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  1. Article ; Online: Immunotherapy with Vespula venom for Vespa velutina nigrithorax anaphylaxis: Preliminary clinical and immunological results.

    Rodríguez-Vázquez, Virginia / Armisén, Margarita / Gómez-Rial, Jose / Lamas-Vázquez, Beatriz / Vidal, Carmen

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2021  Volume 52, Issue 2, Page(s) 345–347

    MeSH term(s) Anaphylaxis ; Animals ; Arthropod Venoms ; Bee Venoms ; Desensitization, Immunologic ; Humans ; Immunotherapy/methods ; Insect Bites and Stings/therapy ; Wasp Venoms ; Wasps
    Chemical Substances Arthropod Venoms ; Bee Venoms ; Wasp Venoms
    Language English
    Publishing date 2021-11-10
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.14039
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: RNA viruses alter house dust mite physiology and allergen production with no detected consequences for allergenicity.

    Vidal-Quist, José Cristian / Declercq, Jozefien / Vanhee, Stijn / Lambrecht, Bart N / Gómez-Rial, José / Vidal, Carmen / Aydogdu, Eylem / Rombauts, Stephane / Hernández-Crespo, Pedro

    Insect molecular biology

    2023  Volume 32, Issue 2, Page(s) 173–186

    Abstract: RNA viruses have recently been detected in association with house dust mites, including laboratory cultures, dust samples, and mite-derived pharmaceuticals used for allergy diagnosis. This study aimed to assess the incidence of viral infection on ... ...

    Abstract RNA viruses have recently been detected in association with house dust mites, including laboratory cultures, dust samples, and mite-derived pharmaceuticals used for allergy diagnosis. This study aimed to assess the incidence of viral infection on Dermatophagoides pteronyssinus physiology and on the allergenic performance of extracts derived from its culture. Transcriptional changes between genetically identical control and virus-infected mite colonies were analysed by RNAseq with the support of a new D. pteronyssinus high-quality annotated genome (56.8 Mb, 108 scaffolds, N50 = 2.73 Mb, 96.7% BUSCO-completeness). Extracts of cultures and bodies from both colonies were compared by inspecting major allergen accumulation by enzyme-linked immunosorbent assay (ELISA), allergen-related enzymatic activities by specific assays, airway inflammation in a mouse model of allergic asthma, and binding to allergic patient's sera IgE by ImmunoCAP. Viral infection induced a significant transcriptional response, including several immunity and stress-response genes, and affected the expression of seven allergens, putative isoallergens and allergen orthologs. Major allergens were unaffected except for Der p 23 that was upregulated, increasing ELISA titers up to 29% in infected-mite extracts. By contrast, serine protease allergens Der p 3, 6 and 9 were downregulated, being trypsin and chymotrypsin enzymatic activities reduced up to 21% in extracts. None of the parameters analysed in our mouse model, nor binding to human IgE were significantly different when comparing control and infected-mite extracts. Despite the described physiological impact of viral infection on the mites, no significant consequences for the allergenicity of derived extracts or their practical use in allergy diagnosis have been detected.
    MeSH term(s) Mice ; Humans ; Animals ; Allergens/analysis ; Allergens/genetics ; Pyroglyphidae/metabolism ; Veterinary Drugs ; Hypersensitivity ; RNA Viruses/metabolism ; Immunoglobulin E
    Chemical Substances Allergens ; Veterinary Drugs ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2023-01-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 33602-6
    ISSN 1365-2583 ; 0962-1075
    ISSN (online) 1365-2583
    ISSN 0962-1075
    DOI 10.1111/imb.12822
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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Role of Monocytes/Macrophages in Covid-19 Pathogenesis: Implications for Therapy.

    Gómez-Rial, Jose / Rivero-Calle, Irene / Salas, Antonio / Martinón-Torres, Federico

    Infection and drug resistance

    2020  Volume 13, Page(s) 2485–2493

    Abstract: Emerging studies from SARS-CoV-2-infected patients indicate a preponderant role of monocytes/macrophages in the pathogenesis of this viral infection, in a similar way to that previously observed in other coronavirus outbreaks (SARS and MERS). The ... ...

    Abstract Emerging studies from SARS-CoV-2-infected patients indicate a preponderant role of monocytes/macrophages in the pathogenesis of this viral infection, in a similar way to that previously observed in other coronavirus outbreaks (SARS and MERS). The clinical presentation of severe patients resembles viral-associated hemophagocytic syndrome, a rare condition previously seen during lethal influenza pandemics and during previous SARS and MERS coronavirus outbreaks. SARS-CoV-2 infection triggers an over-exuberant inflammatory response due to the development of a cytokine storm and the depletion of the adaptative immune compartment, which may prelude sepsis in many cases. The present review summarizes past evidence on the role of monocytes/macrophages in previous coronavirus outbreaks and the emerging knowledge on their role in COVID-19 pathogenesis. Treatment strategies incorporating the blockade of migration and differentiation of monocyte-macrophage, such as granulocyte macrophage-colony stimulating factor inhibitors, might enhance the promising results seen so far with selective cytokine blockade.
    Keywords covid19
    Language English
    Publishing date 2020-07-22
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S258639
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  4. Article ; Online: RNA viruses alter house dust mite physiology and allergen production with no detected consequences for allergenicity

    Vidal‐Quist, José Cristian / Declercq, Jozefien / Vanhee, Stijn / Lambrecht, Bart N. / Gómez‐Rial, José / Vidal, Carmen / Aydogdu, Eylem / Rombauts, Stephane / Hernández‐Crespo, Pedro

    Insect Molecular Biology. 2023 Apr., v. 32, no. 2 p.173-186

    2023  

    Abstract: RNA viruses have recently been detected in association with house dust mites, including laboratory cultures, dust samples, and mite‐derived pharmaceuticals used for allergy diagnosis. This study aimed to assess the incidence of viral infection on ... ...

    Abstract RNA viruses have recently been detected in association with house dust mites, including laboratory cultures, dust samples, and mite‐derived pharmaceuticals used for allergy diagnosis. This study aimed to assess the incidence of viral infection on Dermatophagoides pteronyssinus physiology and on the allergenic performance of extracts derived from its culture. Transcriptional changes between genetically identical control and virus‐infected mite colonies were analysed by RNAseq with the support of a new D. pteronyssinus high‐quality annotated genome (56.8 Mb, 108 scaffolds, N50 = 2.73 Mb, 96.7% BUSCO‐completeness). Extracts of cultures and bodies from both colonies were compared by inspecting major allergen accumulation by enzyme‐linked immunosorbent assay (ELISA), allergen‐related enzymatic activities by specific assays, airway inflammation in a mouse model of allergic asthma, and binding to allergic patient's sera IgE by ImmunoCAP. Viral infection induced a significant transcriptional response, including several immunity and stress‐response genes, and affected the expression of seven allergens, putative isoallergens and allergen orthologs. Major allergens were unaffected except for Der p 23 that was upregulated, increasing ELISA titers up to 29% in infected‐mite extracts. By contrast, serine protease allergens Der p 3, 6 and 9 were downregulated, being trypsin and chymotrypsin enzymatic activities reduced up to 21% in extracts. None of the parameters analysed in our mouse model, nor binding to human IgE were significantly different when comparing control and infected‐mite extracts. Despite the described physiological impact of viral infection on the mites, no significant consequences for the allergenicity of derived extracts or their practical use in allergy diagnosis have been detected.
    Keywords Dermatophagoides pteronyssinus ; RNA ; allergenicity ; allergens ; asthma ; chymotrypsin ; drugs ; dust ; dust mites ; enzyme-linked immunosorbent assay ; genome ; humans ; immunity ; inflammation ; insects ; mice ; models ; molecular biology ; patients ; stress response ; transcription (genetics) ; trypsin
    Language English
    Dates of publication 2023-04
    Size p. 173-186.
    Publishing place John Wiley & Sons, Ltd.
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 33602-6
    ISSN 1365-2583 ; 0962-1075
    ISSN (online) 1365-2583
    ISSN 0962-1075
    DOI 10.1111/imb.12822
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

    Alberto Gómez-Carballa / María José Currás-Tuala / Sara Pischedda / Miriam Cebey-López / José Gómez-Rial / Irene Rivero-Calle / Jacobo Pardo-Seco / Xabier Bello / Sandra Viz-Lasheras / Antonio Justicia-Grande / Julián Montoto-Louzao / Alba Camino-Mera / Isabel Ferreirós-Vidal / Máximo Fraga / José R. Antúnez / Rodolfo Gómez / Federico Martinón-Torres / Antonio Salas

    Genes and Diseases, Vol 11, Iss 3, Pp 100981- (2024)

    2024  

    Keywords Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Language English
    Publishing date 2024-05-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia.

    Gómez-Carballa, Alberto / Currás-Tuala, María José / Pischedda, Sara / Cebey-López, Miriam / Gómez-Rial, José / Rivero-Calle, Irene / Pardo-Seco, Jacobo / Bello, Xabier / Viz-Lasheras, Sandra / Justicia-Grande, Antonio / Montoto-Louzao, Julián / Camino-Mera, Alba / Ferreirós-Vidal, Isabel / Fraga, Máximo / Antúnez, José R / Gómez, Rodolfo / Martinón-Torres, Federico / Salas, Antonio

    Genes & diseases

    2023  Volume 11, Issue 3, Page(s) 100981

    Language English
    Publishing date 2023-06-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2023.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Corrigendum: Case Report: Two Monochorionic Twins With a Critically Different Course of Progressive Osseous Heteroplasia.

    Justicia-Grande, Antonio José / Gómez-Ríal, Jose / Rivero-Calle, Irene / Pischedda, Sara / Curras-Tuala, María José / Gómez-Carballa, Alberto / Cebey-López, Miriam / Pardo-Seco, Jacobo / Méndez-Gallart, Roberto / Fernández-Seara, María José / Salas, Antonio / Martinón-Torres, Federico

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 807812

    Abstract: This corrects the article DOI: 10.3389/fped.2021.662669.]. ...

    Abstract [This corrects the article DOI: 10.3389/fped.2021.662669.].
    Language English
    Publishing date 2021-12-14
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.807812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Case Report: Two Monochorionic Twins With a Critically Different Course of Progressive Osseus Heteroplasia.

    Justicia-Grande, Antonio José / Gómez-Ríal, Jose / Rivero-Calle, Irene / Pischedda, Sara / Curras-Tuala, María José / Gómez-Carballa, Alberto / Cebey-López, Miriam / Pardo-Seco, Jacobo / Méndez-Gallart, Roberto / Fernández-Seara, María José / Salas, Antonio / Martinón-Torres, Federico

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 662669

    Abstract: Progressive osseous heteroplasia (POH; OMIM 166350) is a rare autosomal-dominant genetic disorder in which extra-skeletal bone forms within skin and muscle tissue. POH is one of the clinical manifestations of an inactivating mutation in ... ...

    Abstract Progressive osseous heteroplasia (POH; OMIM 166350) is a rare autosomal-dominant genetic disorder in which extra-skeletal bone forms within skin and muscle tissue. POH is one of the clinical manifestations of an inactivating mutation in the
    Language English
    Publishing date 2021-06-23
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.662669
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  9. Article ; Online: Host Transcriptomic Response Following Administration of Rotavirus Vaccine in Infants' Mimics Wild Type Infection.

    Gómez-Carballa, Alberto / Barral-Arca, Ruth / Cebey-López, Miriam / Currás-Tuala, Maria José / Pischedda, Sara / Gómez-Rial, José / Habgood-Coote, Dominic / Herberg, Jethro A / Kaforou, Myrsini / Martinón-Torres, Federico / Salas, Antonio

    Frontiers in immunology

    2021  Volume 11, Page(s) 580219

    Abstract: Background: Rotavirus (RV) is an enteric pathogen that has devastating impact on childhood morbidity and mortality worldwide. The immunologic mechanism underlying the protection achieved after RV vaccination is not yet fully understood.: Methods: We ... ...

    Abstract Background: Rotavirus (RV) is an enteric pathogen that has devastating impact on childhood morbidity and mortality worldwide. The immunologic mechanism underlying the protection achieved after RV vaccination is not yet fully understood.
    Methods: We compared the transcriptome of children affected by community-acquired RV infection and children immunized with a live attenuated RV vaccine (RotaTeq
    Results: RV vaccination mimics the wild type infection causing similar changes in children's transcriptome, including transcripts associated with cell cycle, diarrhea, nausea, vomiting, intussusception, and abnormal morphology of midgut. A machine learning approach allowed to detect a combination of nine-transcripts that differentiates vaccinated from convalescent-naturally infected children (AUC: 90%; 95%CI: 70-100) and distinguishes between acute-infected and healthy control children (in both cases, AUC: 100%; 95%CI: 100-100). We identified a miRNA hsa-mir-149 that seems to play a role in the host defense against viral pathogens and may have an antiviral role.
    Discussion: Our findings might shed further light in the understanding of RV infection, its functional link to intussusception causes, as well as guide development of antiviral treatments and safer and more effective vaccines. The nine-transcript signature may constitute a marker of vaccine protection and helps to differentiate vaccinated from naturally infected or susceptible children.
    MeSH term(s) Child ; Community-Acquired Infections/immunology ; Disease Resistance/genetics ; Humans ; Infant ; Machine Learning ; MicroRNAs/genetics ; Rotavirus/immunology ; Rotavirus Infections/immunology ; Rotavirus Vaccines/immunology ; Sequence Analysis, RNA ; Transcriptome ; Vaccination ; Vaccines, Attenuated/immunology
    Chemical Substances MIRN149 microRNA, human ; MicroRNAs ; RotaTeq ; Rotavirus Vaccines ; Vaccines, Attenuated
    Language English
    Publishing date 2021-01-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.580219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Vesp v 5 and glycosylated Vesp v 1 are relevant allergens in Vespa velutina nigrithorax anaphylaxis.

    Vidal, Carmen / Armisén, Margarita / Monsalve, Rafael / Gómez-Rial, Jose / González-Fernández, Teresa / Carballada, Francisco / Lombardero, Manuel / González-Quintela, Arturo

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2020  Volume 50, Issue 12, Page(s) 1424–1427

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Allergens/immunology ; Anaphylaxis/blood ; Anaphylaxis/diagnosis ; Anaphylaxis/immunology ; Animals ; Biomarkers/blood ; Female ; Glycosylation ; Humans ; Hyaluronoglucosaminidase/immunology ; Immunoglobulin E/blood ; Insect Bites and Stings/blood ; Insect Bites and Stings/diagnosis ; Insect Bites and Stings/immunology ; Insect Proteins/immunology ; Male ; Middle Aged ; Prospective Studies ; Wasp Venoms/immunology ; Young Adult
    Chemical Substances Allergens ; Biomarkers ; Insect Proteins ; Ves v 5 allergen ; Wasp Venoms ; Immunoglobulin E (37341-29-0) ; Hyaluronoglucosaminidase (EC 3.2.1.35) ; allergen Ves v 1 (EC 3.2.1.35)
    Language English
    Publishing date 2020-09-27
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.13738
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    In stock of ZB MED Cologne/Königswinter

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