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Article: Prediction of the Post-Pubertal Mandibular Length and Y Axis of Growth by Using Various Machine Learning Techniques: A Retrospective Longitudinal Study.

Wood, Tyler / Anigbo, Justina O / Eckert, George / Stewart, Kelton T / Dundar, Mehmet Murat / Turkkahraman, Hakan

2023 Volume 13, Issue 9

Abstract: The aim was to predict the post-pubertal mandibular length and Y axis of growth in males by using ... When predicting the Y axis of growth, accuracies ranged from 96.60% to 98.34%. There was no significant ...

Abstract	The aim was to predict the post-pubertal mandibular length and Y axis of growth in males by using various machine learning (ML) techniques. Cephalometric data obtained from 163 males with Class I Angle malocclusion, were used to train various ML algorithms. Analysis of variances (ANOVA) was used to compare the differences between predicted and actual measurements among methods and between time points. All the algorithms revealed an accuracy range from 95.80% to 97.64% while predicting post-pubertal mandibular length. When predicting the Y axis of growth, accuracies ranged from 96.60% to 98.34%. There was no significant interaction between methods and time points used for predicting the mandibular length (
Language	English
Publishing date	2023-04-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13091553
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Article: The frequencies of Y chromosome microdeletions in infertile males.

Akınsal, Emre Can / Baydilli, Numan / Dündar, Munis / Ekmekçioğlu, Oğuz

Turkish journal of urology

2018 Volume 44, Issue 5, Page(s) 389–392

Abstract: Objective: To determine the frequencies and the characteristics of Y chromosome microdeletions ... and the characteristics of Y chromosome microdeletions were investigated in groups.: Results: Y ... of infertility that could be detected, no Y chromosome microdeletions were detected in some groups (cases ...

Abstract	Objective: To determine the frequencies and the characteristics of Y chromosome microdeletions in infertile males. Material and methods: The records of 1616 infertile males were included in the study. The cases were divided into groups according to the infertility etiology and semen analysis. The frequencies and the characteristics of Y chromosome microdeletions were investigated in groups. Results: Y chromosome microdeletion was detected in 54 (3.3%) of 1616 cases. Microdeletions in the azoospermia factor (AZF) region were the most common (48.1%). When the cases were grouped according to causes of infertility that could be detected, no Y chromosome microdeletions were detected in some groups (cases with Klinefelter Syndrome, hypogonadotropic hypogonadism, congenital absence of vas deferens, and 47, XYY karyotype). Conclusion: Y chromosome microdeletions were detected quite frequently in certain infertility subgroups. Therefore, detailed evaluation of an infertile man by physical examination, semen analysis, hormonal evaluations and when required, karyotype analysis may predict the patients for whom Y chromosome microdeletion analysis is necessary and also prevent cost increases.
Language	English
Publishing date	2018-01-04
Publishing country	Turkey
Document type	Journal Article
ISSN	2149-3235
ISSN	2149-3235
DOI	10.5152/tud.2018.73669
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Article: An uncommon cause of infertility: Y;1 translocation and PGD trial.

Dundar, M / Balta, B / Bahadir, O / Acar, H / Baydilli, N / Baltaci, V / Ekmekcioglu, O / Saatci, C

Genetic counseling (Geneva, Switzerland)

2014 Volume 25, Issue 3, Page(s) 353–355

MeSH term(s)	Adult ; Azoospermia/diagnosis ; Azoospermia/genetics ; Chromosome Banding ; Chromosomes, Human, Pair 1/genetics ; Humans ; In Situ Hybridization, Fluorescence ; Karyotyping ; Male ; Preimplantation Diagnosis ; Translocation, Genetic/genetics
Language	English
Publishing date	2014
Publishing country	Switzerland
Document type	Case Reports ; Letter
ZDB-ID	1044796-9
ISSN	1015-8146
ISSN	1015-8146
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Zs.A 3017: Show issues

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Article ; Online: Utilidad de la aceleración isovolumétrica y los parámetros de ecocardiografía Doppler tisular en la predicción de la recuperación funcional postoperatoria tras cirugía valvular cardiaca.

Tigen, Kursat / Karaahmet, Tansu / Zencirkiran, Hicaz / Cevik, Cihan / Gurel, Emre / Fotbolcu, Hakan / Dundar, Cihan / Sasmazel, Ahmet / Basaran, Yelda

Revista espanola de cardiologia

2010 Volume 63, Issue 4, Page(s) 430–438

Abstract: Introduction and objectives: Postoperative right ventricular (RV) systolic dysfunction is associated with perioperative myocardial ischemia, hypothermic cardiac arrest, cardiopulmonary bypass and pericardial injury. As myocardial acceleration during ... ...

Title translation	Usefulness of isovolumic acceleration and tissue Doppler echocardiographic parameters for predicting postoperative functional recovery after heart valve surgery.
Abstract	Introduction and objectives: Postoperative right ventricular (RV) systolic dysfunction is associated with perioperative myocardial ischemia, hypothermic cardiac arrest, cardiopulmonary bypass and pericardial injury. As myocardial acceleration during isovolumic contraction (IVA) and myocardial velocity during isovolumic contraction (IVV) are little affected by loading conditions, they can predict myocardial function better than conventional parameters. We investigated the usefulness of these parameters for predicting postoperative RV systolic function after isolated heart valve surgery. Methods: Overall, 63 patients who underwent isolated heart valve surgery were evaluated by tissue Doppler echocardiography preoperatively, and immediately and 6 months postoperatively. Results: By the 6-month follow-up, patients' New York Heart Association functional class had improved significantly (P< .026). At that time, functional recovery was observed in 38 of the 63 patients. Logistic regression analysis demonstrated that RV IVA (odds ratio [OR]=3.1; 95% confidence interval [CI], 1.01-9.64; P=.047) and pulmonary artery systolic pressure (OR=1.07; 95% CI, 0.99-1.15; P=.07) were independent predictors of functional recovery 6 months postoperatively. The RV IVA value had recovered by the 6-month follow-up in 39 patients. A positive correlation was observed between functional recovery and IVA recovery (Spearman's correlation, r=0.499; P< .001). The RV IVA was observed to recover in all patient groups regardless of surgical method or atrial rhythm. Conclusions: Preoperative RV IVA and pulmonary artery systolic pressure were independent predictors of functional recovery 6 months after isolated heart valve surgery. Given its association with functional recovery, postoperative improvement in these parameters may be a useful clinical indicator after heart valve surgery.
MeSH term(s)	Echocardiography, Doppler ; Female ; Heart Valves/diagnostic imaging ; Heart Valves/physiopathology ; Heart Valves/surgery ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Recovery of Function
Language	Spanish
Publishing date	2010-04
Publishing country	Spain
Document type	Journal Article
ZDB-ID	128925-1
ISSN	1579-2242 ; 0300-8932
ISSN (online)	1579-2242
ISSN	0300-8932
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Article ; Online: ABCA4

Sinim Kahraman, Neslihan / Özgüç Çalışkan, Büşra / Kandemir, Nefise / Öner, Ayşe / Dündar, Munis / Özkul, Yusuf

Ophthalmic genetics

2024 Volume 45, Issue 2, Page(s) 133–139

Abstract: Purpose: This study aims to evaluate the ABCA4 variants in patients diagnosed with Stargardt disease.: Methods: This is a retrospective study designed to investigate variants in the ABCA4 in Stargardt disease and the clinical findings of the cases. ... ...

Abstract	Purpose: This study aims to evaluate the ABCA4 variants in patients diagnosed with Stargardt disease. Methods: This is a retrospective study designed to investigate variants in the ABCA4 in Stargardt disease and the clinical findings of the cases. Sex, age, age of onset of symptoms, best-corrected visual acuity, color fundus photography, optical coherence tomography, and visual field test of the patients were recorded. Genetic analyses were screened, and patients with at least two variants in the ABCA4 were included in this study. Results: Twenty-seven patients diagnosed with Stargardt disease with the ABCA4 variants were included in this study. Twelve of them (44.4%) were female and fifteen (55.5%) were male. The mean age of the cases was 27.44 years (ranging from 8 to 56 years). Thirty different variants were detected in 54 ABCA4 alleles of 27 patients. The two most common pathogenic variants were c.5882 G>A p.(Gly1961Glu) and c.52C>T p.(Arg18Trp) in this cohort. Two novel variants were identified (c.3855_3856dup, c.1554 + 3_1554 + 4del) and the patient with the c.1554 + 3_1554 + 4del variant additionally had a different ABCA4 variant in trans. The other novel variant was homozygous. Conclusions: In this study, two novel variants were described in a Turkish cohort with Stargardt disease. The variant c.52C>T p.(Arg18Trp) was the most common disease-causing variant besides the c.5882 G>A p.(Gly1961Glu) which was identified frequently in the previous studies. A larger sample size is necessary for describing different pathogenic variants and understanding the phenotype-genotype correlations.
MeSH term(s)	Adult ; Female ; Humans ; Male ; ATP-Binding Cassette Transporters/genetics ; Mutation ; Retrospective Studies ; Stargardt Disease ; Child ; Adolescent ; Young Adult ; Middle Aged
Chemical Substances	ABCA4 protein, human ; ATP-Binding Cassette Transporters
Language	English
Publishing date	2024-02-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1199279-7
ISSN	1744-5094 ; 0167-6784 ; 1381-6810
ISSN (online)	1744-5094
ISSN	0167-6784 ; 1381-6810
DOI	10.1080/13816810.2024.2313490
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Zs.A 1708: Show issues

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Article ; Online: Evaluation of cardiac electromechanics in patients with newly diagnosed hypertension.

Omar, Timor / Hamideyin, Şerif / Karakayali, Muammer / Artaç, İnanç / Karabağ, Yavuz / Dündar, Cihan / Rencüzoğullari, İbrahim

Blood pressure monitoring

2023 Volume 28, Issue 6, Page(s) 303–308

Abstract: Objectives: This study aimed to investigate the relationship between subclinical left ventricular (LV) systolic dysfunction and ECG parameters in newly diagnosed hypertension patients.: Methods: In this cross-sectional study, adults diagnosed with ... ...

Abstract	Objectives: This study aimed to investigate the relationship between subclinical left ventricular (LV) systolic dysfunction and ECG parameters in newly diagnosed hypertension patients. Methods: In this cross-sectional study, adults diagnosed with hypertension based on 24-h ambulatory blood pressure monitor recordings were included. The patients were classified into two groups based on the presence of subclinical LV systolic dysfunction according to LV global longitudinal strain (LVGLS). Findings were compared between the two groups. Results: A total of 244 patients (female, 55.7%) were included. Based on LVGLS, 82 (33.6%) patients had subclinical LV systolic dysfunction. The proportion of early repolarization pattern (ERP) on ECG was significantly higher in patients with subclinical LV systolic dysfunction than in patients with normal LV systolic function [24 (28.6%) vs. 8 (5%), P < 0.001]. PR and corrected QT intervals were also significantly longer in patients with subclinical LV systolic dysfunction than in patients with normal LV systolic function [median (interquartile range), 148 (132-158) vs. 141 (127-152), P = 0.036 and 443 (427-459) vs. 431 (411-455), P = 0.007, respectively]. According to multivariate regression analysis ERP, early (E) wave velocity/late (A) wave velocity (E/A), and LV mass index were independently associated with subclinical LV systolic dysfunction. Conclusion: In newly diagnosed hypertension patients, the ERP on admission ECG could be a sign of subclinical systolic dysfunction.
MeSH term(s)	Adult ; Humans ; Female ; Blood Pressure Monitoring, Ambulatory ; Cross-Sectional Studies ; Blood Pressure ; Hypertension ; Ventricular Dysfunction, Left
Language	English
Publishing date	2023-08-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1324472-3
ISSN	1473-5725 ; 1359-5237
ISSN (online)	1473-5725
ISSN	1359-5237
DOI	10.1097/MBP.0000000000000667
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Zs.A 4626: Show issues

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Article ; Online: Frequency of

Kahraman, Neslihan Sinim / Öner, Ayşe / Özkul, Yusuf / Dündar, Munis

Turkish journal of ophthalmology

2022 Volume 52, Issue 4, Page(s) 270–275

Abstract: Objectives: Hereditary retinal dystrophies are a rare group of diseases which are heterogeneous in genotype and phenotype and result in total blindness. One of the genetic defects that cause hereditary retinal dystrophy is mutation of the : Materials ... ...

Abstract	Objectives: Hereditary retinal dystrophies are a rare group of diseases which are heterogeneous in genotype and phenotype and result in total blindness. One of the genetic defects that cause hereditary retinal dystrophy is mutation of the Materials and methods: The data of patients diagnosed with hereditary retinal dystrophy who were followed up between 2017 and 2021 were retrospectively reviewed. Of these, 460 patients with genetic analysis results were included in the study. The clinical findings of patients with homozygous (biallelic) Results: RPE65 Conclusion: RPE65
MeSH term(s)	Genetic Therapy/methods ; Humans ; Mutation ; Retinal Dystrophies/genetics ; Retinal Dystrophies/therapy ; Retrospective Studies ; cis-trans-Isomerases/genetics
Chemical Substances	retinoid isomerohydrolase (EC 3.1.1.64) ; cis-trans-Isomerases (EC 5.2.-)
Language	English
Publishing date	2022-08-16
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2586160-8
ISSN	2149-8709 ; 2147-2661 ; 2149-8709 ; 1300-0659
ISSN (online)	2149-8709
ISSN	2147-2661 ; 2149-8709 ; 1300-0659
DOI	10.4274/tjo.galenos.2021.74944
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Article ; Online: Event-related delta and theta responses may reflect the valence discrimination in the emotional oddball task.

Bölükbaş, Burcu / Aktürk, Tuba / Ardalı, Hilal / Dündar, Yasemin / Güngör, Ceren / Kahveci, Şaika / Güntekin, Bahar

Cognitive processing

2023 Volume 24, Issue 4, Page(s) 595–608

Abstract: How emotion and cognition interact is still a matter of debate. Investigation of this interaction in terms of the brain oscillatory dynamics appears to be an essential approach. To investigate this topic, we designed two separate three-stimulus oddball ... ...

Abstract	How emotion and cognition interact is still a matter of debate. Investigation of this interaction in terms of the brain oscillatory dynamics appears to be an essential approach. To investigate this topic, we designed two separate three-stimulus oddball tasks, including emotional stimuli with different valences. Twenty healthy young subjects were included in the study. They completed two tasks, namely: the positive emotional oddball task and the negative emotional oddball task. Each task included the target, non-target, and distractor stimuli. Positive and negative pictures were the target stimuli in the positive and negative emotional oddball task. We asked participants to determine the number of target stimuli in each task. During sessions, EEGs were recorded with 32 electrodes. We found that (negative) target stimuli elicit higher delta (1-3.5 Hz) and theta (4-7 Hz) power responses but not the phase-locking responses compared to (positive) distractor stimuli during the negative oddball task. On the other hand, the same effect was not seen during the positive emotional oddball task. Here, we showed that the valence dimension interacted with the target status. Finally, we summarized our results that the presence of negative distractors attenuated the target effect of the positive stimuli due to the negative bias.
MeSH term(s)	Humans ; Reaction Time/physiology ; Emotions/physiology ; Electroencephalography/methods ; Brain/physiology ; Cognition/physiology
Language	English
Publishing date	2023-08-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2075054-7
ISSN	1612-4790 ; 1612-4782
ISSN (online)	1612-4790
ISSN	1612-4782
DOI	10.1007/s10339-023-01158-w
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Article ; Online: Investigation the effects of 2-aminoethoxydiphenyl borate (2-APB) on aminoglycoside nephrotoxicity.

Kendirlinan, Özge / Kuyucu, Yurdun / Güzelel, Bilge / Dündar Yenilmez, Ebru / Tuli, Abdullah / Seydaoğlu, Gülşah / Mete, Ufuk Özgü

Ultrastructural pathology

2024 Volume 48, Issue 1, Page(s) 29–41

Abstract: Investigation the protective effect of transient receptor potential channel modulator 2-Aminoethoxydiphenyl Borate (2-APB) on aminoglycoside nephrotoxicity caused by reactive oxygen species, calcium-induced apoptosis and inflammation was aimed. Forty ... ...

Abstract	Investigation the protective effect of transient receptor potential channel modulator 2-Aminoethoxydiphenyl Borate (2-APB) on aminoglycoside nephrotoxicity caused by reactive oxygen species, calcium-induced apoptosis and inflammation was aimed. Forty Wistar rats were divided (n=8) as follows: Control group; DMSO group; 2-APB group; Gentamicin group (injected 100 mg/kg gentamicin intramuscularly for 10 days); Gentamicin+ 2-APB group (injected 2 mg/kg 2-APB intraperitoneally, then after 30 minutes 100 mg/kg gentamicin was injected intramuscularly for 10 days). Blood samples were collected for biochemical analyses, kidney tissue samples were collected for light, electron microscopic and immunohistochemical investigations. In gentamicin group glomerular degeneration, tubular dilatation, vacuolization, desquamation of tubular cells and hyaline cast formation in luminal space and leukocyte infiltration were seen. Disorganization of microvilli of tubular cells, apical cytoplasmic blebbing, lipid accumulation, myelin figure like structure formation, increased lysosomes, mitochondrial swelling and disorganization of cristae structures, apoptotic changes and widening of intercellular space were found. TNF-α, IL-6 and caspase 3 expressions were increased. BUN and creatinine concentrations were increased. Increase in MDA levels and decrease in SOD activities were determined. Even though degeneration still continues in gentamicin+2-APB treatment group, severity and the area it occupied were decreased and the glomerular and tubule structures were generally preserved. TNF-α, IL-6, caspase 3 immunoreactivities and BUN, creatinine, MDA concentrations were reduced and SOD activities were increased markedly compared to gentamicin group. In conclusion, it has been considered that 2-APB can prevent gentamicin mediated nephrotoxicity with its anti-oxidant, anti-apoptotic and anti-inflammatory effects.
MeSH term(s)	Rats ; Animals ; Kidney ; Caspase 3/metabolism ; Caspase 3/pharmacology ; Aminoglycosides/adverse effects ; Aminoglycosides/metabolism ; Rats, Wistar ; Creatinine/metabolism ; Creatinine/pharmacology ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Kidney Diseases/chemically induced ; Kidney Diseases/prevention & control ; Anti-Bacterial Agents/adverse effects ; Antioxidants/pharmacology ; Gentamicins/toxicity ; Gentamicins/metabolism ; Superoxide Dismutase/metabolism ; Oxidative Stress
Chemical Substances	2-aminoethoxydiphenyl borate (E4ES684O93) ; Caspase 3 (EC 3.4.22.-) ; Aminoglycosides ; Creatinine (AYI8EX34EU) ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Anti-Bacterial Agents ; Antioxidants ; Gentamicins ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	603269-2
ISSN	1521-0758 ; 0191-3123
ISSN (online)	1521-0758
ISSN	0191-3123
DOI	10.1080/01913123.2023.2278629
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Zs.A 1566: Show issues

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Article ; Online: Genome-wide identification and in-silico analysis of papain-family cysteine protease encoding genes in Tetrahymena thermophila.

Duran, Şeyma / Üstüntanir Dede, Ayça Fulya / Dündar Orhan, Yeliz / Arslanyolu, Muhittin

European journal of protistology

2023 Volume 92, Page(s) 126033

Abstract: Tetrahymena thermophila is a promising host for recombinant protein production, but its utilization in biotechnology is mostly limited due to the presence of intracellular and extracellular papain-family cysteine proteases (PFCPs). In this study, we ... ...

Abstract	Tetrahymena thermophila is a promising host for recombinant protein production, but its utilization in biotechnology is mostly limited due to the presence of intracellular and extracellular papain-family cysteine proteases (PFCPs). In this study, we employed bioinformatics approaches to investigate the T. thermophila PFCP genes and their encoded proteases (TtPFCPs), the most prominent protease family in the genome. Results from the multiple sequence alignment, protein modeling, and conserved motif analyses revealed that all TtPFCPs showed considerably high homology with mammalian cysteine cathepsins and contained conserved amino acid motifs. The total of 121 TtPFCP-encoding genes, 14 of which were classified as non-peptidase homologs, were found. Remaining 107 true TtPFCPs were divided into four distinct subgroups depending on their homology with mammalian lysosomal cathepsins: cathepsin L-like (TtCATLs), cathepsin B-like (TtCATBs), cathepsin C-like (TtCATCs), and cathepsin X-like (TtCATXs) PFCPs. The majority of true TtPFCPs (96 out of the total) were in TtCATL-like peptidase subgroup. Both phylogenetic and chromosomal localization analyses of TtPFCPs supported the hypothesis that TtPFCPs likely evolved through tandem gene duplication events and predominantly accumulated on micronuclear chromosome 5. Additionally, more than half of the identified TtPFCP genes are expressed in considerably low quantities compared to the rest of the TtPFCP genes, which are expressed at a higher level. However, their expression patterns fluctuate based on the stage of the life cycle. In conclusion, this study provides the first comprehensive in-silico analysis of TtPFCP genes and encoded proteases. The results would help designing an effective strategy for protease knockout mutant cell lines to discover biological function and to improve the recombinant protein production in T. thermophila.
MeSH term(s)	Animals ; Papain/genetics ; Tetrahymena thermophila/genetics ; Base Sequence ; Amino Acid Sequence ; Phylogeny ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Mammals/genetics
Chemical Substances	Papain (EC 3.4.22.2) ; Recombinant Proteins
Language	English
Publishing date	2023-11-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047872-0
ISSN	1618-0429 ; 0932-4739
ISSN (online)	1618-0429
ISSN	0932-4739
DOI	10.1016/j.ejop.2023.126033
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