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Article: Determination of the Microinjected Cytosolic Concentration by Using Mathematical Models of Fluid Dynamics.

Rivas, Manuel / Reina, Manuel

Alternatives to laboratory animals : ATLA

2022 Volume 50, Issue 2, Page(s) 136–145

Abstract: The precise determination of the intracellular concentration of a drug is a major challenge in drug discovery. Microinjection is a very effective technique for the introduction of macromolecules into single cells. However, due to the large number of ... ...

Abstract	The precise determination of the intracellular concentration of a drug is a major challenge in drug discovery. Microinjection is a very effective technique for the introduction of macromolecules into single cells. However, due to the large number of parameters that need to be adjusted and the complex physical mechanisms involved, there are currently no means by which the concentration of a microinjected intracellular compound could be theoretically estimated. In this paper, we present a method for the theoretical estimation of intracellular drug concentration, based on the framework of classical fluid mechanism theory - specifically, the modified Bernoulli equation. We introduce into Bernoulli's classical equation the effect of friction due to the non-laminar regimes of the injected fluid. We also study the compatibility of our theoretical estimation model with variations in injection time and concentration of the compound inside the microinjection needle. Finally, microinjected calcium concentrations estimated with the theoretical model were compared with those determined experimentally in several cell types, by using a Fura-2-based Ca
MeSH term(s)	Hydrodynamics ; Microinjections ; Models, Theoretical
Language	English
Publishing date	2022-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	605800-0
ISSN	0261-1929
ISSN	0261-1929
DOI	10.1177/02611929211073038
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Article: Determination of the Microinjected Cytosolic Concentration by Using Mathematical Models of Fluid Dynamics

Rivas, Manuel / Reina, Manuel

ATLA. Alternatives to laboratory animals. , v. 50, no. 2

2022

Abstract	The precise determination of the intracellular concentration of a drug is a major challenge in drug discovery. Microinjection is a very effective technique for the introduction of macromolecules into single cells. However, due to the large number of parameters that need to be adjusted and the complex physical mechanisms involved, there are currently no means by which the concentration of a microinjected intracellular compound could be theoretically estimated. In this paper, we present a method for the theoretical estimation of intracellular drug concentration, based on the framework of classical fluid mechanism theory — specifically, the modified Bernoulli equation. We introduce into Bernoulli’s classical equation the effect of friction due to the non-laminar regimes of the injected fluid. We also study the compatibility of our theoretical estimation model with variations in injection time and concentration of the compound inside the microinjection needle. Finally, microinjected calcium concentrations estimated with the theoretical model were compared with those determined experimentally in several cell types, by using a Fura-2-based Ca2+ imaging technique.
Keywords	calcium ; drugs ; equations ; fluid mechanics ; friction ; laboratories ; theoretical models
Language	English
Dates of publication	2022-03
Size	p. 136-145.
Publishing place	SAGE Publications
Document type	Article
ZDB-ID	605800-0
ISSN	0261-1929
ISSN	0261-1929
DOI	10.1177/02611929211073038
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Analysis and Simulation of the Compressive Strength of Bioinspired Lightweight Structures Manufactured by a Stereolithography 3D Printer.

Alía García, Cristina / Rodríguez Ortiz, Álvaro / Arenas Reina, José Manuel / Cano-Moreno, Juan David / Gómez Gómez, Manuel

Biomimetics (Basel, Switzerland)

2024 Volume 9, Issue 4

Abstract: The use of metamaterials is a good alternative when looking for structures that can withstand compression forces without increasing their weight. In this sense, using nature as a reference can be an appropriate option to design this type of material. ... ...

Abstract	The use of metamaterials is a good alternative when looking for structures that can withstand compression forces without increasing their weight. In this sense, using nature as a reference can be an appropriate option to design this type of material. Therefore, in this work, a comparative study of a selection of eight representative models of a wide variety of existing solutions, both bioinspired and proposed by various researchers, is presented. These models have been manufactured using stereolithography (SLA) printing, which allows complex geometries to be obtained in a simple way that would be more complicated to achieve by other procedures. Additionally, the manufacturing cost of each model has been determined. The compression tests of the different models have made it possible to evaluate the breaking force and its corresponding deformation. Likewise, a finite element analysis of the manufactured models has been carried out to simulate their behavior under compression, achieving results very similar to those obtained in the experimental tests. In this way, it has been concluded that, among the three-dimensional patterns, the structure called "3D auxetic" is the one that supports the greatest breaking force due to the topographic characteristics of its bar structure. Similarly, among the two-dimensional patterns, the structure called "Auxetic 1", with a topography based on curves, is capable of supporting the greatest deformation in the compression direction before breaking. Moreover, the highest resistance-force-to-cost ratio has been obtained with a "3D auxetic" structure.
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Journal Article
ISSN	2313-7673
ISSN (online)	2313-7673
DOI	10.3390/biomimetics9040240
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sensitivity of Mass Geometry Parameters on E-Scooter Comfort: Design Guide.

Cano-Moreno, Juan David / Arenas Reina, José Manuel / Parra Lanillos, Victorina Del Carmen / Islán Marcos, Manuel Enrique

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 2

Abstract: E-scooter vibrations are a problem recently studied. Theoretical models based on dynamic simulations and also real measurements have confirmed the high impact of e-scooter vibrations on driver comfort and health. Some authors recommend improving e- ... ...

Abstract	E-scooter vibrations are a problem recently studied. Theoretical models based on dynamic simulations and also real measurements have confirmed the high impact of e-scooter vibrations on driver comfort and health. Some authors recommend improving e-scooter damping systems, including tyres. However, it has not been suggested nor has any research been published studying how to improve e-scooter frame design for reducing driver vibrations and improving comfort. In this paper, we have modelled a real e-scooter to have a reference. Then, we have developed a multibody dynamic model for running dynamic simulations studying the influence of mass geometry parameters of the e-scooter frame (mass, centre of gravity and inertia moment). Acceleration results have been analysed based on the UNE-2631 standard for obtaining comfort values. Based on results, a qualitative e-scooter frame design guide for mitigating vibrations and increasing the comfort of e-scooter driver has been developed. Some application cases have been running on the multibody dynamic simulation model, finding improvements of comfort levels higher than 9% in comparison with the e-scooter reference model. The dynamic model has been qualitatively validated from real measurements. In addition, a basic sensor proposal and comfort colour scale is proposed for giving feedback to e-scooter drivers.
Language	English
Publishing date	2024-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24020399
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Somatotype Analysis of International Football Players with Cerebral Palsy: A Comparison with Non-Disabled Football Players.

Doménech, Carmen / Roche, Enrique / Reina, Raul / Sarabia, José Manuel

Journal of functional morphology and kinesiology

2023 Volume 8, Issue 4

Abstract: Football for people with cerebral palsy is a para-sport involving ambulant athletes with impairments, such as hypertonia, ataxia, or athetosis. The objective of the present study was to describe the somatotype of a representative sample of international ... ...

Abstract	Football for people with cerebral palsy is a para-sport involving ambulant athletes with impairments, such as hypertonia, ataxia, or athetosis. The objective of the present study was to describe the somatotype of a representative sample of international football players according to different functional profiles of cerebral palsy, including spastic diparesis, athetosis/ataxia, spastic hemiparesis, and minimum impairment criteria, and to compare it with non-disabled football players. A total of 144 international para-footballers and 39 non-disabled footballers participated in the study, and their somatotype was calculated using anthropometric measurements. A Kruskal-Wallis test was used to compare the groups to determine and assess the differences between the different functional profiles, and the analysis of anthropometric variables and body composition showed no differences. Regarding somatotype, a predominance of the mesomorphic component was observed in all subgroups, and differences in somatotype were also found between non-disabled footballers and para-footballers with spastic hemiparesis and minimum impairment criteria. This study suggests that there may be a degree of homogeneity in terms of somatotype among footballers with or without physical impairments, such as hypertonia, athetosis, or ataxia. Furthermore, it provides reference values of international-level para-football players for the different sport classes, which can help coaches and trainers monitor athletes' physical conditions.
Language	English
Publishing date	2023-12-11
Publishing country	Switzerland
Document type	Journal Article
ISSN	2411-5142
ISSN (online)	2411-5142
DOI	10.3390/jfmk8040166
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cutaneous Manifestations of COVID-19 in the Lower Limbs: A Narrative Review.

Palomo-Toucedo, Inmaculada C / López-Sánchez, Manuel Jesús / Reina-Bueno, María / Coheña-Jiménez, Manuel

International journal of environmental research and public health

2022 Volume 19, Issue 14

Abstract: In 2020, the World Health Organization declared the COVID-19 pandemic. This infectious pathology can be associated with different manifestations in different body systems, among which are dermatological lesions. The purpose of this work is to determine ... ...

Abstract	In 2020, the World Health Organization declared the COVID-19 pandemic. This infectious pathology can be associated with different manifestations in different body systems, among which are dermatological lesions. The purpose of this work is to determine the most frequent dermatological signs, in the lower limbs, produced by SARS-CoV-2. To carry this out, a bibliographic search was performed in the following databases: PubMed, SciELO, ScienceDirect, Cochrane Database of Systematic Reviews, and the Google Scholar literature. The inclusion criteria were articles that included confirmed subjects or those with a clinical suspicion of COVID-19, written in the Spanish or English languages, and the results presented clinical manifestations in the lower extremities. Initially, 128 scientific documents were identified and, after reading the title and abstract, 18 articles were selected. The most frequent skin lesions on the lower limbs are acral lesions such as pernio erythema or ischemic lesions, maculopapular rash, petechiae, and erythematous plaques.
MeSH term(s)	COVID-19 ; Humans ; Lower Extremity ; Pandemics ; SARS-CoV-2 ; Skin Diseases/epidemiology ; Systematic Reviews as Topic
Language	English
Publishing date	2022-07-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19148861
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Detection of the Lines of Research in Favor of the Implementation and Development of Organizational Culture of Innovation through a Bibliometric Analysis

Lourdes Pineda-Celaya / María Paz Andrés Reina / Manuel González Pérez

Innovar: Revista de Ciencias Administrativas y Sociales, Vol 33, Iss

2023 Volume 89

Abstract: This paper analyzes the lines of research derived from the implementation and development of the organizational culture of innovation in order to identify the trends followed within this field of study. In doing so, we identified potential and recent- ... ...

Abstract	This paper analyzes the lines of research derived from the implementation and development of the organizational culture of innovation in order to identify the trends followed within this field of study. In doing so, we identified potential and recent-interest trends that could contribute both to the development of this scientific field and to the search of companies for competitive advantages. The most productive authors, journals and countries were also identified, thus offering a solid basis for future research. The methodology consisted of the analysis of bibliometric indicators from scientific articles in Scopus database published between 1980 and 2000. The Web of Science was not considered since the results obtained in both databases were similar. Among the relevant findings related to administration, in publishing terms, the United States is the most productive country, followed by the United Kingdom and Australia. The analysis of topological data between keywords and science areas shows that the analyzed sample focuses on inter- and multidisciplinary studies, and that most theories and basic frameworks were created between 1980 and 2000. These findings provide a basic framework for qualitative and quantitative research that could be applied by experts in the field of management.
Keywords	organizational culture ; organizational culture of innovation ; innovation ; bibliometrics ; Social Sciences ; H ; Commerce ; HF1-6182 ; Business ; HF5001-6182
Subject code	001
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Universidad Nacional de Colombia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Manuel Reina: sus mejores versos

Reina, Manuel / Blanco-Belmonte, Marcos Rafael

(Los poetas ; Año 1, Nr. 11)

1928

Title variant	Sus mejores versos
Author's details	prólogo de M. R. Blanco Belmonte. Portada de Alonso. Ilustraciones y retrato del autor por Cuevas
Series title	Los poetas ; Año 1, Nr. 11
Language	Spanish
Size	78 S., Ill., 1 Portr.
Publishing place	Madrid
Document type	Book
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Chronic Effects of Rotational Inertial Devices on Adolescents’ Physical Capacities in Team Sports

Samuel López-Mariscal / Álvaro Reina-Gómez / Luís Suárez-Arrones / Manuel Ortega-Becerra

Sustainability, Vol 15, Iss 14575, p

A Systematic Review

2023 Volume 14575

Abstract: Inertial training is one of the most popular training methodologies in recent years and one of the objects of study in recent literature. The aim of this systematic review is to evaluate the current literature surrounding the chronic effect of rotational ...

Abstract	Inertial training is one of the most popular training methodologies in recent years and one of the objects of study in recent literature. The aim of this systematic review is to evaluate the current literature surrounding the chronic effect of rotational inertial devices on the physical capacities of team sports athletes through jumping performance, sprinting time, and change of direction performance. This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocols. Three databases were screened up to January 2023. Eight studies were included in the final analysis. The results revealed the effectiveness of rotational inertial devices as flywheels or conic pulleys, showing significant improvements (from trivial to large effect size) in jump performances, significant improvements in some tests for change of direction ability and non-consistent results for sprint tests with significant improvements mainly in short distances. In conclusion, inertial training has been shown to be a useful way to improve performance in young athletes in team sports.
Keywords	inertial training ; eccentric overload ; strength training ; young athletes ; team sports ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	796
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Measuring the Innovation Orientation of Organizational Culture

Lourdes Pineda-Celaya / María-Paz Andrés-Reina / Manuel González-Pérez

Sustainability, Vol 14, Iss 2035, p

An Application to the Service Provider Companies of the State-Owned Oil Company PEMEX in the Southeast of Mexico

2022 Volume 2035

Abstract: Organizational culture (OC) is one of the key factors that enables the development of innovation. A great deal of research has analyzed the characteristics that make up an innovation-focused OC; however, none have unified them. This article analyzes and ... ...

Abstract	Organizational culture (OC) is one of the key factors that enables the development of innovation. A great deal of research has analyzed the characteristics that make up an innovation-focused OC; however, none have unified them. This article analyzes and integrates the literature on the characteristics of an innovation OC. Its objective was to test whether there is a specific set of distinctive characteristics of an innovation-focused OC that, once identified, can be implemented and developed by firms. To this end, this study proposed and tested a model for measuring the innovation orientation of an OC. This study collected samples from small- and medium-sized companies from the oil-producing states of Mexico, obtaining information from 176 companies. To determine the group of characteristics that make up an organizational culture of innovation (OCI), the authors applied non-experimental, descriptive, transactional research with a quantitative approach. Results were obtained through the application of the following statistical techniques: Bonnet test, KMO index, Bartlett’s sphericity, Chi-square, confirmatory factor analysis, Cronbach’s alpha, principal component analysis and structural equations, which made it possible to measure the level of innovation of the OCI of these companies and to determine the characteristics that comprise it. The proposed model allowed us to identify the existence of a specific group of behavioral characteristics that emanate from a company’s personnel and another group of characteristics that arise from the company itself. Both integrated groups determine whether the OC is focused on innovation. The results also confirmed that the level of innovation of a company depends greatly on its personnel. The authors found no previous work that analyzed these characteristics from the joint perspectives of employees, middle managers and managers. This research considered the opinions of these agents, which confers greater veracity to the findings obtained. The limitations and implications are ...
Keywords	organizational culture ; innovation ; innovation organizational culture ; characteristics ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	650
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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