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Article ; Online: Multifold Post-Modification of Macrocycles and Cages by Isocyanate-Induced Azadefluorination Cyclisation.

Pausch, Tobias / David, Tim / Fleck-Kunde, Tom / Pols, Hendrik / Gurke, Johannes / Schmidt, Bernd M

Angewandte Chemie (International ed. in English)

2024 Volume 63, Issue 15, Page(s) e202318362

Abstract: We present the multiple post-modification of organic macrocycles and cages, introducing functional groups into two- and three-dimensional supramolecular scaffolds bearing fluorine substituents, which opens up new possibilities in multi-step ... ...

Abstract	We present the multiple post-modification of organic macrocycles and cages, introducing functional groups into two- and three-dimensional supramolecular scaffolds bearing fluorine substituents, which opens up new possibilities in multi-step supramolecular chemistry employing the vast chemical space of readily available isocyanates. The mechanism and scope of the reaction that proceeds after isocyanate addition to the benzylamine motif via an azadefluorination cyclisation (ADFC) were investigated using DFT calculations, and a series of aromatic isocyanates with different electronic properties were tested. The compounds show excellent chemical stability and were fully characterised. They can be used for subsequent cross-coupling reactions, and ADFC can be used directly to generate cross-linked membranes from macrocycles or cages when using ditopic isocyanates. Single-crystal X-ray (SC-XRD) analysis shows the proof of the formation of the desired supramolecular entity together with the connectivity predicted by calculations and from
Language	English
Publishing date	2024-02-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202318362
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Article ; Online: Reliably estimating prevalences of atopic children: an epidemiological study in an extensive and representative primary care database.

Pols, David H J / Nielen, Mark M J / Korevaar, Joke C / Bindels, Patrick J E / Bohnen, Arthur M

NPJ primary care respiratory medicine

2017 Volume 27, Issue 1, Page(s) 23

Abstract: ... Researchers in the Netherlands, led by David Pols from the Erasmus University Medical Center Rotterdam ...

Abstract	Electronic health records stored in primary care databases might be a valuable source to study the epidemiology of atopic disorders and their impact on health-care systems and costs. However, the prevalence of atopic disorders in such databases varies considerably and needs to be addressed. For this study, all children aged 0-18 years listed in a representative primary care database in the period 2002-2014, with sufficient data quality, were selected. The effects of four different strategies on the prevalences of atopic disorders were examined: (1) the first strategy examined the diagnosis as recorded in the electronic health records, whereas the (2) second used additional requirements (i.e., the patient had at least two relevant consultations and at least two relevant prescriptions). Strategies (3) and (4) assumed the atopic disorders to be chronic based on strategy 1 and 2, respectively. When interested in cases with a higher probability of a clinically relevant disorder, strategy 2 yields a realistic estimation of the prevalence of atopic disorders derived from primary care data. Using this strategy, of the 478,076 included children, 28,946 (6.1%) had eczema, 29,182 (6.1%) had asthma, and 28,064 (5.9%) had allergic rhinitis; only 1251 (0.3%) children had all three atopic disorders. Prevalence rates are highly dependent on the clinical atopic definitions used. The strategy using cases with a higher probability of clinically relevant cases, yields realistic prevalences to establish the impact of atopic disorders on health-care systems. However, studies are needed to solve the problem of identifying atopic disorders that are missed or misclassified. Atopic disorders: CLINICAL INFORMATION IMPROVES PREVALENCE ESTIMATES: The prevalence of atopic disorders in children can be more reliably calculated by incorporating clinical information with diagnosis data. Researchers in the Netherlands, led by David Pols from the Erasmus University Medical Center Rotterdam, examined the electronic health records of more than 660,000 children, aged 0 to 18, from a Dutch primary care database to determine the number of cases of atopic eczema, asthma, and allergic rhinitis. They looked for diagnosed children who also had at least two relevant clinical consultations and at least two relevant prescriptions. This strategy helps correct for the problem of overestimation, because it doesnot assume that a child, once diagnosed, will have an atopic disorder for life. However, other methods are still needed to identify cases that are missed or misclassified in the health database.
Language	English
Publishing date	2017-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2780812-9
ISSN	2055-1010 ; 2055-1010
ISSN (online)	2055-1010
ISSN	2055-1010
DOI	10.1038/s41533-017-0025-y
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Article ; Online: Risks for comorbidity in children with atopic disorders: an observational study in Dutch general practices.

Pols, David H J / Bohnen, Arthur M / Nielen, Mark M J / Korevaar, Joke C / Bindels, Patrick J E

BMJ open

2017 Volume 7, Issue 11, Page(s) e018091

Abstract: Objective: This study aimed to investigate both atopic and non-atopic comorbid symptoms and diseases in children with physician-diagnosed atopic disorders (atopic eczema, asthma and allergic rhinitis).: Methods: All children aged 0-18 years listed in ...

Abstract	Objective: This study aimed to investigate both atopic and non-atopic comorbid symptoms and diseases in children with physician-diagnosed atopic disorders (atopic eczema, asthma and allergic rhinitis). Methods: All children aged 0-18 years listed in a nationwide primary care database (the Netherlands Institute for Health Services Research-Primary Care Database) with routinely collected healthcare data in 2014 were selected. Children with atopic disorders were matched on age and gender with non-atopic controls within the same general practice. A total of 404 International Classification of Primary Care codes were examined. Logistic regression analyses were performed to examine the associations between the presence of atopic disorders and (non-)atopic symptoms and diseases by calculating ORs. Results: Having one of the atopic disorders significantly increased the risk of having other atopic-related symptoms, even if the child was not registered as having the related atopic disorder. Regarding non-atopic comorbidity, children with atopic eczema (n=15 530) were at significantly increased risk for (infectious) skin diseases (OR: 1.2-3.4). Airway symptoms or (infectious) diseases (OR: 2.1-10.3) were observed significantly more frequently in children with asthma (n=7887). Children with allergic rhinitis (n=6835) had a significantly distinctive risk of ear-nose-throat-related symptoms and diseases (OR: 1.5-3.9). Neither age nor gender explained these increased risks. Conclusion: General practitioners are not always fully aware of relevant atopic and non-atopic comorbidity. In children known to have at least one atopic disorder, specific attention is required to avoid possible insufficient treatment and unnecessary loss of quality of life.
MeSH term(s)	Adolescent ; Asthma/epidemiology ; Child ; Child, Preschool ; Comorbidity ; Dermatitis, Atopic/epidemiology ; Female ; General Practice/statistics & numerical data ; Humans ; Infant ; Infant, Newborn ; Logistic Models ; Male ; Netherlands/epidemiology ; Prevalence ; Quality of Life ; Rhinitis, Allergic/epidemiology
Language	English
Publishing date	2017-11-12
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2747269-3
ISSN	2044-6055 ; 2044-6055 ; 2053-3624
ISSN (online)	2044-6055
ISSN	2044-6055 ; 2053-3624
DOI	10.1136/bmjopen-2017-018091
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Article ; Online: Atopic children and use of prescribed medication: A comprehensive study in general practice.

Pols, David H J / Nielen, Mark M J / Bohnen, Arthur M / Korevaar, Joke C / Bindels, Patrick J E

PloS one

2017 Volume 12, Issue 8, Page(s) e0182664

Abstract: Purpose: A comprehensive and representative nationwide general practice database was explored to study associations between atopic disorders and prescribed medication in children.: Method: All children aged 0-18 years listed in the NIVEL Primary Care ...

Abstract	Purpose: A comprehensive and representative nationwide general practice database was explored to study associations between atopic disorders and prescribed medication in children. Method: All children aged 0-18 years listed in the NIVEL Primary Care Database in 2014 were selected. Atopic children with atopic eczema, asthma and allergic rhinitis (AR) were matched with controls (not diagnosed with any of these disorders) within the same general practice on age and gender. Logistic regression analyses were performed to study the differences in prescribed medication between both groups by calculating odds ratios (OR); 93 different medication groups were studied. Results: A total of 45,964 children with at least one atopic disorder were identified and matched with controls. Disorder-specific prescriptions seem to reflect evidence-based medicine guidelines for atopic eczema, asthma and AR. However, these disorder-specific prescriptions were also prescribed for children who were not registered as having that specific disorder. For eczema-related medication, about 3.7-8.4% of the children with non-eczematous atopic morbidity received these prescriptions, compared to 1.4-3.5% of the non-atopic children. The same pattern was observed for anti-asthmatics (having non-asthmatic atopic morbidity: 0.8-6.2% vs. controls: 0.3-2.1%) and AR-related medication (having non-AR atopic morbidity: 4.7-12.5% vs. controls: 2.8-3.1%). Also, non-atopic related medication, such as laxatives and antibiotics were more frequently prescribed for atopic children. Conclusions: The present study shows that atopic children received more prescriptions, compared to non-atopic children. Non-atopic controls frequently received specific prescriptions for atopic disorders. This indicates that children with atopic disorders need better monitoring by their GP.
MeSH term(s)	Adolescent ; Asthma/drug therapy ; Child ; Child, Preschool ; Dermatitis, Atopic/drug therapy ; Dermatologic Agents/therapeutic use ; Drug Utilization Review ; Female ; General Practice/organization & administration ; Humans ; Infant ; Male ; Netherlands ; Rhinitis, Allergic/drug therapy
Chemical Substances	Dermatologic Agents
Language	English
Publishing date	2017-08-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0182664
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Article: Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization.

Bhatia, Sanil / Spanier, Lukas / Bickel, David / Dienstbier, Niklas / Woloschin, Vitalij / Vogt, Melina / Pols, Henrik / Lungerich, Beate / Reiners, Jens / Aghaallaei, Narges / Diedrich, Daniela / Frieg, Benedikt / Schliehe-Diecks, Julian / Bopp, Bertan / Lang, Franziska / Gopalswamy, Mohanraj / Loschwitz, Jennifer / Bajohgli, Baubak / Skokowa, Julia /

Borkhardt, Arndt / Hauer, Julia / Hansen, Finn K / Smits, Sander H J / Jose, Joachim / Gohlke, Holger / Kurz, Thomas

ACS central science

2022 Volume 8, Issue 5, Page(s) 636–655

Abstract: Heat shock proteins 90 (Hsp90) are promising therapeutic targets due to their involvement in stabilizing several aberrantly expressed oncoproteins. In cancerous cells, Hsp90 expression is elevated, thereby exerting antiapoptotic effects, which is ... ...

Abstract	Heat shock proteins 90 (Hsp90) are promising therapeutic targets due to their involvement in stabilizing several aberrantly expressed oncoproteins. In cancerous cells, Hsp90 expression is elevated, thereby exerting antiapoptotic effects, which is essential for the malignant transformation and tumor progression. Most of the Hsp90 inhibitors (Hsp90i) under investigation target the ATP binding site in the N-terminal domain of Hsp90. However, adverse effects, including induction of the prosurvival resistance mechanism (heat shock response or HSR) and associated dose-limiting toxicity, have so far precluded their clinical approval. In contrast, modulators that interfere with the C-terminal domain (CTD) of Hsp90 do not inflict HSR. Since the CTD dimerization of Hsp90 is essential for its chaperone activity, interfering with the dimerization process by small-molecule protein-protein interaction inhibitors is a promising strategy for anticancer drug research. We have developed a first-in-class small-molecule inhibitor (
Language	English
Publishing date	2022-04-27
Publishing country	United States
Document type	Journal Article
ISSN	2374-7943
ISSN	2374-7943
DOI	10.1021/acscentsci.2c00013
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Article ; Online: The Effect of Vitamin D Supplementation on Hypothyroidism in the Randomized Controlled D-Health Trial.

Waterhouse, Mary / Pham, Hai / Rahman, Sabbir T / Baxter, Catherine / Duarte Romero, Briony / Armstrong, Bruce K / Ebeling, Peter R / English, Dallas R / Hartel, Gunter / van der Pols, Jolieke C / Venn, Alison J / Webb, Penelope M / Whiteman, David C / McLeod, Donald S A / Neale, Rachel E

Thyroid : official journal of the American Thyroid Association

2023 Volume 33, Issue 11, Page(s) 1302–1310

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Male ; Female ; Humans ; Middle Aged ; Aged ; Thyroxine ; Australia/epidemiology ; Vitamin D/therapeutic use ; Vitamins/therapeutic use ; Pharmaceutical Preparations ; Dietary Supplements/analysis ; Hypothyroidism/drug therapy ; Hypothyroidism/epidemiology ; Hypothyroidism/prevention & control ; Double-Blind Method ; Randomized Controlled Trials as Topic
Chemical Substances	Thyroxine (Q51BO43MG4) ; Vitamin D (1406-16-2) ; Vitamins ; Pharmaceutical Preparations
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1086044-7
ISSN	1557-9077 ; 1050-7256
ISSN (online)	1557-9077
ISSN	1050-7256
DOI	10.1089/thy.2023.0317
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Article ; Online: Vitamin D supplementation and hospitalization for infection in older adults: A post-hoc analysis of data from the Australian D-Health Trial.

Pham, Hai / Waterhouse, Mary / Baxter, Catherine / Romero, Briony Duarte / McLeod, Donald Sa / Armstrong, Bruce K / Ebeling, Peter R / English, Dallas R / Hartel, Gunter / O'Connell, Rachel L / van der Pols, Jolieke C / Venn, Alison J / Webb, Penelope M / Whiteman, David C / Neale, Rachel E

The American journal of clinical nutrition

2022 Volume 117, Issue 2, Page(s) 350–356

Abstract: Background: Evidence suggests that vitamin D influences the immune system. Recent studies indicate that vitamin D supplementation may reduce the severity of infections, but this has not been confirmed.: Objectives: The objective of this study was to ... ...

Abstract	Background: Evidence suggests that vitamin D influences the immune system. Recent studies indicate that vitamin D supplementation may reduce the severity of infections, but this has not been confirmed. Objectives: The objective of this study was to assess the effect of vitamin D supplementation on hospitalization for infection. Methods: The D-Health Trial was a randomized, double-blind, placebo-controlled trial of monthly 60,000 international units of vitamin D Results: Participants (46% women, mean age: 69 y), were followed up for a median of 5 y. Vitamin D supplementation had little or no effect on the incidence of hospitalization for any infection [incidence rate ratio (IRR): 0.95; 95% CI: 0.86, 1.05], respiratory tract (IRR: 0.93; 95% CI: 0.81, 1.08), skin (IRR: 0.95; 95% CI: 0.76, 1.20), gastrointestinal infections (IRR: 1.03; 95% CI: 0.84, 1.26), or hospitalizations lasting >3 d (IRR: 0.94; 95% CI: 0.81, 1.09), with all CIs consistent with a null finding. People supplemented with vitamin D had fewer hospitalizations lasting >6 d (IRR: 0.80; 95% CI: 0.65, 0.99). Conclusions: We did not find a protective effect of vitamin D on hospitalization for infection, but it reduced the number of extended hospitalizations. In populations where few people are vitamin D deficient, the effect of population-wide supplementation is likely to be small, but these findings support previous studies suggesting that vitamin D plays a role in infectious disease. The D-Health Trial is registered at the Australian New Zealand Clinical Trials Registry as ACTRN12613000743763.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Australia/epidemiology ; Vitamin D/therapeutic use ; Vitamins/therapeutic use ; Cholecalciferol/therapeutic use ; Dietary Supplements ; Hospitalization ; Double-Blind Method
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2022-12-23
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280048-2
ISSN	1938-3207 ; 0002-9165
ISSN (online)	1938-3207
ISSN	0002-9165
DOI	10.1016/j.ajcnut.2022.11.015
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Article ; Online: The effect of vitamin D supplementation on risk of keratinocyte cancer: an exploratory analysis of the D-Health randomized controlled trial.

Ali, Sitwat / Pham, Hai / Waterhouse, Mary / Baxter, Catherine / Romero, Briony Duarte / McLeod, Donald S A / Armstrong, Bruce K / Ebeling, Peter R / English, Dallas R / Hartel, Gunter / van der Pols, Jolieke C / Venn, Alison J / Webb, Penelope M / Whiteman, David C / Neale, Rachel E

The British journal of dermatology

2022 Volume 187, Issue 5, Page(s) 667–675

Abstract: Background: Vitamin D may play a role in prevention of keratinocyte cancer (KC), but observational studies examining the association between serum 25-hydroxy vitamin D concentration and KC are largely uninformative because sun exposure causes both KC ... ...

Abstract	Background: Vitamin D may play a role in prevention of keratinocyte cancer (KC), but observational studies examining the association between serum 25-hydroxy vitamin D concentration and KC are largely uninformative because sun exposure causes both KC and vitamin D production. There is scant evidence from clinical trials of supplementary vitamin D. Objectives: To examine the effect of vitamin D supplementation on the risk of developing KC. Methods: We used data from the D-Health Trial, a randomized placebo-controlled trial of vitamin D supplementation (60 000 international units monthly for 5 years) among Australians aged ≥60 years. KC outcomes were captured through linkage to a national administrative dataset for those who consented (N = 20 334; 95%). We used negative binomial regression to analyse the incidence of KC excisions and the incidence of actinic lesions treated using cryotherapy or serial curettage, and flexible parametric survival models for analysis of time to first KC excision. Results: Randomization to vitamin D supplementation did not reduce the incidence of KC lesions treated by excision [incidence rate ratio (IRR) 1·04; 95% confidence interval (CI) 0·98-1·11], the incidence of actinic lesions treated using other methods (IRR 1·01; 95% CI 0·95-1·08) or time to first histologically confirmed KC excision (hazard ratio 1·02; 95% CI 0·97-1·08). However, in subgroup analysis vitamin D increased the incidence of KC excisions in adults aged ≥ 70 years (IRR 1·13, 95% CI 1·04-1·23; P-value for interaction = 0·01). Conclusions: Vitamin D supplementation did not reduce the incidence of KC or other actinic lesions. What is already known about this topic? Laboratory studies have suggested possible protective effects of vitamin D on skin cancer. Observational studies investigating the association between vitamin D and risk of keratinocyte cancer are largely uninformative as ultraviolet radiation both causes skin cancer and is the primary source of vitamin D. The evidence from randomized controlled trials of vitamin D is limited and inconclusive. What does this study add? This population-based, randomized controlled trial suggests that supplementing older adults with a high monthly dose of vitamin D for 5 years does not affect the incidence of keratinocyte cancer.
MeSH term(s)	Humans ; Aged ; Ultraviolet Rays ; Australia/epidemiology ; Vitamins ; Vitamin D ; Skin Neoplasms/epidemiology ; Skin Neoplasms/etiology ; Skin Neoplasms/prevention & control ; Dietary Supplements ; Keratinocytes ; Randomized Controlled Trials as Topic
Chemical Substances	Vitamins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2022-08-10
Publishing country	England
Document type	Journal Article
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.21742
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Article ; Online: The effect of vitamin D supplementation on the gut microbiome in older Australians - Results from analyses of the D-Health Trial.

Pham, Hai / Waterhouse, Mary / Rahman, Sabbir / Baxter, Catherine / Duarte Romero, Briony / McLeod, Donald S A / Ebeling, Peter R / English, Dallas R / Hartel, Gunter / O'Connell, Rachel L / van der Pols, Jolieke C / Venn, Alison J / Webb, Penelope M / Whiteman, David C / Huygens, Flavia / Neale, Rachel E

Gut microbes

2023 Volume 15, Issue 1, Page(s) 2221429

Abstract: Observational studies suggest a link between vitamin D and the composition of the gut microbiome, but there is little evidence from randomized controlled trials of vitamin D supplementation. We analyzed data from the D-Health Trial, a randomized, double- ... ...

Abstract	Observational studies suggest a link between vitamin D and the composition of the gut microbiome, but there is little evidence from randomized controlled trials of vitamin D supplementation. We analyzed data from the D-Health Trial, a randomized, double-blind, placebo-controlled trial. We recruited 21,315 Australians aged 60-84 y and randomized them to 60,000 IU of vitamin D
MeSH term(s)	Aged ; Female ; Humans ; Male ; Australia ; Bacteroidetes ; Dietary Supplements ; Double-Blind Method ; Firmicutes ; Gastrointestinal Microbiome ; RNA, Ribosomal, 16S ; Vitamin D ; Aged, 80 and over
Chemical Substances	RNA, Ribosomal, 16S ; Vitamin D (1406-16-2)
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2575755-6
ISSN	1949-0984 ; 1949-0984
ISSN (online)	1949-0984
ISSN	1949-0984
DOI	10.1080/19490976.2023.2221429
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Article ; Online: Vitamin D supplementation and cognition-Results from analyses of the D-Health trial.

Pham, Hai / Waterhouse, Mary / Rahman, Sabbir / Baxter, Catherine / Romero, Briony Duarte / McLeod, Donald S A / Armstrong, Bruce K / Ebeling, Peter R / English, Dallas R / Hartel, Gunter / Kimlin, Michael G / O'Connell, Rachel L / van der Pols, Jolieke C / Venn, Alison J / Webb, Penelope M / Whiteman, David C / Almeida, Osvaldo P / Neale, Rachel E

Journal of the American Geriatrics Society

2023 Volume 71, Issue 6, Page(s) 1773–1784

Abstract: Background: Observational studies have consistently found a link between low serum 25-hydroxyvitamin D concentration and higher risk of cognitive impairment. Results from randomized controlled trials have been mixed, and few have been conducted in the ... ...

Abstract	Background: Observational studies have consistently found a link between low serum 25-hydroxyvitamin D concentration and higher risk of cognitive impairment. Results from randomized controlled trials have been mixed, and few have been conducted in the general population. Methods: We recruited 21,315 community-dwelling Australians aged between 60 and 84 years to participate in the D-Health Trial, a randomized, double-blind, placebo-controlled trial. The intervention was monthly oral doses of 60,000 international units of vitamin D or placebo for 5 years. We assessed cognitive function in a randomly sampled group of participants aged ≥70 years using the Telephone Interview for Cognitive Status (TICS) at 2 and 5 years after randomization. The primary outcome for this analysis was TICS score; the secondary outcome was the proportion of people who had cognitive impairment (defined as TICS score ≤25). We analyzed data using mixed models (linear and logistic). Results: We interviewed 3887 participants at year 2 and 3614 participants at year 5. The mean TICS score at these time points was 32.3 and 32.2, respectively. Vitamin D supplementation did not affect cognitive function as measured by TICS score (mean difference between vitamin D and placebo groups 0.04; 95% CI -0.14 to 0.23), or alter risk of cognitive impairment (odds ratio 1.00; 95% CI 0.75 to 1.33). Conclusions: Monthly bolus doses of vitamin D supplementation neither enhanced nor hindered cognitive function among older adults. Population-wide vitamin D supplementation of older adults that are largely vitamin D replete is unlikely to substantially benefit cognition.
MeSH term(s)	Humans ; Aged ; Aged, 80 and over ; Dietary Supplements ; Australia/epidemiology ; Vitamins/therapeutic use ; Vitamin D ; Cognition ; Double-Blind Method ; Cholecalciferol ; Randomized Controlled Trials as Topic
Chemical Substances	Vitamins ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2023-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.18247
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