LIVIVO - Search results -

Search results

Result 1 - 10 of total 94

Search options

Article ; Online: Interesting effects of interleukins and immune cells on acute respiratory distress syndrome.

Saki, Najmaldin / Javan, Mohammadreza / Moghimian-Boroujeni, Bahareh / Kast, Richard Eric

2023 Volume 23, Issue 7, Page(s) 2979–2996

Abstract: Acute respiratory distress syndrome (ARDS) is a medical condition characterized by widespread inflammation in the lungs with consequent proportional loss of gas exchange function. ARDS is linked with severe pulmonary or systemic infection. Several ... ...

Abstract	Acute respiratory distress syndrome (ARDS) is a medical condition characterized by widespread inflammation in the lungs with consequent proportional loss of gas exchange function. ARDS is linked with severe pulmonary or systemic infection. Several factors, including secretory cytokines, immune cells, and lung epithelial and endothelial cells, play a role in the development and progression of this disease. The present study is based on Pubmed database information (1987-2022) using the words "Acute respiratory distress syndrome", "Interleukin", "Cytokines" and "Immune cells". Cytokines and immune cells play an important role in this disease, with particular emphasis on the balance between pro-inflammatory and anti-inflammatory factors. Neutrophils are one of several important mediators of Inflammation, lung tissue destruction, and malfunction during ARDS. Some immune cells, such as macrophages and eosinophils, play a dual role in releasing inflammatory mediators, recruitment inflammatory cells and the progression of ARDS, or releasing anti-inflammatory mediators, clearing the lung of inflammatory cells, and helping to improve the disease. Different interleukins play a role in the development or inhibition of ARDS by helping to activate various signaling pathways, helping to secrete other inflammatory or anti-inflammatory interleukins, and playing a role in the production and balance between immune cells involved in ARDS. As a result, immune cells and, inflammatory cytokines, especially interleukins play an important role in the pathogenesis of this disease Therefore, understanding the relevant mechanisms will help in the proper diagnosis and treatment of this disease.
MeSH term(s)	Humans ; Endothelial Cells/pathology ; Bronchoalveolar Lavage Fluid ; Respiratory Distress Syndrome/metabolism ; Respiratory Distress Syndrome/pathology ; Respiratory Distress Syndrome/therapy ; Interleukins ; Cytokines/metabolism ; Inflammation ; Anti-Inflammatory Agents
Chemical Substances	Interleukins ; Cytokines ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-06-18
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-023-01118-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5481: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Dapsone, colchicine and olanzapine as treatment adjuncts to prevent COVID-19 associated adult respiratory distress syndrome (ARDS).

Altschuler, Eric L / Kast, Richard E

Medical hypotheses

2020 Volume 141, Page(s) 109774

MeSH term(s)	Adult ; Betacoronavirus ; COVID-19 ; Chemotaxis, Leukocyte/drug effects ; Colchicine/administration & dosage ; Colchicine/therapeutic use ; Coronavirus Infections/complications ; Dapsone/administration & dosage ; Dapsone/therapeutic use ; Humans ; Interleukin-8/physiology ; Neutrophils/drug effects ; Olanzapine/administration & dosage ; Olanzapine/therapeutic use ; Pandemics ; Pneumonia, Viral/complications ; Respiratory Distress Syndrome/drug therapy ; Respiratory Distress Syndrome/etiology ; SARS-CoV-2
Chemical Substances	Interleukin-8 ; Dapsone (8W5C518302) ; Olanzapine (N7U69T4SZR) ; Colchicine (SML2Y3J35T)
Keywords	covid19
Language	English
Publishing date	2020-04-23
Publishing country	United States
Document type	Letter
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2020.109774
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1132: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Globus Lucidus: A porcine study of an intracranial implant designed to deliver closed, repetitive photodynamic and photochemical therapy in glioblastoma.

Bader, Nicolas / Peschmann, Christian / Kast, Richard Eric / Heiland, Tim / Merz, Tamara / McCook, Oscar / Alfieri, Alex / Karpel-Massler, Georg / Capanni, Felix / Halatsch, Marc-Eric

Photodiagnosis and photodynamic therapy

2024 Volume 46, Page(s) 104059

Abstract: Objective: Herein we describe initial results in a porcine model of a fully implantable device designed to allow closed, repetitive photodynamic treatment of glioblastoma (GBM).: Methods: This implant, Globus Lucidus, is a transparent quartz glass ... ...

Abstract	Objective: Herein we describe initial results in a porcine model of a fully implantable device designed to allow closed, repetitive photodynamic treatment of glioblastoma (GBM). Methods: This implant, Globus Lucidus, is a transparent quartz glass sphere with light-emitting diodes releasing wavelengths of 630 nm (19.5 mW/cm Results: Surgery, implants, and repeated irradiations using the different wavelengths were generally well tolerated. Social behavior, wound healing, body weight, and temperature remained unaffected. Histopathological analyses revealed consistent leukocyte infiltration around the intracerebral implant sites with no significant differences between experimental and control groups. Conclusion: This Globus Lucidus porcine study prepares the groundwork for adjuvant, long-term, repeated PDT of the GBM infiltration zone. This is the first report of a fully implantable PDT/PCT device for the potential treatment of GBM. A preclinical effectivity study of Globus Lucidus PDT/PCT is warranted and in advanced stages of planning.
Language	English
Publishing date	2024-03-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2149918-4
ISSN	1873-1597 ; 1572-1000
ISSN (online)	1873-1597
ISSN	1572-1000
DOI	10.1016/j.pdpdt.2024.104059
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: OPALS: A New Osimertinib Adjunctive Treatment of Lung Adenocarcinoma or Glioblastoma Using Five Repurposed Drugs.

Kast, Richard E / Halatsch, Marc-Eric / Rosell, Rafael

Cells

2021 Volume 10, Issue 5

Abstract: Background: Pharmacological targeting aberrant activation of epidermal growth factor receptor tyrosine kinase signaling is an established approach to treating lung adenocarcinoma. Osimertinib is a tyrosine kinase approved and effective in treating lung ... ...

Abstract	Background: Pharmacological targeting aberrant activation of epidermal growth factor receptor tyrosine kinase signaling is an established approach to treating lung adenocarcinoma. Osimertinib is a tyrosine kinase approved and effective in treating lung adenocarcinomas that have one of several common activating mutations in epidermal growth factor receptor. The emergence of resistance to osimertinib after a year or two is the rule. We developed a five-drug adjuvant regimen designed to increase osimertinib's growth inhibition and thereby delay the development of resistance. Areas of Uncertainty: Although the assembled preclinical data is strong, preclinical data and the following clinical trial results can be discrepant. The safety of OPALS drugs when used individually is excellent. We have no data from humans on their tolerability when used as an ensemble. That there is no data from the individual drugs to suspect problematic interaction does not exclude the possibility. Data sources: All relevant PubMed.org articles on the OPALS drugs and corresponding pathophysiology of lung adenocarcinoma and glioblastoma were reviewed. Therapeutic Opinion: The five drugs of OPALS are in wide use in general medicine for non-oncology indications. OPALS uses the anti-protozoal drug pyrimethamine, the antihistamine cyproheptadine, the antibiotic azithromycin, the antihistamine loratadine, and the potassium sparing diuretic spironolactone. We show how these inexpensive and generically available drugs intersect with and inhibit lung adenocarcinoma growth drive. We also review data showing that both OPALS adjuvant drugs and osimertinib have data showing they may be active in suppressing glioblastoma growth.
MeSH term(s)	Acrylamides/administration & dosage ; Adenocarcinoma of Lung/drug therapy ; Aniline Compounds/administration & dosage ; Animals ; Azithromycin/administration & dosage ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Cell Line, Tumor ; Chemotherapy, Adjuvant/methods ; Cyproheptadine/administration & dosage ; Drug Repositioning ; Drug Resistance, Neoplasm/drug effects ; ErbB Receptors/antagonists & inhibitors ; Glioblastoma/drug therapy ; Humans ; Loratadine/administration & dosage ; Lung Neoplasms/drug therapy ; Mice ; Neoplasm Metastasis/drug therapy ; Pyrimethamine/administration & dosage ; Spironolactone/administration & dosage
Chemical Substances	Acrylamides ; Aniline Compounds ; Spironolactone (27O7W4T232) ; Cyproheptadine (2YHB6175DO) ; osimertinib (3C06JJ0Z2O) ; Loratadine (7AJO3BO7QN) ; Azithromycin (83905-01-5) ; ErbB Receptors (EC 2.7.10.1) ; Pyrimethamine (Z3614QOX8W)
Language	English
Publishing date	2021-05-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10051148
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Dapsone, colchicine and olanzapine as treatment adjuncts to prevent COVID-19 associated adult respiratory distress syndrome (ARDS)

Altschuler, Eric L / Kast, Richard E

Med Hypotheses

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32344275
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Dapsone, colchicine and olanzapine as treatment adjuncts to prevent COVID-19 associated adult respiratory distress syndrome (ARDS)

Altschuler, Eric L. / Kast, Richard E.

Medical Hypotheses

2020 Volume 141, Page(s) 109774

Keywords	General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2020.109774
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.A 1132: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Tumor Treating Fields (TTFields) combined with the drug repurposing approach CUSP9v3 induce metabolic reprogramming and synergistic anti-glioblastoma activity in vitro.

Cao, Qiyu / Hajosch, Annika / Kast, Richard Eric / Loehmann, Christopher / Hlavac, Michal / Fischer-Posovszky, Pamela / Strobel, Hannah / Westhoff, Mike-Andrew / Siegelin, Markus D / Wirtz, Christian Rainer / Halatsch, Marc-Eric / Karpel-Massler, Georg

British journal of cancer

2024 Volume 130, Issue 8, Page(s) 1365–1376

Abstract: Background: Glioblastoma represents a brain tumor with a notoriously poor prognosis. First-line therapy may include adjunctive Tumor Treating Fields (TTFields) which are electric fields that are continuously delivered to the brain through non-invasive ... ...

Abstract	Background: Glioblastoma represents a brain tumor with a notoriously poor prognosis. First-line therapy may include adjunctive Tumor Treating Fields (TTFields) which are electric fields that are continuously delivered to the brain through non-invasive arrays. On a different note, CUSP9v3 represents a drug repurposing strategy that includes 9 repurposed drugs plus metronomic temozolomide. Here, we examined whether TTFields enhance the antineoplastic activity of CUSP9v3 against this disease. Methods: We performed preclinical testing of a multimodal approach of TTFields and CUSP9v3 in different glioblastoma models. Results: TTFields had predominantly synergistic inhibitory effects on the cell viability of glioblastoma cells and non-directed movement was significantly impaired when combined with CUSP9v3. TTFields plus CUSP9v3 significantly enhanced apoptosis, which was associated with a decreased mitochondrial outer membrane potential (MOMP), enhanced cleavage of effector caspase 3 and reduced expression of Bcl-2 and Mcl-1. Moreover, oxidative phosphorylation and expression of respiratory chain complexes I, III and IV was markedly reduced. Conclusion: TTFields strongly enhance the CUSP9v3-mediated anti-glioblastoma activity. TTFields are currently widely used for the treatment of glioblastoma patients and CUSP9v3 was shown to have a favorable safety profile in a phase Ib/IIa trial (NCT02770378) which facilitates transition of this multimodal approach to the clinical setting.
MeSH term(s)	Humans ; Glioblastoma/drug therapy ; Drug Repositioning ; Metabolic Reprogramming ; Temozolomide/pharmacology ; Antineoplastic Agents/therapeutic use ; Brain Neoplasms/drug therapy ; Electric Stimulation Therapy ; Combined Modality Therapy
Chemical Substances	Temozolomide (YF1K15M17Y) ; Antineoplastic Agents
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-024-02608-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.142: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: OPALS

Richard E. Kast / Marc-Eric Halatsch / Rafael Rosell

Cells, Vol 10, Iss 1148, p

A New Osimertinib Adjunctive Treatment of Lung Adenocarcinoma or Glioblastoma Using Five Repurposed Drugs

2021 Volume 1148

Abstract	Background: Pharmacological targeting aberrant activation of epidermal growth factor receptor tyrosine kinase signaling is an established approach to treating lung adenocarcinoma. Osimertinib is a tyrosine kinase approved and effective in treating lung adenocarcinomas that have one of several common activating mutations in epidermal growth factor receptor. The emergence of resistance to osimertinib after a year or two is the rule. We developed a five-drug adjuvant regimen designed to increase osimertinib’s growth inhibition and thereby delay the development of resistance. Areas of Uncertainty: Although the assembled preclinical data is strong, preclinical data and the following clinical trial results can be discrepant. The safety of OPALS drugs when used individually is excellent. We have no data from humans on their tolerability when used as an ensemble. That there is no data from the individual drugs to suspect problematic interaction does not exclude the possibility. Data Sources: All relevant PubMed.org articles on the OPALS drugs and corresponding pathophysiology of lung adenocarcinoma and glioblastoma were reviewed. Therapeutic Opinion: The five drugs of OPALS are in wide use in general medicine for non-oncology indications. OPALS uses the anti-protozoal drug pyrimethamine, the antihistamine cyproheptadine, the antibiotic azithromycin, the antihistamine loratadine, and the potassium sparing diuretic spironolactone. We show how these inexpensive and generically available drugs intersect with and inhibit lung adenocarcinoma growth drive. We also review data showing that both OPALS adjuvant drugs and osimertinib have data showing they may be active in suppressing glioblastoma growth.
Keywords	EGFR ; NSCLC ; osimertinib ; repurposing ; cancer stem cells ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Ritonavir and Disulfiram May Be Synergistic in Lowering Active Interleukin-18 Levels in Acute Pancreatitis, and thereby Hasten Recovery

Richard Eric Kast

JOP Journal of the Pancreas, Vol 9, Iss 3, Pp 350-

2016 Volume 353

Abstract: This short note reviews the role of interleukin-18 (IL-18) in acute pancreatitis. IL-18 is a narrow yet important aspect of acute pancreatitis. Narrow because many other inflammatory mediators are active in acute pancreatitis, but important because: a) ... ...

Abstract	This short note reviews the role of interleukin-18 (IL-18) in acute pancreatitis. IL-18 is a narrow yet important aspect of acute pancreatitis. Narrow because many other inflammatory mediators are active in acute pancreatitis, but important because: a) many of the other inflammatory mediators arise secondary to IL-18; and B) we happen to have several medicines, in use for other purposes for decades, that pre-clinical and murine studies have indicated happily have ability to lower active IL-18 formation. Also giving IL-18 particular importance is: c) the cause of early mortality in acute pancreatitis is mostly due to systemic inflammation, for which IL-18 is an important driving force [1, 2, 3].
Keywords	Captopril ; Caspase 1 ; Disulfiram ; Inflammation ; Interleukin-18 ; Pancreatitis ; Ritonavir ; Medicine ; R ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951 ; Diseases of the digestive system. Gastroenterology ; RC799-869
Subject code	610
Publishing date	2016-05-01T00:00:00Z
Publisher	E S Burioni Ricerche Bibliografiche
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Ritonavir and disulfiram may be synergistic in lowering active interleukin-18 levels in acute pancreatitis, and thereby hasten recovery.

Kast, Richard Eric

JOP : Journal of the pancreas

2008 Volume 9, Issue 3, Page(s) 350–353

Abstract: Interleukin-18 (IL-18) is one of the mediators of both pancreas damage and systemic complications like hypotension and multi-organ dysfunction during acute pancreatitis. IL-18 is generated intracellularly from pro-IL-18 by caspase-1 mediated proteolysis. ...

Abstract	Interleukin-18 (IL-18) is one of the mediators of both pancreas damage and systemic complications like hypotension and multi-organ dysfunction during acute pancreatitis. IL-18 is generated intracellularly from pro-IL-18 by caspase-1 mediated proteolysis. Active caspase-1 itself is generated intracellularly by the action of the inflammasome, autocatalysis and other stimuli. The anti-retroviral drug ritonavir inhibits conversion of inactive pro-caspase-1 to active caspase-1. Since ritonavir is well tolerated in short-term use it may therefore prove useful in treating acute pancreatitis by lowering caspase-1 mediated IL-18 formation and the many inflammatory mediators downstream from that. The alcoholism treatment drug disulfiram has been in continuous use since the 1950s. It likewise has a low risk profile. Disulfiram inhibits several human proteases, among them caspase-1. Given the current morbidity and mortality of pancreatitis, research should be directed to ritonavir and disulfiram as treatment options for illnesses like pancreatitis where excessive IL-18 contributes to pathology. The first clinically used angiotensin converting enzyme inhibitor, captopril, has shown potent caspase-1 inhibiting activity as well and should be investigated in rodent models of human pancreatitis.
MeSH term(s)	Acute Disease ; Animals ; Antihypertensive Agents/pharmacology ; Captopril/pharmacology ; Caspase Inhibitors ; Disulfiram/administration & dosage ; Disulfiram/pharmacology ; Drug Synergism ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/pharmacology ; Humans ; Interleukin-18/blood ; Interleukin-18/metabolism ; Interleukin-18/physiology ; Models, Biological ; Pancreatitis/blood ; Pancreatitis/drug therapy ; Pancreatitis/etiology ; Remission Induction ; Ritonavir/administration & dosage ; Ritonavir/pharmacology ; Time Factors
Chemical Substances	Antihypertensive Agents ; Caspase Inhibitors ; Enzyme Inhibitors ; Interleukin-18 ; Captopril (9G64RSX1XD) ; Ritonavir (O3J8G9O825) ; Disulfiram (TR3MLJ1UAI)
Language	English
Publishing date	2008-05-08
Publishing country	Italy
Document type	Letter ; Review
ZDB-ID	2039637-5
ISSN	1590-8577 ; 1590-8577
ISSN (online)	1590-8577
ISSN	1590-8577
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito