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  1. Article ; Online: Addressing Patient Concerns with Blood Transfusion from Donors Vaccinated Against COVID-19: A Clinician Primer.

    Forkin, Katherine T / Guinn, Nicole R / Warner, Matthew A / Panigrahi, Anil K

    Anesthesiology

    2024  Volume 140, Issue 5, Page(s) 1020–1025

    MeSH term(s) Humans ; COVID-19/prevention & control ; Blood Transfusion
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000004913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Enhancer-promoter entanglement explains their transcriptional interdependence.

    Panigrahi, Anil K / Lonard, David M / O'Malley, Bert W

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 4, Page(s) e2216436120

    Abstract: Enhancers not only activate target promoters to stimulate messenger RNA (mRNA) synthesis, but they themselves also undergo transcription to produce enhancer RNAs (eRNAs), the significance of which is not well understood. Transcription at the ... ...

    Abstract Enhancers not only activate target promoters to stimulate messenger RNA (mRNA) synthesis, but they themselves also undergo transcription to produce enhancer RNAs (eRNAs), the significance of which is not well understood. Transcription at the participating enhancer-promoter pair appears coordinated, but it is unclear why and how. Here, we employ cell-free transcription assays using constructs derived from the human
    MeSH term(s) Humans ; Enhancer Elements, Genetic/genetics ; Promoter Regions, Genetic/genetics ; RNA/genetics ; RNA, Messenger/genetics ; Transcriptional Activation ; Transcription, Genetic ; Gene Expression Regulation
    Chemical Substances RNA (63231-63-0) ; RNA, Messenger
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2216436120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Estimating Blood Loss.

    Goodnough, Lawrence T / Panigrahi, Anil K

    Anesthesia and analgesia

    2017  Volume 125, Issue 1, Page(s) 13–14

    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000002121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Differentiation between various types and subtypes of intracranial meningiomas with advanced MRI.

    Panigrahi, Mousam / Bodhey, Narendra K / Pati, Saroj K / Hussain, Nighat / Sharma, Anil K / Shukla, Arvind K

    SA journal of radiology

    2022  Volume 26, Issue 1, Page(s) 2480

    Abstract: Background: Meningiomas are the most prevalent of all intracranial tumours. Although they are mostly benign, about 20% of meningiomas are atypical or malignant. Knowledge of their histologic grade can be clinically useful while planning surgery.: ... ...

    Abstract Background: Meningiomas are the most prevalent of all intracranial tumours. Although they are mostly benign, about 20% of meningiomas are atypical or malignant. Knowledge of their histologic grade can be clinically useful while planning surgery.
    Objectives: To differentiate between various grades and subtypes of meningiomas with advanced MR parameters.
    Method: We assessed the advanced MR imaging characteristics of 27 histopathologically confirmed meningiomas on a 3T MRI, of which 23 were grade I meningiomas (2 fibroblastic, 9 meningothelial, 9 transitional, 3 unspecified) and 4 were grade II/III meningiomas (2 atypical, 1 papillary, 1 anaplastic). Analysis of the ADC, FA, λ1, λ2, λ3 and mean diffusivity was performed using standard post-processing software.
    Results: The mean size of atypical meningiomas (5.9 cm ± 0.7 cm) was significantly higher (
    Conclusion: Tumour size and ASL perfusion are two parameters that could differentiate between typical and atypical meningiomas while ADC, FA, λ3, CP, CS, rCBF and rCBV may be helpful in distinguishing different subtypes of typical meningiomas.
    Language English
    Publishing date 2022-10-26
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 2475950-8
    ISSN 2078-6778 ; 1027-202X
    ISSN (online) 2078-6778
    ISSN 1027-202X
    DOI 10.4102/sajr.v26i1.2480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Blood transfusion in cardiac surgeries - Toward a personalized protocol.

    Min, Yan / Dalal, Alex R / Pedroza, Albert J / Pham, Tho D / Panigrahi, Anil K / Goldstone, Andrew B / MacArthur, John W / Woo, Y Joseph / Baiocchi, Michael / Fischbein, Michael P

    American journal of surgery

    2023  Volume 227, Page(s) 237–238

    MeSH term(s) Humans ; Cardiac Surgical Procedures ; Blood Transfusion
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2023.07.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Blood Transfusion Therapy.

    Goodnough, Lawrence Tim / Panigrahi, Anil K

    The Medical clinics of North America

    2016  Volume 101, Issue 2, Page(s) 431–447

    Abstract: Transfusion of red blood cells (RBCs) is a balance between providing benefit for patients while avoiding risks of transfusion. Randomized, controlled trials of restrictive RBC transfusion practices have shown equivalent patient outcomes compared with ... ...

    Abstract Transfusion of red blood cells (RBCs) is a balance between providing benefit for patients while avoiding risks of transfusion. Randomized, controlled trials of restrictive RBC transfusion practices have shown equivalent patient outcomes compared with liberal transfusion practices, and meta-analyses have shown improved in-hospital mortality, reduced cardiac events, and reduced bacterial infections. This body of level 1 evidence has led to substantial, improved blood utilization and reduction of inappropriate blood transfusions with implementation of clinical decision support via electronic medical records, along with accompanying educational initiatives.
    MeSH term(s) Anemia/therapy ; Blood Transfusion/methods ; Clinical Decision-Making ; Humans ; Meta-Analysis as Topic ; Practice Guidelines as Topic ; Randomized Controlled Trials as Topic ; Transfusion Reaction ; Virus Diseases/transmission
    Keywords covid19
    Language English
    Publishing date 2016-12-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215710-x
    ISSN 1557-9859 ; 0025-7125
    ISSN (online) 1557-9859
    ISSN 0025-7125
    DOI 10.1016/j.mcna.2016.09.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Rapid Blood Transfusion: The Importance of Hemodilution and Needleless Connectors.

    Burbridge, Mark A / Panigrahi, Anil K / Stone, Sarah A / Jaffe, Richard A / Brock-Utne, John

    Cureus

    2021  Volume 13, Issue 3, Page(s) e13999

    Abstract: Introduction:  Large-bore cannulas are critical to administering IV fluids and blood products during resuscitation and treatment of hemorrhage. Although catheter flow rates for crystalloid solutions are well defined, rapid administration of blood ... ...

    Abstract Introduction:  Large-bore cannulas are critical to administering IV fluids and blood products during resuscitation and treatment of hemorrhage. Although catheter flow rates for crystalloid solutions are well defined, rapid administration of blood products is poorly characterized. In this in vitro study, we examined the effects of hemodilution and needleless connectors on red blood cell (RBC) flow rates.
    Methods:  To determine RBC flow rates through large-bore cannulae, a crystalloid solution (Normosol®, Hospira, Lake Forest, IL) or RBC units were warmed and delivered under pressure (360 mmHg) using a Level 1 H-1200 Fast Flow Fluid Warmer (Smiths Medical, St. Paul, MN). Flow rates for crystalloid, packed RBCs and diluted RBCs were determined using a stopwatch. Additionally, the effect of the MaxPlus® clear needleless connector (CareFusion, San Diego, CA) was measured in all three infusion groups.
    Results:  Flow rates for undiluted RBC units were 53% slower than crystalloid solution (220 mL/min vs. 463 mL/min; p=0.0003), however, when RBC units were diluted to a hematocrit of ~30% flow rate improved to 369 mL/min (p=0.005). The addition of the MaxPlus® needleless connector reduced flow of crystalloid solution by 47% (245 mL/min; p=0.0001), undiluted RBCs by 64% (78 mL/min; p=0.01), and diluted RBCs by 51% (180 mL/min; p=0.00003). Compared to undiluted RBC units, hemodilution increased RBC delivery rate through a MaxPlus® connector by 130% (p=0.004) and by 68% (p=0.02) when the catheter was directly connected to the Level 1 tubing (MaxPlus® excluded).
    Conclusion:  In settings requiring rapid transfusion of RBC units, needleless connectors should not be used and hemodilution should be considered in order to decrease the time required to deliver an equivalent red cell mass.
    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.13999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Differentiation between various types and subtypes of intracranial meningiomas with advanced MRI

    Mousam Panigrahi / Narendra K. Bodhey / Saroj K. Pati / Nighat Hussain / Anil K. Sharma / Arvind K. Shukla

    South African Journal of Radiology, Vol 26, Iss 1, Pp e1-e

    2022  Volume 9

    Abstract: Background: Meningiomas are the most prevalent of all intracranial tumours. Although they are mostly benign, about 20% of meningiomas are atypical or malignant. Knowledge of their histologic grade can be clinically useful while planning surgery. ... ...

    Abstract Background: Meningiomas are the most prevalent of all intracranial tumours. Although they are mostly benign, about 20% of meningiomas are atypical or malignant. Knowledge of their histologic grade can be clinically useful while planning surgery. Objectives: To differentiate between various grades and subtypes of meningiomas with advanced MR parameters. Method: We assessed the advanced MR imaging characteristics of 27 histopathologically confirmed meningiomas on a 3T MRI, of which 23 were grade I meningiomas (2 fibroblastic, 9 meningothelial, 9 transitional, 3 unspecified) and 4 were grade II/III meningiomas (2 atypical, 1 papillary, 1 anaplastic). Analysis of the ADC, FA, λ1, λ2, λ3 and mean diffusivity was performed using standard post-processing software. Results: The mean size of atypical meningiomas (5.9 cm ± 0.7 cm) was significantly higher (p = 0.038, 95% confidence interval [CI]) than that of typical meningiomas (4.6 cm ± 1.6 cm) with a cut-off value of 6.05 cm (75% sensitivity and 87% specificity). The mean cerebral blood flow (CBF) (ASL) of atypical meningiomas (286.70 ± 8.06) was significantly higher (p = 0.0000141, 95% CI) than that of typical meningiomas (161.09 ± 87.04) with a cut-off value of 276.75 (66.7% sensitivity and 75% specificity). Among the typical meningiomas, transitional subtypes had the lowest ADC. High FA and planar coefficient (CP) values and low λ3 and spherical coefficient (CS) values were seen in fibroblastic meningiomas. Fibroblastic meningiomas also showed the lowest vascularity among typical meningiomas. Conclusion: Tumour size and ASL perfusion are two parameters that could differentiate between typical and atypical meningiomas while ADC, FA, λ3, CP, CS, rCBF and rCBV may be helpful in distinguishing different subtypes of typical meningiomas.
    Keywords meningioma ; asl ; t1 perfusion ; adc ; dti ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 610
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher AOSIS
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Indian monsoon variability during the past ∼8.5 cal kyr as recorded in the sediments of the northeastern Arabian Sea

    Ravichandran, M. / Gupta, Anil K. / Mohan, K. / Tiwari, Sameer K. / Lakshumanan, C. / Panigrahi, M.K.

    Quaternary international. 2022 Mar. 20,

    2022  

    Abstract: We analyzed benthic and planktic foraminifera, total organic carbon and stable isotopes ratios of carbon and oxygen from 100 samples of marine sediment Core ABP, 25/03, off Gujarat in the northeastern Arabian Sea. Factor and cluster analyses of thirty ... ...

    Abstract We analyzed benthic and planktic foraminifera, total organic carbon and stable isotopes ratios of carbon and oxygen from 100 samples of marine sediment Core ABP, 25/03, off Gujarat in the northeastern Arabian Sea. Factor and cluster analyses of thirty highest-ranked benthic foraminifer species enabled to identify seven biofacies in the study sequence characterizing major changes in deep-sea environments during the past ∼8.5 cal kyr. The benthic foraminiferal data has been combined with population abundances of upwelling indicator planktic foraminifer Globigerina bulloides and mixed layer species from Core ABP, 25/03 and compared with that from ODP Hole 723A and Core ABP, 25/02, western and eastern Arabian Sea, respectively. A major change in benthic foraminifera occurs during ∼8.5 to 6 cal kyr BP, when the summer monsoon was stronger whereas during 6 to 2 cal kyr BP, the data suggest a weak summer monsoon. Planktic foraminifer Globigerina bulloides does not show any significant trend in the study core, but deep thermocline species Neogloboquadrina dutertrei and mixed layer species show significant trend with an inverse correlation with the TOC. This core records high TOC from ∼6.5 to 4 cal kyr BP and during the last 2 cal kyr and low TOC during ∼8.5 to 6.5 cal kyr BP and 4 to 2 cal kyr BP. It is interesting to note intervals of high mixed layer species coincide with high Neogloboquadrina dutertrei percentages and low TOC values at Core ABP, 25/03 during 8.5 to 6.5 cal kyr BP.The faunal data is supported by carbon and oxygen isotope ratios (δ¹³C and δ¹⁸O) of shells of benthic foraminifer Cibicides spp. to strengthen our understanding of changes in the eastern Arabian Sea since ∼8.5 cal kyr BP.
    Keywords Retaria ; fauna ; marine sediments ; monsoon season ; oxygen ; oxygen isotopes ; summer ; total organic carbon ; Arabian Sea ; India
    Language English
    Dates of publication 2022-0320
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ISSN 1040-6182
    DOI 10.1016/j.quaint.2022.03.016
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: A Study of Impact of Fixed-Dose Albumin Infusion on Outcome in Patients With Cirrhosis and Infection: A Randomized Open-label Clinical Trial.

    Devisetty, Jayadeep V / Mallick, Bipadabhanjan / Praharaj, Dibyaloahan / Tiwari, Anirudh / Kumar, Raj / Nath, Preetam / Panigrahi, Sarat C / Anand, Anil C / Acharya, Subrat K / Chawla, Yogesh K

    Journal of clinical and experimental hepatology

    2023  Volume 14, Issue 1, Page(s) 101270

    Abstract: Background and aim: Antibiotics and albumin infusion constitute the standard of treatment in patients with decompensated cirrhosis who have spontaneous bacterial peritonitis (SBP). Recent studies have also shown that the use of albumin in patients with ... ...

    Abstract Background and aim: Antibiotics and albumin infusion constitute the standard of treatment in patients with decompensated cirrhosis who have spontaneous bacterial peritonitis (SBP). Recent studies have also shown that the use of albumin in patients with advanced liver disease who have infections other than SBP leads to the resolution of acute and chronic liver failure and prevents the development of nosocomial infections. The recommended dose of albumin for these patients is out of reach for many in resource-limited settings like India. The evidence for this recommendation is also scarce. This study aimed to assess the efficacy of a lower dose of albumin infusion in addition to antibiotics on short-term mortality and morbidity in patients with cirrhosis and infections.
    Patients and methods: A prospective, open-label, randomized control study was performed. Consecutive patients with cirrhosis and infections were randomized in a 2:1 ratio into two groups: group A (116) and group B (58) patients. In addition to antibiotics and standard medical therapy, group A was given albumin in a dose of 20 g/day for five days, and group B was given the recommended dose (1.5 g/kg/body weight and 1 g/kg body weight on days one and three, respectively). The primary outcome was in-hospital mortality. Secondary outcomes were improvements in clinical and laboratory parameters.
    Results: Except for etiology, all the baseline clinical and laboratory variables in both groups were comparable. The in-hospital mortality in groups A and B was (11 [10.67%] vs. 6 [10.09%], (
    Conclusion: Low-dose albumin infusion in patients with cirrhosis and infections can have the same results as standard-dose albumin and can be used in resource-limited situations.
    Clinical trial registration number: CTRI/2020/03/023794.
    Language English
    Publishing date 2023-08-19
    Publishing country India
    Document type Journal Article
    ISSN 0973-6883
    ISSN 0973-6883
    DOI 10.1016/j.jceh.2023.08.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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