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Article: The Fork in the Road: Histone Partitioning During DNA Replication.

Annunziato, Anthony T

2015 Volume 6, Issue 2, Page(s) 353–371

Abstract: In the following discussion the distribution of histones at the replication fork is examined, with specific attention paid to the question of H3/H4 tetramer "splitting." After a presentation of early experiments surrounding this topic, more recent ... ...

Abstract	In the following discussion the distribution of histones at the replication fork is examined, with specific attention paid to the question of H3/H4 tetramer "splitting." After a presentation of early experiments surrounding this topic, more recent contributions are detailed. The implications of these findings with respect to the transmission of histone modifications and epigenetic models are also addressed.
Language	English
Publishing date	2015-06-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes6020353
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Article ; Online: The Utilization of Minimally Invasive Surgery for Os Trigonum Syndrome: A Systematic Review.

Anastasio, Albert T / Baumann, Anthony N / Walley, Kempland C / Curtis, Deven P / Johns, William L / Amendola, Annunziato

The American journal of sports medicine

2024 , Page(s) 3635465231198425

Abstract: Background: A symptomatic os trigonum is a common cause of posterior ankle pain that has been traditionally managed with open excision. Minimally invasive surgery (MIS) has been proposed as an alternative to open excision for improved outcomes and ... ...

Abstract	Background: A symptomatic os trigonum is a common cause of posterior ankle pain that has been traditionally managed with open excision. Minimally invasive surgery (MIS) has been proposed as an alternative to open excision for improved outcomes and decreased complication rates; however, no systematic review to date has examined the utilization of MIS for a symptomatic os trigonum. Purpose: To examine patient outcomes, return to sport, and complications associated with MIS for a symptomatic os trigonum. Study design: Systematic review; Level of evidence, 4. Methods: A systematic review was performed on February 22, 2023, using the PubMed, CINAHL, MEDLINE, and Web of Science databases from database inception until February 22, 2023, on the topic of MIS for a symptomatic os trigonum. Results: Of 885 articles retrieved from an initial search, 17 articles (N = 435 patients) met full inclusion criteria. The mean age of the cohort was 26.01 ± 4.68 years, with a mean follow-up time of 34.63 ± 18.20 months. For patients treated with MIS, the mean preoperative American Orthopaedic Foot and Ankle Society (AOFAS) score was 55.85 ± 12.75, the mean final postoperative AOFAS score was 94.88 ± 4.04, the mean preoperative visual analog scale pain score was 7.20 ± 0.43, and the mean final postoperative visual analog scale score was 0.71 ± 0.48. The mean time to return to sport for patients undergoing MIS was 7.76 ± 1.42 weeks. MIS had an overall complication rate of 5.0%, the majority of which consisted of transient neurapraxia of the sural or superficial peroneal nerve. Conclusion: Minimally invasive management of a symptomatic os trigonum appears to be a viable alternative to open surgery in terms of outcomes, return to sport, and complication rates. More high-quality evidence will be required to definitely recommend minimally invasive approaches as the standard of care over open surgery.
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	197482-8
ISSN	1552-3365 ; 0363-5465
ISSN (online)	1552-3365
ISSN	0363-5465
DOI	10.1177/03635465231198425
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Article: Assembling chromatin: the long and winding road.

Annunziato, Anthony T

Biochimica et biophysica acta

2013 Volume 1819, Issue 3-4, Page(s) 196–210

Abstract: It has been over 35 years since the acceptance of the "chromatin subunit" hypothesis, and the recognition that nucleosomes are the fundamental repeating units of chromatin fibers. Major subjects of inquiry in the intervening years have included the steps ...

Abstract	It has been over 35 years since the acceptance of the "chromatin subunit" hypothesis, and the recognition that nucleosomes are the fundamental repeating units of chromatin fibers. Major subjects of inquiry in the intervening years have included the steps involved in chromatin assembly, and the chaperones that escort histones to DNA. The following commentary offers an historical perspective on inquiries into the processes by which nucleosomes are assembled on replicating and nonreplicating chromatin. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly.
MeSH term(s)	Animals ; Chromatin/chemistry ; Chromatin/metabolism ; Chromatin Assembly and Disassembly/physiology ; DNA Replication/physiology ; Histone Chaperones/metabolism ; Histones/metabolism ; Humans ; Protein Processing, Post-Translational ; Protein Transport/physiology
Chemical Substances	Chromatin ; Histone Chaperones ; Histones
Language	English
Publishing date	2013-03
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
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Article ; Online: The Fork in the Road

Anthony T. Annunziato

Genes, Vol 6, Iss 2, Pp 353-

Histone Partitioning During DNA Replication

2015 Volume 371

Abstract	In the following discussion the distribution of histones at the replication fork is examined, with specific attention paid to the question of H3/H4 tetramer "splitting." After a presentation of early experiments surrounding this topic, more recent contributions are detailed. The implications of these findings with respect to the transmission of histone modifications and epigenetic models are also addressed.
Keywords	chromatin ; nucleosome ; tetramer ; histone ; acetylation ; methylation ; replication ; splitting ; epigenetics ; Genetics ; QH426-470 ; Biology (General) ; QH301-705.5 ; Science ; Q
Language	English
Publishing date	2015-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Assembling chromatin: The long and winding road

Annunziato, Anthony T

BBA - Gene Regulatory Mechanisms. 2012 , v. 1819, no. 3-4

2012

Abstract: It has been over 35years since the acceptance of the “chromatin subunit” hypothesis, and the recognition that nucleosomes are the fundamental repeating units of chromatin fibers. Major subjects of inquiry in the intervening years have included the steps ... ...

Abstract	It has been over 35years since the acceptance of the “chromatin subunit” hypothesis, and the recognition that nucleosomes are the fundamental repeating units of chromatin fibers. Major subjects of inquiry in the intervening years have included the steps involved in chromatin assembly, and the chaperones that escort histones to DNA. The following commentary offers an historical perspective on inquiries into the processes by which nucleosomes are assembled on replicating and nonreplicating chromatin. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly.
Keywords	DNA ; histones ; nucleosomes
Language	English
Dates of publication	2012-03
Size	p. 196-210.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2406725-8
ISSN	1876-4320 ; 1874-9399
ISSN (online)	1876-4320
ISSN	1874-9399
DOI	10.1016/j.bbagrm.2011.07.005
Database	NAL-Catalogue (AGRICOLA)

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Article: Split decision: what happens to nucleosomes during DNA replication?

Annunziato, Anthony T

The Journal of biological chemistry

2005 Volume 280, Issue 13, Page(s) 12065–12068

MeSH term(s)	Animals ; Chromatin/metabolism ; DNA Replication ; Dimerization ; Histones/chemistry ; Humans ; Microscopy, Electron ; Models, Biological ; Models, Genetic ; Nucleosomes/metabolism ; Nucleosomes/physiology
Chemical Substances	Chromatin ; Histones ; Nucleosomes
Language	English
Publishing date	2005-01-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.R400039200
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Article ; Online: Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.

Tong, Kevin / Keller, Thomas / Hoffman, Charles S / Annunziato, Anthony T

Eukaryotic cell

2012 Volume 11, Issue 9, Page(s) 1095–1103

Abstract: The Hat1 histone acetyltransferase has been implicated in the acetylation of histone H4 during chromatin assembly. In this study, we have characterized the Hat1 complex from the fission yeast Schizosaccharomyces pombe and have examined its role in ... ...

Abstract	The Hat1 histone acetyltransferase has been implicated in the acetylation of histone H4 during chromatin assembly. In this study, we have characterized the Hat1 complex from the fission yeast Schizosaccharomyces pombe and have examined its role in telomeric silencing. Hat1 is found associated with the RbAp46 homologue Mis16, an essential protein. The Hat1 complex acetylates lysines 5 and 12 of histone H4, the sites that are acetylated in newly synthesized H4 in a wide range of eukaryotes. Deletion of hat1 in S. pombe is itself sufficient to cause the loss of silencing at telomeres. This is in contrast to results obtained with an S. cerevisiae hat1Δ strain, which must also carry mutations of specific acetylatable lysines in the H3 tail domain for loss of telomeric silencing to occur. Notably, deletion of hat1 from S. pombe resulted in an increase of acetylation of histone H4 in subtelomeric chromatin, concomitant with derepression of this region. A similar loss of telomeric silencing was also observed after growing cells in the presence of the deacetylase inhibitor trichostatin A. However, deleting hat1 did not cause loss of silencing at centromeres or the silent mating type locus. These results point to a direct link between Hat1, H4 acetylation, and the establishment of repressed telomeric chromatin in fission yeast.
MeSH term(s)	Acetylation ; Amino Acid Sequence ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Gene Deletion ; Gene Silencing ; Histone Acetyltransferases/antagonists & inhibitors ; Histone Acetyltransferases/genetics ; Histone Acetyltransferases/metabolism ; Histones/metabolism ; Hydroxamic Acids/pharmacology ; Lysine/metabolism ; Molecular Sequence Data ; Schizosaccharomyces/genetics ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Schizosaccharomyces pombe Proteins/metabolism ; Telomere/genetics
Chemical Substances	Carrier Proteins ; Histones ; Hydroxamic Acids ; Mis16 protein, S pombe ; Schizosaccharomyces pombe Proteins ; trichostatin A (3X2S926L3Z) ; Histone Acetyltransferases (EC 2.3.1.48) ; histone acetyltransferase type B complex (EC 2.3.1.48) ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2012-07-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2077635-4
ISSN	1535-9786 ; 1535-9778
ISSN (online)	1535-9786
ISSN	1535-9778
DOI	10.1128/EC.00123-12
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Article ; Online: Complications and Risk Factors for Morbidity in Elective Hip Arthroscopy: A Review of 1325 Cases.

Anthony, Chris A / Pugely, Andrew J / Gao, Yubo / Westermann, Robert R / Martin, Christopher T / Wolf, Brian R / Amendola, Annunziato

American journal of orthopedics (Belle Mead, N.J.)

2017 Volume 46, Issue 1, Page(s) E1–E9

Abstract: We conducted a study of elective hip arthroscopy patients to determine type and incidence of complications and rates of and risk factors for minor and major morbidity. Retrospectively searching the National Surgical Quality Improvement Program database, ... ...

Abstract	We conducted a study of elective hip arthroscopy patients to determine type and incidence of complications and rates of and risk factors for minor and major morbidity. Retrospectively searching the National Surgical Quality Improvement Program database, we identified 1325 patients who underwent elective hip arthroscopy between 2006 and 2013. Univariate and subsequent multivariate analyses were used to identify risk factors for complications. Of the 1325 patients identified, 16 (1.21%) had at least 1 complication, and 6 (0.45%) had at least 1 major complication. The most common complication was bleeding resulting in transfusion (6 patients, 0.45%). Multivariate analysis found age over 65 years was an independent predictor of any complication (odds ratio [OR], 6.52; 95% confidence interval [CI], 1.35-31.54) and minor morbidity (OR, 7.97; 95% CI, 1.21-52.72). Short-term morbidity after elective hip arthroscopy was low, and we conclude that hip arthroscopy should be considered a low-risk procedure. Surgeons who perform hip arthroscopy should be aware that age over 65 years is a risk factor for complications. These results may aid surgeons in counseling patients and may aid health systems in performing quality assessments.
MeSH term(s)	Adult ; Aged ; Arthroscopy/adverse effects ; Databases, Factual ; Elective Surgical Procedures/adverse effects ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Postoperative Hemorrhage/epidemiology ; Postoperative Hemorrhage/etiology ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2365753-4
ISSN	1934-3418 ; 1078-4519
ISSN (online)	1934-3418
ISSN	1078-4519
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Article: In vitro analysis of histone acetyltransferase activity.

Benson, Laura J / Annunziato, Anthony T

Methods (San Diego, Calif.)

2004 Volume 33, Issue 1, Page(s) 45–52

Abstract: Interest in histone acetylation has risen dramatically in recent years. In the following report, we present methods for the analysis of histone acetyltransferase activity in vitro. Protocols are described for radiolabeling histone proteins and N-terminal ...

Abstract	Interest in histone acetylation has risen dramatically in recent years. In the following report, we present methods for the analysis of histone acetyltransferase activity in vitro. Protocols are described for radiolabeling histone proteins and N-terminal "tail" peptides, and for the analysis of acetylation by immunoblotting. Techniques for acetylating immobilized histone peptides are also described.
MeSH term(s)	Acetylation ; Acetyltransferases/metabolism ; Electrophoresis, Polyacrylamide Gel/methods ; HeLa Cells ; Histone Acetyltransferases ; Histones/metabolism ; Humans ; Peptide Fragments/metabolism
Chemical Substances	Histones ; Peptide Fragments ; Acetyltransferases (EC 2.3.1.-) ; Histone Acetyltransferases (EC 2.3.1.48)
Language	English
Publishing date	2004-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1066584-5
ISSN	1095-9130 ; 1046-2023
ISSN (online)	1095-9130
ISSN	1046-2023
DOI	10.1016/j.ymeth.2003.10.019
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Article ; Online: Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4.

Nagarajan, Prabakaran / Ge, Zhongqi / Sirbu, Bianca / Doughty, Cheryl / Agudelo Garcia, Paula A / Schlederer, Michaela / Annunziato, Anthony T / Cortez, David / Kenner, Lukas / Parthun, Mark R

PLoS genetics

2013 Volume 9, Issue 6, Page(s) e1003518

Abstract: Histone acetyltransferase 1 is an evolutionarily conserved type B histone acetyltransferase that is thought to be responsible for the diacetylation of newly synthesized histone H4 on lysines 5 and 12 during chromatin assembly. To understand the function ... ...

Abstract	Histone acetyltransferase 1 is an evolutionarily conserved type B histone acetyltransferase that is thought to be responsible for the diacetylation of newly synthesized histone H4 on lysines 5 and 12 during chromatin assembly. To understand the function of this enzyme in a complex organism, we have constructed a conditional mouse knockout model of Hat1. Murine Hat1 is essential for viability, as homozygous deletion of Hat1 results in neonatal lethality. The lungs of embryos and pups genetically deficient in Hat1 were much less mature upon histological evaluation. The neonatal lethality is due to severe defects in lung development that result in less aeration and respiratory distress. Many of the Hat1(-/-) neonates also display significant craniofacial defects with abnormalities in the bones of the skull and jaw. Hat1(-/-) mouse embryonic fibroblasts (MEFs) are defective in cell proliferation and are sensitive to DNA damaging agents. In addition, the Hat1(-/-) MEFs display a marked increase in genome instability. Analysis of histone dynamics at sites of replication-coupled chromatin assembly demonstrates that Hat1 is not only responsible for the acetylation of newly synthesized histone H4 but is also required to maintain the acetylation of histone H3 on lysines 9, 18, and 27 during replication-coupled chromatin assembly.
MeSH term(s)	Acetylation ; Animals ; Cell Proliferation ; Cell Survival/genetics ; Chromatin Assembly and Disassembly/genetics ; DNA Replication/genetics ; Embryonic Development/genetics ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Genomic Instability ; Histone Acetyltransferases/genetics ; Histones/genetics ; Humans ; Jumonji Domain-Containing Histone Demethylases/genetics ; Mice ; Mice, Knockout
Chemical Substances	Histones ; Jumonji Domain-Containing Histone Demethylases (EC 1.14.11.-) ; Kdm6b protein, mouse (EC 1.5.-) ; Histone Acetyltransferases (EC 2.3.1.48) ; histone acetyltransferase type B complex (EC 2.3.1.48)
Language	English
Publishing date	2013-06-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1003518
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