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  1. Article ; Online: Transcatheter Repair for Patients with Tricuspid Regurgitation.

    Girgis, Reda E / Loyaga-Rendon, Renzo / Murphy, Edward T

    The New England journal of medicine

    2023  Volume 389, Issue 9, Page(s) 864–865

    MeSH term(s) Humans ; Tricuspid Valve Insufficiency/diagnostic imaging ; Tricuspid Valve Insufficiency/surgery ; Patients
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2306962
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  2. Article ; Online: Why succinate? Physiological regulation by a mitochondrial coenzyme Q sentinel.

    Murphy, Michael P / Chouchani, Edward T

    Nature chemical biology

    2022  Volume 18, Issue 5, Page(s) 461–469

    Abstract: Metabolites once considered solely in catabolism or anabolism turn out to have key regulatory functions. Among these, the citric acid cycle intermediate succinate stands out owing to its multiple roles in disparate pathways, its dramatic concentration ... ...

    Abstract Metabolites once considered solely in catabolism or anabolism turn out to have key regulatory functions. Among these, the citric acid cycle intermediate succinate stands out owing to its multiple roles in disparate pathways, its dramatic concentration changes and its selective cell release. Here we propose that succinate has evolved as a signaling modality because its concentration reflects the coenzyme Q (CoQ) pool redox state, a central redox couple confined to the mitochondrial inner membrane. This connection is of general importance because CoQ redox state integrates three bioenergetic parameters: mitochondrial electron supply, oxygen tension and ATP demand. Succinate, by equilibrating with the CoQ pool, enables the status of this central bioenergetic parameter to be communicated from mitochondria to the rest of the cell, into the circulation and to other cells. The logic of this form of regulation explains many emerging roles of succinate in biology, and suggests future research questions.
    MeSH term(s) Energy Metabolism ; Mitochondria/metabolism ; Oxidation-Reduction ; Succinic Acid/metabolism ; Ubiquinone/metabolism
    Chemical Substances Ubiquinone (1339-63-5) ; Succinic Acid (AB6MNQ6J6L)
    Language English
    Publishing date 2022-04-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2202962-X
    ISSN 1552-4469 ; 1552-4450
    ISSN (online) 1552-4469
    ISSN 1552-4450
    DOI 10.1038/s41589-022-01004-8
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  3. Article: Pulmonary, circulatory and renal considerations in the early postoperative management of the lung transplant recipient.

    Girgis, Reda E / Hadley, Ryan J / Murphy, Edward T

    Global cardiology science & practice

    2023  Volume 2023, Issue 3, Page(s) e202318

    Abstract: Lung transplantation volumes and survival rates continue to increase worldwide. Primary graft dysfunction (PGD) and acute kidney injury (AKI) are common early postoperative complications that significantly affect short-term mortality and long-term ... ...

    Abstract Lung transplantation volumes and survival rates continue to increase worldwide. Primary graft dysfunction (PGD) and acute kidney injury (AKI) are common early postoperative complications that significantly affect short-term mortality and long-term outcomes. These conditions share overlapping risk factors and are driven, in part, by circulatory derangements. The prevalence of severe PGD is up to 20% and is the leading cause of early death. Patients with pulmonary hypertension are at a higher risk. Prevention and management are based on principles learned from acute lung injury of other causes. Targeting the lowest effective cardiac filling pressure will reduce alveolar edema formation in the setting of increased pulmonary capillary permeability. AKI is reported in up to one-half of lung transplant recipients and is strongly associated with one-year mortality as well as long-term chronic kidney disease. Optimization of renal perfusion is critical to reduce the incidence and severity of AKI. In this review, we highlight key early post-transplant pulmonary, circulatory, and renal perturbations and our center's management approach.
    Language English
    Publishing date 2023-08-01
    Publishing country Qatar
    Document type Journal Article ; Review
    ZDB-ID 2738381-7
    ISSN 2305-7823
    ISSN 2305-7823
    DOI 10.21542/gcsp.2023.18
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  4. Article: Predictors of early mortality after lung transplantation for idiopathic pulmonary arterial hypertension.

    Girgis, Reda E / Manandhar-Shrestha, Nabin K / Krishnan, Sheila / Murphy, Edward T / Loyaga-Rendon, Renzo

    Pulmonary circulation

    2024  Volume 14, Issue 2, Page(s) e12371

    Abstract: Lung transplantation remains an important therapeutic option for idiopathic pulmonary arterial hypertension (IPAH), yet short-term survival is the poorest among the major diagnostic categories. We sought to develop a prediction model for 90-day mortality ...

    Abstract Lung transplantation remains an important therapeutic option for idiopathic pulmonary arterial hypertension (IPAH), yet short-term survival is the poorest among the major diagnostic categories. We sought to develop a prediction model for 90-day mortality using the United Network for Organ Sharing database for adults with IPAH transplanted between 2005 and 2021. Variables with a
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1002/pul2.12371
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  5. Article ; Online: HTLV-1 and blood donation.

    Murphy, Edward L

    British journal of haematology

    2023  Volume 204, Issue 1, Page(s) 29–30

    Abstract: Human T-cell leukaemia virus type 1 (HTLV-1) is a human retrovirus that causes adult T-cell ...

    Abstract Human T-cell leukaemia virus type 1 (HTLV-1) is a human retrovirus that causes adult T-cell lymphoma and HTLV-associated myelopathy. In this issue, Rosadas et al. use data from a recent WHO report to describe how blood banks test for HTLV-1 and how this testing contributes to public health surveillance for the virus. Commentary on: Rosadas et al. HTLV-1 screening of blood donations: we are systematically missing opportunities. Br J Haematol 2023;202:1220-1223.
    MeSH term(s) Adult ; Humans ; Human T-lymphotropic virus 1 ; Blood Donation ; Leukemia-Lymphoma, Adult T-Cell ; HTLV-I Infections
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19051
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  6. Article: Evaluating the Clinical Performance of a Novel, Precision Oral Appliance Therapy Medical Device Made Wholly From a Medical Grade Class VI Material for the Treatment of Obstructive Sleep Apnea.

    Sall, Edward / Smith, Kent / Desai, Aditi / Carollo, John A / Murphy, Mark T / Kim, Sung / Liptak, Leonard A

    Cureus

    2023  Volume 15, Issue 12, Page(s) e50107

    Abstract: Objective The objective of this study is to evaluate the clinical performance of a novel, precision, oral appliance therapy (OAT) medical device made entirely from a US Pharmacopeia (USP) medical grade class VI qualified material for the treatment of ... ...

    Abstract Objective The objective of this study is to evaluate the clinical performance of a novel, precision, oral appliance therapy (OAT) medical device made entirely from a US Pharmacopeia (USP) medical grade class VI qualified material for the treatment of obstructive sleep apnea (OSA). Methods This was a multi-center, single-arm, chart-based, retrospective study of 91 patients diagnosed with OSA, treated utilizing a novel, precision, OAT medical device. Performance criteria were overall efficacy (reduction of OSA events to less than 10 per hour); efficacy for patients with severe OSA (reduction of OSA events to less than 20 per hour and a 50% improvement); and compliance (the rate of continuation of treatment after at least a one-year follow-up, or, conversely, the rate of discontinuation of treatment due to material-related adverse events or side effects after one year).  Results Eighty-nine percent of all subjects diagnosed with all levels of OSA severity were successfully treated to an apnea hypopnea index ("AHI") < 10 events per hour. Ninety-eight percent of subjects diagnosed with mild to moderate OSA were successfully treated to an AHI < 10. Eighty percent of subjects with severe OSA, without screening or excluding subjects for airway collapse profile, were successfully treated to an AHI < 20 with a 50% improvement in AHI. After a minimum one-year follow-up period, 96% of patients were confirmed to remain in active treatment. No subjects were reported to discontinue treatment due to adverse events or side effects. Conclusions This novel, precision OAT medical device made from the USP Class VI qualified material demonstrated efficacy and safety for the treatment of patients with OSA.
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.50107
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  7. Article ; Online: Somatic

    Kim, Daehong / Myllymäki, Mikko / Kankainen, Matti / Jarvinen, Timo / Park, Giljun / Bruhn, Roberta / Murphy, Edward L / Mustjoki, Satu

    Haematologica

    2022  Volume 107, Issue 2, Page(s) 550–554

    MeSH term(s) Blood Donors ; CD8-Positive T-Lymphocytes/metabolism ; Carrier State ; Human T-lymphotropic virus 2 ; Humans ; Mutation ; STAT3 Transcription Factor/genetics
    Chemical Substances STAT3 Transcription Factor ; STAT3 protein, human
    Language English
    Publishing date 2022-02-01
    Publishing country Italy
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2021.279140
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  8. Article: Robotic excision of aortic valve papillary fibroelastoma and concomitant maze procedure.

    Murphy, Edward T

    Global cardiology science & practice

    2013  Volume 2012, Issue 2, Page(s) 93–100

    Abstract: Cardiothoracic surgeons have utilized the surgical robot to provide a minimally invasive approach to a number of intracardiac operations, including tumor resection, valve repair, and ablation of atrial arrhythmia. We report the case of a 58 year-old ... ...

    Abstract Cardiothoracic surgeons have utilized the surgical robot to provide a minimally invasive approach to a number of intracardiac operations, including tumor resection, valve repair, and ablation of atrial arrhythmia. We report the case of a 58 year-old woman who was found to have a mobile mass on her aortic valve during evaluation of atrial fibrillation. Both of these conditions were addressed when she underwent a combined robotic biatrial Maze procedure and excision of the mass, which proved to be a papillary fibroelastoma of the aortic valve.
    Language English
    Publishing date 2013-11-01
    Publishing country Qatar
    Document type Journal Article
    ZDB-ID 2738381-7
    ISSN 2305-7823
    ISSN 2305-7823
    DOI 10.5339/gcsp.2012.27
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  9. Article ; Online: Vulnerability to APOBEC3G linked to the pathogenicity of deltaretroviruses.

    Shichijo, Takafumi / Yasunaga, Jun-Ichirou / Sato, Kei / Nosaka, Kisato / Toyoda, Kosuke / Watanabe, Miho / Zhang, Wenyi / Koyanagi, Yoshio / Murphy, Edward L / Bruhn, Roberta L / Koh, Ki-Ryang / Akari, Hirofumi / Ikeda, Terumasa / Harris, Reuben S / Green, Patrick L / Matsuoka, Masao

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 13, Page(s) e2309925121

    Abstract: ... and human T-cell leukemia virus type 1 (HTLV-1) induces adult T-cell leukemia-lymphoma (ATL ... We analyzed the proviral sequences of HTLV-1, HTLV-2, and simian T-cell leukemia virus type 1 (STLV-1 ...

    Abstract Human retroviruses are derived from simian ones through cross-species transmission. These retroviruses are associated with little pathogenicity in their natural hosts, but in humans, HIV causes AIDS, and human T-cell leukemia virus type 1 (HTLV-1) induces adult T-cell leukemia-lymphoma (ATL). We analyzed the proviral sequences of HTLV-1, HTLV-2, and simian T-cell leukemia virus type 1 (STLV-1) from Japanese macaques (
    MeSH term(s) Humans ; Cell Line ; Virulence ; Human T-lymphotropic virus 1/metabolism ; Leukemia-Lymphoma, Adult T-Cell/genetics ; Proviruses/genetics ; Transforming Growth Factor beta/metabolism ; Basic-Leucine Zipper Transcription Factors/genetics ; Basic-Leucine Zipper Transcription Factors/metabolism ; APOBEC-3G Deaminase/genetics
    Chemical Substances Transforming Growth Factor beta ; Basic-Leucine Zipper Transcription Factors ; APOBEC3G protein, human (EC 3.5.4.5) ; APOBEC-3G Deaminase (EC 3.5.4.5)
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2309925121
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  10. Article: Identification of stress-induced epigenetic methylation onto dopamine D2 gene and neurological and behavioral consequences.

    Blum, Kenneth / Bowirrat, Abdalla / Baron, David / Elman, Igor / Makale, Milan T / Cadet, Jean Lud / Thanos, Panayotis K / Hanna, Colin / Ahmed, Rania / Gondre-Lewis, Marjorie C / Dennen, Catherine A / Braverman, Eric R / Soni, Diwanshu / Carney, Paul / Khalsa, Jag / Modestino, Edward J / Barh, Debmalya / Bagchi, Debasis / Badgaiyan, Rajendra D /
    McLaughlin, Thomas / Cortese, Rene / Ceccanti, Mauro / Murphy, Kevin T / Gupta, Ashim / Makale, Miles T / Sunder, Keerthy / Gold, Mark S

    Gene & protein in disease

    2024  Volume 3, Issue 1

    Abstract: The D2 dopamine receptor ( ...

    Abstract The D2 dopamine receptor (
    Language English
    Publishing date 2024-01-05
    Publishing country Singapore
    Document type Journal Article
    ISSN 2811-003X
    ISSN 2811-003X
    DOI 10.36922/gpd.1966
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