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  1. Article ; Online: Severe COVID-19-A Review of Suggested Mechanisms Based on the Role of Extracellular Matrix Stiffness.

    Kerch, Garry

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: The severity of COVID-19 commonly depends on age-related tissue stiffness. The aim was to review publications that explain the effect of microenvironmental extracellular matrix stiffness on cellular processes. Platelets and endothelial cells are ... ...

    Abstract The severity of COVID-19 commonly depends on age-related tissue stiffness. The aim was to review publications that explain the effect of microenvironmental extracellular matrix stiffness on cellular processes. Platelets and endothelial cells are mechanosensitive. Increased tissue stiffness can trigger cytokine storm with the upregulated expression of pro-inflammatory cytokines, such as tumor necrosis factor alpha and interleukin IL-6, and tissue integrity disruption, leading to enhanced virus entry and disease severity. Increased tissue stiffness in critically ill COVID-19 patients triggers platelet activation and initiates plague formation and thrombosis development. Cholesterol content in cell membrane increases with aging and further enhances tissue stiffness. Membrane cholesterol depletion decreases virus entry to host cells. Membrane cholesterol lowering drugs, such as statins or novel chitosan derivatives, have to be further developed for application in COVID-19 treatment. Statins are also known to decrease arterial stiffness mitigating cardiovascular diseases. Sulfated chitosan derivatives can be further developed for potential use in future as anticoagulants in prevention of severe COVID-19. Anti-TNF-α therapies as well as destiffening therapies have been suggested to combat severe COVID-19. The inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells pathway must be considered as a therapeutic target in the treatment of severe COVID-19 patients. The activation of mechanosensitive platelets by higher matrix stiffness increases their adhesion and the risk of thrombus formation, thus enhancing the severity of COVID-19.
    MeSH term(s) Humans ; COVID-19 ; Endothelial Cells ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Chitosan/therapeutic use ; COVID-19 Drug Treatment ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Thrombosis/drug therapy ; Interleukin-6 ; Extracellular Matrix ; Cholesterol/therapeutic use
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Chitosan (9012-76-4) ; Tumor Necrosis Factor Inhibitors ; Interleukin-6 ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2023-01-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nanocomposite Hydrogels and Extracellular Matrix-Advantages and Associated Risks.

    Kerch, Garry

    Gels (Basel, Switzerland)

    2023  Volume 9, Issue 9

    Abstract: Hydrogels can be considered as mimics of the extracellular matrix (ECM). Through integrins, the cytoskeleton is connected to the ECM, and cytoskeleton tension depends on ECM stiffness. A number of age-related diseases depend on cellular processes related ...

    Abstract Hydrogels can be considered as mimics of the extracellular matrix (ECM). Through integrins, the cytoskeleton is connected to the ECM, and cytoskeleton tension depends on ECM stiffness. A number of age-related diseases depend on cellular processes related to cytoskeleton function. Some examples of cancer initiation and progression and heart disease in relation to ECM stiffness have been analyzed. The incorporation of rigid particles into the ECM can increase ECM stiffness and promote the formation of internal residual stresses. Water migration, changes in water binding energy to biomactomolecules, and changes in the state of water from tightly bound water to free and loosely bound water lead to changes in the stiffness of the ECM. Cardiac tissue engineering, ECM stiffness and cancer, the equivalence of ECM stiffness, oxidative stress, inflammation, multi-layer polyelectrolyte complex hydrogels and bioprinting, residual internal stresses, viscoelastic hydrogels, hydrogel nanocomposites, and the effect of water have been reported. Special attention has been paid to the role of bound water and internal stresses in ECM stiffness. The risks related to rigid particle incorporation into the ECM have been discussed. The potential effect of polyphenols, chitosan, and chitosan oligosaccharide on ECM stiffness and the potential for anti-TNF-α and anti-NF-κB therapies have been discussed.
    Language English
    Publishing date 2023-09-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels9090754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Role of Changes in State of Bound Water and Tissue Stiffness in Development of Age-Related Diseases.

    Kerch, Garry

    Polymers

    2020  Volume 12, Issue 6

    Abstract: An essential effect of environmental stiffness on biological processes in cells at present is generally accepted. An increase in arterial stiffness with advanced age has been reported in many publications. The aim of the present review is to summarize ... ...

    Abstract An essential effect of environmental stiffness on biological processes in cells at present is generally accepted. An increase in arterial stiffness with advanced age has been reported in many publications. The aim of the present review is to summarize current information about possible chemical reactions and physical processes that lead to tissue stiffening and result in age-related diseases in order to find methods that can prevent or retard time-dependent tissue stiffening. The analysis of published data shows that bound water acts as a plasticizer of biological tissues, a decrease in bound water content results in an increase in biological tissue stiffness, and increased tissue stiffness leads to NF-kB activation and triggered actin polymerization-NF-kB activation is associated with age-related diseases. It can be suggested that changes in bound water content through changing tissue stiffness can affect cellular processes and the development of pathologies related to aging. Both age-related diseases and COVID-19 may be associated with tight-junction disruption and increased tissue stiffness and permeability.
    Keywords covid19
    Language English
    Publishing date 2020-06-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym12061362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Role of Changes in State of Bound Water and Tissue Stiffness in Development of Age-Related Diseases

    Garry Kerch

    Polymers, Vol 12, Iss 1362, p

    2020  Volume 1362

    Abstract: An essential effect of environmental stiffness on biological processes in cells at present is generally accepted. An increase in arterial stiffness with advanced age has been reported in many publications. The aim of the present review is to summarize ... ...

    Abstract An essential effect of environmental stiffness on biological processes in cells at present is generally accepted. An increase in arterial stiffness with advanced age has been reported in many publications. The aim of the present review is to summarize current information about possible chemical reactions and physical processes that lead to tissue stiffening and result in age-related diseases in order to find methods that can prevent or retard time-dependent tissue stiffening. The analysis of published data shows that bound water acts as a plasticizer of biological tissues, a decrease in bound water content results in an increase in biological tissue stiffness, and increased tissue stiffness leads to NF-kB activation and triggered actin polymerization—NF-kB activation is associated with age-related diseases. It can be suggested that changes in bound water content through changing tissue stiffness can affect cellular processes and the development of pathologies related to aging. Both age-related diseases and COVID-19 may be associated with tight-junction disruption and increased tissue stiffness and permeability.
    Keywords bound water ; hydration ; stiffness ; age-related diseases ; Organic chemistry ; QD241-441 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Role of Changes in State of Bound Water and Tissue Stiffness in Development of Age-Related Diseases

    Kerch, Garry

    Abstract: An essential effect of environmental stiffness on biological processes in cells at present is generally accepted. An increase in arterial stiffness with advanced age has been reported in many publications. The aim of the present review is to summarize ... ...

    Abstract An essential effect of environmental stiffness on biological processes in cells at present is generally accepted. An increase in arterial stiffness with advanced age has been reported in many publications. The aim of the present review is to summarize current information about possible chemical reactions and physical processes that lead to tissue stiffening and result in age-related diseases in order to find methods that can prevent or retard time-dependent tissue stiffening. The analysis of published data shows that bound water acts as a plasticizer of biological tissues, a decrease in bound water content results in an increase in biological tissue stiffness, and increased tissue stiffness leads to NF-kB activation and triggered actin polymerization-NF-kB activation is associated with age-related diseases. It can be suggested that changes in bound water content through changing tissue stiffness can affect cellular processes and the development of pathologies related to aging. Both age-related diseases and COVID-19 may be associated with tight-junction disruption and increased tissue stiffness and permeability.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #827012
    Database COVID19

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  6. Article ; Online: Polymer hydration and stiffness at biointerfaces and related cellular processes.

    Kerch, Garry

    Nanomedicine : nanotechnology, biology, and medicine

    2017  Volume 14, Issue 1, Page(s) 13–25

    Abstract: The direct and indirect (by changing mechanical properties) effects of hydration at interfaces on cellular processes and tissue diseases are reviewed. The essential effect of substrate stiffness on cellular processes was demonstrated in the last decade. ... ...

    Abstract The direct and indirect (by changing mechanical properties) effects of hydration at interfaces on cellular processes and tissue diseases are reviewed. The essential effect of substrate stiffness on cellular processes was demonstrated in the last decade. The combined effect of surface stiffness and hydration at interfaces has garnered much less attention, though hydration and dehydration play important roles in biological processes. This review focuses on the studies that demonstrate how hydration affects biological processes at interfaces. Elevated sodium and dehydration stimulate inflammatory signaling in endothelial cells and promote atherosclerosis. Various types of implant and blood contacting device coatings with varied surface stiffness and hydration have been reported. Effect of hydration on polymer modulus of elasticity and viscoelasticity was discussed taking into account cells adhesion, migration, proliferation, differentiation on surfaces with various degree of hydration. Future directions of research were considered, including the use of nanotechnology to regulate the hydration degree.
    MeSH term(s) Animals ; Cell Physiological Phenomena ; Dehydration/pathology ; Humans ; Hydrophobic and Hydrophilic Interactions ; Nanotechnology ; Polymers/chemistry ; Prostheses and Implants/adverse effects
    Chemical Substances Polymers
    Language English
    Publishing date 2017-09-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2183417-9
    ISSN 1549-9642 ; 1549-9634
    ISSN (online) 1549-9642
    ISSN 1549-9634
    DOI 10.1016/j.nano.2017.08.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The potential of chitosan and its derivatives in prevention and treatment of age-related diseases.

    Kerch, Garry

    Marine drugs

    2015  Volume 13, Issue 4, Page(s) 2158–2182

    Abstract: Age-related, diet-related and protein conformational diseases, such as atherosclerosis, diabetes mellitus, cancer, hypercholesterolemia, cardiovascular and neurodegenerative diseases are common in the elderly population. The potential of chitosan, ... ...

    Abstract Age-related, diet-related and protein conformational diseases, such as atherosclerosis, diabetes mellitus, cancer, hypercholesterolemia, cardiovascular and neurodegenerative diseases are common in the elderly population. The potential of chitosan, chitooligosaccharides and their derivatives in prevention and treatment of age-related dysfunctions is reviewed and discussed in this paper. The influence of oxidative stress, low density lipoprotein oxidation, increase of tissue stiffness, protein conformational changes, aging-associated chronic inflammation and their pathobiological significance have been considered. The chitosan-based functional food also has been reviewed.
    MeSH term(s) Aging ; Animals ; Chitosan/analogs & derivatives ; Chitosan/metabolism ; Chitosan/therapeutic use ; Chronic Disease/prevention & control ; Chronic Disease/therapy ; Dietary Supplements ; Foods, Specialized ; Humans ; Oligosaccharides/metabolism ; Oligosaccharides/therapeutic use ; Oxidative Stress
    Chemical Substances Oligosaccharides ; Chitosan (9012-76-4)
    Language English
    Publishing date 2015-04-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md13042158
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  8. Article ; Online: The Potential of Chitosan and Its Derivatives in Prevention and Treatment of Age-Related Diseases

    Garry Kerch

    Marine Drugs, Vol 13, Iss 4, Pp 2158-

    2015  Volume 2182

    Abstract: Age-related, diet-related and protein conformational diseases, such as atherosclerosis, diabetes mellitus, cancer, hypercholesterolemia, cardiovascular and neurodegenerative diseases are common in the elderly population. The potential of chitosan, ... ...

    Abstract Age-related, diet-related and protein conformational diseases, such as atherosclerosis, diabetes mellitus, cancer, hypercholesterolemia, cardiovascular and neurodegenerative diseases are common in the elderly population. The potential of chitosan, chitooligosaccharides and their derivatives in prevention and treatment of age-related dysfunctions is reviewed and discussed in this paper. The influence of oxidative stress, low density lipoprotein oxidation, increase of tissue stiffness, protein conformational changes, aging-associated chronic inflammation and their pathobiological significance have been considered. The chitosan-based functional food also has been reviewed.
    Keywords chitosan ; chitooligosacharides ; age-related diseases ; protein conformations ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2015-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Chitosan films and coatings prevent losses of fresh fruit nutritional quality: A review

    Kerch, Garry

    Trends in food science & technology

    2015  Volume 46, Issue 2 Part A, Page(s) 159

    Language English
    Document type Article
    ZDB-ID 1049246-x
    ISSN 0924-2244
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Z 5184: Show issues

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  10. Article: Chitosan films and coatings prevent losses of fresh fruit nutritional quality: A review

    Kerch, Garry

    Trends in food science & technology. 2015 Dec., v. 46

    2015  

    Abstract: Consumption of fruits and vegetables, that are rich in antioxidant vitamins and polyphenols, can decrease the risk of the development of age-related chronic diseases. A gradual decline in moisture, sensory properties, vitamin C and polyphenols contents ... ...

    Abstract Consumption of fruits and vegetables, that are rich in antioxidant vitamins and polyphenols, can decrease the risk of the development of age-related chronic diseases. A gradual decline in moisture, sensory properties, vitamin C and polyphenols contents was observed during fruits and vegetables storage.The recent studies on the effect of chitosan-based coatings on the changes of nutritional quality of fruits and vegetables during postharvest storage have been summarized in this review. The latest data of the application of chitosan-based coatings for prevention of the decrease in contents of natural antioxidants ascorbic acid, anthocyanins, and total polyphenols in various fruits and vegetables during postharvest storage have been reviewed. The mechanisms of action and the role of polyphenols and vitamin C in prevention of age-related diseases has been also discussed.Barrier and mechanical properties of chitosan-based films and coatings can be improved by the development of nanocomposite chitosan films and coatings incorporating also rosemary, sunflower, lavender, olive, and carp oils. Layer-by-layer self assembly can be used in the formation of multinanolayer edible coatings.
    Keywords anthocyanins ; antioxidants ; ascorbic acid ; carp oil ; chitosan ; chronic diseases ; coatings ; edible films ; fruit quality ; fruits ; Helianthus annuus ; Lavandula ; mechanical properties ; mechanism of action ; nanocomposites ; nutritive value ; olives ; polyphenols ; raw fruit ; risk ; rosemary ; sensory properties
    Language English
    Dates of publication 2015-12
    Size p. 159-166.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1049246-x
    ISSN 1879-3053 ; 0924-2244
    ISSN (online) 1879-3053
    ISSN 0924-2244
    DOI 10.1016/j.tifs.2015.10.010
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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