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  1. Article ; Online: Editorial: Resmetirom - a promising treatment option for NASH and liver fibrosis.

    Targher, Giovanni

    Alimentary pharmacology & therapeutics

    2023  Volume 59, Issue 1, Page(s) 128–129

    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/drug therapy ; Liver Cirrhosis/drug therapy ; Pyridazines ; Uracil
    Chemical Substances resmetirom (RE0V0T1ES0) ; Pyridazines ; Uracil (56HH86ZVCT)
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Editorial
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17747
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article: Long-term outcomes in patients with non-alcoholic fatty liver disease: further evidence that a multidisciplinary and patient-centred approach to treatment is needed.

    Targher, Giovanni

    Hepatobiliary surgery and nutrition

    2022  Volume 11, Issue 1, Page(s) 143–146

    Language English
    Publishing date 2022-02-24
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-21-528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tirzepatide adds hepatoprotection to its armoury.

    Targher, Giovanni

    The lancet. Diabetes & endocrinology

    2022  Volume 10, Issue 6, Page(s) 374–375

    MeSH term(s) Gastric Inhibitory Polypeptide ; Glucagon-Like Peptide-1 Receptor ; Humans
    Chemical Substances Glucagon-Like Peptide-1 Receptor ; Gastric Inhibitory Polypeptide (59392-49-3) ; tirzepatide (OYN3CCI6QE)
    Language English
    Publishing date 2022-04-22
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(22)00074-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Non-Alcoholic Fatty Liver Disease Research 2016

    Lonardo, Amedeo / Targher, Giovanni

    2018  

    Abstract: This new book entitled Non-Alcoholic Fatty Liver Disease Research 2016 covers a selection of recent research topics and current review articles in the field of nonalcoholic fatty liver disease (NAFLD) that have been recently published in a monographic ... ...

    Abstract This new book entitled Non-Alcoholic Fatty Liver Disease Research 2016 covers a selection of recent research topics and current review articles in the field of nonalcoholic fatty liver disease (NAFLD) that have been recently published in a monographic Special Issue of the International Journal of Molecular Sciences (IJMS) journal. NAFLD is an "umbrella" definition that encompasses a spectrum of histopathological liver changes ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) with/without fibrosis, "cryptogenic" cirrhosis and hepatocellular carcinoma. NAFLD has become one of the most common forms of chronic liver disease worldwide and its prevalence is expected to continue rising. It is now becoming increasingly clear that the clinical and economic burden of NAFLD does not only affect the liver, but also affects the risk of developing cardiovascular disease, type 2 diabetes mellitus, colo-rectal neoplasms, chronic kidney disease and other extra-hepatic diseases that have a considerable impact on health-care expenditures. Against this background, further research is needed to better understand the natural history, and the molecular pathogenesis of NAFLD, as well as to elucidate the underlying mechanisms by which NAFLD contributes to the increased cardiometabolic risk, and to disclose novel and effective treatment strategies for this increasingly prevalent and burdensome disease.Some of the leading international researchers in this area expressed a willingness to contribute to this book providing an updated, state-of-the-art view on the aforementioned topics, and also suggesting novel research avenues for NAFLD.
    Keywords Medical emergencies. Critical care. Intensive care. First aid ; Biology (General)
    Size 1 electronic resource (566 p.)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020099206
    ISBN 9783038976004 ; 9783038976011 ; 3038976008 ; 3038976016
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Role of Glucocorticoids in Metabolic Dysfunction-Associated Steatotic Liver Disease.

    Polyzos, Stergios A / Targher, Giovanni

    Current obesity reports

    2024  

    Abstract: Purpose of the review: To summarize published data on the association between glucocorticoids and metabolic dysfunction-associated steatotic liver disease (MASLD), focusing on the possible pathophysiological links and related treatment considerations.!## ...

    Abstract Purpose of the review: To summarize published data on the association between glucocorticoids and metabolic dysfunction-associated steatotic liver disease (MASLD), focusing on the possible pathophysiological links and related treatment considerations.
    Recent findings: Glucocorticoids, commonly used for managing many inflammatory and autoimmune diseases, may contribute to the development and progression of MASLD. Glucocorticoids may induce hyperglycemia and hyperinsulinemia, thus increasing systemic and hepatic insulin resistance, a hallmark of MASLD pathogenesis. Furthermore, glucocorticoids increase adipose tissue lipolysis, and hepatic de novo lipogenesis and decrease hepatic fatty acid β-oxidation, thus promoting MASLD development. Preclinical evidence also suggests that glucocorticoids may adversely affect hepatic inflammation and fibrosis. 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and 5α-reductase are implicated in the link between glucocorticoids and MASLD, the former enzyme increasing and the latter reducing the glucocorticoid action on the liver. Treatment considerations exist due to the pathogenic link between glucocorticoids and MASLD. Since iatrogenic hypercortisolism is common, glucocorticoids should be used at the minimum daily dose to control the subjective disease. Furthermore, the pharmacologic inhibition of 11β-HSD1 has provided favorable results in MASLD, both in preclinical studies and early MASH clinical trials. Glucocorticoids are closely linked to MASLD pathophysiology, with specific clinical and therapeutic implications.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2162-4968
    ISSN (online) 2162-4968
    DOI 10.1007/s13679-024-00556-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Is it time for non-alcoholic fatty liver disease screening in patients with type 2 diabetes mellitus?

    Targher, Giovanni

    Hepatobiliary surgery and nutrition

    2020  Volume 9, Issue 2, Page(s) 239–241

    Language English
    Publishing date 2020-03-13
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn.2019.10.21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Concordance between MAFLD and NAFLD diagnostic criteria in 'real-world' data.

    Targher, Giovanni

    Liver international : official journal of the International Association for the Study of the Liver

    2020  Volume 40, Issue 11, Page(s) 2879–2880

    MeSH term(s) Humans ; Metabolic Syndrome ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/epidemiology
    Language English
    Publishing date 2020-08-01
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.14623
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 1632: Show issues Location:
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  8. Article ; Online: Editorial: a diabetologist's perspective on the diagnosis and monitoring of NAFLD.

    Targher, Giovanni

    Alimentary pharmacology & therapeutics

    2020  Volume 52, Issue 4, Page(s) 710–711

    MeSH term(s) Diabetes Mellitus, Type 2/diagnosis ; Humans ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Physicians ; Primary Health Care
    Language English
    Publishing date 2020-09-04
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.15906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Thyroid hormone receptor-beta agonists: new MASLD therapies on the horizon.

    Byrne, Christopher D / Targher, Giovanni / Tilg, Herbert

    Gut

    2024  Volume 73, Issue 4, Page(s) 573–581

    MeSH term(s) Humans ; Thyroid Hormone Receptors beta
    Chemical Substances Thyroid Hormone Receptors beta
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-330596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 160: Show issues Location:
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  10. Article: What's Past Is Prologue: History of Nonalcoholic Fatty Liver Disease.

    Targher, Giovanni

    Metabolites

    2020  Volume 10, Issue 10

    Abstract: Since the initial descriptions in the early 1980s by Dr. Ludwig et al. and Drs. Schaffner and Thaler, who firstly coined the terms nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD), this liver disease has become a global ... ...

    Abstract Since the initial descriptions in the early 1980s by Dr. Ludwig et al. and Drs. Schaffner and Thaler, who firstly coined the terms nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD), this liver disease has become a global health problem worldwide, causing considerable liver-related and extra-hepatic morbidity and mortality. Based on pathophysiological insights gained from the past decades, it has been clearly established that NAFLD is a metabolic liver disease whose etiology and pathogenesis extends beyond the liver and that NAFLD has important clinical implications, especially in terms of an increased risk of developing both cardiovascular disease (which represents the leading cause of death in this patient population) and other extra-hepatic manifestations, such as type 2 diabetes mellitus, chronic kidney disease, and some extra-hepatic cancers. The aim of this brief commentary is to discuss a recent review article written by Dr. Lonardo and colleagues, who raised awareness of the history of NAFLD. Since "What's past is prologue", I believe that this review article focusing on the history of NAFLD may contribute to better understanding the disease itself, as well as to anticipating the lines of the future clinical and pharmacological research of this common and burdensome liver disease.
    Language English
    Publishing date 2020-10-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo10100397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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