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  1. Article: Ovarian volume is more closely related to the different manifestations of polycystic ovary syndrome than follicle number per ovary.

    Afrine, Shazia / Haque, Jasmine Ara / Morshed, Md Shahed / Banu, Hurjahan / Hossain, Ahmed / Hasanat, Muhammad Abul

    Clinical and experimental reproductive medicine

    2023  Volume 50, Issue 3, Page(s) 200–205

    Abstract: Objective: Polycystic ovary (PCO), a diagnostic component of polycystic ovary syndrome (PCOS), requires either an ovarian volume (OV) criterion or a follicle number per ovary (FNPO) criterion. This study investigated the association of OV and FNPO ... ...

    Abstract Objective: Polycystic ovary (PCO), a diagnostic component of polycystic ovary syndrome (PCOS), requires either an ovarian volume (OV) criterion or a follicle number per ovary (FNPO) criterion. This study investigated the association of OV and FNPO criteria with various manifestations of PCOS.
    Methods: This cross-sectional study was conducted at a university hospital among 100 patients newly diagnosed with PCOS (according to the revised Rotterdam criteria). Fasting blood samples were collected to measure glucose, total testosterone (TT), luteinizing hormone (LH), follicle-stimulating hormone (FSH), lipid, insulin, and hemoglobin A1c levels. An oral glucose tolerance test was performed. Transabdominal or transvaginal ultrasound of the ovaries was done, depending on patients' marital status. All investigations were conducted in the follicular phase of the menstrual cycle. OV >10 mL and/or FNPO ≥12 indicated PCO. A homeostasis model assessment of insulin resistance (IR) value ≥2.6 indicated IR, and metabolic syndrome (MS) was defined according to the international harmonization criteria.
    Results: Seventy-six participants fulfilled the OV criterion, 70 fulfilled the FNPO criterion, and 89 overall had PCO. Both maximum OV and mean OV had a significant correlation with TT levels (<italic>r</italic>=0.239, <italic>p</italic>=0.017 and <italic>r</italic>=0.280, <italic>p</italic>=0.005, respectively) and the LH/FSH ratio (<italic>r</italic>=0.212, <italic>p</italic>=0.034 and <italic>r</italic>=0.200, <italic>p</italic>=0.047, respectively). Mean OV also had a significant correlation with fasting insulin levels (<italic>r</italic>=0.210, <italic>p</italic>=0.036). Multivariate binary logistic regression analysis showed that IR (odds ratio [OR], 9.429; 95% confidence interval [CI], 1.701 to 52.271; <italic>p</italic>=0.010) and MS (OR, 7.952; 95% CI, 1.821 to 34.731; <italic>p</italic>=0.006) had significant predictive associations with OV alone, even after adjustment for age and body mass index.
    Conclusion: OV may be more closely related to the androgenic and metabolic characteristics of PCOS than FNPO.
    Language English
    Publishing date 2023-06-13
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2653899-4
    ISSN 2233-8241 ; 2233-8233
    ISSN (online) 2233-8241
    ISSN 2233-8233
    DOI 10.5653/cerm.2023.05897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Spectrum of thyroid dysfunctions among hospitalized patients with non-critically ill coronavirus disease 2019

    Nusrat Sultana / Hurjahan Banu / Md Shahed Morshed / Touhida Akter / Ahmed Abu Saleh / Muhammad Abul Hasanat / Shohael Mahmud Arafat

    Bangabandhu Sheikh Mujib Medical University Journal, Vol 16, Iss

    A cross-sectional study

    2023  Volume 2

    Abstract: Background: Patients with coronavirus disease 2019 (COVID-19) particularly critically ill ones may present with different types of thyroid abnormalities. However, data regarding thyroid function tests (TFTs) among noncritical patients with COVID-19 are ... ...

    Abstract Background: Patients with coronavirus disease 2019 (COVID-19) particularly critically ill ones may present with different types of thyroid abnormalities. However, data regarding thyroid function tests (TFTs) among noncritical patients with COVID-19 are scarce. This study aimed to assess thyroid functions and their associations with the severity of illness among non-critically ill hospitalized patients with COVID-19. Methods: This cross-sectional study assessed TFTs in 87 (aged 18-65 years) RT-PCR-confirmed COVID-19 patients admitted to a tertiary-care hospital in Bangladesh. Diagnosis of non–critical illness and severity (mild, moderate, and severe) were defined by WHO’s interim guidance. Patients having known thyroid dysfunctions or taking drugs that may affect thyroid functions were excluded from the study. Serum TSH, FT4, and FT3 were measured by chemiluminescent immunoassay. Results: Majority of the patients (72%) had normal thyroid function. Among the abnormalities, the highest frequency was isolated hyperthyroxinemia (12.6%) and the rest were subclinical hypothyroidism (6.9%), subclinical thyrotoxicosis (4.6%), thyrotoxicosis (2.3%), isolated tri-iodothyroninemia (1.1%), and hypothyroidism (1.1%). Serum TSH, FT4, and FT3 levels were similar across the spectrum of noncritical illness. No significant correlation was found between the inflammatory markers (C-reactive protein, ferritin, and D-dimer) and TSH levels. Conclusions: More than one-fourth of non-critically ill hospitalized patients with COVID-19 presented with a spectrum of thyroid abnormalities with isolated hyperthyroxinemia being the most common. However, TFTs had no significant associations with the severity of illness among noncritically ill patients with COVID-19. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 81-86
    Keywords coronavirus ; COVID-19 ; thyroid function test ; isolated hyperthyroxinemia ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Bangabandhu Sheikh Mujib Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Sex-Specific Total Testosterone and Dehydroepiandrosterone Sulfate Status in Noncritically Ill Hospitalized Patients with Coronavirus Disease 2019: A Cross-Sectional Study.

    Banu, Hurjahan / Morshed, Md Shahed / Sultana, Nusrat / Akter, Touhida / Hasanat, Muhammad Abul / Saleh, Ahmed Abu / Arafat, Mahmud Shohael

    International journal of fertility & sterility

    2023  Volume 18, Issue 1, Page(s) 54–59

    Abstract: Background: In individuals with coronavirus disease 2019 (COVID-19), male subjects have consistently been linked to poor severity and prognosis. Data on sex hormones in non-critical COVID-19-infected patients are scarce. The aim of this study was to ... ...

    Abstract Background: In individuals with coronavirus disease 2019 (COVID-19), male subjects have consistently been linked to poor severity and prognosis. Data on sex hormones in non-critical COVID-19-infected patients are scarce. The aim of this study was to assess the status of total testosterone (TT) and dehydroepiandrosterone sulfate (DHEAS) among noncritical patients with COVID-19 according to sex and their associations with clinical and biochemical features.
    Materials and methods: This cross-sectional observational study was done in the COVID-19 unit of a University hospital during the period of September 2021 to February 2022 among 91 adults (18-65 years) with reverse transcriptase- polymerase chain reaction confirmed noncritical COVID-19 patients. Blood was drawn by venipuncture before receiving steroids between 07:00 to 09:00 a.m. in a fasting state to measure serum TT and DHEAS by chemiluminescent microparticle immunoassay. Diagnosis and classification of COVID-19 were done according to World Health Organization's interim guidance. Age- and sex-specific laboratory reference values were used to classify the TT and DHEAS status of the patients.
    Results: Only three males (8.1%) had low TT and the rest had normal TT. On the other hand, 15 (27.8%) of the females had high TT with normal levels in the rest. Similarly, 11 (29.7%) males had low DHEAS. Females had low, normal, and high DHEAS in four (7.4%), 48 (88.9%), and two (3.7%) cases respectively. Males with moderate severity of COVID-19 had significantly lower DHEAS (post hoc P=0.038) than the mild group. Both TT (P=0.008) and DHEAS (P=0.023) significantly correlated with neutrophils/lymphocytes ratio and only DHEAS with platelets/lymphocytes ratio (P=0.044) in males. In females, TT significantly correlated with serum sodium (P=0.034).
    Conclusion: In noncritical COVID-19 patients, substantial gender variations in TT and DHEAS were detected and correlated with severity markers in males.
    Language English
    Publishing date 2023-11-01
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2570865-X
    ISSN 2008-0778 ; 2008-076X
    ISSN (online) 2008-0778
    ISSN 2008-076X
    DOI 10.22074/ijfs.2023.1978415.1407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Prevalence of Type 2 Diabetes Mellitus Among Urban Bihari Communities in Dhaka, Bangladesh: A Cross-sectional Study in a Minor Ethnic Group.

    Asaduzzaman, Muhammad / Chowdhury, Shahanaz / Shahed, Jahid Hossen / Kafi, Mohammad Abdullah Heel / Uzzaman, Md Nazim / Flowra, Mahfuza Talukder / Ahmed, Msa Mansur

    Cureus

    2018  Volume 10, Issue 1, Page(s) e2116

    Abstract: Introduction The prevalence, disease progression, and treatment outcomes for patients with type 2 diabetes vary significantly between ethnic groups. The Bihari community constitutes one of the most vulnerable populations in Bangladesh on the basis of ... ...

    Abstract Introduction The prevalence, disease progression, and treatment outcomes for patients with type 2 diabetes vary significantly between ethnic groups. The Bihari community constitutes one of the most vulnerable populations in Bangladesh on the basis of access to health services and other fundamental rights. Our study aimed at finding out the prevalence and risk factors of type 2 diabetes among the Bihari adults in Dhaka city. Methods This cross-sectional community-based study was carried out among stranded Pakistanis (known as Bihari) living in camps in the Mirpur area from July 2014 to June 2015. Laboratory-based oral glucose tolerance test (OGTT) was the basis for the diagnosis of type 2 diabetes mellitus (DM). Anthropometric measurements, blood pressure, biochemical tests, family history, and socioeconomic information were obtained to determine the risk factors. Results The prevalence of diabetes mellitus (DM), impaired glucose tolerance (IGT), and impaired fasting glucose (IFG) were estimated at 10.11%, 8.74%, and 4.55%, respectively. Increased diastolic blood pressure, serum triglyceride, and cholesterol level were observed to be significantly (p < 0.05) associated with diabetes. Also, the presence of diabetes, high blood pressure, and obesity among relatives significantly increased the probability of diabetes. Conclusions To the best of our knowledge, this is the first study on diabetes prevalence among the Bihari community in Bangladesh. The prevalence of type 2 diabetes mellitus was found to be higher among the Bihari community compared to the general population in Bangladesh. Health planners and policymakers should realize the alarming situation and identified risk factors and consider the minor ethnic groups during decision-making regarding prevention and control of diabetes and other noncommunicable diseases.
    Language English
    Publishing date 2018-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.2116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Rituximab and nephrotic syndrome: a new therapeutic hope?

    Ahmed, Muhammad Shahed / Wong, Christopher F

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2008  Volume 23, Issue 1, Page(s) 11–17

    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Murine-Derived ; Glomerulonephritis, Membranous/complications ; Glomerulosclerosis, Focal Segmental/complications ; Humans ; Immunologic Factors/therapeutic use ; Nephrotic Syndrome/drug therapy ; Nephrotic Syndrome/etiology ; Rituximab
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Murine-Derived ; Immunologic Factors ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2008-01
    Publishing country England
    Document type Comment ; Editorial ; Review
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfm683
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2198: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: Survival akin to injury, hospitalized patients with acute kidney injury based on the AKIN classification.

    Ahmed, Muhammad Shahed / Lim, Rebecca / Selvaratnam, Veenesh / James, Angharad / Kelly, Patrick O / Abraham, Kottarathil A / Wong, Christopher F

    Clinical nephrology

    2012  Volume 78, Issue 5, Page(s) 370–375

    Abstract: Introduction: Acute kidney injury (AKI) is often associated with severe consequences. The aim of the study was to determine whether the acute kidney injury network classification predicts hospital stay, renal recovery and mortality.: Methods: ... ...

    Abstract Introduction: Acute kidney injury (AKI) is often associated with severe consequences. The aim of the study was to determine whether the acute kidney injury network classification predicts hospital stay, renal recovery and mortality.
    Methods: Hospitalized patients who were referred to the nephrology service over 6 months were studied retrospective with further 12 months prospective follow up. Statistical analysis was performed on their demography and outcome.
    Results: Among the 238 patients who were referred, 166 had AKI, median age 74 years and 32% were diabetics. 10% (n = 17) required acute renal replacement therapy. The overall all-cause mortality of AKI group (n = 166) compared to non-AKI group (n = 72) at 1 year was 55% as opposed to 27.8% (p < 0.001). There was a significant statistical difference in the composite outcome and survival between the AKI stages in terms of renal recovery (p = 0.018). The AKI group had a median 8 day increase in length of stay compared to the non-AKI group (20 vs. 12 days; p = 0.0175). However, there was no significant statistical difference between pre and post admission AKI (p value = 0.191).
    Conclusion: The AKIN staging of AKI predicts both early and late mortality. AKI has a major impact on inpatient and 1-year-survival, renal recovery and length of stay. AKI and renal recovery following the insult were independent prognosticators. Early identification and management of AKI cases can help to prevent progression of the severity of AKI and therefore, mandates timely referral to nephrology team to prevent progression of AKIN class and its consequences.
    MeSH term(s) Acute Kidney Injury/classification ; Acute Kidney Injury/mortality ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Disease Progression ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Prospective Studies ; Retrospective Studies
    Language English
    Publishing date 2012-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185101-9
    ISSN 0301-0430
    ISSN 0301-0430
    DOI 10.5414/CN106948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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