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Article ; Online: Association between the loudness dependence of auditory evoked potential, serotonergic neurotransmission and treatment outcome in patients with depression.

Ip, Cheng-Teng / Ganz, Melanie / Ozenne, Brice / Olbrich, Sebastian / Beliveau, Vincent / Dam, Vibeke H / Köhler-Forsberg, Kristin / Jørgensen, Martin B / Frøkjær, Vibe G / Knudsen, Gitte M

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

2023 Volume 70, Page(s) 32–44

Abstract: Previous studies have suggested that the loudness dependence of auditory evoked potential (LDAEP) is associated with the effectiveness of antidepressant treatment in patients with major depressive disorders (MDD). Furthermore, both LDAEP and the cerebral ...

Abstract	Previous studies have suggested that the loudness dependence of auditory evoked potential (LDAEP) is associated with the effectiveness of antidepressant treatment in patients with major depressive disorders (MDD). Furthermore, both LDAEP and the cerebral serotonin 4 receptor (5-HT
MeSH term(s)	Humans ; Serotonin/metabolism ; Depressive Disorder, Major/diagnostic imaging ; Depressive Disorder, Major/drug therapy ; Depression ; Serotonin and Noradrenaline Reuptake Inhibitors/therapeutic use ; Evoked Potentials, Auditory/physiology ; Selective Serotonin Reuptake Inhibitors/therapeutic use ; Treatment Outcome ; Synaptic Transmission ; Electroencephalography
Chemical Substances	Serotonin (333DO1RDJY) ; Serotonin and Noradrenaline Reuptake Inhibitors ; Selective Serotonin Reuptake Inhibitors
Language	English
Publishing date	2023-02-28
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1082947-7
ISSN	1873-7862 ; 0924-977X
ISSN (online)	1873-7862
ISSN	0924-977X
DOI	10.1016/j.euroneuro.2023.02.008
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Article ; Online: Shared and Distinct Renal Transcriptome Signatures in 3 Standard Mouse Models of Chronic Kidney Disease.

Marstrand-Jørgensen, Adam B / Sembach, Frederikke Emilie / Bak, Stine Thorhauge / Ougaard, Maria / Christensen-Dalsgaard, Mikkel / Rønn Madsen, Martin / Jensen, Ditte Marie / Secher, Thomas / Heimbürger, Sebastian Møller Nguyen / Fink, Lisbeth N / Hansen, Ditte / Hansen, Henrik H / Østergaard, Mette Viberg / Christensen, Michael / Dalbøge, Louise S

Nephron

2024 , Page(s) 1–16

Abstract: Introduction: Several mouse models with diverse disease etiologies are used in preclinical research for chronic kidney disease (CKD). Here, we performed a head-to-head comparison of renal transcriptome signatures in standard mouse models of CKD to ... ...

Abstract	Introduction: Several mouse models with diverse disease etiologies are used in preclinical research for chronic kidney disease (CKD). Here, we performed a head-to-head comparison of renal transcriptome signatures in standard mouse models of CKD to assess shared and distinct molecular changes in three mouse models commonly employed in preclinical CKD research and drug discovery. Methods: All experiments were conducted on male C57BL/6J mice. Mice underwent sham, unilateral ureter obstruction (UUO), or unilateral ischemic-reperfusion injury (uIRI) surgery and were terminated two- and 6-weeks post-surgery, respectively. The adenine-supplemented diet-induced (ADI) model of CKD was established by feeding with adenine diet for 6 weeks and compared to control diet feeding. For all models, endpoints included plasma biochemistry, kidney histology, and RNA sequencing. Results: All models displayed increased macrophage infiltration (F4/80 IHC) and fibrosis (collagen 1a1 IHC). Compared to corresponding controls, all models were characterized by an extensive number of renal differentially expressed genes (≥11,000), with a notable overlap in transcriptomic signatures across models. Gene expression markers of fibrosis, inflammation, and kidney injury supported histological findings. Interestingly, model-specific transcriptome signatures included several genes representing current drug targets for CKD, emphasizing advantages and limitations of the three CKD models in preclinical target and drug discovery. Conclusion: The UUO, uIRI, and ADI mouse models of CKD have significant commonalities in their renal global transcriptome profile. Model-specific renal transcriptional signatures should be considered when selecting the specific model in preclinical target and drug discovery.
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	207121-6
ISSN	2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
ISSN (online)	2235-3186 ; 1423-0186
ISSN	1660-8151 ; 0028-2766
DOI	10.1159/000535918
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Article ; Online: NeuroPharm study: EEG wakefulness regulation as a biomarker in MDD.

Ip, Cheng-Teng / Ganz, Melanie / Dam, Vibeke H / Ozenne, Brice / Rüesch, Annia / Köhler-Forsberg, Kristin / Jørgensen, Martin B / Frokjaer, Vibe G / Søgaard, Birgitte / Christensen, Søren R / Knudsen, Gitte M / Olbrich, Sebastian

Journal of psychiatric research

2021 Volume 141, Page(s) 57–65

Abstract: While several electroencephalogram (EEG)-based biomarkers have been proposed as diagnostic or predictive tools in major depressive disorder (MDD), there is a clear lack of replication studies in this field. Markers that link clinical features such as ... ...

Abstract	While several electroencephalogram (EEG)-based biomarkers have been proposed as diagnostic or predictive tools in major depressive disorder (MDD), there is a clear lack of replication studies in this field. Markers that link clinical features such as disturbed wakefulness regulation in MDD with neurophysiological patterns are particularly promising candidates for e.g., EEG-informed choices of antidepressive treatment. We investigate if we in an independent MDD sample can replicate abnormal findings of EEG-vigilance regulation during rest and as a predictor for antidepressive treatment response. EEG-resting state was recorded in 91 patients and 35 healthy controls from the NeuroPharm trial. EEG-vigilance was assessed using the Vigilance Algorithm Leipzig (VIGALL). We compared the vigilance regulation during rest between patients and healthy controls and between remitters/responders and non-remitters/non-responders after eight weeks of SSRI/SNRI treatment using two different sets of response criteria (NeuroPharm and iSPOT-D). We replicated previous findings showing hyperstable EEG-wakefulness regulation in patients in comparison to healthy subjects. Responders defined by the iSPOT-D criteria showed a higher propensity toward low vigilance stages in comparison to patients with no response at pretreatment, however, this did not apply when using the NeuroPharm criteria. EEG-wakefulness regulation patterns normalized toward patterns of healthy controls after 8 weeks of treatment. This replication study supports the diagnostic value of EEG-vigilance regulation and its usefulness as a biomarker for the choice of treatment in MDD.
MeSH term(s)	Arousal ; Biomarkers ; Depressive Disorder, Major/drug therapy ; Electroencephalography ; Humans ; Wakefulness
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-06-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2021.06.021
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Article ; Online: Pretreatment qEEG biomarkers for predicting pharmacological treatment outcome in major depressive disorder: Independent validation from the NeuroPharm study.

Ip, Cheng-Teng / Olbrich, Sebastian / Ganz, Melanie / Ozenne, Brice / Köhler-Forsberg, Kristin / Dam, Vibeke H / Beniczky, Sándor / Jørgensen, Martin B / Frokjaer, Vibe G / Søgaard, Birgitte / Christensen, Søren R / Knudsen, Gitte M

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

2021 Volume 49, Page(s) 101–112

Abstract: Several electroencephalogram (EEG) biomarkers for prediction of drug response in major depressive disorder (MDD) have been proposed, but validations in larger independent datasets are missing. In the current study, we investigated the prognostic value of ...

Abstract	Several electroencephalogram (EEG) biomarkers for prediction of drug response in major depressive disorder (MDD) have been proposed, but validations in larger independent datasets are missing. In the current study, we investigated the prognostic value of previously suggested EEG biomarkers. We gathered data that matched prior studies in terms of EEG methodology, clinical criteria for MDD, and statistical approach as closely as possible. The NeuroPharm study is a non-randomized and open label prospective clinical trial. One hundred antidepressant free patients with MDD were enrolled in the study and 79 (57 female) were included in the per-protocol analysis. The biomarkers candidates for cross-validation were derived from prior studies such as iSPOT-D and EMBARC and include frontal and occipital alpha power and asymmetry and delta and theta activity at anterior cingulate cortex (ACC). The alpha asymmetry, reported in two out of six prior studies, could be partially validated. We found that in female patients, larger right than left frontal alpha power prior to drug treatment was associated with better clinical outcome 8 weeks later. Moreover, female non-responder had higher central left alpha power relative to the right. In contrast to prior reports, we found that lower theta activity at ACC was present in remitters and was associated with greater improvement at week 8. We provide evidence that in women with MDD, alpha asymmetry seems to be the most promising EEG biomarker for prediction of treatment response. Registration number: NCT02869035.
MeSH term(s)	Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Biomarkers ; Depressive Disorder, Major/diagnosis ; Depressive Disorder, Major/drug therapy ; Electroencephalography/methods ; Female ; Humans ; Prospective Studies ; Treatment Outcome
Chemical Substances	Antidepressive Agents ; Biomarkers
Language	English
Publishing date	2021-04-25
Publishing country	Netherlands
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1082947-7
ISSN	1873-7862 ; 0924-977X
ISSN (online)	1873-7862
ISSN	0924-977X
DOI	10.1016/j.euroneuro.2021.03.024
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Zs.A 3288: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Plasma GDF15 levels are similar between subjects after bariatric surgery and matched controls and are unaffected by meals.

Martinussen, Christoffer / Svane, Maria Saur / Bojsen-Møller, Kirstine N / Jensen, Christian Zinck / Kristiansen, Viggo B / Bookout, Angie Lynn / Jørgensen, Sebastian Beck / Holst, Jens Juul / Wewer Albrechtsen, Nicolai J / Madsbad, Sten / Kuhre, Rune Ehrenreich

American journal of physiology. Endocrinology and metabolism

2021 Volume 321, Issue 4, Page(s) E443–E452

Abstract: Growth differentiating factor 15 (GDF15) is expressed in the intestine and is one of the most recently identified satiety peptides. The mechanisms controlling its secretion are unclear. The present study investigated whether plasma GDF15 concentrations ... ...

Abstract	Growth differentiating factor 15 (GDF15) is expressed in the intestine and is one of the most recently identified satiety peptides. The mechanisms controlling its secretion are unclear. The present study investigated whether plasma GDF15 concentrations are meal-related and if potential responses depend on macronutrient type or are affected by previous bariatric surgery. The study included
MeSH term(s)	Adult ; Bariatric Surgery/methods ; Biomarkers/blood ; Blood Glucose/analysis ; Body Mass Index ; Case-Control Studies ; Cross-Over Studies ; Female ; Follow-Up Studies ; Gastrointestinal Tract/metabolism ; Growth Differentiation Factor 15/blood ; Humans ; Insulin/blood ; Male ; Meals ; Middle Aged ; Obesity, Morbid/blood ; Obesity, Morbid/pathology ; Obesity, Morbid/surgery ; Postprandial Period ; Prognosis ; Randomized Controlled Trials as Topic ; Weight Loss
Chemical Substances	Biomarkers ; Blood Glucose ; GDF15 protein, human ; Growth Differentiation Factor 15 ; Insulin
Language	English
Publishing date	2021-08-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603841-4
ISSN	1522-1555 ; 0193-1849
ISSN (online)	1522-1555
ISSN	0193-1849
DOI	10.1152/ajpendo.00190.2021
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Article ; Online: GDF15 acts synergistically with liraglutide but is not necessary for the weight loss induced by bariatric surgery in mice.

Frikke-Schmidt, Henriette / Hultman, Karin / Galaske, Joseph W / Jørgensen, Sebastian B / Myers, Martin G / Seeley, Randy J

Molecular metabolism

2019 Volume 21, Page(s) 13–21

Abstract: Objective: Analogues of GDF15 (Growth Differentiation Factor 15) are promising new anti-obesity therapies as pharmacological treatment with GDF15 results in dramatic reductions of food intake and body weight. GDF15 exerts its central anorexic effects by ...

Abstract	Objective: Analogues of GDF15 (Growth Differentiation Factor 15) are promising new anti-obesity therapies as pharmacological treatment with GDF15 results in dramatic reductions of food intake and body weight. GDF15 exerts its central anorexic effects by binding to the GFRAL receptor exclusively expressed in the Area Postrema (AP) and the Nucleus of the Solitary Tract (NTS) of the hindbrain. We sought to determine if GDF15 is an indispensable factor for other interventions that cause weight loss and which are also known to act via these hindbrain regions. Methods: To explore the role of GDF15 on food choice we performed macronutrient intake studies in mice treated pharmacologically with GDF15 and in mice having either GDF15 or GFRAL deleted. Next we performed vertical sleeve gastrectomy (VSG) surgeries in a cohort of diet-induced obese Gdf15-null and control mice. To explore the anatomical co-localization of neurons in the hindbrain responding to GLP-1 and/or GDF15 we used GLP-1R reporter mice treated with GDF15, as well as naïve mouse brain and human brain stained by ISH and IHC, respectively, for GLP-1R and GFRAL. Lastly we performed a series of food intake experiments where we treated mice with targeted genetic disruption of either Gdf15 or Gfral with liraglutide; Glp1r-null mice with GDF15; or combined liraglutide and GDF15 treatment in wild-type mice. Results: We found that GDF15 treatment significantly lowered the preference for fat intake in mice, whereas no changes in fat intake were observed after genetic deletion of Gdf15 or Gfral. In addition, deletion of Gdf15 did not alter the food intake or bodyweight after sleeve gastrectomy. Lack of GDF15 or GFRAL signaling did not alter the ability of the GLP-1R agonist liraglutide to reduce food intake. Similarly lack of GLP-1R signaling did not reduce GDF15's anorexic effect. Interestingly, there was a significant synergistic effect on weight loss when treating wild-type mice with both GDF15 and liraglutide. Conclusion: These data suggest that while GDF15 does not play a role in the potent effects of VSG in mice there seems to be a potential therapeutic benefit of activating GFRAL and GLP-1R systems simultaneously.
MeSH term(s)	Animals ; Area Postrema/metabolism ; Bariatric Surgery ; Body Weight/drug effects ; Diet, High-Fat/adverse effects ; Drug Synergism ; Eating/drug effects ; Gastrectomy ; Gene Deletion ; Glial Cell Line-Derived Neurotrophic Factor Receptors/genetics ; Glial Cell Line-Derived Neurotrophic Factor Receptors/metabolism ; Glucagon-Like Peptide-1 Receptor/metabolism ; Growth Differentiation Factor 15/genetics ; Growth Differentiation Factor 15/metabolism ; Growth Differentiation Factor 15/therapeutic use ; Humans ; Hypoglycemic Agents/therapeutic use ; Liraglutide/therapeutic use ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Obesity/drug therapy ; Obesity/etiology ; Solitary Nucleus/metabolism ; Weight Loss/drug effects
Chemical Substances	GFRAL protein, mouse ; GLP1R protein, human ; Gdf15 protein, mouse ; Glial Cell Line-Derived Neurotrophic Factor Receptors ; Glp1r protein, mouse ; Glucagon-Like Peptide-1 Receptor ; Growth Differentiation Factor 15 ; Hypoglycemic Agents ; Liraglutide (839I73S42A)
Language	English
Publishing date	2019-01-14
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2212-8778
ISSN (online)	2212-8778
DOI	10.1016/j.molmet.2019.01.003
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Article ; Online: Decreased number of colonic tuft cells in quiescent ulcerative colitis patients.

Kjærgaard, Sebastian / Jensen, Thorbjørn S R / Feddersen, Ulrike R / Bindslev, Niels / Grunddal, Kaare V / Poulsen, Steen S / Rasmussen, Hanne B / Budtz-Jørgensen, Esben / Berner-Hansen, Mark

European journal of gastroenterology & hepatology

2020 Volume 33, Issue 6, Page(s) 817–824

Abstract: Background: Colonic tuft cells are epithelial chemosensory cells involved in barrier integrity, modulation of inflammatory responses and gut homeostasis. Recent evidence indicates an involvement of tuft cells in ulcerative colitis pathogenesis, though ... ...

Abstract	Background: Colonic tuft cells are epithelial chemosensory cells involved in barrier integrity, modulation of inflammatory responses and gut homeostasis. Recent evidence indicates an involvement of tuft cells in ulcerative colitis pathogenesis, though mechanisms remain largely unknown.Here, we quantified the colonic tuft cell population in patients with quiescent ulcerative colitis as compared to patients without identified colonic disease (controls). Methods: In this retrospective study, we obtained endoscopic colonic sigmoid biopsies from 14 patients with quiescent ulcerative colitis and from 17 controls. In a blinded central-reading design, we identified tuft cells by immunohistochemistry using a cyclooxygenase-1 antibody as a marker and performed a simple counting by visual inspection. Poisson regression was employed for statistics and results were adjusted for gender, age and smoking status. Results: Ulcerative colitis patients demonstrated a 55% reduced tuft cell count in colonic mucosa compared with the control group (95% confidence limit: range 31-71%, P = 0.0002). Ulcerative colitis patients had a mean tuft cells count of 46 tuft cells/mm2 (95% CI, 36-59), while controls demonstrated a mean of 104 tuft cells/mm2 (95% CI, 79-136). No interactions of other covariates, such as age, smoking status, total duration of ulcerative colitis disease and duration of clinical remission prior to study inclusion were detected between ulcerative colitis patients and controls. Conclusion: Quiescent ulcerative colitis patients have a relatively low number of colonic tuft cells. Further studies are warranted to explore the potential involvement of tuft cells in ulcerative colitis pathogenesis.
MeSH term(s)	Colitis ; Colitis, Ulcerative/diagnosis ; Colon ; Humans ; Intestinal Mucosa ; Retrospective Studies
Language	English
Publishing date	2020-10-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000001959
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Zs.A 2932: Show issues

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Article ; Online: GDF15 acts synergistically with liraglutide but is not necessary for the weight loss induced by bariatric surgery in mice

Henriette Frikke-Schmidt / Karin Hultman / Joseph W. Galaske / Sebastian B. Jørgensen / Martin G. Myers, Jr. / Randy J. Seeley

Molecular Metabolism, Vol 21, Iss , Pp 13-

2019 Volume 21

Abstract	Objective: Analogues of GDF15 (Growth Differentiation Factor 15) are promising new anti-obesity therapies as pharmacological treatment with GDF15 results in dramatic reductions of food intake and body weight. GDF15 exerts its central anorexic effects by binding to the GFRAL receptor exclusively expressed in the Area Postrema (AP) and the Nucleus of the Solitary Tract (NTS) of the hindbrain. We sought to determine if GDF15 is an indispensable factor for other interventions that cause weight loss and which are also known to act via these hindbrain regions. Methods: To explore the role of GDF15 on food choice we performed macronutrient intake studies in mice treated pharmacologically with GDF15 and in mice having either GDF15 or GFRAL deleted. Next we performed vertical sleeve gastrectomy (VSG) surgeries in a cohort of diet-induced obese Gdf15-null and control mice. To explore the anatomical co-localization of neurons in the hindbrain responding to GLP-1 and/or GDF15 we used GLP-1R reporter mice treated with GDF15, as well as naïve mouse brain and human brain stained by ISH and IHC, respectively, for GLP-1R and GFRAL. Lastly we performed a series of food intake experiments where we treated mice with targeted genetic disruption of either Gdf15 or Gfral with liraglutide; Glp1r-null mice with GDF15; or combined liraglutide and GDF15 treatment in wild-type mice. Results: We found that GDF15 treatment significantly lowered the preference for fat intake in mice, whereas no changes in fat intake were observed after genetic deletion of Gdf15 or Gfral. In addition, deletion of Gdf15 did not alter the food intake or bodyweight after sleeve gastrectomy. Lack of GDF15 or GFRAL signaling did not alter the ability of the GLP-1R agonist liraglutide to reduce food intake. Similarly lack of GLP-1R signaling did not reduce GDF15's anorexic effect. Interestingly, there was a significant synergistic effect on weight loss when treating wild-type mice with both GDF15 and liraglutide. Conclusion: These data suggest that while GDF15 does ...
Keywords	Internal medicine ; RC31-1245
Subject code	616
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise.

Klein, Anders B / Nicolaisen, Trine S / Ørtenblad, Niels / Gejl, Kasper D / Jensen, Rasmus / Fritzen, Andreas M / Larsen, Emil L / Karstoft, Kristian / Poulsen, Henrik E / Morville, Thomas / Sahl, Ronni E / Helge, Jørn W / Lund, Jens / Falk, Sarah / Lyngbæk, Mark / Ellingsgaard, Helga / Pedersen, Bente K / Lu, Wei / Finan, Brian /

Jørgensen, Sebastian B / Seeley, Randy J / Kleinert, Maximilian / Kiens, Bente / Richter, Erik A / Clemmensen, Christoffer

Nature communications

2021 Volume 12, Issue 1, Page(s) 1041

Abstract: Growing evidence supports that pharmacological application of growth differentiation factor 15 (GDF15) suppresses appetite but also promotes sickness-like behaviors in rodents via GDNF family receptor α-like (GFRAL)-dependent mechanisms. Conversely, the ... ...

Abstract	Growing evidence supports that pharmacological application of growth differentiation factor 15 (GDF15) suppresses appetite but also promotes sickness-like behaviors in rodents via GDNF family receptor α-like (GFRAL)-dependent mechanisms. Conversely, the endogenous regulation of GDF15 and its physiological effects on energy homeostasis and behavior remain elusive. Here we show, in four independent human studies that prolonged endurance exercise increases circulating GDF15 to levels otherwise only observed in pathophysiological conditions. This exercise-induced increase can be recapitulated in mice and is accompanied by increased Gdf15 expression in the liver, skeletal muscle, and heart muscle. However, whereas pharmacological GDF15 inhibits appetite and suppresses voluntary running activity via GFRAL, the physiological induction of GDF15 by exercise does not. In summary, exercise-induced circulating GDF15 correlates with the duration of endurance exercise. Yet, higher GDF15 levels after exercise are not sufficient to evoke canonical pharmacological GDF15 effects on appetite or responsible for diminishing exercise motivation.
MeSH term(s)	Adult ; Animals ; Appetite Regulation/physiology ; Creatine Kinase/blood ; Creatine Kinase/genetics ; Exercise/physiology ; Feeding Behavior/physiology ; Gene Expression Regulation ; Glial Cell Line-Derived Neurotrophic Factor Receptors/deficiency ; Glial Cell Line-Derived Neurotrophic Factor Receptors/genetics ; Growth Differentiation Factor 15/blood ; Growth Differentiation Factor 15/genetics ; Growth Differentiation Factor 15/metabolism ; Humans ; Interleukin-10/blood ; Interleukin-10/genetics ; Interleukin-6/administration & dosage ; Leptin/blood ; Leptin/genetics ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Mice, Knockout ; Motivation/physiology ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Myocardium/metabolism ; Physical Conditioning, Animal ; Physical Endurance/physiology ; Time Factors
Chemical Substances	GDF15 protein, human ; Gdf15 protein, mouse ; Glial Cell Line-Derived Neurotrophic Factor Receptors ; Growth Differentiation Factor 15 ; IL10 protein, human ; IL6 protein, human ; Interleukin-6 ; LEP protein, human ; Leptin ; Interleukin-10 (130068-27-8) ; Creatine Kinase (EC 2.7.3.2)
Language	English
Publishing date	2021-02-15
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-21309-x
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Article ; Online: International review of blood donation nucleic acid amplification testing.

Faddy, Helen M / Osiowy, Carla / Custer, Brian / Busch, Michael / Stramer, Susan L / Adesina, Opeyemi / van de Laar, Thijs / Tsoi, Wai-Chiu / Styles, Claire / Kiely, Phil / Margaritis, Angelo / Kwon, So-Yong / Qiu, Yan / Deng, Xuelian / Lewin, Antoine / Jørgensen, Signe Winther / Erikstrup, Christian / Juhl, David / Sauleda, Silvia /

Camacho Rodriguez, Bernardo Armando / Coral, Lisbeth Jennifer Catherine Soto / Gaviria García, Paula Andrea / Oota, Sineenart / O'Brien, Sheila F / Wendel, Silvano / Castro, Emma / Navarro Pérez, Laura / Harvala, Heli / Davison, Katy / Reynolds, Claire / Jarvis, Lisa / Grabarczyk, Piotr / Kopacz, Aneta / Łętowska, Magdalena / O'Flaherty, Niamh / Young, Fiona / Williams, Padraig / Burke, Lisa / Chua, Sze Sze / Muylaert, An / Page, Isabel / Jones, Ann / Niederhauser, Christoph / Vermeulen, Marion / Laperche, Syria / Gallian, Pierre / Sawadogo, Salam / Satake, Masahiro / Gharehbaghian, Ahmad / Addas-Carvalho, Marcelo / Blanco, Sebastián / Gallego, Sandra V / Seltsam, Axel / Weber-Schehl, Marijke / Al-Riyami, Arwa Z / Al Maamari, Khuloud / Alawi, Fatma Ba / Pandey, Hem Chandra / Mbanya, Dora / França, Rochele Azevedo / Charlewood, Richard

Vox sanguinis

2024 Volume 119, Issue 4, Page(s) 315–325

Abstract: ... for human immunodeficiency virus [HIV], 0.0063% for hepatitis C virus [HCV], 0.0247% for hepatitis B virus [HBV], 0.0323 ...

Abstract	Background and objectives: Nucleic acid amplification testing (NAT), in blood services context, is used for the detection of viral and parasite nucleic acids to reduce transfusion-transmitted infections. This project reviewed NAT for screening blood donations globally. Materials and methods: A survey on NAT usage, developed by the International Society of Blood Transfusion Working Party on Transfusion-transmitted Infectious Diseases (ISBT WP-TTID), was distributed through ISBT WP-TTID members. Data were analysed using descriptive statistics. Results: Forty-three responses were received from 32 countries. Increased adoption of blood donation viral screening by NAT was observed over the past decade. NAT-positive donations were detected for all viruses tested in 2019 (proportion of donations positive by NAT were 0.0099% for human immunodeficiency virus [HIV], 0.0063% for hepatitis C virus [HCV], 0.0247% for hepatitis B virus [HBV], 0.0323% for hepatitis E virus [HEV], 0.0014% for West Nile virus [WNV] and 0.00005% for Zika virus [ZIKV]). Globally, over 3100 NAT-positive donations were identified as NAT yield or solely by NAT in 2019 and over 22,000 since the introduction of NAT, with HBV accounting for over half. NAT-positivity rate was higher in first-time donors for all viruses tested except WNV. During 2019, a small number of participants performed NAT for parasites (Trypanosoma cruzi, Babesia spp., Plasmodium spp.). Conclusion: This survey captures current use of blood donation NAT globally. There has been increased NAT usage over the last decade. It is clear that NAT contributes to improving blood transfusion safety globally; however, there is a need to overcome economic barriers for regions/countries not performing NAT.
MeSH term(s)	Humans ; Blood Donation ; Zika Virus Infection ; Blood Donors ; Zika Virus ; Hepatitis B virus/genetics ; Transfusion Reaction ; Nucleic Acids ; Nucleic Acid Amplification Techniques ; Hepatitis B/diagnosis
Chemical Substances	Nucleic Acids
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	80313-3
ISSN	1423-0410 ; 0042-9007
ISSN (online)	1423-0410
ISSN	0042-9007
DOI	10.1111/vox.13592
Database	MEDical Literature Analysis and Retrieval System OnLINE

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