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  1. Article ; Online: Toward a new threshold for the P value?

    Laccourreye, O / Maisonneuve, H

    European annals of otorhinolaryngology, head and neck diseases

    2018  Volume 135, Issue 5, Page(s) 299

    MeSH term(s) Biomedical Research ; Humans ; Models, Statistical ; Probability ; Societies
    Language English
    Publishing date 2018-06-08
    Publishing country France
    Document type Editorial
    ZDB-ID 2558008-5
    ISSN 1879-730X ; 1879-7296
    ISSN (online) 1879-730X
    ISSN 1879-7296
    DOI 10.1016/j.anorl.2018.05.010
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  2. Article ; Online: Photophysical Properties of 4-Dicyanomethylene-2-methyl-6-(p-dimethylamino-styryl)-4H-pyran Revisited: Fluorescence versus Photoisomerization.

    Casimiro, Lorenzo / Maisonneuve, Stéphane / Retailleau, Pascal / Silvi, Serena / Xie, Juan / Métivier, Rémi

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2020  Volume 26, Issue 63, Page(s) 14256

    Abstract: Invited for the cover of this issue are Juan Xie, Rémi Métivier and co-workers at Université Paris-Saclay and Università di Bologna. The image depicts the fluorescence of the DCM molecule reported in this manuscript. Read the full text of the article at ... ...

    Abstract Invited for the cover of this issue are Juan Xie, Rémi Métivier and co-workers at Université Paris-Saclay and Università di Bologna. The image depicts the fluorescence of the DCM molecule reported in this manuscript. Read the full text of the article at 10.1002/chem.202002828.
    Language English
    Publishing date 2020-10-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202004202
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  3. Article ; Online: Photophysical Properties of 4-Dicyanomethylene-2-methyl-6-(p-dimethylamino-styryl)-4H-pyran Revisited: Fluorescence versus Photoisomerization.

    Casimiro, Lorenzo / Maisonneuve, Stéphane / Retailleau, Pascal / Silvi, Serena / Xie, Juan / Métivier, Rémi

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2020  Volume 26, Issue 63, Page(s) 14341–14350

    Abstract: Although 4-dicyanomethylene-2-methyl-6-(p-dimethylamino-styryl)-4H-pyran (DCM) has been known ...

    Abstract Although 4-dicyanomethylene-2-methyl-6-(p-dimethylamino-styryl)-4H-pyran (DCM) has been known for many decades as a bright and photostable fluorophore, used for a wide variety of applications in chemistry, biology and physics, only little attention has been paid so far to the presence of multiple isomers and conformers, namely s-trans-(E), s-cis-(E), s-trans-(Z), and s-cis-(Z). In particular, light-induced E-Z isomerization plays a great role on the overall photophysical properties of DCM. Herein, we give a full description of a photoswitchable DCM derivative by a combination of structural, theoretical and spectroscopic methods. The main s-trans-(E) isomer is responsible for most of the fluorescence features, whereas the s-cis-(E) conformer only contributes marginally. The non-emitting Z isomers are generated in large conversion yields upon illumination with visible light (e.g., 485 or 514 nm) and converted back to the E forms by UV irradiation (e.g., 365 nm). Such photoswitching is efficient and reversible, with high fatigue resistance. The E→Z and Z→E photoisomerization quantum yields were determined in different solvents and at different irradiation wavelengths. Interestingly, the fluorescence and photoisomerization properties are strongly influenced by the solvent polarity: the fluorescence is predominant at higher polarity, whereas photoisomerization becomes more efficient at lower polarity. Intermediate medium (THF) represents an optimized situation with a good balance between these two features.
    Language English
    Publishing date 2020-09-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202002828
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  4. Article ; Online: (p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin Activity.

    Maisonneuve, Etienne / Castro-Camargo, Manuela / Gerdes, Kenn

    Cell

    2018  Volume 172, Issue 5, Page(s) 1135

    Language English
    Publishing date 2018-03-09
    Publishing country United States
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2018.02.023
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    Zs.A 1167: Show issues Location:
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  5. Article ; Online: (p)ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity.

    Maisonneuve, Etienne / Castro-Camargo, Manuela / Gerdes, Kenn

    publication RETRACTED

    Cell

    2013  Volume 154, Issue 5, Page(s) 1140–1150

    Abstract: ... to resuscitate. The persistence phenotype depends hierarchically on the signaling nucleotide (p)ppGpp, Lon ... protease, inorganic polyphosphate, and toxin-antitoxins. We show that the level of (p)ppGpp varies ... stochastically in a population of exponentially growing cells and that the high (p)ppGpp level in rare cells ...

    Abstract Persistence refers to the phenomenon in which isogenic populations of antibiotic-sensitive bacteria produce rare cells that transiently become multidrug tolerant. Whether slow growth in a rare subset of cells underlies the persistence phenotype has not be examined in wild-type bacteria. Here, we show that an exponentially growing population of wild-type Escherichia coli cells produces rare cells that stochastically switch into slow growth, that the slow-growing cells are multidrug tolerant, and that they are able to resuscitate. The persistence phenotype depends hierarchically on the signaling nucleotide (p)ppGpp, Lon protease, inorganic polyphosphate, and toxin-antitoxins. We show that the level of (p)ppGpp varies stochastically in a population of exponentially growing cells and that the high (p)ppGpp level in rare cells induces slow growth and persistence. (p)ppGpp triggers slow growth by activating toxin-antitoxin loci through a regulatory cascade depending on inorganic polyphosphate and Lon protease.
    MeSH term(s) Antitoxins/metabolism ; Bacterial Toxins/metabolism ; Drug Resistance, Multiple, Bacterial ; Escherichia coli/drug effects ; Escherichia coli/growth & development ; Escherichia coli/metabolism ; Guanosine Pentaphosphate/metabolism ; Polyphosphates/metabolism ; Protease La/metabolism ; Transcription, Genetic
    Chemical Substances Antitoxins ; Bacterial Toxins ; Polyphosphates ; Guanosine Pentaphosphate (38918-96-6) ; Protease La (EC 3.4.21.53)
    Language English
    Publishing date 2013-08-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2013.07.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases.

    Germain, Elsa / Roghanian, Mohammad / Gerdes, Kenn / Maisonneuve, Etienne

    publication RETRACTED

    Proceedings of the National Academy of Sciences of the United States of America

    2015  Volume 112, Issue 16, Page(s) 5171–5176

    Abstract: ... strong support for a model proposing (p)ppGpp (guanosine tetra and penta-phosphate) as the master ... regulator of persistence. Stochastic variation of [(p)ppGpp] in single cells induced TA-encoded mRNases via ... However, even though it was known that activation of HipA stimulated (p)ppGpp synthesis, our model did not ...

    Abstract The model organism Escherichia coli codes for at least 11 type II toxin-antitoxin (TA) modules, all implicated in bacterial persistence (multidrug tolerance). Ten of these encode messenger RNA endonucleases (mRNases) inhibiting translation by catalytic degradation of mRNA, and the 11th module, hipBA, encodes HipA (high persister protein A) kinase, which inhibits glutamyl tRNA synthetase (GltX). In turn, inhibition of GltX inhibits translation and induces the stringent response and persistence. Previously, we presented strong support for a model proposing (p)ppGpp (guanosine tetra and penta-phosphate) as the master regulator of persistence. Stochastic variation of [(p)ppGpp] in single cells induced TA-encoded mRNases via a pathway involving polyphosphate and Lon protease. Polyphosphate activated Lon to degrade all known type II antitoxins of E. coli. In turn, the activated mRNases induced persistence and multidrug tolerance. However, even though it was known that activation of HipA stimulated (p)ppGpp synthesis, our model did not explain how hipBA induced persistence. Here we show that, in support of and consistent with our initial model, HipA-induced persistence depends not only on (p)ppGpp but also on the 10 mRNase-encoding TA modules, Lon protease, and polyphosphate. Importantly, observations with single cells convincingly show that the high level of (p)ppGpp caused by activation of HipA does not induce persistence in the absence of TA-encoded mRNases. Thus, slow growth per se does not induce persistence in the absence of TA-encoded toxins, placing these genes as central effectors of bacterial persistence.
    MeSH term(s) Alleles ; Antitoxins/metabolism ; Bacterial Toxins/metabolism ; Endonucleases/metabolism ; Enzyme Activation ; Escherichia coli Proteins/metabolism ; Guanosine Pentaphosphate/metabolism ; Guanosine Tetraphosphate/metabolism ; Models, Molecular ; RNA, Messenger/metabolism ; Stochastic Processes ; Time-Lapse Imaging
    Chemical Substances Antitoxins ; Bacterial Toxins ; Escherichia coli Proteins ; RNA, Messenger ; hipA protein, E coli (144515-93-5) ; Guanosine Tetraphosphate (33503-72-9) ; Guanosine Pentaphosphate (38918-96-6) ; Endonucleases (EC 3.1.-)
    Language English
    Publishing date 2015-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1423536112
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    Zs.A 1148: Show issues Location:
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  7. Article ; Online: Epidemiology and burden of pancreatic cancer.

    Maisonneuve, Patrick

    Presse medicale (Paris, France : 1983)

    2019  Volume 48, Issue 3 Pt 2, Page(s) e113–e123

    Abstract: Pancreatic cancer, although infrequent, has a very poor prognosis, making it currently the fourth common causes of cancer mortality in most developed countries including the European Union (EU). Its incidence varies across regions, which suggests that ... ...

    Abstract Pancreatic cancer, although infrequent, has a very poor prognosis, making it currently the fourth common causes of cancer mortality in most developed countries including the European Union (EU). Its incidence varies across regions, which suggests that lifestyle factors play an important role in its etiology, although part of the variation could be ascribed to difference in diagnostic and coding practices. Because pancreatic cancer is strongly age-dependent, increasing population longevity and ageing will lead to an increase of the global burden of pancreatic cancer. It was estimated that, by 2040, the total number of cases in the EU will increase by more than 30%. Pancreatic cancer is a multifactorial disease and many risk factors have been identified. Hereditary factors are responsible for less than 10% of the cases while tobacco smoking and excess body weight, the two most important potentially modifiable risk factors, are responsible for 10 to 30% of the cases, affording a unique opportunity for preventing one of our deadliest cancers.
    MeSH term(s) Global Health ; Humans ; Incidence ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/epidemiology ; Risk Factors
    Language English
    Publishing date 2019-03-14
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2019.02.030
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    Zs.A 794: Show issues Location:
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  8. Article ; Online: The YmgB-SpoT interaction triggers the stringent response in Escherichia coli.

    Guiraud, Paul / Germain, Elsa / Byrne, Deborah / Maisonneuve, Etienne

    The Journal of biological chemistry

    2023  Volume 299, Issue 12, Page(s) 105429

    Abstract: Virtually all bacterial species synthesize (p)ppGpp (guanosine penta- or tetraphosphate ... and metabolism. In Escherichia coli, (p)ppGpp levels are controlled by two homologous enzymes: the (p ... several protein candidates that can modulate (p)ppGpp levels in E. coli. In this work, we show that the putative ...

    Abstract Virtually all bacterial species synthesize (p)ppGpp (guanosine penta- or tetraphosphate), a pleiotropic regulator of the so-called stringent response, which controls many aspects of cellular physiology and metabolism. In Escherichia coli, (p)ppGpp levels are controlled by two homologous enzymes: the (p)ppGpp synthetase RelA and the bifunctional synthetase/hydrolase SpoT. We recently identified several protein candidates that can modulate (p)ppGpp levels in E. coli. In this work, we show that the putative two-component system connector protein YmgB can promote SpoT-dependent accumulation of ppGpp in E. coli. Importantly, we determined that the control of SpoT activities by YmgB is independent of its proposed role in the two-component Rcs system, and these two functions can be uncoupled. Using genetic and structure-function analysis, we show that the regulation of SpoT activities by YmgB occurs by functional and direct binding in vivo and in vitro to the TGS and Helical domains of SpoT. These results further support the role of these domains in controlling the reciprocal enzymatic states.
    MeSH term(s) Escherichia coli/metabolism ; Guanosine Pentaphosphate/genetics ; Bacteria/metabolism ; Guanosine Tetraphosphate ; Hydrolases/metabolism ; Ligases/genetics ; Ligases/metabolism ; Gene Expression Regulation, Bacterial ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism
    Chemical Substances Guanosine Pentaphosphate (38918-96-6) ; Guanosine Tetraphosphate (33503-72-9) ; Hydrolases (EC 3.-) ; Ligases (EC 6.-) ; YmgB protein, E coli ; Escherichia coli Proteins
    Language English
    Publishing date 2023-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.105429
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    Uc I Zs.108: Show issues Location:
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  9. Article ; Online: Response.

    Maisonneuve, Patrick / Lowenfels, Albert B

    Chest

    2022  Volume 161, Issue 5, Page(s) e326–e327

    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2022.02.002
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  10. Article ; Online: Response.

    Maisonneuve, Patrick / Lowenfels, Albert B

    Chest

    2022  Volume 161, Issue 5, Page(s) e333

    Language English
    Publishing date 2022-05-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.12.642
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