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  1. Book: Vasculitis

    Jayne, David

    (Best practice & research. Clinical rheumatology ; volume 32, number 1 (February 2018))

    2018  

    Author's details David Jayne, Raashid Ahmed Luqmani, guest editors
    Series title Best practice & research. Clinical rheumatology ; volume 32, number 1 (February 2018)
    Best practice & research
    Collection Best practice & research
    Language English
    Size 165 Seiten, Illustrationen
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT019941578
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1036 -32,1- verfügbar in Königswinter Königswinter

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  2. Book: Vasculitis

    Jayne, David

    clinical and basic science

    (Nephrology, dialysis, transplantation ; 30,S1)

    2015  

    Author's details guest ed. by David Jayne
    Series title Nephrology, dialysis, transplantation ; 30,S1
    Collection
    Language English
    Size i181 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018663895
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 2198 -30,S1- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: Response to: Correspondence on 'EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update' by Hellmich

    Hellmich, Bernhard / Jayne, David

    Annals of the rheumatic diseases

    2024  

    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2024-225606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 167: Show issues

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  4. Article: Antineutrophil Cytoplasmic Antibody-associated Vasculitis Management 2020: Where Are We Now?

    Jayne, David

    The Journal of rheumatology

    2021  Volume 48, Issue 4, Page(s) 479–481

    MeSH term(s) Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Antibodies, Antineutrophil Cytoplasmic ; Humans
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2021-03-01
    Publishing country Canada
    Document type Editorial ; Comment
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.201351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1168: Show issues Location:
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    Zs.MO 135: Show issues

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  5. Book: Vasculitis

    Jayne, David

    (Best practice & research : Clinical rheumatology ; 23,3)

    2009  

    Author's details David Jayne, guest ed
    Series title Best practice & research : Clinical rheumatology ; 23,3
    Best practice & research
    Best practice & research ; Clinical rheumatology
    Collection Best practice & research
    Best practice & research ; Clinical rheumatology
    Language English
    Size S. 305 - 453 : Ill.
    Publisher Elsevier
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015991806
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1036 -23,3- verfügbar in Königswinter Königswinter

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  6. Article ; Online: ANCA-associated vasculitis - Treatment Standard.

    Chalkia, Aglaia / Jayne, David

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2023  

    Abstract: ANCA-associated Vasculitides (AAV) are characterized by small vessel necrotizing inflammation and prior to the advent of immunosuppressive therapy frequently had a fatal outcome. Treatment has transformed AAV into a relapsing/remitting disease with ... ...

    Abstract ANCA-associated Vasculitides (AAV) are characterized by small vessel necrotizing inflammation and prior to the advent of immunosuppressive therapy frequently had a fatal outcome. Treatment has transformed AAV into a relapsing/remitting disease with increased drug-related toxicities and organ damage. The use of glucocorticoids, cyclophosphamide and immunosuppressives (including azathioprine, mycophenolate, methotrexate) was optimised through a sequence of clinical trials establishing a standard of care against which subsequent targeted therapies could be developed. Improved understanding of pathophysiology has supported the development of B cell depletion and complement inhibition, in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), and interleukin 5 inhibition for eosinophilic granulomatosis with polyangiitis (EGPA), leading to the approval of newer agents for these conditions. There has been an increased attention on minimising the adverse effects of treatment and of understanding the epidemiology of co-morbidities in AAV. This review will focus on recent evidence from clinical trials, especially with respect to glucocorticoids, avacopan, plasma exchange, rituximab and mepolizumab, and their interpretation in the 2022 management recommendations by the European League of Associations of Rheumatology (EULAR).
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 329: Show issues

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  7. Article ; Online: Wearable Sensors as a Preoperative Assessment Tool: A Review.

    Syversen, Aron / Dosis, Alexios / Jayne, David / Zhang, Zhiqiang

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 2

    Abstract: Surgery is a common first-line treatment for many types of disease, including cancer. Mortality rates after general elective surgery have seen significant decreases whilst postoperative complications remain a frequent occurrence. Preoperative assessment ... ...

    Abstract Surgery is a common first-line treatment for many types of disease, including cancer. Mortality rates after general elective surgery have seen significant decreases whilst postoperative complications remain a frequent occurrence. Preoperative assessment tools are used to support patient risk stratification but do not always provide a precise and accessible assessment. Wearable sensors (WS) provide an accessible alternative that offers continuous monitoring in a non-clinical setting. They have shown consistent uptake across the perioperative period but there has been no review of WS as a preoperative assessment tool. This paper reviews the developments in WS research that have application to the preoperative period. Accelerometers were consistently employed as sensors in research and were frequently combined with photoplethysmography or electrocardiography sensors. Pre-processing methods were discussed and missing data was a common theme; this was dealt with in several ways, commonly by employing an extraction threshold or using imputation techniques. Research rarely processed raw data; commercial devices that employ internal proprietary algorithms with pre-calculated heart rate and step count were most commonly employed limiting further feature extraction. A range of machine learning models were used to predict outcomes including support vector machines, random forests and regression models. No individual model clearly outperformed others. Deep learning proved successful for predicting exercise testing outcomes but only within large sample-size studies. This review outlines the challenges of WS and provides recommendations for future research to develop WS as a viable preoperative assessment tool.
    MeSH term(s) Humans ; Algorithms ; Biological Transport ; Electrocardiography ; Exercise Test ; Wearable Electronic Devices
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24020482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Complement inhibition in ANCA vasculitis.

    Jayne, David

    Nephrologie & therapeutique

    2019  Volume 15, Issue 6, Page(s) 409–412

    Abstract: A role for the alternative complement pathway has emerged in the understanding of ANCA vasculitis pathogenesis. Current therapies of ANCA vasculitis are limited by partial efficacy and toxicity and many patients pursue a relapsing course. Improved ... ...

    Abstract A role for the alternative complement pathway has emerged in the understanding of ANCA vasculitis pathogenesis. Current therapies of ANCA vasculitis are limited by partial efficacy and toxicity and many patients pursue a relapsing course. Improved therapies are needed. Inhibition of the alternative complement pathway component C5a is attractive due to its role in neutrophil activation and migration, and engagement of other inflammatory and thrombotic mechanisms. Two inhibitors of C5a are in clinical development for ANCA vasculitis: avacopan, an oral C5a receptor inhibitor has demonstrated efficacy, safety and steroid sparing in two Phase II trials; and IFX-1, a monoclonal antibody to C5a which is entering Phase II development. Complement inhibition has the potential to contribute to remission induction protocols achieving a higher quality of remission as well as replacing steroids. Confirmation of safety, especially infective risk, and the potential to replace steroids depends on further studies and a role in relapse prevention needs to be explored.
    MeSH term(s) Aniline Compounds/pharmacology ; Aniline Compounds/therapeutic use ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/immunology ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Clinical Trials, Phase II as Topic ; Complement C5a/antagonists & inhibitors ; Complement C5a/immunology ; Complement Inactivating Agents/pharmacology ; Complement Inactivating Agents/therapeutic use ; Complement Pathway, Alternative/drug effects ; Humans ; Neutrophil Activation/drug effects ; Nipecotic Acids/pharmacology ; Nipecotic Acids/therapeutic use
    Chemical Substances Aniline Compounds ; Antibodies, Monoclonal ; Complement Inactivating Agents ; Nipecotic Acids ; Complement C5a (80295-54-1) ; vilobelimab (F5T0RF9ZJA) ; avacopan (O880NM097T)
    Language English
    Publishing date 2019-10-17
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2019.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6298: Show issues Location:
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  9. Article ; Online: Response to: 'Every doctor an educator?'

    Hettle, David / Edwards, Lisa-Jayne

    Medical teacher

    2023  Volume 45, Issue 7, Page(s) 792–793

    Language English
    Publishing date 2023-02-28
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424426-6
    ISSN 1466-187X ; 0142-159X
    ISSN (online) 1466-187X
    ISSN 0142-159X
    DOI 10.1080/0142159X.2023.2184674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Neurocognitive functioning among children and young people with Duchenne Muscular Dystrophy: A systematic review and meta-analysis.

    Gregg, Jayne / Wilson, Colin / Curran, David / Hanna, Donncha

    The Clinical neuropsychologist

    2024  , Page(s) 1–28

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639080-8
    ISSN 1744-4144 ; 0920-1637 ; 1385-4046
    ISSN (online) 1744-4144
    ISSN 0920-1637 ; 1385-4046
    DOI 10.1080/13854046.2024.2324500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3065: Show issues Location:
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