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Article ; Online: Electric-field-controlled interface dipole modulation for Si-based memory devices.

Miyata, Noriyuki

2018 Volume 8, Issue 1, Page(s) 8486

Abstract: Various nonvolatile memory devices have been investigated to replace Si-based flash memories or emulate synaptic plasticity for next-generation neuromorphic computing. A crucial criterion to achieve low-cost high-density memory chips is material ... ...

Abstract	Various nonvolatile memory devices have been investigated to replace Si-based flash memories or emulate synaptic plasticity for next-generation neuromorphic computing. A crucial criterion to achieve low-cost high-density memory chips is material compatibility with conventional Si technologies. In this paper, we propose and demonstrate a new memory concept, interface dipole modulation (IDM) memory. IDM can be integrated as a Si field-effect transistor (FET) based memory device. The first demonstration of this concept employed a HfO
Language	English
Publishing date	2018-05-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-26692-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High-speed Atomic Force Microscopy Observation of Internal Structure Movements in Living

Kobayashi, Kohei / Kodera, Noriyuki / Miyata, Makoto

Bio-protocol

2022 Volume 12, Issue 5, Page(s) e4344

Abstract: ... Dozens ... ...

Abstract	Dozens of
Language	English
Publishing date	2022-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2833269-6
ISSN	2331-8325 ; 2331-8325
ISSN (online)	2331-8325
ISSN	2331-8325
DOI	10.21769/BioProtoc.4344
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Electric-field-controlled interface dipole modulation for Si-based memory devices

Noriyuki Miyata

Scientific Reports, Vol 8, Iss 1, Pp 1-

2018 Volume 9

Abstract: Abstract Various nonvolatile memory devices have been investigated to replace Si-based flash memories or emulate synaptic plasticity for next-generation neuromorphic computing. A crucial criterion to achieve low-cost high-density memory chips is material ...

Abstract	Abstract Various nonvolatile memory devices have been investigated to replace Si-based flash memories or emulate synaptic plasticity for next-generation neuromorphic computing. A crucial criterion to achieve low-cost high-density memory chips is material compatibility with conventional Si technologies. In this paper, we propose and demonstrate a new memory concept, interface dipole modulation (IDM) memory. IDM can be integrated as a Si field-effect transistor (FET) based memory device. The first demonstration of this concept employed a HfO2/Si MOS capacitor where the interface monolayer (ML) TiO2 functions as a dipole modulator. However, this configuration is unsuitable for Si-FET-based devices due to its large interface state density (D it ). Consequently, we propose, a multi-stacked amorphous HfO2/1-ML TiO2/SiO2 IDM structure to realize a low D it and a wide memory window. Herein we describe the quasi-static and pulse response characteristics of multi-stacked IDM MOS capacitors and demonstrate flash-type and analog memory operations of an IDM FET device.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2018-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Low-Temperature Direct Synthesis of Multilayered h-BN without Catalysts by Inductively Coupled Plasma-Enhanced Chemical Vapor Deposition.

Yamamoto, Masaya / Murata, Hiromasa / Miyata, Noriyuki / Takashima, Hiroshi / Nagao, Masayoshi / Mimura, Hidenori / Neo, Yoichiro / Murakami, Katsuhisa

ACS omega

2023 Volume 8, Issue 6, Page(s) 5497–5505

Abstract: Low-temperature direct synthesis of thick multilayered hexagonal-boron nitride (h-BN) on semiconducting and insulating substrates is required to produce high-performance electronic devices based on two-dimensional (2D) materials. In this study, ... ...

Abstract	Low-temperature direct synthesis of thick multilayered hexagonal-boron nitride (h-BN) on semiconducting and insulating substrates is required to produce high-performance electronic devices based on two-dimensional (2D) materials. In this study, multilayered h-BN with a thickness exceeding 5 nm was directly synthesized on quartz and Si at low temperatures, between 400 and 500 °C, by inductively coupled plasma-enhanced chemical vapor deposition using borazine as the precursor material. The quality and thickness of the h-BN crystals were investigated with respect to synthesis parameters, namely, temperature, radio frequency power, N
Language	English
Publishing date	2023-01-31
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c06757
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Article ; Online: A prospective study of surgeons' workloads and associated factors in real-world practice.

Harada, Shigeru / Abe, Takashige / Furumido, Jun / Takahashi, Keita / Hori, Kanta / Abe, Noriyuki / Kon, Masafumi / Murai, Sachiyo / Miyata, Haruka / Kikuchi, Hiroshi / Matsumoto, Ryuji / Osawa, Takahiro / Shinohara, Nobuo

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9741

Abstract: New technologies such as laparoscopic and robotic surgery are spreading, and there is a demand for physicians to keep up with novel methods. In contrast to the recent focus on healthcare professional burnout, the mental and physical costs during surgery ... ...

Abstract	New technologies such as laparoscopic and robotic surgery are spreading, and there is a demand for physicians to keep up with novel methods. In contrast to the recent focus on healthcare professional burnout, the mental and physical costs during surgery are not well-understood. We aimed to quantify surgeons' workloads in daily urological surgical practice and clarify potential background factors associated with such workloads. Urologists in Hokkaido, Japan, were invited to this study. Between December 2020 and December 2021, participants repeatedly reported workloads, which were assessed using the National Aeronautics and Space Administration-Task Load Index (NASA-TLX), after each surgery in conjunction with participants' names, patients' backgrounds, their roles (independent operator, operator under supervision, instructor, and 1st or 2nd assistant), and surgical outcomes, via SurveyMonkey
MeSH term(s)	Humans ; Female ; Workload ; Male ; Surgeons ; Prospective Studies ; Adult ; Middle Aged ; Japan ; Urologic Surgical Procedures ; Surveys and Questionnaires ; Laparoscopy
Language	English
Publishing date	2024-04-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-59596-1
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Article: Study of Direct-Contact HfO₂/Si Interfaces.

Miyata, Noriyuki

Materials (Basel, Switzerland)

2012 Volume 5, Issue 3, Page(s) 512–527

Abstract: Controlling monolayer Si oxide at the HfO₂/Si interface is a challenging issue in scaling the equivalent oxide thickness of HfO₂/Si gate stack structures. A concept that the author proposes to control the Si oxide interface by using ultra-high vacuum ... ...

Abstract	Controlling monolayer Si oxide at the HfO₂/Si interface is a challenging issue in scaling the equivalent oxide thickness of HfO₂/Si gate stack structures. A concept that the author proposes to control the Si oxide interface by using ultra-high vacuum electron-beam HfO₂ deposition is described in this review paper, which enables the so-called direct-contact HfO₂/Si structures to be prepared. The electrical characteristics of the HfO₂/Si metal-oxide-semiconductor capacitors are reviewed, which suggest a sufficiently low interface state density for the operation of metal-oxide-semiconductor field-effect-transistors (MOSFETs) but reveal the formation of an unexpected strong interface dipole. Kelvin probe measurements of the HfO₂/Si structures provide obvious evidence for the formation of dipoles at the HfO₂/Si interfaces. The author proposes that one-monolayer Si-O bonds at the HfO₂/Si interface naturally lead to a large potential difference, mainly due to the large dielectric constant of the HfO₂. Dipole scattering is demonstrated to not be a major concern in the channel mobility of MOSFETs.
Language	English
Publishing date	2012-03-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma5030512
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Article ; Online: Dietary supplementation with 1-kestose induces altered locomotor activity and increased striatal dopamine levels with a change in gut microbiota in male mice.

Altaisaikhan, Altanzul / Yoshihara, Kazufumi / Hata, Tomokazu / Miyata, Noriyuki / Asano, Yasunari / Suematsu, Takafumi / Kadota, Yoshihiro / Sudo, Nobuyuki

Physiological reports

2023 Volume 11, Issue 23, Page(s) e15882

Abstract: 1-Kestose (KES), a dietary fiber and prebiotic carbohydrate, benefits various physiological functions. This study aimed to examine whether diets supplemented with KES over three consecutive generations could significantly affect some host physiological ... ...

Abstract	1-Kestose (KES), a dietary fiber and prebiotic carbohydrate, benefits various physiological functions. This study aimed to examine whether diets supplemented with KES over three consecutive generations could significantly affect some host physiological aspects, including behavioral phenotypes and gut microbial ecology. Mice that received KES-supplemented diets for three generations demonstrated increased activity compared with those fed diets lacking KES. Furthermore, the KES group showed increased striatal dopamine (DA) and serotonin (5-HT) levels. The observed increase in DA levels within the striatum was positively correlated with locomotor activity in the KES group but not in the control (CON) group. The α-diversities were significantly lower in the KES group compared to the CON group. The three-dimensional principal coordinate analysis revealed a substantial distinction between the KES and CON groups across each generation. At the genus level, most gut microbiota genera exhibited lower abundances in the KES group than in the CON group, except for Bifidobacteria and Akkermansia. Spearman's rank-order analysis indicated significant negative correlations between the striatal DA levels and α-diversity values. These findings suggest that prolonged supplementation with KES may stimulate increased locomotor activity along with elevated striatal DA levels, which are potentially associated with KES-induced alterations in the gut microbiota.
MeSH term(s)	Mice ; Animals ; Male ; Dopamine ; Gastrointestinal Microbiome ; Trisaccharides ; Prebiotics
Chemical Substances	Dopamine (VTD58H1Z2X) ; 1-kestose (02LN7O412C) ; Trisaccharides ; Prebiotics
Language	English
Publishing date	2023-12-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.15882
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Article ; Online: Multidisciplinary treatment of advanced cervical esophageal adenocarcinoma derived from a gastric inlet patch: A case report.

Okamoto, Koichi / Yamaguchi, Takahisa / Asakawa, Tetsuya / Kaida, Daisuke / Miyata, Takashi / Hayashi, Tomoyuki / Ojima, Toshihiko / Fujita, Hideto / Inaki, Noriyuki / Kinami, Shinichi / Ninomiya, Itasu / Takamura, Hiroyuki

Oncology letters

2024 Volume 27, Issue 3, Page(s) 120

Abstract: A gastric inlet patch (GIP) is an ectopic gastric mucosal lesion usually arising at the cervical esophagus that may rarely cause esophageal adenocarcinoma (EAC). To the best of our knowledge, this is the first case of a GIP-derived EAC that was ... ...

Abstract	A gastric inlet patch (GIP) is an ectopic gastric mucosal lesion usually arising at the cervical esophagus that may rarely cause esophageal adenocarcinoma (EAC). To the best of our knowledge, this is the first case of a GIP-derived EAC that was successfully treated using a multidisciplinary treatment approach. A 64-year-old man was referred to the Department of Gastrointestinal Surgery, Kanazawa University Hospital (Kanazawa, Japan) for surgical treatment of refractory recurrent cervical EAC derived from GIP who had previously been treated with induction chemotherapy, definitive chemoradiotherapy and photodynamic therapy (PDT). Esophagogastroduodenoscopy revealed a stenotic tumor at the GIP site in the cervical esophagus and submucosal tumors with suspected multiple intramural metastases in the anal side of the thoracic esophagus. The patient underwent robot-assisted thoracoscopic esophagectomy with laryngopharyngectomy and cervical lymphadenectomy as radical salvage surgery 4 months after the last PDT procedure. After postoperative adjuvant chemotherapy using oral administration of tegafur/gimeracil/oteracil (oral 5-fluorouracil prodrug) for 1 year; at present, the patient is alive without recurrence 3 years after the operation.
Language	English
Publishing date	2024-01-25
Publishing country	Greece
Document type	Case Reports
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2024.14253
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Article ; Online: DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma.

Harachi, Mio / Masui, Kenta / Shimizu, Erika / Murakami, Kumiko / Onizuka, Hiromi / Muragaki, Yoshihiro / Kawamata, Takakazu / Nakayama, Hisako / Miyata, Mariko / Komori, Takashi / Cavenee, Webster K / Mischel, Paul S / Kurata, Atsushi / Shibata, Noriyuki

Acta neuropathologica communications

2024 Volume 12, Issue 1, Page(s) 40

Abstract: DNA methylation is crucial for chromatin structure and gene expression and its aberrancies, including the global "hypomethylator phenotype", are associated with cancer. Here we show that an underlying mechanism for this phenotype in the large proportion ... ...

Abstract	DNA methylation is crucial for chromatin structure and gene expression and its aberrancies, including the global "hypomethylator phenotype", are associated with cancer. Here we show that an underlying mechanism for this phenotype in the large proportion of the highly lethal brain tumor glioblastoma (GBM) carrying receptor tyrosine kinase gene mutations, involves the mechanistic target of rapamycin complex 2 (mTORC2), that is critical for growth factor signaling. In this scenario, mTORC2 suppresses the expression of the de novo DNA methyltransferase (DNMT3A) thereby inducing genome-wide DNA hypomethylation. Mechanistically, mTORC2 facilitates a redistribution of EZH2 histone methyltransferase into the promoter region of DNMT3A, and epigenetically represses the expression of DNA methyltransferase. Integrated analyses in both orthotopic mouse models and clinical GBM samples indicate that the DNA hypomethylator phenotype consistently reprograms a glutamate metabolism network, eventually driving GBM cell invasion and survival. These results nominate mTORC2 as a novel regulator of DNA hypomethylation in cancer and an exploitable target against cancer-promoting epigenetics.
MeSH term(s)	Mice ; Animals ; Glioblastoma/pathology ; Cell Line, Tumor ; Mechanistic Target of Rapamycin Complex 2/genetics ; Mechanistic Target of Rapamycin Complex 2/metabolism ; DNA Methylation ; Phenotype ; Brain Neoplasms/pathology ; DNA/metabolism ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Protein-Tyrosine Kinases/genetics
Chemical Substances	Mechanistic Target of Rapamycin Complex 2 (EC 2.7.11.1) ; DNA (9007-49-2) ; Methyltransferases (EC 2.1.1.-) ; Protein-Tyrosine Kinases (EC 2.7.10.1)
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-024-01750-x
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Article ; Online: Association between interstitial lung abnormality and mortality in patients with esophageal cancer.

Hata, Akinori / Yanagawa, Masahiro / Miyata, Tomo / Hiraoka, Yu / Shirae, Motohiro / Ninomiya, Keisuke / Doi, Shuhei / Yamagata, Kazuki / Yoshida, Yuriko / Kikuchi, Noriko / Ogawa, Ryo / Hatabu, Hiroto / Tomiyama, Noriyuki

Japanese journal of radiology

2024

Abstract: Purpose: To investigate the relationship between interstitial lung abnormalities (ILAs) and mortality in patients with esophageal cancer and the cause of mortality.: Materials and methods: This retrospective study investigated patients with ... ...

Abstract	Purpose: To investigate the relationship between interstitial lung abnormalities (ILAs) and mortality in patients with esophageal cancer and the cause of mortality. Materials and methods: This retrospective study investigated patients with esophageal cancer from January 2011 to December 2015. ILAs were visually scored on baseline CT using a 3-point scale (0 = non-ILA, 1 = indeterminate for ILA, and 2 = ILA). ILAs were classified into subcategories of non-subpleural, subpleural non-fibrotic, and subpleural fibrotic. Five-year overall survival (OS) was compared between patients with and without ILAs using the multivariable Cox proportional hazards model. Subgroup analyses were performed based on cancer stage and ILA subcategories. The prevalences of treatment complications and death due to esophageal cancer and pneumonia/respiratory failure were analyzed using Fisher's exact test. Results: A total of 478 patients with esophageal cancer (age, 66.8 years ± 8.6 [standard deviation]; 64 women) were evaluated in this study. Among them, 267 patients showed no ILAs, 125 patients were indeterminate for ILAs, and 86 patients showed ILAs. ILAs were a significant factor for shorter OS (hazard ratio [HR] = 1.68, 95% confidence interval [CI] 1.10-2.55, P = 0.016) in the multivariable Cox proportional hazards model adjusting for age, sex, smoking history, clinical stage, and histology. On subgroup analysis using patients with clinical stage IVB, the presence of ILAs was a significant factor (HR = 3.78, 95% CI 1.67-8.54, P = 0.001). Subpleural fibrotic ILAs were significantly associated with shorter OS (HR = 2.22, 95% CI 1.25-3.93, P = 0.006). There was no significant difference in treatment complications. Patients with ILAs showed a higher prevalence of death due to pneumonia/respiratory failure than those without ILAs (non-ILA, 2/95 [2%]; ILA, 5/39 [13%]; P = 0.022). The prevalence of death due to esophageal cancer was similar in patients with and without ILA (non-ILA, 82/95 [86%]; ILA 32/39 [82%]; P = 0.596). Conclusion: ILAs were significantly associated with shorter survival in patients with esophageal cancer.
Language	English
Publishing date	2024-04-25
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2488907-6
ISSN	1867-108X ; 1867-1071
ISSN (online)	1867-108X
ISSN	1867-1071
DOI	10.1007/s11604-024-01563-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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