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  1. Article ; Online: Sentinel Lymph node detection in endometrial cancer - Anatomical and scientific facts.

    Kimmig, Rainer / Thangarajah, Fabinshi / Buderath, Paul

    Best practice & research. Clinical obstetrics & gynaecology

    2024  Volume 94, Page(s) 102483

    Abstract: Anatomical and functional aspects of the lymphatic drainage of the uterine corpus in endometrial cancer are demonstrated. Main lymphatic pathway runs along the upper pelvic pathway from the uterine artery first line to the medial external iliac nodes, ... ...

    Abstract Anatomical and functional aspects of the lymphatic drainage of the uterine corpus in endometrial cancer are demonstrated. Main lymphatic pathway runs along the upper pelvic pathway from the uterine artery first line to the medial external iliac nodes, followed by the lateral external and common iliac node basin. The second important pathway runs along the ovarian vessels directly to the paraaortic nodes. Pathways may visualized best by injection of indocyanine green (ICG) into the uterus. In contrast to the upper pelvic pathway visualized by cervical injection, the paraaortic drainage can only be marked by corporal injection. Lymphatic drainage works downstream (peripheral to central, with respect to vascular valves) only. Clinically, pelvic sentinel node excision replaced systematic lymphadenectomy for diagnostic purposes and even paraaortic node staging can be omitted in most of pelvic node negative patients. For therapeutic purposes compartmental resection of the uterus together with its lymphovascular system and first line nodes "en bloc" could be an option as performed in peritoneal mesometrial resection/targeted compartmental lymphadenctomy (PMMR/TCL).
    Language English
    Publishing date 2024-02-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2050090-7
    ISSN 1532-1932 ; 1521-6934
    ISSN (online) 1532-1932
    ISSN 1521-6934
    DOI 10.1016/j.bpobgyn.2024.102483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Peritoneal mesometrial resection with lymphadenectomy following prior hysterectomy in intermediate/high-risk endometrial cancer: feasibility and safety.

    Buderath, Paul / Elgharib, Mohamed / Kimmig, Rainer

    Archives of gynecology and obstetrics

    2024  Volume 309, Issue 4, Page(s) 1569–1574

    Abstract: Objective: Peritoneal mesometrial resection (PMMR) plus targeted compartmental lymphadenectomy (TCL) aims at removal of the locoregional cancer field in endometrial cancer (EC). Optimal locoregional control without adjuvant radiotherapy should be ... ...

    Abstract Objective: Peritoneal mesometrial resection (PMMR) plus targeted compartmental lymphadenectomy (TCL) aims at removal of the locoregional cancer field in endometrial cancer (EC). Optimal locoregional control without adjuvant radiotherapy should be achieved concomitantly sparing systematic lymphadenectomy (LNE) for most of the patients. However, intermediate/high-risk EC is often definitely diagnosed postoperatively in simple hysterectomy specimen. Our aim was to evaluate feasibility and safety of a completing PMMR + TCL in patients following prior hysterectomy.
    Methods: We evaluated data from 32 patients with intermediate/high-risk EC treated with PMMR + TCL or systematic pelvic and periaortic LNE following prior hysterectomy. Perioperative data on disease characteristics and morbidity were collected and patients were contacted for follow-up to determine the recurrence and survival status.
    Results: We report data from 32 patients with a mean follow-up of 31.7 months. The recurrence rate was 12.5% (4/32) without any isolated locoregional recurrences. Only 21.9% of patients received adjuvant radiotherapy. Rates of intra- and postoperative complications were 6.3% and 18.8%, respectively.
    Conclusion: Our data suggest that robotic PMMR can be performed following prior hysterectomy when previously unknown risk factors arise, albeit with a moderate increase in morbidity. Moreover, despite a relevant reduction of adjuvant radiotherapy, follow-up data suggest an excellent locoregional control even without adjuvant radiotherapy.
    MeSH term(s) Female ; Humans ; Feasibility Studies ; Neoplasm Staging ; Neoplasm Recurrence, Local/pathology ; Lymph Node Excision/adverse effects ; Endometrial Neoplasms/radiotherapy ; Endometrial Neoplasms/surgery ; Endometrial Neoplasms/pathology ; Hysterectomy ; Radiotherapy, Adjuvant/adverse effects
    Language English
    Publishing date 2024-01-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-023-07275-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Vulvakarzinom

    Kimmig, Rainer

    (Manual / Tumorzentrum München an den Medizinischen Fakultäten der Ludwig-Maximilians-Universität und der Technischen Universität)

    2001  

    Institution Tumorzentrum München
    Author's details Hrsg.: Tumorzentrum München, Geschäftsstelle. Bd.-Hrsg.: Rainer Kimmig
    Series title Manual / Tumorzentrum München an den Medizinischen Fakultäten der Ludwig-Maximilians-Universität und der Technischen Universität
    Keywords Vulvakrebs
    Subject Carcinoma vulvae ; Vulvakarzinom
    Language German
    Size VII, 48 S. : Ill., graph. Darst.
    Edition 1. Aufl.
    Publisher Zuckschwerdt
    Publishing place München u.a.
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT013366318
    ISBN 3-88603-769-X ; 978-3-88603-769-8
    Database Catalogue ZB MED Medicine, Health

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    2002 A 2544 order for loan Magazin

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  4. Article: The Diversity of Liquid Biopsies and Their Potential in Breast Cancer Management.

    Keup, Corinna / Kimmig, Rainer / Kasimir-Bauer, Sabine

    Cancers

    2023  Volume 15, Issue 22

    Abstract: Analyzing blood as a so-called liquid biopsy in breast cancer (BC) patients has the potential to adapt therapy management. Circulating tumor cells (CTCs), extracellular vesicles (EVs), cell-free DNA (cfDNA) and other blood components mirror the tumoral ... ...

    Abstract Analyzing blood as a so-called liquid biopsy in breast cancer (BC) patients has the potential to adapt therapy management. Circulating tumor cells (CTCs), extracellular vesicles (EVs), cell-free DNA (cfDNA) and other blood components mirror the tumoral heterogeneity and could support a range of clinical decisions. Multi-cancer early detection tests utilizing blood are advancing but are not part of any clinical routine yet. Liquid biopsy analysis in the course of neoadjuvant therapy has potential for therapy (de)escalation.Minimal residual disease detection via serial cfDNA analysis is currently on its way. The prognostic value of blood analytes in early and metastatic BC is undisputable, but the value of these prognostic biomarkers for clinical management is controversial. An interventional trial confirmed a significant outcome benefit when therapy was changed in case of newly emerging cfDNA mutations under treatment and thus showed the clinical utility of cfDNA analysis for therapy monitoring. The analysis of PIK3CA or ESR1 variants in plasma of metastatic BC patients to prescribe targeted therapy with alpesilib or elacestrant has already arrived in clinical practice with FDA-approved tests available and is recommended by ASCO. The translation of more liquid biopsy applications into clinical practice is still pending due to a lack of knowledge of the analytes' biology, lack of standards and difficulties in proving clinical utility.
    Language English
    Publishing date 2023-11-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15225463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Malignome des Corpus uteri

    Kimmig, Rainer

    [Empfehlungen zur Diagnostik, Therapie und Nachsorge]

    (Manual / Tumorzentrum München an den Medizinischen Fakultäten der Ludwig-Maximilians-Universität und der Technischen Universität)

    2000  

    Institution Tumorzentrum München
    Author's details Hrsg.: Tumorzentrum München. Bd.-Hrsg.: Rainer Kimmig
    Series title Manual / Tumorzentrum München an den Medizinischen Fakultäten der Ludwig-Maximilians-Universität und der Technischen Universität
    Keywords Gebärmutterkörperkrebs
    Subject Korpuskarzinom ; Carcinoma corporis uteri ; Corpuscarcinom
    Language German
    Size VIII, 79 S. : graph. Darst.
    Edition 2., überarb. Aufl.
    Publisher Zuckschwerdt
    Publishing place München u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT012861780
    ISBN 3-88603-726-6 ; 978-3-88603-726-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2000 A 5475 order for loan Magazin

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  6. Article ; Online: CCN1-Mediated Signaling in Placental Villous Tissues after SARS-CoV-2 Infection in Term Pregnant Women: Implications for Dysregulated Angiogenesis.

    Ma, Yuyang / Duan, Liyan / Reisch, Beatrix / Kimmig, Rainer / Iannaccone, Antonella / Gellhaus, Alexandra

    Current issues in molecular biology

    2024  Volume 46, Issue 4, Page(s) 3533–3550

    Abstract: The global spread of SARS-CoV-2 has increased infections among pregnant women. This study aimed to explore placental pathology alterations and angiogenic factor levels in term pregnant women after SARS-CoV-2 infection in a retrospective single-center ... ...

    Abstract The global spread of SARS-CoV-2 has increased infections among pregnant women. This study aimed to explore placental pathology alterations and angiogenic factor levels in term pregnant women after SARS-CoV-2 infection in a retrospective single-center study. Additionally, we investigated the role and underlying mechanism of the vascular inflammation-promoting, cysteine-rich protein 61 (CYR61/CCN1) in this context. All analyses were performed in term pregnant women infected with or without SARS-CoV-2. The sFlt-1, PlGF, and sEng serum levels were quantified using ELISA. Placental protein expressions were examined by immunoblot and immunostaining. Additionally, the effect of CCN1 protein on SGHPL-5 trophoblast cells was examined. We found that SARS-CoV-2 activated the inflammatory response in pregnant women, leading to pronounced vascular alterations in placental villous tissues. Elevated serum anti-angiogenic factors (sFlt-1, sEng) upon SARS-CoV-2 infection may directly contribute to these pathological changes. Upregulated CCN1 and pNF-κB in placental villous tissues of infected patients are identified as crucial factors in placental alterations. As a conclusion, CCN1 was significantly elevated in the placentas of term pregnant women infected with SARS-CoV-2. By activating a cascade of inflammatory responses, CCN1 induced the production of the anti-angiogenic factors sFlt-1 and sEng, which may lead to abnormal placental vascular architecture.
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb46040221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5122: Show issues Location:
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  7. Article ; Online: Immunoglobulins and serum proteins impair anti-tumor NK cell effector functions in malignant ascites.

    Hrvat, Antonio / Benders, Sonja / Kimmig, Rainer / Brandau, Sven / Mallmann-Gottschalk, Nina

    Frontiers in immunology

    2024  Volume 15, Page(s) 1360615

    Abstract: Introduction: Malignant ascites indicates ovarian cancer progression and predicts poor clinical outcome. Various ascites components induce an immunosuppressive crosstalk between tumor and immune cells, which is poorly understood. In our previous study, ... ...

    Abstract Introduction: Malignant ascites indicates ovarian cancer progression and predicts poor clinical outcome. Various ascites components induce an immunosuppressive crosstalk between tumor and immune cells, which is poorly understood. In our previous study, imbalanced electrolytes, particularly high sodium content in malignant ascites, have been identified as a main immunosuppressive mechanism that impaired NK and T-cell activity.
    Methods: In the present study, we explored the role of high concentrations of ascites proteins and immunoglobulins on antitumoral NK effector functions. To this end, a coculture system consisting of healthy donor NK cells and ovarian cancer cells was used. The anti-EGFR antibody Cetuximab was added to induce antibody-dependent cellular cytotoxicity (ADCC). NK activity was assessed in the presence of different patient ascites samples and immunoglobulins that were isolated from ascites.
    Results: Overall high protein concentration in ascites impaired NK cell degranulation, conjugation to tumor cells, and intracellular calcium signaling. Immunoglobulins isolated from ascites samples competitively interfered with NK ADCC and inhibited the conjugation to target cells. Furthermore, downregulation of regulatory surface markers CD16 and DNAM-1 on NK cells was prevented by ascites-derived immunoglobulins during NK cell activation.
    Conclusion: Our data show that high protein concentrations in biological fluids are able to suppress antitumoral activity of NK cells independent from the mechanism mediated by imbalanced electrolytes. The competitive interference between immunoglobulins of ascites and specific therapeutic antibodies could diminish the efficacy of antibody-based therapies and should be considered in antibody-based immunotherapies.
    MeSH term(s) Humans ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Ascites/immunology ; Female ; Antibody-Dependent Cell Cytotoxicity/immunology ; Ovarian Neoplasms/immunology ; Ovarian Neoplasms/metabolism ; Cell Line, Tumor ; Immunoglobulins/metabolism ; Receptors, IgG/metabolism ; Receptors, IgG/immunology ; Cell Degranulation/immunology ; Cell Degranulation/drug effects ; Antigens, Differentiation, T-Lymphocyte/metabolism ; Antigens, Differentiation, T-Lymphocyte/immunology ; Cetuximab/pharmacology
    Chemical Substances Immunoglobulins ; Receptors, IgG ; Antigens, Differentiation, T-Lymphocyte ; Cetuximab (PQX0D8J21J)
    Language English
    Publishing date 2024-04-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1360615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Rekonstruktive Operationen an der Vulva – Schritt für Schritt (Teil II)

    Rusch, Peter / Dornhöfer, Nadja / Aktas, Bahriye / Kimmig, Rainer

    Frauenheilkunde up2date

    2023  Volume 17, Issue 03, Page(s) 229–236

    Keywords Vulvafeldresektion ; anatomische Rekonstruktion ; ontogenetische Krebsfeldchirurgie ; körperliche Integrität
    Language German
    Publishing date 2023-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2272764-4
    ISSN 1611-650X ; 1439-3719
    ISSN (online) 1611-650X
    ISSN 1439-3719
    DOI 10.1055/a-1377-0640
    Database Thieme publisher's database

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  9. Article ; Online: Multiple Parasitic Myomas in the Pelvis-Treatment by Robotic Access.

    Eichbaum, Michael H R / Mitsiev, Ivo / Kimmig, Rainer / Eichbaum, Christine / Asrar, Horia

    Journal of minimally invasive gynecology

    2023  Volume 30, Issue 5, Page(s) 353–354

    MeSH term(s) Humans ; Female ; Robotic Surgical Procedures ; Leiomyoma/surgery ; Myoma ; Pelvis ; Uterine Neoplasms/surgery ; Laparoscopy ; Treatment Outcome
    Language English
    Publishing date 2023-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2186934-0
    ISSN 1553-4669 ; 1553-4650
    ISSN (online) 1553-4669
    ISSN 1553-4650
    DOI 10.1016/j.jmig.2023.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4205: Show issues Location:
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  10. Article: Combinatorial Power of cfDNA, CTCs and EVs in Oncology.

    Keup, Corinna / Kimmig, Rainer / Kasimir-Bauer, Sabine

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 4

    Abstract: Liquid biopsy is a promising technique for clinical management of oncological patients. The diversity of analytes circulating in the blood useable for liquid biopsy testing is enormous. Circulating tumor cells (CTCs), cell-free DNA (cfDNA) and ... ...

    Abstract Liquid biopsy is a promising technique for clinical management of oncological patients. The diversity of analytes circulating in the blood useable for liquid biopsy testing is enormous. Circulating tumor cells (CTCs), cell-free DNA (cfDNA) and extracellular vesicles (EVs), as well as blood cells and other soluble components in the plasma, were shown as liquid biopsy analytes. A few studies directly comparing two liquid biopsy analytes showed a benefit of one analyte over the other, while most authors concluded the benefit of the additional analyte. Only three years ago, the first studies to examine the value of a characterization of more than two liquid biopsy analytes from the same sample were conducted. We attempt to reflect on the recent development of multimodal liquid biopsy testing in this review. Although the analytes and clinical purposes of the published multimodal studies differed significantly, the additive value of the analytes was concluded in almost all projects. Thus, the blood components, as liquid biopsy reservoirs, are complementary rather than competitive, and orthogonal data sets were even shown to harbor synergistic effects. The unmistakable potential of multimodal liquid biopsy testing, however, is dampened by its clinical utility, which is yet to be proven, the lack of methodical standardization and insufficiently mature reimbursement, logistics and data handling.
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12040870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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