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Article ; Online: Reply.

Banan, Babak / Lin, Yiing / Chapman, William

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

2016 Volume 22, Issue 11, Page(s) 1617–1618

Language	English
Publishing date	2016
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2006866-9
ISSN	1527-6473 ; 1527-6465
ISSN (online)	1527-6473
ISSN	1527-6465
DOI	10.1002/lt.24597
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Zs.A 4702: Show issues

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Article ; Online: Botulinum Injection Into the Proximal Intestinal Wall of Diet-Induced Obese Mice Leads to Weight Loss and Improves Glucose and Fat Tolerance.

Sundaresan, Sinju / Antoun, Joseph / Banan, Babak / Adcock, Jamie / Johnson, Connor / Claire, Brendan / Dixon, Kala / Flynn, Joyce / Shibao, Cyndya A / Abumrad, Naji

Diabetes

2022 Volume 71, Issue 7, Page(s) 1424–1438

Abstract: Botulinum neurotoxin (available commercially as BOTOX) has been used successfully for treatment of several neuromuscular disorders, including blepharospasm, dystonia, spasticity, and cerebral palsy in children. Our data demonstrate that injection of ... ...

Abstract	Botulinum neurotoxin (available commercially as BOTOX) has been used successfully for treatment of several neuromuscular disorders, including blepharospasm, dystonia, spasticity, and cerebral palsy in children. Our data demonstrate that injection of Botox into the proximal intestinal wall of diet-induced obese (DIO) mice induces weight loss and reduces food intake. This was associated with amelioration of hyperglycemia, hyperlipidemia, and significant improvement of glucose tolerance without alteration of energy expenditure. We also observed accelerated gastrointestinal transit and significant reductions in glucose and lipid absorption, which may account, at least in part, for the observed weight loss and robust metabolic benefits, although possible systemic effects occurring as a consequence of central and/or peripheral signaling cannot be ignored. The observed metabolic benefits were found to be largely independent of weight loss, as demonstrated by pair-feeding experiments. Effects lasted ∼8 weeks, for as long as the half-life of Botox as reported in prior rodent studies. These results have valuable clinical implications. If the observed effects are translatable in humans, this approach could lay the foundation for therapeutic approaches geared toward robust and sustained weight loss, mimicking some of the benefits of bariatric operations without its cost and complications.
MeSH term(s)	Animals ; Botulinum Toxins, Type A/therapeutic use ; Diet ; Glucose ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Obesity/metabolism ; Weight Loss
Chemical Substances	Botulinum Toxins, Type A (EC 3.4.24.69) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-04-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db21-0708
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Article ; Online: Development of a novel murine model of lymphatic metastasis.

Banan, Babak / Beckstead, Jacob A / Dunavant, Lauren E / Sohn, Yoojin / Adcock, Jamie M / Nomura, Sachiyo / Abumrad, Naji / Goldenring, James R / Fingleton, Barbara

Clinical & experimental metastasis

2020 Volume 37, Issue 2, Page(s) 247–255

Abstract: Current laboratory models of lymphatic metastasis generally require either genetically modified animals or are technically challenging. Herein, we have developed a robust protocol for the induction of intralymphatic metastasis in wild-type mice with ... ...

Abstract	Current laboratory models of lymphatic metastasis generally require either genetically modified animals or are technically challenging. Herein, we have developed a robust protocol for the induction of intralymphatic metastasis in wild-type mice with reproducible outcomes. To determine an optimal injection quantity and timeline for tumorigenesis, C57Bl/6 mice were injected directly into the mesenteric lymph duct (MLD) with varying numbers of syngeneic murine colon cancer cells (MC38) or gastric cancer cells (YTN16) expressing GFP/luciferase and monitored over 2-4 weeks. Tumor growth was tracked via whole-animal in vivo bioluminescence imaging (IVIS). Our data indicate that the injection of tumor cells into the MLD is a viable model for lymphatic metastasis as necropsies revealed large tumor burdens and metastasis in regional lymph nodes. This protocol enables a closer study of the role of lymphatics in cancer metastasis and opens a window for the development of novel approaches for treatment of metastatic diseases.
MeSH term(s)	Animals ; Cell Line, Tumor/transplantation ; Colonic Neoplasms/pathology ; Disease Models, Animal ; Female ; Green Fluorescent Proteins/chemistry ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Humans ; Luciferases/chemistry ; Luciferases/genetics ; Luciferases/metabolism ; Luminescent Measurements ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Lymphatic Metastasis/diagnostic imaging ; Lymphatic Metastasis/pathology ; Lymphatic Vessels ; Male ; Mesentery ; Mice ; Mice, Inbred C57BL ; Stomach Neoplasms/pathology ; Tomography, Optical ; Tumor Burden
Chemical Substances	Green Fluorescent Proteins (147336-22-9) ; Luciferases (EC 1.13.12.-)
Language	English
Publishing date	2020-02-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	604952-7
ISSN	1573-7276 ; 0262-0898
ISSN (online)	1573-7276
ISSN	0262-0898
DOI	10.1007/s10585-020-10025-3
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Zs.A 1855: Show issues

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Article ; Online: Intestinal Lymph Collection via Cannulation of the Mesenteric Lymphatic Duct in Mice.

Banan, Babak / Wei, Yan / Simo, Ornella / Tso, Patrick / Abumrad, Naji N / Flynn, Charles Robb / Sundaresan, Sinju / Albaugh, Vance L

The Journal of surgical research

2020 Volume 260, Page(s) 399–408

Abstract: Background: We have optimized a technique for cannulation of mesenteric lymph duct (MLD) in mice. Mice have low rates of intestinal lymph production; the MLDs are smaller and associated with fragile vasculature. Previous protocols for lymph collection ... ...

Abstract	Background: We have optimized a technique for cannulation of mesenteric lymph duct (MLD) in mice. Mice have low rates of intestinal lymph production; the MLDs are smaller and associated with fragile vasculature. Previous protocols for lymph collection based on the open lymph fistula model were associated with low success rates in mice. Bariatric surgery procedures worsen success rates due to postoperative adhesions and GI rearrangement. We have used this procedure to collect mesenteric lymph from mice undergoing bile diversion from gall bladder to ileum (GB-IL). Hypothesis: We hypothesize that peptide YY (PYY) levels in mesenteric lymph will increase following nutrient delivery in mice undergoing bile diversion from gall bladder to ileum (GB-IL). Methods and results: We observe that cannulation of the MLD using a needled-catheter maintains lymph vessel integrity, prevents excessive lymph leakage, and is less traumatic, leading to high success rates (>95%). PYY levels in mesenteric lymph after GB-IL were significantly higher post nutrient infusion. The procedure takes approximately 20 min; small rodent surgical experience and practice are required for success. Conclusions: Intestinal lymph can be collected from mice, including those undergoing bariatric surgical procedures with high success rates by cannulation of the mesenteric lymph duct.
MeSH term(s)	Animals ; Bariatric Surgery ; Bile ; Biliary Tract Surgical Procedures ; Biomarkers/metabolism ; Catheterization/methods ; Female ; Gallbladder/surgery ; Ileum/surgery ; Lymph/metabolism ; Lymphatic Vessels/surgery ; Male ; Mesentery/surgery ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Peptide YY/metabolism
Chemical Substances	Biomarkers ; Peptide YY (106388-42-5)
Language	English
Publishing date	2020-11-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80170-7
ISSN	1095-8673 ; 0022-4804
ISSN (online)	1095-8673
ISSN	0022-4804
DOI	10.1016/j.jss.2020.11.004
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Zs.A 178: Show issues

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Article ; Online: Cancer Odor Database (COD): a critical databank for cancer diagnosis research.

Janfaza, Sajjad / Banan Nojavani, Maryam / Khorsand, Babak / Nikkhah, Maryam / Zahiri, Javad

Database : the journal of biological databases and curation

2017 Volume 2017

Abstract: Database url: http://bioinf.modares.ac.ir/software/cod/. ...

Abstract	Database url: http://bioinf.modares.ac.ir/software/cod/.
MeSH term(s)	Biomedical Research ; Databases, Factual ; Humans ; Internet ; Neoplasms/metabolism ; Odorants ; Software ; User-Computer Interface ; Volatile Organic Compounds
Chemical Substances	Volatile Organic Compounds
Language	English
Publishing date	2017--01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2496706-3
ISSN	1758-0463 ; 1758-0463
ISSN (online)	1758-0463
ISSN	1758-0463
DOI	10.1093/database/bax055
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Article ; Online: Improving Liver Graft Function Using CD47 Blockade in the Setting of Normothermic Machine Perfusion.

Garcia-Aroz, Sandra / Xu, Min / Ahmed, Ola / Hollingshead, Joshua / Wang, Xuanchuan / Banan, Babak / Khan, Adeel / Kang, Liang-I / Zhang, Zhengyan / Upadhya, Gundumi / Manning, Pamela / Lin, Yiing / Chapman, William C

Transplantation

2021 Volume 106, Issue 1, Page(s) 37–47

Abstract: Background: Toward the goal of using more livers for transplantation, transplant centers are looking to increase the use of organs from "marginal" donors. Livers from these donors, however, have been shown to be more susceptible to preservation and ... ...

Abstract	Background: Toward the goal of using more livers for transplantation, transplant centers are looking to increase the use of organs from "marginal" donors. Livers from these donors, however, have been shown to be more susceptible to preservation and reperfusion injury. Methods: Using a porcine model of donation after circulatory death, we studied the use of antibody-mediated CD47 blockade to further improve liver graft function undergoing normothermic machine perfusion. Livers from 20 pigs (5 per group) were brought under either 30 or 60 min of warm ischemia time followed by the administration of CD47 monoclonal antibody (CD47mAb) treatment or immunoglobulin G control antibodies and 6 h of normothermic extracorporeal liver perfusion. Results: After 6 h of normothermic extracorporeal liver perfusion, CD47mAb-treated livers with 30 or 60 min warm ischemia time had significantly lower alanine transaminase levels and higher bile production compared with their respective control groups. Blockade of the CD47 signaling pathway resulted in significantly lower thrombospondin-1 protein levels, lower expression of caspase-3, and higher expression of phosphorylated extracellular signal-regulated kinase. Conclusions: These findings suggested that CD47mAb treatment decreases ischemia/reperfusion injury through CD47/thrombospondin-1 signaling downregulation and the presence of necrosis/apoptosis after reperfusion and could increase liver regeneration during normothermic perfusion of the liver.
MeSH term(s)	Animals ; CD47 Antigen ; Liver ; Liver Transplantation/adverse effects ; Organ Preservation/methods ; Perfusion/adverse effects ; Perfusion/methods ; Reperfusion Injury/etiology ; Reperfusion Injury/prevention & control ; Swine ; Warm Ischemia/adverse effects
Chemical Substances	CD47 Antigen
Language	English
Publishing date	2021-02-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000003688
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 509: Show issues

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Article ; Online: Development of a normothermic extracorporeal liver perfusion system toward improving viability and function of human extended criteria donor livers.

Banan, Babak / Watson, Rao / Xu, Min / Lin, Yiing / Chapman, William

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

2016 Volume 22, Issue 7, Page(s) 979–993

Abstract: Donor organ shortages have led to an increased interest in finding new approaches to recover organs from extended criteria donors (ECD). Normothermic extracorporeal liver perfusion (NELP) has been proposed as a superior preservation method to reduce ... ...

Abstract	Donor organ shortages have led to an increased interest in finding new approaches to recover organs from extended criteria donors (ECD). Normothermic extracorporeal liver perfusion (NELP) has been proposed as a superior preservation method to reduce ischemia/reperfusion injury (IRI), precondition suboptimal grafts, and treat ECD livers so that they can be successfully used for transplantation. The aim of this study was to investigate the beneficial effects of a modified NELP circuit on discarded human livers. Seven human livers that were rejected for transplantation were placed on a modified NELP circuit for 8 hours. Perfusate samples and needle core biopsies were obtained at hourly intervals. A defatting solution that contained exendin-4 (50 nM) and L-carnitine (10 mM) was added to the perfusate for 2 steatotic livers. NELP provided normal temperature, electrolytes, and pH and glucose levels in the perfusate along with physiological vascular flows and pressures. Functional, biochemical, and microscopic evaluation revealed no additional injuries to the grafts during NELP with an improved oxygen extraction ratio (>0.5) and stabilized markers of hepatic injury. All livers synthesized adequate amounts of bile and coagulation factors. We also demonstrated a mild reduction (10%) of macroglobular steatosis with the use of the defatting solution. Histology demonstrated normal parenchymal architecture and a minimal to complete lack of IRI at the end of NELP. In conclusion, a modified NELP circuit preserved hepatocyte architecture, recovered synthetic functions, and hepatobiliary parameters of ECD livers without additional injuries to the grafts. This approach has the potential to increase the donor pool for clinical transplantation. Liver Transplantation 22 979-993 2016 AASLD.
MeSH term(s)	Adult ; Aged ; Allografts/pathology ; Biopsy, Large-Core Needle ; Carnitine/therapeutic use ; Donor Selection/methods ; Fatty Liver/drug therapy ; Female ; Humans ; Liver ; Liver Transplantation/methods ; Male ; Middle Aged ; Organ Preservation/instrumentation ; Organ Preservation/methods ; Organ Preservation Solutions/chemistry ; Organ Preservation Solutions/therapeutic use ; Peptides/therapeutic use ; Perfusion/methods ; Reperfusion Injury/prevention & control ; Temperature ; Tissue Survival ; Venoms/therapeutic use ; Warm Ischemia
Chemical Substances	Organ Preservation Solutions ; Peptides ; Venoms ; exenatide (9P1872D4OL) ; Carnitine (S7UI8SM58A)
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2006866-9
ISSN	1527-6473 ; 1527-6465
ISSN (online)	1527-6473
ISSN	1527-6465
DOI	10.1002/lt.24451
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Zs.A 4702: Show issues

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Article: Role of alloimmunity and autoimmunity in allograft rejection.

Banan, Babak / Xu, Zhongping / Gunasekaran, Muthukumar / Mohanakumar, T

Clinical transplants

2014 , Page(s) 325–332

Abstract: Pathophysiology of chronic rejection strongly supports that inflammation and subsequent tissue remodeling during the post-transplant period cause exposure of cryptic self-antigens (SAgs) or their determinants within the graft, which, along with a ... ...

Abstract	Pathophysiology of chronic rejection strongly supports that inflammation and subsequent tissue remodeling during the post-transplant period cause exposure of cryptic self-antigens (SAgs) or their determinants within the graft, which, along with a subsequent cytokine response, leads to loss of peripheral tolerance. These events lead to the activation of cell-mediated immunity towards development of de novo immune responses to SAgs. There is also evidence for a role for interplay between allo- and autoimmunity in the development of chronic rejection. Experimental results using murine models of Obliterative Airway Disease (OAD) akin to chronic lung allograft rejection have clearly demonstrated that autoimmune responses to Collagen V (ColV) and K-alpha 1 Tubulin (KalT) were induced by administration of antibodies (Abs) against class I major histocompatibility complex antigens. Further, inhibition of interleukin (IL)-17 abrogated the autoimmune response and development of OAD. This shows an important relationship between alloimmunity, autoimmunity to SAgs such as KalT, and a significant role for IL-17 pathway of immune activation. Recent reports demonstrate that in addition to lung transplant recipients, kidney transplant recipients diagnosed with transplant glomerulopathy can develop de novo Abs to Sags, including Col-IV and fibronectin and heart transplant recipients can develop immune responses to cardiac myosin and vimentin. Abs to SAgs were identified frequently with donor specific anti-human leukocyte antigen antibodies, supporting the concept of crosstalk between auto- and alloimmunity. The increased frequency of SAg specific interferon-gamma and IL-17 cells with reduction in IL-10 demonstrates tolerance breakdown to SAgs which may play a significant role in the pathogenesis of chronic rejection.
MeSH term(s)	Autoantibodies/immunology ; Autoimmunity/immunology ; Graft Rejection/immunology ; Heart Transplantation ; Humans ; Isoantibodies/immunology ; Kidney Transplantation ; Transplantation, Homologous
Chemical Substances	Autoantibodies ; Isoantibodies
Language	English
Publishing date	2014-08-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	607631-2
ISSN	0890-9016
ISSN	0890-9016
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Article ; Online: Bile acids and bariatric surgery.

Albaugh, Vance L / Banan, Babak / Ajouz, Hana / Abumrad, Naji N / Flynn, Charles R

Molecular aspects of medicine

2017 Volume 56, Page(s) 75–89

Abstract: Bariatric surgery, specifically Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), are the most effective and durable treatments for morbid obesity and potentially a viable treatment for type 2 diabetes (T2D). The resolution rate of ... ...

Abstract	Bariatric surgery, specifically Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), are the most effective and durable treatments for morbid obesity and potentially a viable treatment for type 2 diabetes (T2D). The resolution rate of T2D following these procedures is between 40 and 80% and far surpasses that achieved by medical management alone. The molecular basis for this improvement is not entirely understood, but has been attributed in part to the altered enterohepatic circulation of bile acids. In this review we highlight how bile acids potentially contribute to improved lipid and glucose homeostasis, insulin sensitivity and energy expenditure after these procedures. The impact of altered bile acid levels in enterohepatic circulation is also associated with changes in gut microflora, which may further contribute to some of these beneficial effects. We highlight the beneficial effects of experimental surgical procedures in rodents that alter bile secretory flow without gastric restriction or altering nutrient flow. This information suggests a role for bile acids beyond dietary fat emulsification in altering whole body glucose and lipid metabolism strongly, and also suggests emerging roles for the activation of the bile acid receptors farnesoid x receptor (FXR) and G-protein coupled bile acid receptor (TGR5) in these improvements. The limitations of rodent studies and the current state of our understanding is reviewed and the potential effects of bile acids mediating the short- and long-term metabolic improvements after bariatric surgery is critically examined.
MeSH term(s)	Animals ; Bile Acids and Salts/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/microbiology ; Diabetes Mellitus, Type 2/pathology ; Diabetes Mellitus, Type 2/surgery ; Enterohepatic Circulation ; Gastrectomy ; Gastric Bypass ; Gastrointestinal Microbiome/physiology ; Gene Expression Regulation ; Glucose/metabolism ; Homeostasis/physiology ; Humans ; Insulin Resistance ; Obesity, Morbid/metabolism ; Obesity, Morbid/microbiology ; Obesity, Morbid/pathology ; Obesity, Morbid/surgery ; Receptors, Cytoplasmic and Nuclear/genetics ; Receptors, Cytoplasmic and Nuclear/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Rodentia ; Signal Transduction
Chemical Substances	Bile Acids and Salts ; GPBAR1 protein, human ; Receptors, Cytoplasmic and Nuclear ; Receptors, G-Protein-Coupled ; farnesoid X-activated receptor (0C5V0MRU6P) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2017-04-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	197640-0
ISSN	1872-9452 ; 0098-2997
ISSN (online)	1872-9452
ISSN	0098-2997
DOI	10.1016/j.mam.2017.04.001
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Zs.A 1189: Show issues

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Article ; Online: Kidney injury-mediated disruption of intestinal lymphatics involves dicarbonyl-modified lipoproteins.

Zhong, Jianyong / Yang, Hai-Chun / Yermalitsky, Valery / Shelton, Elaine L / Otsuka, Tadashi / Wiese, Carrie B / May-Zhang, Linda S / Banan, Babak / Abumrad, Naji / Huang, Jiansheng / Cavnar, Ashley B / Kirabo, Annet / Yancey, Patricia G / Fogo, Agnes B / Vickers, Kasey C / Linton, MacRae F / Davies, Sean S / Kon, Valentina

Kidney international

2021 Volume 100, Issue 3, Page(s) 585–596

Abstract: Kidney disease affects intestinal structure and function. Although intestinal lymphatics are central in absorption and remodeling of dietary and synthesized lipids/lipoproteins, little is known about how kidney injury impacts the intestinal lymphatic ... ...

Abstract	Kidney disease affects intestinal structure and function. Although intestinal lymphatics are central in absorption and remodeling of dietary and synthesized lipids/lipoproteins, little is known about how kidney injury impacts the intestinal lymphatic network, or lipoproteins transported therein. To study this, we used puromycin aminoglycoside-treated rats and NEP25 transgenic mice to show that proteinuric injury expanded the intestinal lymphatic network, activated lymphatic endothelial cells and increased mesenteric lymph flow. The lymph was found to contain increased levels of cytokines, immune cells, and isolevuglandin (a highly reactive dicarbonyl) and to have a greater output of apolipoprotein AI. Plasma levels of cytokines and isolevuglandin were not changed. However, isolevuglandin was also increased in the ileum of proteinuric animals, and intestinal epithelial cells exposed to myeloperoxidase produced more isolevuglandin. Apolipoprotein AI modified by isolevuglandin directly increased lymphatic vessel contractions, activated lymphatic endothelial cells, and enhanced the secretion of the lymphangiogenic promoter vascular endothelial growth factor-C by macrophages. Inhibition of isolevuglandin synthesis by a carbonyl scavenger reduced intestinal isolevuglandin adduct level and lymphangiogenesis. Thus, our data reveal a novel mediator, isolevuglandin modified apolipoprotein AI, and uncover intestinal lymphatic network structure and activity as a new pathway in the crosstalk between kidney and intestine that may contribute to the adverse impact of kidney disease on other organs.
MeSH term(s)	Animals ; Apolipoprotein A-I ; Endothelial Cells ; Kidney ; Lymphangiogenesis ; Lymphatic Vessels ; Mice ; Rats ; Vascular Endothelial Growth Factor C
Chemical Substances	Apolipoprotein A-I ; Vascular Endothelial Growth Factor C
Language	English
Publishing date	2021-06-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2021.05.028
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Zs.A 797: Show issues

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