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  1. Article ; Online: The vasculature of neurogenic niches: Properties and function.

    Karakatsani, Andromachi / Álvarez-Vergara, María I / Ruiz de Almodóvar, Carmen

    Cells & development

    2023  Volume 174, Page(s) 203841

    Abstract: In the adult rodent brain, neural stem cells (NSCs) reside in the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the hippocampus. In these areas, NSCs and their progeny integrate intrinsic signals and extrinsic cues ...

    Abstract In the adult rodent brain, neural stem cells (NSCs) reside in the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the hippocampus. In these areas, NSCs and their progeny integrate intrinsic signals and extrinsic cues provided by their microenvironment that control their behavior. The vasculature in the SVZ and SGZ, and the choroid plexus (ChP) in the SVZ, have emerged as critical compartments of the neurogenic niches as they provide a rich repertoire of cues to regulate NSC quiescence, proliferation, self-renewal and differentiation. Physical contact between NSCs and blood vessels is also a feature within the niches and supports different processes such as quiescence, migration and vesicle transport. In this review, we provide a description of the brain and choroid plexus vasculature in both stem cell niches, highlighting the main properties and role of the vasculature in each niche. We also summarize the current understanding of how blood vessel- and ChP-derived signals influence the behavior of NSCs in physiological adulthood, as well as upon aging.
    MeSH term(s) Neural Stem Cells/physiology ; Neurogenesis/physiology ; Brain ; Lateral Ventricles/physiology ; Cell Differentiation
    Language English
    Publishing date 2023-04-14
    Publishing country Netherlands
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2667-2901
    ISSN (online) 2667-2901
    DOI 10.1016/j.cdev.2023.203841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Contribution of cell death signaling to blood vessel formation.

    Tisch, Nathalie / Ruiz de Almodóvar, Carmen

    Cellular and molecular life sciences : CMLS

    2021  Volume 78, Issue 7, Page(s) 3247–3264

    Abstract: The formation of new blood vessels is driven by proliferation of endothelial cells (ECs), elongation of maturing vessel sprouts and ultimately vessel remodeling to create a hierarchically structured vascular system. Vessel regression is an essential ... ...

    Abstract The formation of new blood vessels is driven by proliferation of endothelial cells (ECs), elongation of maturing vessel sprouts and ultimately vessel remodeling to create a hierarchically structured vascular system. Vessel regression is an essential process to remove redundant vessel branches in order to adapt the final vessel density to the demands of the surrounding tissue. How exactly vessel regression occurs and whether and to which extent cell death contributes to this process has been in the focus of several studies within the last decade. On top, recent findings challenge our simplistic view of the cell death signaling machinery as a sole executer of cellular demise, as emerging evidences suggest that some of the classic cell death regulators even promote blood vessel formation. This review summarizes our current knowledge on the role of the cell death signaling machinery with a focus on the apoptosis and necroptosis signaling pathways during blood vessel formation in development and pathology.
    MeSH term(s) Animals ; Blood Vessels/cytology ; Cell Death ; Endothelium, Vascular/cytology ; Humans ; Neovascularization, Pathologic ; Neovascularization, Physiologic ; Signal Transduction
    Language English
    Publishing date 2021-03-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-020-03738-x
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  3. Article ; Online: The vasculature of neurogenic niches: Properties and function

    Karakatsani, Andromachi / Álvarez-Vergara, María I. / Ruiz de Almodóvar, Carmen

    Cells & Development. 2023 June, v. 174 p.203841-

    2023  

    Abstract: In the adult rodent brain, neural stem cells (NSCs) reside in the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the hippocampus. In these areas, NSCs and their progeny integrate intrinsic signals and extrinsic cues ...

    Abstract In the adult rodent brain, neural stem cells (NSCs) reside in the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the hippocampus. In these areas, NSCs and their progeny integrate intrinsic signals and extrinsic cues provided by their microenvironment that control their behavior. The vasculature in the SVZ and SGZ, and the choroid plexus (ChP) in the SVZ, have emerged as critical compartments of the neurogenic niches as they provide a rich repertoire of cues to regulate NSC quiescence, proliferation, self-renewal and differentiation. Physical contact between NSCs and blood vessels is also a feature within the niches and supports different processes such as quiescence, migration and vesicle transport. In this review, we provide a description of the brain and choroid plexus vasculature in both stem cell niches, highlighting the main properties and role of the vasculature in each niche. We also summarize the current understanding of how blood vessel- and ChP-derived signals influence the behavior of NSCs in physiological adulthood, as well as upon aging.
    Keywords adulthood ; adults ; blood ; choroid plexus ; hippocampus ; physiological transport ; progeny ; rodents ; stem cells ; Neurogenesis ; Neurogenic niche ; Blood vessels ; Angiocrine molecules ; Neurovascular ; Vasculature ; Endothelial cell
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ISSN 2667-2901
    DOI 10.1016/j.cdev.2023.203841
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Direct contribution of angiogenic factors to neurodevelopment: a focus on angiopoietins

    Luck, Robert / Karakatsani, Andromachi / Ruiz de Almodovar, Carmen

    Neuroforum

    2020  Volume 26, Issue 4, Page(s) 239

    Language German
    Document type Article
    ZDB-ID 1238592-X
    ISSN 0947-0875
    Database Current Contents Medicine

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    Zs.A 4805: Show issues Location:
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  5. Book ; Online ; Thesis: The impact of inflammation, hypoxia, and vasculopathy on pain development in the α-galactosidase A mouse model of Morbus Fabry

    Spitzel, Marlene [Verfasser] / Sommer, Claudia [Gutachter] / Üçeyler, Nurcan [Gutachter] / Ruiz de Almodóvar, Carmen [Gutachter] / Blum, Robert [Gutachter]

    2023  

    Author's details Marlene Spitzel ; Gutachter: Claudia Sommer, Nurcan Üçeyler, Carmen Ruiz de Almodóvar, Robert Blum
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universität Würzburg
    Publishing place Würzburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article ; Online: Neurovascular Communication during CNS Development.

    Paredes, Isidora / Himmels, Patricia / Ruiz de Almodóvar, Carmen

    Developmental cell

    2018  Volume 45, Issue 1, Page(s) 10–32

    Abstract: A precise communication between the nervous and the vascular systems is crucial for proper formation and function of the central nervous system (CNS). Interestingly, this communication does not only occur by neural cells regulating the growth and ... ...

    Abstract A precise communication between the nervous and the vascular systems is crucial for proper formation and function of the central nervous system (CNS). Interestingly, this communication does not only occur by neural cells regulating the growth and properties of the vasculature, but new studies show that blood vessels actively control different neurodevelopmental processes. Here, we review the current knowledge on how neurons in particular influence growing blood vessels during CNS development and on how vessels participate in shaping the neural compartment. We also review the identified molecular mechanisms of this bidirectional communication.
    MeSH term(s) Animals ; Central Nervous System/blood supply ; Central Nervous System/growth & development ; Humans ; Neovascularization, Physiologic/physiology
    Language English
    Publishing date 2018--09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2018.01.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Blood Vessels as Regulators of Neural Stem Cell Properties.

    Karakatsani, Andromachi / Shah, Bhavin / Ruiz de Almodovar, Carmen

    Frontiers in molecular neuroscience

    2019  Volume 12, Page(s) 85

    Abstract: In the central nervous system (CNS), a precise communication between the vascular and neural compartments is essential for proper development and function. Recent studies demonstrate that certain neuronal populations secrete various molecular cues to ... ...

    Abstract In the central nervous system (CNS), a precise communication between the vascular and neural compartments is essential for proper development and function. Recent studies demonstrate that certain neuronal populations secrete various molecular cues to regulate blood vessel growth and patterning in the spinal cord and brain during development. Interestingly, the vasculature is now emerging as a critical component that regulates stem cell niches during neocortical development, as well as during adulthood. In this review article, we will first provide an overview of blood vessel development and maintenance in embryonic and adult neurogenic niches. We will also summarize the current understanding of how blood vessel-derived signals influence the behavior of neural stem cells (NSCs) during early development as well as in adulthood, with a focus on their metabolism.
    Language English
    Publishing date 2019-04-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2019.00085
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  8. Article: Cellular and Molecular Mechanisms of Spinal Cord Vascularization.

    Vieira, Jose Ricardo / Shah, Bhavin / Ruiz de Almodovar, Carmen

    Frontiers in physiology

    2020  Volume 11, Page(s) 599897

    Abstract: During embryonic central nervous system (CNS) development, the neural and the vascular systems communicate with each other in order to give rise to a fully functional and mature CNS. The initial avascular CNS becomes vascularized by blood vessel ... ...

    Abstract During embryonic central nervous system (CNS) development, the neural and the vascular systems communicate with each other in order to give rise to a fully functional and mature CNS. The initial avascular CNS becomes vascularized by blood vessel sprouting from different vascular plexus in a highly stereotypical and controlled manner. This process is similar across different regions of the CNS. In particular for the developing spinal cord (SC), blood vessel ingression occurs from a perineural vascular plexus during embryonic development. In this review, we provide an updated and comprehensive description of the cellular and molecular mechanisms behind this stereotypical and controlled patterning of blood vessels in the developing embryonic SC, identified using different animal models. We discuss how signals derived from neural progenitors and differentiated neurons guide the SC growing vasculature. Lastly, we provide a perspective of how the molecular mechanisms identified during development could be used to better understand pathological situations.
    Language English
    Publishing date 2020-12-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2020.599897
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  9. Article ; Online: VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1.

    Ruiz de Almodovar, Carmen / Fabre, Pierre J / Knevels, Ellen / Coulon, Cathy / Segura, Inmaculada / Haddick, Patrick C G / Aerts, Liesbeth / Delattin, Nicolas / Strasser, Geraldine / Oh, Won-Jong / Lange, Christian / Vinckier, Stefan / Haigh, Jody / Fouquet, Coralie / Gu, Chengua / Alitalo, Kari / Castellani, Valerie / Tessier-Lavigne, Marc / Chedotal, Alain /
    Charron, Frederic / Carmeliet, Peter

    Neuron

    2023  Volume 111, Issue 8, Page(s) 1348

    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2023.03.029
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  10. Article ; Online: Malaria parasites differentially sense environmental elasticity during transmission.

    Ripp, Johanna / Kehrer, Jessica / Smyrnakou, Xanthoula / Tisch, Nathalie / Tavares, Joana / Amino, Rogerio / Ruiz de Almodovar, Carmen / Frischknecht, Friedrich

    EMBO molecular medicine

    2021  Volume 13, Issue 4, Page(s) e13933

    Abstract: Transmission of malaria-causing parasites to and by the mosquito relies on active parasite migration and constitutes bottlenecks in the Plasmodium life cycle. Parasite adaption to the biochemically and physically different environments must hence be a ... ...

    Abstract Transmission of malaria-causing parasites to and by the mosquito relies on active parasite migration and constitutes bottlenecks in the Plasmodium life cycle. Parasite adaption to the biochemically and physically different environments must hence be a key evolutionary driver for transmission efficiency. To probe how subtle but physiologically relevant changes in environmental elasticity impact parasite migration, we introduce 2D and 3D polyacrylamide gels to study ookinetes, the parasite forms emigrating from the mosquito blood meal and sporozoites, the forms transmitted to the vertebrate host. We show that ookinetes adapt their migratory path but not their speed to environmental elasticity and are motile for over 24 h on soft substrates. In contrast, sporozoites evolved more short-lived rapid gliding motility for rapidly crossing the skin. Strikingly, sporozoites are highly sensitive to substrate elasticity possibly to avoid adhesion to soft endothelial cells on their long way to the liver. Hence, the two migratory stages of Plasmodium evolved different strategies to overcome the physical challenges posed by the respective environments and barriers they encounter.
    MeSH term(s) Animals ; Elasticity ; Endothelial Cells ; Malaria ; Parasites ; Plasmodium ; Sporozoites
    Language English
    Publishing date 2021-03-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2467145-9
    ISSN 1757-4684 ; 1757-4676
    ISSN (online) 1757-4684
    ISSN 1757-4676
    DOI 10.15252/emmm.202113933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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