Article: Copy number variants selected during pig domestication inferred from whole genome resequencing.
Frontiers in veterinary science
2024 Volume 11, Page(s) 1364267
Abstract: Over extended periods of natural and artificial selection, China has developed numerous exceptional pig breeds. Deciphering the germplasm characteristics of these breeds is crucial for their preservation and utilization. While many studies have employed ... ...
Abstract | Over extended periods of natural and artificial selection, China has developed numerous exceptional pig breeds. Deciphering the germplasm characteristics of these breeds is crucial for their preservation and utilization. While many studies have employed single nucleotide polymorphism (SNP) analysis to investigate the local pig germplasm characteristics, copy number variation (CNV), another significant type of genetic variation, has been less explored in understanding pig resources. In this study, we examined the CNVs of 18 Wanbei pigs (WBP) using whole genome resequencing data with an average depth of 12.61. We identified a total of 8,783 CNVs (~30.07 Mb, 1.20% of the pig genome) in WBP, including 8,427 deletions and 356 duplications. Utilizing fixation index (Fst), we determined that 164 CNVs were within the top 1% of the Fst value and defined as under selection. Functional enrichment analyses of the genes associated with these selected CNVs revealed genes linked to reproduction ( |
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Language | English |
Publishing date | 2024-03-05 |
Publishing country | Switzerland |
Document type | Journal Article |
ZDB-ID | 2834243-4 |
ISSN | 2297-1769 |
ISSN | 2297-1769 |
DOI | 10.3389/fvets.2024.1364267 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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