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Article ; Online: Identifying Signs and Symptoms of Obstructive Sleep Apnea in a Men's Health Clinic: The Utility of Home Sleep Apnea Testing During COVID-19.

Hart, Alexander / Robertus, Steffanie / Dyken, Mark / Pearlman, Amy

2021 Volume 15, Issue 3, Page(s) 15579883211029460

Abstract: The objective of the study was to identify symptoms of men presenting for an outpatient urology visit that prompted referral for a Home Sleep Apnea Test (HSAT) to assess for obstructive sleep apnea (OSA) by a single provider. To assess the proportion of ... ...

Abstract	The objective of the study was to identify symptoms of men presenting for an outpatient urology visit that prompted referral for a Home Sleep Apnea Test (HSAT) to assess for obstructive sleep apnea (OSA) by a single provider. To assess the proportion of patients referred for the HSAT who underwent the test and, out of these patients, the proportion of men diagnosed with sleep apnea, we performed a retrospective chart review of men 18-99 years old seen by a single provider in the Department of Urology referred for an HSAT to evaluate for presenting symptoms. Patients with a prior diagnosis of OSA were excluded. Eighteen patients were identified (mean age at time of referral 51 + SD 13 years). Half of patients reported erectile dysfunction/concerns, 56% reported nocturia, 44% had been diagnosed with testosterone deficiency, and 39% reported low libido. Nearly all (89%) of patients snored, all reported fatigue, 56% were over the age of 50, 44% had a BMI >35, and 78% had hypertension. Twelve patients completed the HSAT, all of whom were diagnosed with OSA for which continuous positive airway pressure (CPAP) therapy was initiated. Men presenting with genitourinary concerns to an outpatient urology clinic may also have OSA. About half of included patients reported genitourinary concerns. Hundred percent of patients who completed their sleep study were diagnosed with OSA. Genitourinary concerns, in addition to signs and symptoms commonly associated with OSA, should prompt consideration of sleep apnea evaluation.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/epidemiology ; COVID-19/prevention & control ; Continuous Positive Airway Pressure ; Home Care Services ; Humans ; Male ; Male Urogenital Diseases/complications ; Middle Aged ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/therapy
Language	English
Publishing date	2021-06-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2275106-3
ISSN	1557-9891 ; 1557-9883
ISSN (online)	1557-9891
ISSN	1557-9883
DOI	10.1177/15579883211029460
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prediction and job-related outcomes of procrastination in the workplace.

Pearlman-Avnion, Shiri / Zibenberg, Alexander

Journal of prevention & intervention in the community

2018 Volume 46, Issue 3, Page(s) 263–278

Abstract: In the current study, we examined whether the impact of the Big Five on procrastination in an organizational context is similar to that in academic settings, and examined the role of dis-regulation of anxiety as a potential moderator of these ... ...

Abstract	In the current study, we examined whether the impact of the Big Five on procrastination in an organizational context is similar to that in academic settings, and examined the role of dis-regulation of anxiety as a potential moderator of these relationships. One hundred and seven Israeli employees participated in the study. The results showed that agreeableness and conscientiousness were negatively associated with procrastination, while neuroticism was positively associated with procrastination in the workplace. Moreover, the findings supported the hypothesis that dis-regulation of anxiety moderates the relationships between personality traits and workplace procrastination. These findings suggest that the link between personality traits and workplace procrastination is not stable, is affected by different contexts, and interacts with other personality characteristics (specifically, dis-regulation of anxiety).
MeSH term(s)	Adult ; Anxiety/psychology ; Female ; Humans ; Israel ; Male ; Middle Aged ; Personality ; Personality Inventory ; Procrastination ; Self-Control ; Workplace/psychology
Language	English
Publishing date	2018-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1354884-0
ISSN	1540-7330 ; 1085-2352
ISSN (online)	1540-7330
ISSN	1085-2352
DOI	10.1080/10852352.2018.1470418
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Article ; Online: Preventing sexual violence among high school students through norms correction and bystander intervention: A school-based cluster trial of Your Voice Your View.

Orchowski, Lindsay M / Malone, Sandra / Sokolovsky, Alexander W / Pearlman, Deborah N / Rizzo, Christie / Zlotnick, Caron / Berkowitz, Alan / Fortson, Beverly L

Journal of community psychology

2023 Volume 51, Issue 7, Page(s) 2861–2886

Abstract: Risk for sexual violence begins early in the lifespan; thus, interventions are needed to decrease the risk for sexual violence among high school youth. The current study evaluates the Your Voice Your View (YVYV) sexual violence prevention program using a ...

Abstract	Risk for sexual violence begins early in the lifespan; thus, interventions are needed to decrease the risk for sexual violence among high school youth. The current study evaluates the Your Voice Your View (YVYV) sexual violence prevention program using a school-based cluster trial among 26 high schools in the Northeastern United States. YVYV, includes: 1) a series of four classroom workshops designed to engage students as allies in violence prevention through bystander intervention skills training, address risks for sexual aggression, and reduce risk for victimization; 2) a Lunch and Learn teacher training workshop; and 3) a 4-week social norms poster campaign based on normative data from the school. Schools were matched based on size and demographics and randomly assigned to the intervention group or a wait-list control group. A sample of 2685 10th grade students enrolled in the research and completed assessments at baseline, 2-month and 6-month follow-up periods. The magnitude of the difference in sexual aggression did not vary by condition at either follow-up period. The magnitude of 6-month differences in experiencing unwanted sexual intercourse varied significantly by condition (IRR = 0.33 [0.14-0.76]), demonstrating a small protective effect favoring intervention schools (Cohen's f
MeSH term(s)	Adolescent ; Humans ; Sex Offenses/prevention & control ; Violence/prevention & control ; Sexual Behavior ; Schools ; Students
Language	English
Publishing date	2023-04-10
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1491194-2
ISSN	1520-6629 ; 0090-4392
ISSN (online)	1520-6629
ISSN	0090-4392
DOI	10.1002/jcop.23047
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Article ; Online: EGFR inhibits DNA mismatch repair.

Hsieh, Peggy / Pearlman, Alexander H

Proceedings of the National Academy of Sciences of the United States of America

2015 Volume 112, Issue 18, Page(s) 5556–5557

MeSH term(s)	DNA/biosynthesis ; DNA Mismatch Repair ; Humans ; Neoplasms/metabolism ; Proliferating Cell Nuclear Antigen/metabolism ; Receptor, Epidermal Growth Factor/metabolism
Chemical Substances	Proliferating Cell Nuclear Antigen ; DNA (9007-49-2) ; Receptor, Epidermal Growth Factor (EC 2.7.10.1)
Language	English
Publishing date	2015-05-05
Publishing country	United States
Document type	Comment ; Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1505168112
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Article ; Online: CCR2-positive monocytes contribute to the pathogenesis of early diabetic retinopathy in mice.

Saadane, Aicha / Veenstra, Alexander A / Minns, Martin S / Tang, Jie / Du, Yunpeng / Abubakr Elghazali, Fatima / Lessieur, Emma M / Pearlman, Eric / Kern, Timothy S

Diabetologia

2023 Volume 66, Issue 3, Page(s) 590–602

Abstract: Aims/hypothesis: Accumulating evidence suggests that leucocytes play a critical role in diabetes-induced vascular lesions and other abnormalities that characterise the early stages of diabetic retinopathy. However, the role of monocytes has yet to be ... ...

Abstract	Aims/hypothesis: Accumulating evidence suggests that leucocytes play a critical role in diabetes-induced vascular lesions and other abnormalities that characterise the early stages of diabetic retinopathy. However, the role of monocytes has yet to be fully investigated; therefore, we used Ccr2 Methods: Experimental diabetes was induced in wild-type and Ccr2 Results: In nondiabetic mice, CCR2 was highly expressed on monocytes, and Ccr2 Conclusions/interpretation: CCR2
MeSH term(s)	Animals ; Mice ; Diabetic Retinopathy/metabolism ; Monocytes/metabolism ; Endothelial Cells/metabolism ; Superoxides/metabolism ; Retinal Degeneration/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Mice, Inbred C57BL ; Retinal Vessels/pathology ; Receptors, CCR2/genetics ; Receptors, CCR2/metabolism
Chemical Substances	Superoxides (11062-77-4) ; Ccr2 protein, mouse ; Receptors, CCR2
Language	English
Publishing date	2023-01-26
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1694-9
ISSN	1432-0428 ; 0012-186X
ISSN (online)	1432-0428
ISSN	0012-186X
DOI	10.1007/s00125-022-05860-w
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Article ; Online: The effect of a ketogenic diet and synergy with rapamycin in a mouse model of breast cancer.

Zou, Yiyu / Fineberg, Susan / Pearlman, Alexander / Feinman, Richard D / Fine, Eugene J

PloS one

2020 Volume 15, Issue 12, Page(s) e0233662

Abstract: Background: The effects of diet in cancer, in general, and breast cancer in particular, are not well understood. Insulin inhibition in ketogenic, high fat diets, modulate downstream signaling molecules and are postulated to have therapeutic benefits. ... ...

Abstract	Background: The effects of diet in cancer, in general, and breast cancer in particular, are not well understood. Insulin inhibition in ketogenic, high fat diets, modulate downstream signaling molecules and are postulated to have therapeutic benefits. Obesity and diabetes have been associated with higher incidence of breast cancer. Addition of anti-cancer drugs together with diet is also not well studied. Methods: Two diets, one ketogenic, the other standard mouse chow, were tested in a spontaneous breast cancer model in 34 mice. Subgroups of 3-9 mice were assigned, in which the diet were implemented either with or without added rapamycin, an mTOR inhibitor and potential anti-cancer drug. Results: Blood glucose and insulin concentrations in mice ingesting the ketogenic diet (KD) were significantly lower, whereas beta hydroxybutyrate (BHB) levels were significantly higher, respectively, than in mice on the standard diet (SD). Growth of primary breast tumors and lung metastases were inhibited, and lifespans were longer in the KD mice compared to mice on the SD (p<0.005). Rapamycin improved survival in both mouse diet groups, but when combined with the KD was more effective than when combined with the SD. Conclusions: The study provides proof of principle that a ketogenic diet a) results in serum insulin reduction and ketosis in a spontaneous breast cancer mouse model; b) can serve as a therapeutic anti-cancer agent; and c) can enhance the effects of rapamycin, an anti-cancer drug, permitting dose reduction for comparable effect. Further, the ketogenic diet in this model produces superior cancer control than standard mouse chow whether with or without added rapamycin.
MeSH term(s)	3-Hydroxybutyric Acid/metabolism ; Animals ; Antineoplastic Agents/pharmacology ; Blood Glucose/drug effects ; Breast Neoplasms/blood ; Breast Neoplasms/diet therapy ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Diet, Ketogenic/methods ; Disease Models, Animal ; Female ; Insulin/blood ; Ketosis/physiopathology ; Mice ; Sirolimus/pharmacology
Chemical Substances	Antineoplastic Agents ; Blood Glucose ; Insulin ; 3-Hydroxybutyric Acid (TZP1275679) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2020-12-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0233662
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Article ; Online: Identifying Signs and Symptoms of Obstructive Sleep Apnea in a Men’s Health Clinic

Alexander Hart MPH / Steffanie Robertus / Mark Dyken MD / Amy Pearlman MD

American Journal of Men's Health, Vol

The Utility of Home Sleep Apnea Testing During COVID-19

2021 Volume 15

Abstract	The objective of the study was to identify symptoms of men presenting for an outpatient urology visit that prompted referral for a Home Sleep Apnea Test (HSAT) to assess for obstructive sleep apnea (OSA) by a single provider. To assess the proportion of patients referred for the HSAT who underwent the test and, out of these patients, the proportion of men diagnosed with sleep apnea, we performed a retrospective chart review of men 18–99 years old seen by a single provider in the Department of Urology referred for an HSAT to evaluate for presenting symptoms. Patients with a prior diagnosis of OSA were excluded. Eighteen patients were identified (mean age at time of referral 51 + SD 13 years). Half of patients reported erectile dysfunction/concerns, 56% reported nocturia, 44% had been diagnosed with testosterone deficiency, and 39% reported low libido. Nearly all (89%) of patients snored, all reported fatigue, 56% were over the age of 50, 44% had a BMI >35, and 78% had hypertension. Twelve patients completed the HSAT, all of whom were diagnosed with OSA for which continuous positive airway pressure (CPAP) therapy was initiated. Men presenting with genitourinary concerns to an outpatient urology clinic may also have OSA. About half of included patients reported genitourinary concerns. Hundred percent of patients who completed their sleep study were diagnosed with OSA. Genitourinary concerns, in addition to signs and symptoms commonly associated with OSA, should prompt consideration of sleep apnea evaluation.
Keywords	Medicine ; R
Subject code	150
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Thesis ; Online: Prostate cancer health disparity in African American and Caucasian American men characterized through the landscape of genomic instability

Pearlman, Alexander

2009

Abstract: In 2008, prostate cancer was the most prevalent cancer in men in the United States with 186,320 estimated new cases and 28,660 deaths. When detected early, prostate cancer can be curable, but procedures that offer the best prognosis such as radical ... ...

Abstract	In 2008, prostate cancer was the most prevalent cancer in men in the United States with 186,320 estimated new cases and 28,660 deaths. When detected early, prostate cancer can be curable, but procedures that offer the best prognosis such as radical prostatectomy - the complete removal of the prostate gland - often result in severe side. Clinical measures of metastatic potential of a localized prostate tumor often result in overly aggressive treatment. The goals of this research were to: (1) provide clinicians diagnostic markers with strong predictive power, (2) to reveal the mechanisms behind metastatic potential, and (3) identify targets for preventative and disease treatment. An integrated analysis combining data from genomic DNA copy number, gene expression and genome wide association was performed. We utilized the principles of evolutionary selection to build a model comparing the primary cancers of African American men and Caucasian American men with those of metastases which allowed us to delineate genes that select for metastatic potential versus those that oppose it. Results from this study suggest that a racial disparity exists, reflected in the somatic tumor genomes of African American and Caucasian American men. This genomic racial disparity involves putative prostate cancer candidate genes such as PTEN/PREX2a, AR and ERCC1 along with several novel candidates such as VASP and NME4. A comprehensive analysis in the context of putative protein interactions and gene sets revealed an enrichment for gene ontologies involved in cell adhesion, proliferation and cytoskeleton formation. Overall, the results imply that racial disparity for metastatic disease is driven by a variety of genes, each with variable selective influence over the function of three interconnected pathways controlling cellular structure and growth.
Keywords	Genetics\|Bioinformatics\|Oncology
Subject code	570
Language	ENG
Publishing date	2009-01-01 00:00:01.0
Publisher	New York University
Publishing country	us
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ectopic Otoconin 90 expression in triple negative breast cancer cell lines is associated with metastasis functions.

Pearlman, Alexander / Rahman, Mohammed Tanjimur / Upadhyay, Kinnari / Loke, Johnny / Ostrer, Harry

PloS one

2019 Volume 14, Issue 2, Page(s) e0211737

Abstract: Triple negative breast cancer (TNBC) is an aggressive tumor with propensity to metastasize and poor treatment options. Improving treatment options would be impactful; thus, finding a tumor-specific cell surface protein with metastasis promoting functions ...

Abstract	Triple negative breast cancer (TNBC) is an aggressive tumor with propensity to metastasize and poor treatment options. Improving treatment options would be impactful; thus, finding a tumor-specific cell surface protein with metastasis promoting functions that could be knocked out was the goal of this study. The Otoconin 90 gene (OC90), frequently amplified in tumors on chromosome 8q24.22, was identified as a potential therapeutic candidate. Normally OC90 is expressed in the cochlea with no known function in other normal tissues. In silico analysis of The Cancer Genome Atlas (TCGA) multi-tumor RNAseq cohorts revealed that OC90 is expressed in many tumor types at high prevalence and genomic amplification is associated with the elevated mRNA expression. In vitro assays in TNBC cell lines revealed OC90 expression with control over cell viability, apoptosis and invasion. RNA-seq analysis of OC90-siRNA knockdown and OC90-overexpression in BT20, BT549, HCC38 cell lines identified co-expressed transcripts, HMGA2, POLE2 and TRIB3. Altered expression of HMGA2, POLE2 and TRIB3 was predictive of survival among members of the Metabric breast cancer cohort. Thus, OC90 represents a potential therapeutic target whose knockdown could improve the treatment of TNBC.
MeSH term(s)	Apoptosis ; Blotting, Western ; Cell Line, Tumor ; Ectopic Gene Expression ; Female ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Glycoproteins/metabolism ; Humans ; Real-Time Polymerase Chain Reaction ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology
Chemical Substances	Glycoproteins ; OC90 protein, human
Language	English
Publishing date	2019-02-14
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0211737
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Article ; Online: The effect of a ketogenic diet and synergy with rapamycin in a mouse model of breast cancer.

Yiyu Zou / Susan Fineberg / Alexander Pearlman / Richard D Feinman / Eugene J Fine

PLoS ONE, Vol 15, Iss 12, p e

2020 Volume 0233662

Abstract: Background The effects of diet in cancer, in general, and breast cancer in particular, are not well understood. Insulin inhibition in ketogenic, high fat diets, modulate downstream signaling molecules and are postulated to have therapeutic benefits. ... ...

Abstract	Background The effects of diet in cancer, in general, and breast cancer in particular, are not well understood. Insulin inhibition in ketogenic, high fat diets, modulate downstream signaling molecules and are postulated to have therapeutic benefits. Obesity and diabetes have been associated with higher incidence of breast cancer. Addition of anti-cancer drugs together with diet is also not well studied. Methods Two diets, one ketogenic, the other standard mouse chow, were tested in a spontaneous breast cancer model in 34 mice. Subgroups of 3-9 mice were assigned, in which the diet were implemented either with or without added rapamycin, an mTOR inhibitor and potential anti-cancer drug. Results Blood glucose and insulin concentrations in mice ingesting the ketogenic diet (KD) were significantly lower, whereas beta hydroxybutyrate (BHB) levels were significantly higher, respectively, than in mice on the standard diet (SD). Growth of primary breast tumors and lung metastases were inhibited, and lifespans were longer in the KD mice compared to mice on the SD (p<0.005). Rapamycin improved survival in both mouse diet groups, but when combined with the KD was more effective than when combined with the SD. Conclusions The study provides proof of principle that a ketogenic diet a) results in serum insulin reduction and ketosis in a spontaneous breast cancer mouse model; b) can serve as a therapeutic anti-cancer agent; and c) can enhance the effects of rapamycin, an anti-cancer drug, permitting dose reduction for comparable effect. Further, the ketogenic diet in this model produces superior cancer control than standard mouse chow whether with or without added rapamycin.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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