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Article: Zwitterionic relatives to the classic [(P-P)Rh(solv)2]+ ions: neutral catalysts active for H-E bond additions to olefins (E=C, Si, B).

Betley, Theodore A / Peters, Jonas C

Angewandte Chemie (International ed. in English)

2003 Volume 42, Issue 21, Page(s) 2385–2389

Language	English
Publishing date	2003-05-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.200250378
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Article ; Online: In vitro

Nyazema, Kudzai B / Shey, Bong-Akee / Sei, Clara J / Peters, Remco P H / Maningi, Nontuthuko E / Fischer, Gerald W / Bernard Fourie, P

Journal of clinical tuberculosis and other mycobacterial diseases

2024 Volume 35, Page(s) 100435

Abstract: Antimicrobial resistance alongside other challenges in tuberculosis (TB) therapeutics have stirred renewed interest in host-directed interventions, including the role of antibodies as adjunct therapeutic agents. This study assessed the binding efficacy ... ...

Abstract	Antimicrobial resistance alongside other challenges in tuberculosis (TB) therapeutics have stirred renewed interest in host-directed interventions, including the role of antibodies as adjunct therapeutic agents. This study assessed the binding efficacy of two novel IgG1 opsonic monoclonal antibodies (MABs; GG9 & JG7) at 5, 10, and 25 µg/mL to live cultures of
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Journal Article
ISSN	2405-5794
ISSN (online)	2405-5794
DOI	10.1016/j.jctube.2024.100435
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Article ; Online: Antimicrobial effects of Medicines for Malaria Venture Pathogen Box compounds on strains of

Mensah, Eric / Fourie, P Bernard / Peters, Remco P H

Antimicrobial agents and chemotherapy

2023 Volume 67, Issue 11, Page(s) e0034823

Abstract: Therapeutic options ... ...

Abstract	Therapeutic options for
MeSH term(s)	Humans ; Neisseria gonorrhoeae ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Gonorrhea/drug therapy ; Ceftriaxone/pharmacology ; Anti-Infective Agents/pharmacology ; Microbial Sensitivity Tests
Chemical Substances	Anti-Bacterial Agents ; Ceftriaxone (75J73V1629) ; Anti-Infective Agents
Language	English
Publishing date	2023-10-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.00348-23
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Carnosinase Gene-Is It Responsible for Diabetic Nephropathy?: Carnosine as a Protective Factor in Diabetic Nephropathy: Association with a Leucine Repeat of the Carnosinase Gene CNDP1. Diabetes 54: 2320-2327, 2005.

Janssen, B / Hohenadel, D / Brinkkoetter, P / Peters, V / Rind, N / Fischer, C / Rychlik, I / Cerna, M / Romzova, M / de Heer, E / Baelde, H / Bakker, S J / Zirie, M / Rondeau, E / Mathieson, P / Saleem, M A / Meyer, J / Köppel, H / Sauerhoefer, S /

Bartram, C R / Nawroth, P / Hammes, H P / Yard, B A / Zschokke, J / van der Woude, F J

Journal of the American Society of Nephrology : JASN

2023 Volume 16, Issue 10, Page(s) 2823–2826

Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/01.asn.0000926760.87704.9b
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Article ; Online: Monocyte state 1 (MS1) cells in critically ill patients with sepsis or non-infectious conditions: association with disease course and host response.

Leite, Giuseppe G F / de Brabander, Justin / Michels, Erik H A / Butler, Joe M / Cremer, Olaf L / Scicluna, Brendon P / Sweeney, Timothy E / Reyes, Miguel / Salomao, Reinaldo / Peters-Sengers, Hessel / van der Poll, Tom

Critical care (London, England)

2024 Volume 28, Issue 1, Page(s) 88

Abstract: Background: Sepsis is a life-threatening condition arising from an aberrant host response to infection. Recent single-cell RNA sequencing investigations identified an immature bone-marrow-derived CD14: Methods: We used the transcriptome deconvolution ...

Abstract	Background: Sepsis is a life-threatening condition arising from an aberrant host response to infection. Recent single-cell RNA sequencing investigations identified an immature bone-marrow-derived CD14 Methods: We used the transcriptome deconvolution method (CIBERSORTx) to estimate the percentage of MS1 cells from blood RNA profiles of patients with sepsis admitted to the intensive care unit (ICU). We compared these profiles to ICU patients without infection and to healthy controls. Host response dysregulation was further studied by gene co-expression network and gene set enrichment analyses of blood leukocytes, and measurement of 15 plasma biomarkers indicative of pathways implicated in sepsis pathogenesis. Results: Sepsis patients (n = 332) were divided into three equally-sized groups based on their MS1 cell levels (low, intermediate, and high). MS1 groups did not differ in demographics or comorbidities. The intermediate and high MS1 groups presented with higher disease severity and more often had shock. MS1 cell abundance did not differ between survivors and non-survivors, or between patients who did or did not acquire a secondary infection. Higher MS1 cell percentages were associated with downregulation of lymphocyte-related and interferon response genes in blood leukocytes, with concurrent upregulation of inflammatory response pathways, including tumor necrosis factor signaling via nuclear factor-κB. Previously described sepsis host response transcriptomic subtypes showed different MS1 cell abundances, and MS1 cell percentages positively correlated with the "quantitative sepsis response signature" and "molecular degree of perturbation" scores. Plasma biomarker levels, indicative of inflammation, endothelial cell activation, and coagulation activation, were largely similar between MS1 groups. In ICU patients without infection (n = 215), MS1 cell percentages and their relation with disease severity, shock, and host response dysregulation were highly similar to those in sepsis patients. Conclusions: High MS1 cell percentages are associated with increased disease severity and shock in critically ill patients with sepsis or a non-infectious condition. High MS1 cell abundance likely indicates broad immune dysregulation, entailing not only immunosuppression but also anomalies reflecting exaggerated inflammatory responses.
MeSH term(s)	Humans ; Monocytes ; Critical Illness ; Sepsis/complications ; Biomarkers ; Leukocytes ; Intensive Care Units
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-024-04868-5
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Article: The potential for deprescribing in a palliative oncology patient population: a cross-sectional study.

van Merendonk, Lisanne N / Peters, Bas J M / Möhlmann, Julia E / Hunting, Cornelis B / Kastelijn, Elisabeth A / van den Broek, Marcel P H

European journal of hospital pharmacy : science and practice

2023 Volume 31, Issue 1, Page(s) 10–15

Abstract: Objectives: The use of preventive medication in palliative oncology patients may be inappropriate due to limited life expectancy. Deprescribing tools are available but time-consuming and not always tailored to this specific population. Our primary goal ... ...

Abstract	Objectives: The use of preventive medication in palliative oncology patients may be inappropriate due to limited life expectancy. Deprescribing tools are available but time-consuming and not always tailored to this specific population. Our primary goal was to identify potentially inappropriate medications (PIMs) in palliative oncology patients with a life expectancy of up to 2 years using an adapted deprescribing tool. Our secondary aim was to identify patient characteristics associated with the presence of PIMs. Methods: Oncology patients with a life expectancy of up to 2 years were included cross-sectionally. An adapted deprescribing tool was developed to identify PIMs. Logistic regression was used to identify factors associated with having PIMs. Results: A total of 218 patients were included in this study of which 56% had at least one PIM with a population mean of 1.1 PIM per patient. Most frequently defined PIMs were antihypertensive drugs and gastric acid inhibitors. Identification of PIMs by review took an estimated 5-10 min per patient. Polypharmacy, age >65 years and inpatient/outpatient status were found to be associated with having at least one PIM. Conclusions: Deprescribing is possible in more than half of palliative oncology patients with a life expectancy of up to 2 years. The adapted deprescribing tool used is non-time consuming and suitable for palliative oncology patients, regardless of age.
MeSH term(s)	Humans ; Aged ; Deprescriptions ; Inappropriate Prescribing/prevention & control ; Cross-Sectional Studies ; Potentially Inappropriate Medication List ; Neoplasms/drug therapy ; Neoplasms/epidemiology
Language	English
Publishing date	2023-12-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2650179-X
ISSN	2047-9964 ; 2047-9956
ISSN (online)	2047-9964
ISSN	2047-9956
DOI	10.1136/ejhpharm-2021-003143
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Article ; Online: Integrated Nematode Management - van ABS naar INM

Visser, J.H.M. / Brinkman, E.P. / Peters, R. / Molendijk, L.P.G.

Gewasbescherming

2022 Volume 53, Issue 5

Keywords	Life Science
Language	Dutch
Publishing country	nl
Document type	Article ; Online
ZDB-ID	772077-4
ISSN	0166-6495
ISSN	0166-6495
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Article ; Online: Community composition of black flies during and after the 2020 vesicular stomatitis virus outbreak in Southern New Mexico, USA.

Whelpley, Madelin J / Zhou, Lawrence H / Rascon, Jeremy / Payne, Bailey / Moehn, Brett / Young, Katherine I / Mire, Chad E / Peters, Debra P C / Rodriguez, Luis L / Hanley, Kathryn A

Parasites & vectors

2024 Volume 17, Issue 1, Page(s) 93

Abstract: Background: Vesicular stomatitis virus (VSV), a vector-borne pathogen of livestock, emerges periodically in the western US. In New Mexico (NM), US, most cases occur close to the Rio Grande River, implicating black flies (Simulium spp.) as a possible ... ...

Abstract	Background: Vesicular stomatitis virus (VSV), a vector-borne pathogen of livestock, emerges periodically in the western US. In New Mexico (NM), US, most cases occur close to the Rio Grande River, implicating black flies (Simulium spp.) as a possible vector. In 2020, VS cases were reported in NM from April to May, although total black fly abundance remained high until September. We investigated the hypothesis that transience of local VSV transmission results from transient abundance of key, competent black fly species. Additionally, we investigated whether irrigation canals in southern NM support a different community of black flies than the main river. Lastly, to gain insight into the source of local black flies, in 2023 we collected black fly larvae prior to the release of water into the Rio Grande River channel. Methods: We randomly sub-sampled adult black flies collected along the Rio Grande during and after the 2020 VSV outbreak. We also collected black fly adults along the river in 2021 and 2022 and at southern NM farms and irrigation canals in 2022. Black fly larvae were collected from dams in the area in 2023. All collections were counted, and individual specimens were subjected to molecular barcoding for species identification. Results: DNA barcoding of adult black flies detected four species in 2020: Simulium meridionale (N = 158), S. mediovittatum (N = 83), S. robynae (N = 26) and S. griseum/notatum (N = 1). Simulium robynae was only detected during the VSV outbreak period, S. meridionale showed higher relative abundance, but lower absolute abundance, during the outbreak than post-outbreak period, and S. mediovittatum was rare during the outbreak period but predominated later in the summer. In 2022, relative abundance of black fly species did not differ significantly between the Rio Grande sites and farm and irrigation canals. Intriguingly, 63 larval black flies comprised 56% Simulium vittatum, 43% S. argus and 1% S. encisoi species that were either extremely rare or not detected in previous adult collections. Conclusions: Our results suggest that S. robynae and S. meridionale could be shaping patterns of VSV transmission in southern NM. Thus, field studies of the source of these species as well as vector competence studies are warranted.
MeSH term(s)	Animals ; Simuliidae ; Vesicular Stomatitis/epidemiology ; New Mexico/epidemiology ; Insect Vectors ; Vesiculovirus ; Larva ; Disease Outbreaks
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-024-06127-6
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Article ; Online: Canadians' knowledge of cancer risk factors and belief in cancer myths.

E, Rydz / J, Telfer / Ek, Quinn / Ss, Fazel / E, Holmes / G, Pennycook / Ce, Peters

BMC public health

2024 Volume 24, Issue 1, Page(s) 329

Abstract: ... differential awareness of known cancer risk factors (p < 0.05) by population density and income, cancer myths ...

Abstract	Background: Many untrue statements about cancer prevention and risks are circulating. The objective of this study was to assess Canadians' awareness of known cancer risk factors and cancer myths (untruths or statements that are not completely true), and to explore how awareness may vary by sociodemographic and cognitive factors. Methods: Cancer myths were identified by conducting scans of published, grey literature, and social media. Intuitive-analytic thinking disposition scores included were actively open- and close-minded thinking, as well as preference for intuitive and effortful thinking. A survey was administered online to participants aged 18 years and older through Prolific. Results were summarized descriptively and analyzed using chi-square tests, as well as Spearman rank and Pearson correlations. Results: Responses from 734 Canadians were received. Participants were better at identifying known cancer risk factors (70% of known risks) compared to cancer myths (49%). Bivariate analyses showed differential awareness of known cancer risk factors (p < 0.05) by population density and income, cancer myths by province, and for both by ethnicity, age, and all thinking disposition scores. Active open-minded thinking and preference for effortful thinking were associated with greater discernment. Tobacco-related risk factors were well-identified (> 90% correctly identified), but recognition of other known risk factors was poor (as low as 23% for low vegetable and fruit intake). Mythical cancer risk factors with high support were consuming additives (61%), feeling stressed (52%), and consuming artificial sweeteners (49%). High uncertainty of causation was observed for glyphosate (66% neither agreed or disagreed). For factors that reduce cancer risk, reasonable awareness was observed for HPV vaccination (60%), but there was a high prevalence in cancer myths, particularly that consuming antioxidants (65%) and organic foods (45%) are protective, and some uncertainty whether drinking red wine (41%), consuming vitamins (32%), and smoking cannabis (30%) reduces cancer risk. Conclusions: While Canadians were able to identify tobacco-related cancer risk factors, many myths were believed and numerous risk factors were not recognized. Cancer myths can be harmful in themselves and can detract the public's attention from and action on established risk factors.
MeSH term(s)	Humans ; Canada/epidemiology ; Neoplasms/epidemiology ; Neoplasms/etiology ; North American People ; Risk Factors ; Surveys and Questionnaires ; Health Knowledge, Attitudes, Practice
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-17832-3
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Article ; Online: Protein-Protein interactive networks identified in bronchoalveolar lavage of severe compared to nonsevere asthma.

Hastie, Annette T / Bishop, Andrew C / Khan, Mohammad S / Bleecker, Eugene R / Castro, Mario / Denlinger, Loren C / Erzurum, Serpil C / Fahy, John V / Israel, Elliot / Levy, Bruce D / Mauger, David T / Meyers, Deborah A / Moore, Wendy C / Ortega, Victor E / Peters, Stephen P / Wenzel, Sally E / Steele, Chad H

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

2024 Volume 54, Issue 4, Page(s) 265–277

Abstract: Introduction: Previous bronchoalveolar lavage fluid (BALF) proteomic analysis has evaluated limited numbers of subjects for only a few proteins of interest, which may differ between asthma and normal controls. Our objective was to examine a more ... ...

Abstract	Introduction: Previous bronchoalveolar lavage fluid (BALF) proteomic analysis has evaluated limited numbers of subjects for only a few proteins of interest, which may differ between asthma and normal controls. Our objective was to examine a more comprehensive inflammatory biomarker panel in quantitative proteomic analysis for a large asthma cohort to identify molecular phenotypes distinguishing severe from nonsevere asthma. Methods: Bronchoalveolar lavage fluid from 48 severe and 77 nonsevere adult asthma subjects were assessed for 75 inflammatory proteins, normalized to BALF total protein concentration. Validation of BALF differences was sought through equivalent protein analysis of autologous sputum. Subjects' data, stratified by asthma severity, were analysed by standard statistical tests, principal component analysis and 5 machine learning algorithms. Results: The severe group had lower lung function and greater health care utilization. Significantly increased BALF proteins for severe asthma compared to nonsevere asthma were fibroblast growth factor 2 (FGF2), TGFα, IL1Ra, IL2, IL4, CCL8, CCL13 and CXCL7 and significantly decreased were platelet-derived growth factor a-a dimer (PDGFaa), vascular endothelial growth factor (VEGF), interleukin 5 (IL5), CCL17, CCL22, CXCL9 and CXCL10. Four protein differences were replicated in sputum. FGF2, PDGFaa and CXCL7 were independently identified by 5 machine learning algorithms as the most important variables for discriminating severe and nonsevere asthma. Increased and decreased proteins identified for the severe cluster showed significant protein-protein interactions for chemokine and cytokine signalling, growth factor activity, and eosinophil and neutrophil chemotaxis differing between subjects with severe and nonsevere asthma. Conclusion: These inflammatory protein results confirm altered airway remodelling and cytokine/chemokine activity recruiting leukocytes into the airways of severe compared to nonsevere asthma as important processes even in stable status.
MeSH term(s)	Adult ; Humans ; Vascular Endothelial Growth Factor A ; Proteomics ; Fibroblast Growth Factor 2 ; Asthma ; Cytokines/metabolism ; Bronchoalveolar Lavage ; Chemokines ; Bronchoalveolar Lavage Fluid
Chemical Substances	Vascular Endothelial Growth Factor A ; Fibroblast Growth Factor 2 (103107-01-3) ; Cytokines ; Chemokines
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	645204-8
ISSN	1365-2222 ; 0954-7894 ; 0960-2178
ISSN (online)	1365-2222
ISSN	0954-7894 ; 0960-2178
DOI	10.1111/cea.14447
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