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  1. Article ; Online: 25-Hydroxyvitamin D serum levels inversely correlate to disease severity and serum C-reactive protein levels in patients with hidradenitis suppurativa.

    Moltrasio, Chiara / Tricarico, Paola Maura / Genovese, Giovanni / Gratton, Rossella / Marzano, Angelo V / Crovella, Sergio

    The Journal of dermatology

    2021  Volume 48, Issue 5, Page(s) 715–717

    MeSH term(s) C-Reactive Protein ; Hidradenitis Suppurativa/diagnosis ; Humans ; Receptors, Immunologic ; Severity of Illness Index ; Vitamin D/analogs & derivatives
    Chemical Substances CRP protein, human ; Receptors, Immunologic ; Vitamin D (1406-16-2) ; C-Reactive Protein (9007-41-4) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2021-02-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.15797
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1950: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye.

    Msaouel, Pavlos / Walker, Cheryl L / Genovese, Giannicola / Tannir, Nizar M

    Molecular & cellular oncology

    2020  Volume 7, Issue 5, Page(s) 1777060

    Abstract: Renal medullary carcinoma (RMC) is a lethal disease that predominantly afflicts young individuals with sickle cell trait. Our recently reported molecular profiling of primary untreated RMC tissues elucidated distinct genomic and immune hallmarks of RMC, ... ...

    Abstract Renal medullary carcinoma (RMC) is a lethal disease that predominantly afflicts young individuals with sickle cell trait. Our recently reported molecular profiling of primary untreated RMC tissues elucidated distinct genomic and immune hallmarks of RMC, and identified MYC-induced replication stress as a targetable vulnerability for this disease.
    Language English
    Publishing date 2020-06-23
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2020.1777060
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  3. Article ; Online: Prognostic impact of admission high-sensitivity C-reactive protein in acute myocardial infarction patients with and without diabetes mellitus.

    Lucci, Claudia / Cosentino, Nicola / Genovese, Stefano / Campodonico, Jeness / Milazzo, Valentina / De Metrio, Monica / Rondinelli, Maurizio / Riggio, Daniela / Biondi, Maria Luisa / Rubino, Mara / Celentano, Katia / Bonomi, Alice / Capra, Nicolò / Veglia, Fabrizio / Agostoni, Piergiuseppe / Bartorelli, Antonio L / Marenzi, Giancarlo

    Cardiovascular diabetology

    2020  Volume 19, Issue 1, Page(s) 183

    Abstract: Background: High-sensitivity C-reactive protein (hs-CRP) elevation frequently occurs in acute ...

    Abstract Background: High-sensitivity C-reactive protein (hs-CRP) elevation frequently occurs in acute myocardial infarction (AMI) and is associated with adverse outcomes. Since diabetes mellitus (DM) is characterized by an underlying chronic inflammation, hs-CRP may have a different prognostic power in AMI patients with and without DM.
    Methods: We prospectively included 2064 AMI patients; hs-CRP was measured at hospital admission. Patients were grouped according to hs-CRP quartiles and DM status. The primary endpoint was a composite of in-hospital mortality, cardiogenic shock, and acute pulmonary edema. Two-year all-cause mortality was the secondary endpoint.
    Results: Twenty-six percent (n = 548) of patients had DM and they had higher hs-CRP levels than non-DM patients (5.32 vs. 3.24 mg/L; P < 0.0001). The primary endpoint incidence in the overall population (7%, 9%, 13%, 22%; P for trend < 0.0001), in DM (14%, 9%, 21%, 27%; P = 0.0001), and non-DM (5%, 8%, 10%, 19%; P < 0.0001) patients increased in parallel with hs-CRP quartiles. The adjusted risk of the primary endpoint increased in parallel with hs-CRP quartiles in DM and non-DM patients but this relationship was less evident in DM patients. In the overall population, the adjusted OR of the primary endpoint associated with an hs-CRP value ≥ 2 mg/L was 2.10 (95% CI 1.46-3.00). For the same risk, hs-CRP was 7 and 2 mg/L in patients with and without DM. A similar behavior was observed for the secondary endpoint when the HR associated with an hs-CRP value ≥ 2 mg/L found in the overall population was 2.25 (95% CI 1.57-3.22). For the same risk, hs-CRP was 8 and 1.5 mg/L in DM and non-DM patients.
    Conclusions: This study shows that hs-CRP predicts in-hospital outcome and two-year mortality in AMI patients with and without DM. However, in DM patients, the same risk of developing events as in non-DM patients is associated to higher hs-CRP levels.
    MeSH term(s) Aged ; Aged, 80 and over ; Biomarkers/blood ; C-Reactive Protein/analysis ; Diabetes Mellitus/blood ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/mortality ; Female ; Hospital Mortality ; Humans ; Incidence ; Inflammation Mediators/blood ; Male ; Middle Aged ; Non-ST Elevated Myocardial Infarction/blood ; Non-ST Elevated Myocardial Infarction/diagnosis ; Non-ST Elevated Myocardial Infarction/mortality ; Patient Admission ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Pulmonary Edema/blood ; Pulmonary Edema/mortality ; Risk Assessment ; Risk Factors ; ST Elevation Myocardial Infarction/blood ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/mortality ; Shock, Cardiogenic/blood ; Shock, Cardiogenic/mortality ; Up-Regulation
    Chemical Substances Biomarkers ; Inflammation Mediators ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2020-10-20
    Publishing country England
    Document type Comparative Study ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2093769-6
    ISSN 1475-2840 ; 1475-2840
    ISSN (online) 1475-2840
    ISSN 1475-2840
    DOI 10.1186/s12933-020-01157-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Mechanism of C–C bond formation in the electrocatalytic reduction of CO2 to acetic acid. A challenging reaction to use renewable energy with chemistry

    Genovese, Chiara / Ampelli, Claudio / Perathoner, Siglinda / Centi, Gabriele

    Green chemistry. 2017 May 22, v. 19, no. 10

    2017  

    Abstract: ... besides H2. The reaction mechanism, particularly the critical step of C–C bond formation, was studied ...

    Abstract Copper nanoparticles on carbon nanotubes are used in the reduction of CO2 to acetic acid (with simultaneous water electrolysis) in a flow electrocatalytic reactor operating at room temperature and atmospheric pressure. A turnover frequency of about 7000 h−1 and a carbon-based Faradaic selectivity to acetic acid of about 56% were observed, indicating potential interest in this approach for using renewable energy. The only other products of reaction detected were formic acid and methanol (the latter in some cases), besides H2. The reaction mechanism, particularly the critical step of C–C bond formation, was studied by comparing the reactivity in tests with CO2 or CO, where formic acid or formaldehyde where initially added. The results indicate the need for having dissolved CO2 to form acetic acid, likely via the reaction of CO2 ̇− with surface adsorbed –CH3 like species. The pathway towards formic acid is instead different from the route of the formation of acetic acid.
    Keywords ambient temperature ; atmospheric pressure ; carbon dioxide ; carbon monoxide ; carbon nanotubes ; chemical bonding ; copper nanoparticles ; electrolysis ; formaldehyde ; formic acid ; green chemistry ; hydrogen ; methanol ; reaction mechanisms ; renewable energy sources
    Language English
    Dates of publication 2017-0522
    Size p. 2406-2415.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2006274-6
    ISSN 1463-9270 ; 1463-9262
    ISSN (online) 1463-9270
    ISSN 1463-9262
    DOI 10.1039/c6gc03422e
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: High-Sensitivity C-Reactive Protein and Acute Kidney Injury in Patients with Acute Myocardial Infarction: A Prospective Observational Study.

    Cosentino, Nicola / Genovese, Stefano / Campodonico, Jeness / Bonomi, Alice / Lucci, Claudia / Milazzo, Valentina / Moltrasio, Marco / Biondi, Maria Luisa / Riggio, Daniela / Veglia, Fabrizio / Ceriani, Roberto / Celentano, Katia / De Metrio, Monica / Rubino, Mara / Bartorelli, Antonio L / Marenzi, Giancarlo

    Journal of clinical medicine

    2019  Volume 8, Issue 12

    Abstract: Background. ...

    Abstract Background.
    Language English
    Publishing date 2019-12-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm8122192
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  6. Article: In memoriam Frank C. Genovese, 1921 - 2014

    Genovese, Frank C

    The American journal of economics and sociology Vol. 74, No. 1 , p. 1-2

    2015  Volume 74, Issue 1, Page(s) 1–2

    Language English
    Size Ill.
    Publisher Wiley
    Publishing place Hoboken, NJ
    Document type Article
    ZDB-ID 2936-1 ; 2011062-5
    ISSN 1536-7150 ; 0002-9246
    ISSN (online) 1536-7150
    ISSN 0002-9246
    Database ECONomics Information System

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  7. Article ; Online: Plasma Triglycerides and HDL-C Levels Predict the Development of Diabetic Kidney Disease in Subjects With Type 2 Diabetes: The AMD Annals Initiative.

    Russo, Giuseppina T / De Cosmo, Salvatore / Viazzi, Francesca / Pacilli, Antonio / Ceriello, Antonio / Genovese, Stefano / Guida, Pietro / Giorda, Carlo / Cucinotta, Domenico / Pontremoli, Roberto / Fioretto, Paola

    Diabetes care

    2016  Volume 39, Issue 12, Page(s) 2278–2287

    Abstract: Objective: Despite the achievement of blood glucose, blood pressure, and LDL cholesterol (LDL-C ... or low HDL cholesterol (HDL-C) levels-contributes to this high residual risk for DKD ... mL/min/1.73 m: Conclusions: In a large population of outpatients with diabetes, low HDL-C and high ...

    Abstract Objective: Despite the achievement of blood glucose, blood pressure, and LDL cholesterol (LDL-C) targets, the risk for diabetic kidney disease (DKD) remains high among patients with type 2 diabetes. This observational retrospective study investigated whether diabetic dyslipidemia-that is, high triglyceride (TG) and/or low HDL cholesterol (HDL-C) levels-contributes to this high residual risk for DKD.
    Research design and methods: Among a total of 47,177 patients attending Italian diabetes centers, 15,362 patients with a baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m
    Results: Overall, 12.8% developed low eGFR, 7.6% an eGFR reduction >30%, 23.2% albuminuria, and 4% albuminuria and either eGFR <60 mL/min/1.73 m
    Conclusions: In a large population of outpatients with diabetes, low HDL-C and high TG levels were independent risk factors for the development of DKD over 4 years.
    MeSH term(s) Aged ; Albuminuria/blood ; Albuminuria/diagnosis ; Albuminuria/epidemiology ; Blood Glucose/metabolism ; Blood Pressure ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Diabetic Nephropathies/blood ; Diabetic Nephropathies/diagnosis ; Diabetic Nephropathies/epidemiology ; Diabetic Nephropathies/physiopathology ; Dyslipidemias/blood ; Dyslipidemias/complications ; Dyslipidemias/diagnosis ; Dyslipidemias/epidemiology ; Female ; Humans ; Incidence ; Italy/epidemiology ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Risk Factors ; Triglycerides/blood
    Chemical Substances Blood Glucose ; Cholesterol, HDL ; Cholesterol, LDL ; Triglycerides
    Language English
    Publishing date 2016-10-04
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc16-1246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1434: Show issues Location:
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  8. Article: I-V and C-V Characterization of a High-Responsivity Graphene/Silicon Photodiode with Embedded MOS Capacitor.

    Luongo, Giuseppe / Giubileo, Filippo / Genovese, Luca / Iemmo, Laura / Martucciello, Nadia / Di Bartolomeo, Antonio

    Nanomaterials (Basel, Switzerland)

    2017  Volume 7, Issue 7

    Abstract: We study the effect of temperature and light on the I-V and C-V characteristics of a graphene ...

    Abstract We study the effect of temperature and light on the I-V and C-V characteristics of a graphene/silicon Schottky diode. The device exhibits a reverse-bias photocurrent exceeding the forward current and achieves a photoresponsivity as high as 2.5 A / W . We show that the enhanced photocurrent is due to photo-generated carriers injected in the graphene/Si junction from the parasitic graphene/SiO₂/Si capacitor connected in parallel to the diode. The same mechanism can occur with thermally generated carriers, which contribute to the high leakage current often observed in graphene/Si junctions.
    Language English
    Publishing date 2017-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano7070158
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  9. Article ; Online: Generation of Human-Induced Pluripotent Stem Cells from Wolfram Syndrome Type 2 Patients Bearing the c.103 + 1G>A CISD2 Mutation for Disease Modeling.

    La Spada, Alberto / Ntai, Aikaterini / Genovese, Stefano / Rondinelli, Maurizio / De Blasio, Pasquale / Biunno, Ida

    Stem cells and development

    2018  Volume 27, Issue 4, Page(s) 287–295

    Abstract: ... Italian family with CISD2 mutation (c.103 + 1G>A), occurring in the consensus intron 1 splicing site ...

    Abstract Wolfram syndrome (WFS) is a rare autosomal premature aging syndrome that shows signs of diabetes mellitus, optic atrophy, and deafness in addition to central nervous system and endocrine complications. The frequent form of WFS type 1 (WFS1) harbors causative mutations in the WFS1 gene, whereas the rare form or WFS type 2 (WFS2) involves CISD2. Mutations in these two genes are recognized by a subset of variable clinical symptoms and a set of overlapping features. In this study, we report on the generation of stable human-induced pluripotent stem cells (hiPSCs) derived from primary fibroblasts of a previously reported Italian family with CISD2 mutation (c.103 + 1G>A), occurring in the consensus intron 1 splicing site in two sisters, deleting the first exon of the transcript. The generated hiPSCs provide a cell model system to study the mutation's role in the multisystemic clinical disorders previously described and test eventual drug effects on the specific and associated clinical phenotype.
    MeSH term(s) Aging, Premature/genetics ; Aging, Premature/pathology ; Cell Proliferation/genetics ; Cells, Cultured ; Family Health ; Female ; Fibroblasts/metabolism ; Hearing Loss, Sensorineural/genetics ; Hearing Loss, Sensorineural/pathology ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Introns/genetics ; Male ; Membrane Proteins/genetics ; Mitochondrial Diseases/genetics ; Mitochondrial Diseases/pathology ; Mutation ; Optic Atrophy/genetics ; Optic Atrophy/pathology ; RNA Splice Sites/genetics ; Siblings
    Chemical Substances CISD2 protein, human ; Membrane Proteins ; RNA Splice Sites
    Language English
    Publishing date 2018-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2142214-X
    ISSN 1557-8534 ; 1547-3287
    ISSN (online) 1557-8534
    ISSN 1547-3287
    DOI 10.1089/scd.2017.0158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3616: Show issues Location:
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  10. Article: Neuroprotective effects of dried camu-camu (Myrciaria dubia HBK McVaugh) residue in C. elegans

    Azevedo, J. C. S. / Borges, K. C. / Genovese, M. I. / Correia, R. T. P. / Vattem, D. A.

    Food research international

    2015  Volume 73, Issue -, Page(s) 135

    Language English
    Document type Article
    ZDB-ID 1111695-x
    ISSN 0963-9969
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

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