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Article: Topical application of cream containing enriched-schizandrin from Schisandra chinensis fruit exert anti-photoaging efficacy in ultraviolet B-irradicated hairless mice.

Mi-Young Yun, - / Nam-San Kim, - / Hwa-Jung Choi, -

Pakistan journal of pharmaceutical sciences

2023 Volume 36, Issue 3, Page(s) 887–894

Abstract: Excessive ultraviolet (UV) B irradiation induced skin photoaging. The aim of this study was to evaluate the anti-photoaging efficacy of enriched-schizandrin from Schisandra chinensis fruit in UVB-induced hairless mice. The cream containing enriched- ... ...

Abstract	Excessive ultraviolet (UV) B irradiation induced skin photoaging. The aim of this study was to evaluate the anti-photoaging efficacy of enriched-schizandrin from Schisandra chinensis fruit in UVB-induced hairless mice. The cream containing enriched-schizandrin from S. chinensis fruit manufactured with another cosmetic ingredient. UVB-photoaged hairless mice topically applied with the cream once a day for 5 weeks. Application of the cream showed normal changes of body weight and food efficiency in the UVB-photoaged hairless mice. The cream application also was decreased interleukin (IL)-1β, matrix metalloproteinase (MMP)-2 and MMP-9 mRNA expressions and then it inhibited MMP-2 protein expression in UVB-photoaged hairless mice. Furthermore, the cream application inhibited epidermal wrinkle formation and decreased wrinkle depth and it restored to wrinkle thickness and collagen degradation of skin in UVB-photoaged hairless mice. Therefore, the cream could recover photoaging generated by UVB irradiation via downregulation of IL-1β, MMP-2, MMP-9 mRNA expressions and suppression of expression of MMP-2 proteins.
MeSH term(s)	Animals ; Mice ; Mice, Hairless ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/metabolism ; Matrix Metalloproteinase 2/genetics ; Matrix Metalloproteinase 2/metabolism ; Schisandra ; Fruit ; Skin/metabolism ; Skin Aging ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Ultraviolet Rays
Chemical Substances	schizandrin (G01BQC0879) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; RNA, Messenger
Language	English
Publishing date	2023-08-15
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Long non-coding RNAs in cancer.

Kim, Mi-Young

Non-coding RNA research

2019 Volume 4, Issue 2, Page(s) 45

Language	English
Publishing date	2019-02-21
Publishing country	Netherlands
Document type	Editorial
ISSN	2468-0540
ISSN (online)	2468-0540
DOI	10.1016/j.ncrna.2019.02.003
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Article: Evaluation of Student Satisfaction with Ubiquitous-Based Tests in Women's Health Nursing Course.

An, Mi-Young / Kim, Yun-Mi

Healthcare (Basel, Switzerland)

2021 Volume 9, Issue 12

Abstract: Learning evaluation using ubiquitous-based tests may be essential during a public health crisis, such as the COVID-19 pandemic, during which theoretical classes and clinical practice are conducted online. However, students may not be as familiar with ... ...

Abstract	Learning evaluation using ubiquitous-based tests may be essential during a public health crisis, such as the COVID-19 pandemic, during which theoretical classes and clinical practice are conducted online. However, students may not be as familiar with ubiquitous-based tests as they are with paper-based tests. This survey study aimed to evaluate students' satisfaction with ubiquitous-based tests and compare the evaluation results of a paper-based test with that of a ubiquitous-based test in nursing education. For the midterm exam of the Women's Health Nursing course, a paper-based test was conducted, while a ubiquitous-based test using a tablet computer was used for the final exam. The Ubiquitous-Based Test Usefulness and Satisfaction tool, which has a five-point Likert-type response scale, was employed to evaluate the post-test usefulness and satisfaction scores of the ubiquitous-based test. The mean score of the ubiquitous-based test usefulness was 4.01 ± 0.67. There was a significant difference in satisfaction levels between the ubiquitous-based and the paper-based test (t = -3.36,
Language	English
Publishing date	2021-11-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare9121664
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Article ; Online: What Affects Quality of Life for People with Type 1 Diabetes?: A Cross-Sectional Observational Study.

Cho, Mi-Kyoung / Kim, Mi-Young

International journal of environmental research and public health

2021 Volume 18, Issue 14

Abstract: This study investigated the association between the quality of life (QOL) and type 1 diabetes mellitus (DM), a lifelong disease that requires constant management. A complex set of factors influence the QOL of people with type 1 DM, and understanding ... ...

Abstract	This study investigated the association between the quality of life (QOL) and type 1 diabetes mellitus (DM), a lifelong disease that requires constant management. A complex set of factors influence the QOL of people with type 1 DM, and understanding these factors requires further research. This research is a cross-sectional descriptive study. A survey on related variables such as acceptance of disease and efficacy for self-management of diabetes, was conducted among 111 participants with type 1 DM. The collected data were analyzed using PASW Statistics program, and factors influencing participants' QOL were identified through hierarchical multiple regression. The study followed the Guidelines of Systematic Reporting of Examination in the STROBE checklist. The results showed that four variables exerted a significant effect on QOL (blood glucose level at hypoglycemia and complications in Model 1; efficacy for self-management of diabetes and acceptance and action in Model 2), and all the variables explained a majority of the variance in QOL. The results indicate that management of severe hypoglycemia and prevention of complications is crucial. Interventions should be developed to enhance coping abilities to improve efficacy for self-management for those with diabetes and promote their acceptance of the disease.
MeSH term(s)	Adaptation, Psychological ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1 ; Humans ; Quality of Life ; Surveys and Questionnaires
Language	English
Publishing date	2021-07-17
Publishing country	Switzerland
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph18147623
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Article: Determination and Analysis of Hyper-Variable

Park, Mi-Jeong / Kim, Eunjin / Jeong, Yeun Sug / Son, Mi-Young / Jang, Yeongseon / Ka, Kang-Hyeon

Mycobiology

2023 Volume 51, Issue 1, Page(s) 26–35

Abstract: The diversity ... ...

Abstract	The diversity of
Language	English
Publishing date	2023-01-11
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2631580-4
ISSN	2092-9323 ; 1229-8093
ISSN (online)	2092-9323
ISSN	1229-8093
DOI	10.1080/12298093.2022.2161157
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Article ; Online: Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma.

Ryu, Tae Young / Lee, Jinkwon / Kang, Yunsang / Son, Mi-Young / Kim, Dae-Soo / Lee, Youn Su / Kim, Mi-Young / Cho, Hyun-Soo

Biochemical and biophysical research communications

2023 Volume 663, Page(s) 41–46

Abstract: Renal cell carcinoma (RCC), also known as kidney cancer, is a common malignant tumor of the urinary system. While surgical treatment is essential, novel therapeutic targets and corresponding drugs for RCC are still needed due to the high relapse rate and ...

Abstract	Renal cell carcinoma (RCC), also known as kidney cancer, is a common malignant tumor of the urinary system. While surgical treatment is essential, novel therapeutic targets and corresponding drugs for RCC are still needed due to the high relapse rate and low five-year survival rate. In this study, we found that SUV420H2 is overexpressed in renal cancers and that high SUV420H2 expression is associated with a poor prognosis, as evidenced by RCC RNA-seq results derived from the TCGA. SUV420H2 knockdown using siRNA led to growth suppression and cell apoptosis in the A498 cell line. Furthermore, we identified DHRS2 as a direct target of SUV420H2 in the apoptosis process through a ChIP assay with a histone 4 lysine 20 (H4K20) trimethylation antibody. Rescue experiments showed that cotreatment with siSUV420H2 and siDHRS2 attenuated cell growth suppression induced by SUV420H2 knockdown only. Additionally, treatment with the SUV420H2 inhibitor A-196 induced cell apoptosis via upregulation of DHRS2. Taken together, our findings suggest that SUV420H2 may be a potential therapeutic target for the treatment of renal cancer.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/pathology ; Epigenesis, Genetic ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Neoplasm Recurrence, Local/genetics ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Apoptosis ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Cell Proliferation ; Carbonyl Reductase (NADPH)/genetics ; Carbonyl Reductase (NADPH)/metabolism
Chemical Substances	Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; DHRS2 protein, human (EC 1.1.1.184) ; Carbonyl Reductase (NADPH) (EC 1.1.1.184)
Language	English
Publishing date	2023-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2023.04.066
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Article: Dietary modulation of gut microbiota for the relief of irritable bowel syndrome.

Kim, Mi-Young / Choi, Sang-Woon

Nutrition research and practice

2021 Volume 15, Issue 4, Page(s) 411–430

Abstract: Irritable bowel syndrome (IBS) is a frequently diagnosed gastrointestinal (GI) disorder characterized by recurrent abdominal pain, bloating, and changes in the stool form or frequency without any structural changes and overt inflammation. It is not a ... ...

Abstract	Irritable bowel syndrome (IBS) is a frequently diagnosed gastrointestinal (GI) disorder characterized by recurrent abdominal pain, bloating, and changes in the stool form or frequency without any structural changes and overt inflammation. It is not a life-threatening condition but causes a considerable level of discomfort and distress. Among the many pathophysiologic factors, such as altered GI motility, visceral hypersensitivity, and low-grade mucosal inflammation, as well as other immunologic, psychologic, and genetic factors, gut microbiota imbalance (dysbiosis), which is frequently found in IBS, has been highlighted as an etiology of IBS. Dysbiosis may affect gut mucosal homeostasis, immune function, metabolic regulation, and even visceral motor function. As diet is shown to play a fundamental role in the gut microbiota profile, this review discusses the influence of diet on IBS occurring through the modulation of gut microbiota. Based on previous studies, it appears that dietary modulation of the gut microbiota may be effective for the alleviation of IBS symptoms and, also an effective IBS management strategy based on the underlying mechanism; especially because, IBS currently has no specific treatment owing to its uncertain etiology.
Language	English
Publishing date	2021-05-26
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2387946-4
ISSN	2005-6168 ; 1976-1457
ISSN (online)	2005-6168
ISSN	1976-1457
DOI	10.4162/nrp.2021.15.4.411
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Z 7762: Show issues

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Article ; Online: Legal Information Retrieval and Entailment Using Transformer-based Approaches.

Kim, Mi-Young / Rabelo, Juliano / Babiker, Housam Khalifa Bashier / Rahman, Md Abed / Goebel, Randy

The review of socionetwork strategies

2024 Volume 18, Issue 1, Page(s) 101–121

Abstract: The challenge of information overload in the legal domain increases every day. The COLIEE competition has created four challenge tasks that are intended to encourage the development of systems and methods to alleviate some of that pressure: a case law ... ...

Abstract	The challenge of information overload in the legal domain increases every day. The COLIEE competition has created four challenge tasks that are intended to encourage the development of systems and methods to alleviate some of that pressure: a case law retrieval (Task 1) and entailment (Task 2), and a statute law retrieval (Task 3) and entailment (Task 4). Here we describe our methods for Task 1 and Task 4. In Task 1, we used a sentence-transformer model to create a numeric representation for each case paragraph. We then created a histogram of the similarities between a query case and a candidate case. The histogram is used to build a binary classifier that decides whether a candidate case should be noticed or not. In Task 4, our approach relies on fine-tuning a pre-trained DeBERTa large language model (LLM) trained on SNLI and MultiNLI datasets. Our method for Task 4 was ranked third among eight participating teams in the COLIEE 2023 competition. For Task 4, We also compared the performance of the DeBERTa model with those of a knowledge distillation model and ensemble methods including Random Forest and Voting.
Language	English
Publishing date	2024-01-11
Publishing country	Japan
Document type	Journal Article
ISSN	1867-3236
ISSN (online)	1867-3236
DOI	10.1007/s12626-023-00153-z
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Article ; Online: Regression Tree Analysis for Stream Biological Indicators Considering Spatial Autocorrelation.

Kim, Mi-Young / Lee, Sang-Woo

International journal of environmental research and public health

2021 Volume 18, Issue 10

Abstract: Multiple studies have been conducted to identify the complex and diverse relationships between stream ecosystems and land cover. However, these studies did not consider spatial dependency inherent from the systemic structure of streams. Therefore, the ... ...

Abstract	Multiple studies have been conducted to identify the complex and diverse relationships between stream ecosystems and land cover. However, these studies did not consider spatial dependency inherent from the systemic structure of streams. Therefore, the present study aimed to analyze the relationship between green/urban areas and topographical variables with biological indicators using regression tree analysis, which considered spatial autocorrelation at two different scales. The results of the principal components analysis suggested that the topographical variables exhibited the highest weights among all components, including biological indicators. Moran's I values verified spatial autocorrelation of biological indicators; additionally, trophic diatom index, benthic macroinvertebrate index, and fish assessment index values were greater than 0.7. The results of spatial autocorrelation analysis suggested that a significant spatial dependency existed between environmental and biological indicators. Regression tree analysis was conducted for each indicator to compensate for the occurrence of autocorrelation; subsequently, the slope in riparian areas was the first criterion of differentiation for biological condition datasets in all regression trees. These findings suggest that considering spatial autocorrelation for statistical analyses of stream ecosystems, riparian proximity, and topographical characteristics for land use planning around the streams is essential to maintain the healthy biological conditions of streams.
MeSH term(s)	Animals ; Ecosystem ; Environmental Biomarkers ; Fishes ; Rivers ; Spatial Analysis
Chemical Substances	Environmental Biomarkers
Language	English
Publishing date	2021-05-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph18105150
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Article ; Online: Cancer epigenetics: Past, present and future.

Lee, Jae Eun / Kim, Mi-Young

Seminars in cancer biology

2021 Volume 83, Page(s) 4–14

Abstract: Cancer was thought to be caused solely by genetic mutations in oncogenes and tumor suppressor genes. In the last 35 years, however, epigenetic changes have been increasingly recognized as another primary driver of carcinogenesis and cancer progression. ... ...

Abstract	Cancer was thought to be caused solely by genetic mutations in oncogenes and tumor suppressor genes. In the last 35 years, however, epigenetic changes have been increasingly recognized as another primary driver of carcinogenesis and cancer progression. Epigenetic deregulation in cancer often includes mutations and/or aberrant expression of chromatin-modifying enzymes, their associated proteins, and even non-coding RNAs, which can alter chromatin structure and dynamics. This leads to changes in gene expression that ultimately contribute to the emergence and evolution of cancer cells. Studies of the deregulation of chromatin modifiers in cancer cells have reshaped the way we approach cancer and guided the development of novel anticancer therapeutics that target epigenetic factors. There remain, however, a number of unanswered questions in this field that are the focus of present research. Areas of particular interest include the actions of emerging classes of epigenetic regulators of carcinogenesis and the tumor microenvironment, as well as epigenetic tumor heterogeneity. In this review, we discuss past findings on epigenetic mechanisms of cancer, current trends in the field of cancer epigenetics, and the directions of future research that may lead to the identification of new prognostic markers for cancer and the development of more effective anticancer therapeutics.
MeSH term(s)	Carcinogenesis/genetics ; Chromatin/genetics ; DNA Methylation ; Epigenesis, Genetic ; Humans ; Neoplasms/genetics ; Tumor Microenvironment/genetics
Chemical Substances	Chromatin
Language	English
Publishing date	2021-03-31
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1033980-2
ISSN	1096-3650 ; 1044-579X
ISSN (online)	1096-3650
ISSN	1044-579X
DOI	10.1016/j.semcancer.2021.03.025
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