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  1. Article ; Online: An Exploratory Case-Study Approach to Understand Multifunctionality in Urban Green Infrastructure Planning in a South African Context

    Burne Van Zyl / Louis G. Lategan / Elizelle J. Cilliers / Sarel S. Cilliers

    Frontiers in Sustainable Cities, Vol

    2021  Volume 3

    Abstract: The United Nations Sustainable Development Goals (SDGs) intend to encourage liveable urban environments by 2030 with a main focus on strategies to achieve environmental and human well-being. In the same way, the multifunctionality principle of green ... ...

    Abstract The United Nations Sustainable Development Goals (SDGs) intend to encourage liveable urban environments by 2030 with a main focus on strategies to achieve environmental and human well-being. In the same way, the multifunctionality principle of green infrastructure planning aims to develop and protect urban green spaces to provide several ecosystem services to increase human well-being whilst protecting the environment. With this in mind, this paper seeks to gather evidence on the nexus between multifunctionality and green infrastructure planning to achieve the SDGs within a South African context. The implementation of green infrastructure to this effect depends on creating awareness of different typologies of green infrastructure elements and the ecosystem services they provide to strengthen the implementation of the green infrastructure concept in urban planning practice. Within the aim of context-specific considerations to green infrastructure planning, green infrastructure typologies possible for implementation within a South Africa urban planning practice context are considerably more limited. A qualitative research approach is employed using case studies identifying specific examples to explore South African green infrastructure typologies and their multifunctionality. Different multifunctionality concepts are recognized by urban planners in South Africa. The research findings highlighted that multifunctionality achieved through green infrastructure planning should inform urban planning practice to promote the integration of ecological considerations. The paper ultimately provides a deeper insight into the expanding field of green infrastructure research in a South African context by underlining context-based multifunctional green infrastructure typologies and accordingly emphasizes, mainstreaming the ecosystem services concept as part of urban planning practice to address the SDGs locally.
    Keywords urban green infrastructure typologies ; urban planning ; urban ecology ; ecosystem services ; multifunctionality ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 710 ; 380
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Closing the Gap Between Urban Planning and Urban Ecology

    Burné van Zyl / E. Juaneé Cilliers / Louis G. Lategan / Sarel S. Cilliers

    Urban Planning, Vol 6, Iss

    A South African Perspective

    2021  Volume 4

    Abstract: Ecological considerations should be an integral part of the decision-making processes of urban planners. Specifically, ecological aspects used in urban ecology, such as green infrastructure and ecosystem services, are substantiated by literature as ... ...

    Abstract Ecological considerations should be an integral part of the decision-making processes of urban planners. Specifically, ecological aspects used in urban ecology, such as green infrastructure and ecosystem services, are substantiated by literature as strategies for improving quality of life, human health, and well-being. Studies dealing with such concepts in the Global South recently gained interest; however, these lack empirical evidence on the integration thereof in mainstream South African urban planning practice. This article conducts a preliminary investigation into the knowledge of ecological aspects of a sample of South African urban planners and their willingness to implement ecological aspects in urban planning practice. The new environmental paradigm scale is employed to determine the environmental worldview (ecocentric or anthropocentric) among respondent and how this relates to their knowledge of ecological aspects. The initial research sample consisted of a total of 283 questionnaires distributed. Although findings of this article are based on a low response rate (15%) of 42 documented responses, it did not affect the validity of the data collected in this context. The initial findings indicated that the environmental worldview of the sample of planners is only one factor influencing their perspective on incorporating ecological considerations. Low to moderate knowledge and awareness regarding ecological aspects such as ecosystem services, green infrastructure, and multi-functionality are argued to be main factors preventing integration in urban planning practice. Findings emphasize the need for context-based implementation strategies and broad recommendations are made for the planning profession as a point of departure to introduce or ingrain ecological considerations.
    Keywords ecosystem services ; green infrastructure planning ; multi-functionality ; south africa ; urban ecology ; urban planners ; urban planning practice ; City planning ; HT165.5-169.9
    Subject code 710
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Cogitatio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Risking health for rental housing: Reviewing service access in the informal backyard rental sector.

    Lategan, Louis G / Erasmus, Shayne / Zietsman, Markus / Cilliers, Elizelle J / Wolf, Mario / Springer, Christian A

    Jamba (Potchefstroom, South Africa)

    2020  Volume 12, Issue 1, Page(s) 947

    Abstract: Informal backyard rentals (IBRs) constitute South Africa's fastest growing housing subsector, flourishing within a relative research vacuum and without national policy intervention to address the vulnerabilities of stakeholders to the health risks ... ...

    Abstract Informal backyard rentals (IBRs) constitute South Africa's fastest growing housing subsector, flourishing within a relative research vacuum and without national policy intervention to address the vulnerabilities of stakeholders to the health risks potentially presented. This article reviewed the literature on IBRs, focussing on past policies and interventions, general characteristics, infrastructure and service access to inform an analysis of potential health risks from the existing literature to guide future research and policy-making. Research followed a qualitative approach to review IBR literature dating after 2004. Relevant publications were identified from bibliographic databases using Boolean search logic and by reviewing citations in and later citations of these publications. Relevant secondary sources were also included. The review evidenced that IBRs have received increasing policy, but limited research attention, and that health hazards have been particularly neglected. Although issues such as shared water and sanitation, inappropriate waste disposal, poor hygiene practices, high densities and poor quality structures have been referenced extensively - alluding to risks and health concerns - few studies have focussed directly on health, risk and vulnerability. The risk analysis completed based on the literature made potential risks explicit, exemplified by references to specific conditions, such as HIV/AIDS, tuberculosis and the coronavirus pandemic, demonstrating pathogenic pathways, contamination and transmission risks conducive to poor health, infection and potential disaster. The review captured and updated the contemporary literature on IBRs, with the subsequent analysis providing a platform for future empirical research on health, infrastructure and IBRs to address potential risks towards positive change in future policies.
    Language English
    Publishing date 2020-10-26
    Publishing country South Africa
    Document type Journal Article ; Review
    ZDB-ID 2650845-X
    ISSN 1996-1421 ; 2072-845X ; 1996-1421
    ISSN (online) 1996-1421 ; 2072-845X
    ISSN 1996-1421
    DOI 10.4102/jamba.v12i1.947
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  4. Article ; Online: Correction to: Characterization of the inhibition mechanism of a tissue factor inhibiting single-chain variable fragment: a combined computational approach.

    Vermeulen, Jan-G / Burt, Felicity / van Heerden, Esta / du Preez, Louis Lategan / Meiring, Muriel

    Journal of molecular modeling

    2020  Volume 26, Issue 5, Page(s) 112

    Abstract: One of the co-author's details (Leon du Preez-lategaan) was printed incorrectly in the above publication. The correct details are provided below. ...

    Abstract One of the co-author's details (Leon du Preez-lategaan) was printed incorrectly in the above publication. The correct details are provided below.
    Language English
    Publishing date 2020-05-03
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1284729-X
    ISSN 0948-5023 ; 1610-2940
    ISSN (online) 0948-5023
    ISSN 1610-2940
    DOI 10.1007/s00894-020-04375-8
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  5. Article ; Online: Characterization of the inhibition mechanism of a tissuefactor inhibiting single-chain variable fragment: a combined computational approach.

    Vermeulen, Jan-G / Burt, Felicity / van Heerden, Esta / du Preez, Louis Lategan / Meiring, Muriel

    Journal of molecular modeling

    2020  Volume 26, Issue 4, Page(s) 87

    Abstract: The interaction of a single-chain variable fragment (scFv) directed against human tissue factor (TF) was predicted using an in silico approach with the aim to establish a most likely mechanism of inhibition. The structure of the TF inhibiting scFv (TFI- ... ...

    Abstract The interaction of a single-chain variable fragment (scFv) directed against human tissue factor (TF) was predicted using an in silico approach with the aim to establish a most likely mechanism of inhibition. The structure of the TF inhibiting scFv (TFI-scFv) was predicted using homology modeling, and complementarity-determining regions (CDRs) were identified. The CDR was utilized to direct molecular docking between the homology model of TFI-scFv and the crystal structure of the extracellular domains of human tissue factor. The rigid-body docking model was refined by means of molecular dynamic (MD) simulations, and the most prevalent cluster was identified. MD simulations predicted improved interaction between TFI-scFv and TF and propose the formation of stable complex for duration of the 600-ns simulation. Analysis of the refined docking model suggests that the interactions between TFI-scFv would interfere with the allosterical activation of coagulation factor VII (FVII) by TF. This interaction would prevent the formation of the active TF:VIIa complex and in so doing inhibit the initiation phase of blood coagulation as observers during in vitro testing.
    MeSH term(s) Antibodies, Neutralizing/chemistry ; Humans ; Molecular Dynamics Simulation ; Single-Chain Antibodies/chemistry ; Thromboplastin/chemistry
    Chemical Substances Antibodies, Neutralizing ; Single-Chain Antibodies ; Thromboplastin (9035-58-9)
    Language English
    Publishing date 2020-03-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1284729-X
    ISSN 0948-5023 ; 1610-2940
    ISSN (online) 0948-5023
    ISSN 1610-2940
    DOI 10.1007/s00894-020-4350-7
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  6. Article: Vinorelbine and cisplatin in advanced squamous cell carcinoma of the cervix: the South African experience.

    Goedhals, Louis / Falkson, Geoffrey / Smith, Brenda Lynn / Falkson, Carla Isadora / Gasmi, Jamal / Lategan, Andries / Burillon, Jean-Philippe / His, Patricia

    Anticancer research

    2005  Volume 25, Issue 3c, Page(s) 2489–2492

    Abstract: Background: This phase II trial was performed to assess the activity and safety of the cisplatin and vinorelbine combination in patients with advanced cervical carcinoma.: Patients and methods: Forty-two patients with advanced cervical cancer were ... ...

    Abstract Background: This phase II trial was performed to assess the activity and safety of the cisplatin and vinorelbine combination in patients with advanced cervical carcinoma.
    Patients and methods: Forty-two patients with advanced cervical cancer were included in the study to receive vinorelbine at 30 mg/m2 on d 1 and d 8 and cisplatin 100 mg/m2 on day 1 every 4 weeks.
    Results: Thirty-seven patients were evaluable for response and 40 patients for tolerance. Twenty-four patients (64.8%) achieved objective responses. The median duration of response was 17.5 months (range 2.5-57 months), median time to progression was 13.2 months (range 0.4-57 months) and median survival was 20.6 months (range 0.4-55 months). This regimen was well-tolerated; no WHO grade 4 neutropenia was observed, grade 3 nausea and vomiting occured in 50% of patients and grade 2 peripheral neuropathy in 5% of patients.
    Conclusion: Vinorelbine-cisplatin is an active and well-tolerated regimen in advanced cervical carcinoma.
    MeSH term(s) Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/pathology ; Cisplatin/administration & dosage ; Cisplatin/adverse effects ; Drug Administration Schedule ; Female ; Humans ; Middle Aged ; Neoplasm Staging ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/pathology ; Vinblastine/administration & dosage ; Vinblastine/adverse effects ; Vinblastine/analogs & derivatives
    Chemical Substances Vinblastine (5V9KLZ54CY) ; Cisplatin (Q20Q21Q62J) ; vinorelbine (Q6C979R91Y)
    Language English
    Publishing date 2005-05
    Publishing country Greece
    Document type Clinical Trial ; Clinical Trial, Phase II ; Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
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