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  1. Article ; Online: p53 and K-ras mutations in lung tissues and sputum samples of individuals exposed to smoky coal emissions in Xuan Wei County, China.

    Keohavong, Phouthone / Lan, Qing / Gao, Weimin

    Mutation research. Genetic toxicology and environmental mutagenesis

    2018  Volume 829-830, Page(s) 70–74

    Abstract: Lung cancer mortality in Xuan Wei County (XWC) is among the highest in China. Lung cancer in XWC is ...

    Abstract Lung cancer mortality in Xuan Wei County (XWC) is among the highest in China. Lung cancer in XWC is associated with exposure, in poorly vented homes, to coal smoke containing high levels of polycyclic aromatic hydrocarbons (PAHs). We have previously investigated mutations in the p53 tumor suppressor gene and the K-ras oncogene in lung carcinomas and in sputum samples from individuals exposed to smoky coal emissions in XWC. This paper summarizes the results concerning p53 and K-ras mutations from these studies, in relation to mutations found in lung cancer patients not exposed to smoky coal emissions.
    MeSH term(s) Coal/toxicity ; Female ; Humans ; Lung Neoplasms/chemically induced ; Lung Neoplasms/genetics ; Male ; Point Mutation ; Proto-Oncogene Proteins p21(ras)/genetics ; Sex Factors ; Smoking/adverse effects ; Sputum/chemistry ; Sputum/drug effects ; Tumor Suppressor Protein p53/genetics
    Chemical Substances Coal ; KRAS protein, human ; TP53 protein, human ; Tumor Suppressor Protein p53 ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2018-03-30
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-3592
    ISSN (online) 1879-3592
    DOI 10.1016/j.mrgentox.2018.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ultra high performance liquid chromatography with tandem mass spectrometry for rapid separation and identification of main constituents in Chinese herbal formula Xuan Hu Suo San.

    Tang, Huaqi / Zhang, Xinyue / Luo, Shilin / Shang, Fei / Chen, Jianping / Wang, Jinghong / Duan, Xiaojie / Gao, Xiaoyan / Sun, Yikun

    Natural product research

    2017  Volume 31, Issue 14, Page(s) 1620–1624

    Abstract: Xuan Hu Suo San (XHSS) is a traditional Chinese medicine that has been extensively applied ...

    Abstract Xuan Hu Suo San (XHSS) is a traditional Chinese medicine that has been extensively applied in the treatment of osteoarthritis for many years, however, its chemical composition has not yet been elucidated. Thus, a rapid, efficient, and precise method based on ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was applied in both positive- and negative-ion modes to rapidly separate and identify the main chemical ingredients in XHSS for the first time. Finally, with the optimised separation and detection method, a total of 57 compounds were simultaneously separated within 13 min, among which 14 compounds were confirmed by comparing retention time and MS data with reference standards and others were tentatively identified by comparing with reference literatures. This rapid and sensitive approach is highly useful for the identification and characterisation of chemical constituents, and provides fundamental and extensive information supporting further metabolic and pharmacokinetic studies of XHSS.
    MeSH term(s) Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/chemistry ; Medicine, Chinese Traditional/methods ; Tandem Mass Spectrometry/methods
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2017-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2017.1285296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Ultra high performance liquid chromatography with tandem mass spectrometry for rapid separation and identification of main constituents in Chinese herbal formula Xuan Hu Suo San

    Tang, Huaqi / Xinyue Zhang / Shilin Luo / Fei Shang / Jianping Chen / Jinghong Wang / Xiaojie Duan / Xiaoyan Gao / Yikun Sun

    Natural product research. 2017 July 18, v. 31, no. 14

    2017  

    Abstract: Xuan Hu Suo San (XHSS) is a traditional Chinese medicine that has been extensively applied ...

    Abstract Xuan Hu Suo San (XHSS) is a traditional Chinese medicine that has been extensively applied in the treatment of osteoarthritis for many years, however, its chemical composition has not yet been elucidated. Thus, a rapid, efficient, and precise method based on ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was applied in both positive- and negative-ion modes to rapidly separate and identify the main chemical ingredients in XHSS for the first time. Finally, with the optimised separation and detection method, a total of 57 compounds were simultaneously separated within 13 min, among which 14 compounds were confirmed by comparing retention time and MS data with reference standards and others were tentatively identified by comparing with reference literatures. This rapid and sensitive approach is highly useful for the identification and characterisation of chemical constituents, and provides fundamental and extensive information supporting further metabolic and pharmacokinetic studies of XHSS.
    Keywords Oriental traditional medicine ; ingredients ; osteoarthritis ; pharmacokinetics ; reference standards ; tandem mass spectrometry ; ultra-performance liquid chromatography
    Language English
    Dates of publication 2017-0718
    Size p. 1620-1624.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2017.1285296
    Database NAL-Catalogue (AGRICOLA)

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  4. Book ; Online: Funding International Development Organizations

    Smith, Christopher / Gao, Xuan / Dollmaier, Thomas

    AIIB Yearbook of International Law 2021

    2022  

    Keywords International law ; Public international law ; International organisations & institutions ; bonds ; capital markets ; financing ; fundraising ; green investment ; infrastructure ; international financial institutions ; jurisdictional immunity ; multilateral development banks ; private sector ; resource mobilization ; sustainable development
    Language English
    Size 1 Online-Ressource
    Publisher Brill
    Document type Book ; Online
    Note English
    HBZ-ID HT030612955
    ISBN 9789004460003 ; 9004460004
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article: Detection of p53 and K-ras mutations in sputum of individuals exposed to smoky coal emissions in Xuan Wei County, China.

    Keohavong, Phouthone / Lan, Qing / Gao, Wei-Min / Zheng, Kui-Cheng / Mady, Hussam H / Melhem, Mona F / Mumford, Judy L

    Carcinogenesis

    2005  Volume 26, Issue 2, Page(s) 303–308

    Abstract: Lung cancer mortality rates in the Xuan Wei County population are among the highest in China and ... sputum samples from 92 individuals with no evidence of lung cancer from Xuan Wei County were screened ... from the sputum of individuals without evidence of lung cancer who were exposed to smoky coal emissions in Xuan ...

    Abstract Lung cancer mortality rates in the Xuan Wei County population are among the highest in China and are associated with exposure to indoor emissions from the burning of smoky coal. Previous studies of lung tumors from both non-smoking women and smoking men in this region showed high frequencies of mutations, consisting mostly of G-->T transversions in the p53 tumor suppressor gene and K-ras oncogene, suggesting that these mutations were caused primarily by polycyclic aromatic hydrocarbons. In this study sputum samples from 92 individuals with no evidence of lung cancer from Xuan Wei County were screened for p53 and K-ras mutations. Sputum cells were collected on glass slides by sputum cytocentrifugation, stained and cytopathologically analyzed. Cytologically non-malignant epithelial cells were taken from each sputum sample using a laser capture microdissection microscope and molecularly analyzed. Cells taken from the sputum of 15 (16.3%) individuals were mutation positive, including 13 (14.1%) individuals each with a p53 mutation, 1 (1.1%) individual with a K-ras mutation and 1 (1.1%) individual with a p53 and a K-ras mutation. p53 mutations were found in both the sputum of individuals with evidence of chronic bronchitis (3 of 46 or 6.5%) and those without evidence of this disease (11 of 46 or 23.9%). Therefore, mutations in the p53 gene and, to a lesser extent, the K-ras gene were frequent in non-malignant epithelial cells taken from the sputum of individuals without evidence of lung cancer who were exposed to smoky coal emissions in Xuan Wei County and were at a high risk for developing the disease.
    MeSH term(s) Air Pollution, Indoor/adverse effects ; Bronchitis, Chronic/genetics ; Bronchitis, Chronic/pathology ; China ; Coal/adverse effects ; Female ; Genes, p53/genetics ; Genes, ras/genetics ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Microdissection ; Mutation/genetics ; Sputum/cytology
    Chemical Substances Coal
    Language English
    Publishing date 2005-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603134-1
    ISSN 1460-2180 ; 0143-3334
    ISSN (online) 1460-2180
    ISSN 0143-3334
    DOI 10.1093/carcin/bgh328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1558: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book: Xin yi ming chuan qi xiao shuo xuan

    Chen, Meilin / Gao, Yuhou

    (Gu ji jin zhu xin yi cong shu ; 古籍今注新譯叢書)

    2004  

    Title variant Ming chuan qi xiao shuo xuan ; 明傳奇小説選
    Author's details Chen mei lin, gao yu hou zhu yi
    Series title Gu ji jin zhu xin yi cong shu
    古籍今注新譯叢書
    Keywords Chinese fiction/History and criticism ; Short stories, Chinese/History and criticism
    Language Chinese
    Size 2, 20, 606 p, 22 cm
    Edition Chu ban
    Publisher San min shu ju
    Publishing place Tai bei
    Document type Book
    ISBN 9571437190 ; 9789571437194
    Database Former special subject collection: coastal and deep sea fishing

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  7. Article: Anti-inflammatory effects of an herbal medicine (Xuan-Ju agent) on carrageenan- and adjuvant-induced paw edema in rats.

    Jia, Wei / Gao, Wen-yuan / Cui, Nai-qiang / Xiao, Pei-gen

    Journal of ethnopharmacology

    2003  Volume 89, Issue 1, Page(s) 139–141

    Abstract: Xuan-Ju agent is an herbal formula containing aqueous extract of Formica fusca, Herba epimedii ... of this agent using carrageenan- and adjuvant-induced paw edema in rats. Xuan-Ju agent showed a marked ... Based on this study, Xuan-Ju agent is considered to be a potentially useful drug suitable for further ...

    Abstract Xuan-Ju agent is an herbal formula containing aqueous extract of Formica fusca, Herba epimedii, Fructus cnidii, and Fructus lycii, all of which are reputed for their beneficial effects in the treatment of the immunodeficient diseases such as rheumatoid arthritis. We performed a study on the anti-inflammatory effects of this agent using carrageenan- and adjuvant-induced paw edema in rats. Xuan-Ju agent showed a marked inhibitory effect on edema in two models of inflammation in rats, at the dose of 0.20, 0.40 and 0.80g/kg. Based on this study, Xuan-Ju agent is considered to be a potentially useful drug suitable for further evaluation for rheumatoid arthritis.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/therapeutic use ; Arthritis, Experimental/drug therapy ; Drugs, Chinese Herbal/therapeutic use ; Edema/chemically induced ; Edema/drug therapy ; Inflammation/drug therapy ; Male ; Phytotherapy ; Rats ; Rats, Wistar
    Chemical Substances Anti-Inflammatory Agents ; Drugs, Chinese Herbal
    Language English
    Publishing date 2003-09-01
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/s0378-8741(03)00272-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book: Tang dai xuan guai chuan qi

    Gao, Jie'en

    (Shu de shi jie ; 93 ; 書的世界 ; 93)

    1990  

    Author's details Gao Jie'en bian zhu
    Series title Shu de shi jie ; 93
    書的世界 ; 93
    Language Chinese
    Size 2, 2, 209 p
    Publisher Guo jia chu ban she
    Publishing place Taibei
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  9. Book: Gao Huiyuan lin zheng yan an jing xuan

    Gao, Huiyuan

    (Quan guo ming lao Zhong yi yao zhuan jia lin zheng yan an jing hua cong shu)

    1995  

    Title translation Gao Huiyuan's selection of clinical cases.
    Author's details Wang Fawei, Yu Youshan, Xue Changlian bian zhu
    Series title Quan guo ming lao Zhong yi yao zhuan jia lin zheng yan an jing hua cong shu
    MeSH term(s) Medicine, Chinese Traditional
    Keywords China
    Language Chinese
    Size 2, 3, 7, 176 p.
    Edition Beijing di 1 ban.
    Publisher Xue yuan chu ban she
    Publishing place Beijing
    Document type Book
    ISBN 9787507704075 ; 7507704076
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Book: Zhongguo tang niao bing yi an xuan

    Gao, Yanbin

    (Tang niao bing xi lie cong shu)

    1993  

    Title translation Case studies of diabetes mellitus in Chinese traditional medicine.
    Author's details zhu bian Gao Yanbin
    Series title Tang niao bing xi lie cong shu
    MeSH term(s) Diabetes Mellitus ; Medicine, Chinese Traditional
    Language Chinese
    Size ii, ii, ii, 409 p.
    Edition Di 1 ban.
    Publisher Heilongjiang ke xue ji shu chu ban she
    Publishing place Ha'erbin Shi
    Document type Book
    ISBN 9787538821963 ; 7538821961
    Database Catalogue of the US National Library of Medicine (NLM)

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