Pp 632-

2020 Volume 633

Keywords	Mycobacterium chimaera ; surgical site infection ; cardiac surgery ; healthcare-associated infection ; tuberculosis and other mycobacteria ; equipment contamination ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Centers for Disease Control and Prevention
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Timing of Cefuroxime Surgical Antimicrobial Prophylaxis and Its Association With Surgical Site Infections.

Sommerstein, Rami / Troillet, Nicolas / Harbarth, Stephan / de Kraker, Marlieke E A / Vuichard-Gysin, Danielle / Kuster, Stefan P / Widmer, Andreas F

JAMA network open

2023 Volume 6, Issue 6, Page(s) e2317370

Abstract: Importance: World Health Organization guidelines recommend administering surgical antimicrobial prophylaxis (SAP), including cefuroxime, within 120 minutes prior to incision. However, data from clinical settings supporting this long interval is limited.! ...

Abstract	Importance: World Health Organization guidelines recommend administering surgical antimicrobial prophylaxis (SAP), including cefuroxime, within 120 minutes prior to incision. However, data from clinical settings supporting this long interval is limited. Objective: To assess whether earlier vs later timing of administration of cefuroxime SAP is associated with the occurrence of surgical site infections (SSI). Design, setting, and participants: This cohort study included adult patients who underwent 1 of 11 major surgical procedures with cefuroxime SAP, documented by the Swissnoso SSI surveillance system between January 2009 and December 2020 at 158 Swiss hospitals. Data were analyzed from January 2021 to April 2023. Exposures: Timing of cefuroxime SAP administration before incision was divided into 3 groups: 61 to 120 minutes before incision, 31 to 60 minutes before incision, and 0 to 30 minutes before incision. In addition, a subgroup analysis was performed with time windows of 30 to 55 minutes and 10 to 25 minutes as a surrogate marker for administration in the preoperating room vs in the operating room, respectively. The timing of SAP administration was defined as the start of the infusion obtained from the anesthesia protocol. Main outcomes and measures: Occurrence of SSI according to Centers for Disease Control and Prevention definitions. Mixed-effects logistic regression models adjusted for institutional, patient, and perioperative variables were applied. Results: Of 538 967 surveilled patients, 222 439 (104 047 men [46.8%]; median [IQR] age, 65.7 [53.9-74.2] years), fulfilled inclusion criteria. SSI was identified in 5355 patients (2.4%). Cefuroxime SAP was administered 61 to 120 minutes prior to incision in 27 207 patients (12.2%), 31 to 60 minutes prior to incision in 118 004 patients (53.1%), and 0 to 30 minutes prior to incision in 77 228 patients (34.7%). SAP administration at 0 to 30 minutes was significantly associated with a lower SSI rate (adjusted odds ratio [aOR], 0.85; 95% CI, 0.78-0.93; P < .001), as was SAP administration 31 to 60 minutes prior to incision (aOR, 0.91; 95% CI, 0.84-0.98; P = .01) compared with administration 61 to 120 minutes prior to incision. Administration 10 to 25 minutes prior to incision in 45 448 patients (20.4%) was significantly associated with a lower SSI rate (aOR, 0.89; 95% CI, 0.82-0.97; P = .009) vs administration within 30 to 55 minutes prior to incision in 117 348 patients (52.8%). Conclusions and relevance: In this cohort study, administration of cefuroxime SAP closer to the incision time was associated with significantly lower odds of SSI, suggesting that cefuroxime SAP should be administrated within 60 minutes prior to incision, and ideally within 10 to 25 minutes.
MeSH term(s)	United States ; Male ; Adult ; Humans ; Aged ; Cefuroxime/therapeutic use ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/prevention & control ; Surgical Wound Infection/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Cohort Studies ; Antibiotic Prophylaxis/methods ; Risk Factors ; Time Factors ; Anti-Infective Agents/therapeutic use
Chemical Substances	Cefuroxime (O1R9FJ93ED) ; Anti-Bacterial Agents ; Anti-Infective Agents
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.17370
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Coronavirus Disease 2019 (COVID-19): Do Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers Have a Biphasic Effect?

Sommerstein, Rami / Kochen, Michael M / Messerli, Franz H / Gräni, Christoph

Journal of the American Heart Association

2020 Volume 9, Issue 7, Page(s) e016509

MeSH term(s)	Angiotensin Receptor Antagonists/adverse effects ; Angiotensin Receptor Antagonists/pharmacology ; Angiotensin-Converting Enzyme 2 ; Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Betacoronavirus/drug effects ; COVID-19 ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/drug therapy ; Comorbidity ; Coronavirus Infections/complications ; Coronavirus Infections/mortality ; Disease Notification ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/drug effects ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index
Chemical Substances	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Keywords	covid19
Language	English
Publishing date	2020-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.120.016509
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Article ; Online: Nosocomial outbreak of vancomycin-resistant

Piezzi, Vanja / Wassilew, Nasstasja / Atkinson, Andrew / D'Incau, Stéphanie / Kaspar, Tanja / Seth-Smith, Helena Mb / Casanova, Carlo / Bittel, Pascal / Jent, Philipp / Sommerstein, Rami / Buetti, Niccolò / Marschall, Jonas

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2023 Volume 27, Issue 48

Abstract: A large clonal outbreak caused by vancomycin- ... ...

Abstract	A large clonal outbreak caused by vancomycin-resistant
MeSH term(s)	Humans ; Vancomycin ; Enterococcus faecium/genetics ; Cross Infection/epidemiology ; Switzerland/epidemiology ; Vancomycin-Resistant Enterococci/genetics ; Disease Outbreaks ; Hospitals, University ; Gram-Positive Bacterial Infections/epidemiology
Chemical Substances	Vancomycin (6Q205EH1VU)
Language	English
Publishing date	2023-01-24
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2022.27.48.2200285
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Zs.A 5066: Show issues

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Article ; Online: Meticillin-resistant Staphylococcus aureus Contact Screening Strategy in a Low Prevalence Setting; a Nested Case-Control Study

Magi Bächli / Rami Sommerstein / Carlo Casanova / Sara Droz / Marianne Küffer / Jonas Marschall

Infection Prevention in Practice, Vol 4, Iss 2, Pp 100211- (2022)

2022

Abstract: Summary: Background: The optimal screening strategy in hospitals to identify secondary cases after contact with a meticillin-resistant Staphylococcus aureus (MRSA) index patient in a low prevalence setting is not well defined. We aimed at identifying ... ...

Abstract	Summary: Background: The optimal screening strategy in hospitals to identify secondary cases after contact with a meticillin-resistant Staphylococcus aureus (MRSA) index patient in a low prevalence setting is not well defined. We aimed at identifying factors associated with documented MRSA transmissions. Method: Single center, retrospective, nested case-control study. We evaluated the screening strategy in our 950 bed tertiary care hospital from 2008 – 2014. Room and ward contacts of MRSA index patients present at time of MRSA identification were screened. We compared characteristics of Staphylococcus aureus Protein A (spa)-type matched contact patients (cases) to negative or spa-type mismatched contact patients (controls). Results: Among 270,000 inpatients from 2008 – 2014, 215 MRSA screenings yielded 3013 contact patients, and 6 (0.2%) spa-type matched pairs. We included 225 controls for the nested case-control study. The contact type for the cases was more frequently “same room” and less frequently “same ward” compared with the controls (P = 0.001). Also, exposure time was longer for cases (median of 6 days [IQR 3–9]) than for controls (1 day [0–3], P=0.016). Conclusion: The extensive MRSA screening strategy revealed only few index/contact matches based on spa-typing. Prolonged exposure time and a shared room were significantly associated with MRSA transmission. A targeted screening strategy may be more useful in a low prevalence setting than screening entire wards.
Keywords	MRSA ; Screening strategy ; Spa type ; Contact patient ; Nosocomial transmission ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Subject code	616
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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