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Article ; Online: Development of nanozyme based sensors as diagnostic tools in clinic applications: a review.

Waris / Hasnat, Abul / Hasan, Shumaila / Bano, Sayfa / Sultana, Saima / Ibhadon, Alex Omo / Khan, Mohammad Zain

2023 Volume 11, Issue 29, Page(s) 6762–6781

Abstract: Since 1970, many artificial enzymes that imitate the activity and structure of natural enzymes have been discovered. Nanozymes are a group of nanomaterials with enzyme-mimetic properties capable of catalyzing natural enzyme processes. Nanozymes have ... ...

Abstract	Since 1970, many artificial enzymes that imitate the activity and structure of natural enzymes have been discovered. Nanozymes are a group of nanomaterials with enzyme-mimetic properties capable of catalyzing natural enzyme processes. Nanozymes have attracted great interest in biomedicine due to their excellent stability, rapid reactivity, and affordable cost. The enzyme-mimetic activities of nanozymes may be modulated by numerous parameters, including the oxidative state of metal ions, pH, hydrogen peroxide (H
MeSH term(s)	Hydrogen Peroxide ; Nanostructures/chemistry ; Biomimetics ; Oxidation-Reduction
Chemical Substances	Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb00451a
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Article: Isolation, characterization and pharmacological potentials of methanol extract of

Taher, Mohammad Abdullah / Laboni, Aysha Akter / Islam, Md Ashraful / Hasnat, Hasin / Hasan, Mohammad Mahmudul / Ferdous, Jannatul / Shompa, Suriya Akter / Khan, Mala

Heliyon

2024 Volume 10, Issue 7, Page(s) e28460

Abstract: The purpose of the current investigation was to conduct a detailed analysis of the chemical components and medicinal properties of the methanolic crude extract derived from the leaves of Cassia fistula. This analysis was carried out using both ... ...

Abstract	The purpose of the current investigation was to conduct a detailed analysis of the chemical components and medicinal properties of the methanolic crude extract derived from the leaves of Cassia fistula. This analysis was carried out using both experimental (in vivo) and computational (in silico) methods. Eleven chemicals were chromatographically isolated using GC-MS/MS, which utilizes a library of NIST and Wiley 2020 versions. FTIR analysis of the extract was performed to identify the functional group of the compounds. The glucose-lowering capacity, analgesic, and anti-diarrheal activities of methanolic crude extract were analyzed utilizing a well-known oral glucose tolerance test, tail immersion method, writhing assay, and castor oil-induced diarrheal mice methods, respectively. After 60 min, 120 min, and 180 min of loading the drugs, a significant reduction of blood glucose levels was examined (p < 0.05) in all the extracts of this plant (200 mg/kg, 400 mg/kg and 600 mg/kg) utilized in this research at a time-dependent manner. Similarly, all the crude extracts showed significant (p < 0.05) effects against pain centrally and peripherally compared to the standard drug morphine (2 mg/kg bw) and diclofenac sodium (50 mg/kg bw). Moreover, the methanol extract (400 mg/kg bw) manifested anti-diarrheal efficacy by inhibiting 72.0 % of the diarrheal episode in mice compared to the standard drug loperamide (inhibition = 80.0%). The results of the computational investigations corroborated existing in-vivo findings. Greater or close to equivalent binding affinity to the active binding sites of kappa opioid receptor, glucose transporter 3 (GLUT 3), and cyclooxygenase 2 was indicative of the potential anti-diarrheal, hypoglycemic, and analgesic characteristics of the isolated compounds (COX-2). Moreover, anticancer and antimicrobial potentiality was also found impressive through evaluation of binding affinity with epidermal growth factor receptor (EGFR) and dihydrofolate reductase (DHFR) receptors. Results from this study indicated that C. fistula might be a beneficial natural resource for treating diarrhea, hyperglycemia, and pain. However, additional research is required to conduct a comprehensive phytochemical screening and establish precise action mechanisms of the crude extract or the plant-derived compounds.
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28460
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Article ; Online: Addressing antimicrobial resistance in low and middle-income countries: overcoming challenges and implementing effective strategies.

Rony, Moustaq Karim Khan / Sharmi, Priyanka Das / Alamgir, Hasnat M

Environmental science and pollution research international

2023 Volume 30, Issue 45, Page(s) 101896–101902

Abstract: Antimicrobial resistance (AMR) has become a critical worldwide health crisis. It poses major challenges for healthcare systems across the globe, demanding immediate attention and action. Low and middle-income countries (LMICs), in particular, encounter ... ...

Abstract	Antimicrobial resistance (AMR) has become a critical worldwide health crisis. It poses major challenges for healthcare systems across the globe, demanding immediate attention and action. Low and middle-income countries (LMICs), in particular, encounter unique obstacles in addressing AMR due to various factors. This article aims to examine specific challenges and propose effective strategies to combat this issue. Through a comprehensive review of existing literature, this article identifies common barriers and successful interventions in tackling AMR. The research highlights several challenges faced by LMICs in addressing AMR, including limited access to quality healthcare services, socioeconomic disparities, limited awareness, inadequate surveillance systems and data collection, limited regulatory frameworks and quality control, as well as weak healthcare infrastructure and infection prevention practices. The research suggests strategies like improving healthcare access, promoting responsible antimicrobial use, enhancing surveillance, ensuring quality antimicrobial drugs, and fostering global collaboration to address these challenges. By understanding the challenges encountered by LMICs, it is possible to mitigate the impact of AMR and contribute to global efforts in combating this growing threat.
Language	English
Publishing date	2023-08-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-29434-4
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Article ; Online: High temperatures on mental health: Recognizing the association and the need for proactive strategies-A perspective.

Rony, Moustaq Karim Khan / Alamgir, Hasnat M

Health science reports

2023 Volume 6, Issue 12, Page(s) e1729

Abstract: Background and aims: The influence of temperature on various aspects of daily life is often underestimated, and its effects on mental health are not widely recognized. Understanding and addressing the relationship between temperature and mental well- ... ...

Abstract	Background and aims: The influence of temperature on various aspects of daily life is often underestimated, and its effects on mental health are not widely recognized. Understanding and addressing the relationship between temperature and mental well-being is crucial in the context of climate change and rising global temperatures. This perspective aimed to investigate the effects of high temperatures on mental health and identify proactive strategies to mitigate these effects. Methods: This perspective adopted a twofold approach, including a comprehensive literature review and socioecological framework. The literature review involved extensive searches across Google Scholar, PubMed, and Scopus to identify relevant, peer-reviewed articles, and reports from diverse disciplines. Results: The perspective emphasized the significance of recognizing heat stress and its consequences on mental well-being. Chronic heat stress can lead to increased stress, anxiety, and cognitive impairment. Vulnerable populations include, the very young, older adults, and individuals with pre-existing mental health conditions. Socioeconomic factors can further exacerbate vulnerability, highlighting the need for tailored strategies to manage mental health challenges during high temperatures. Additionally, the article identified and discussed proactive coping strategies to minimize both the psychological and physical impacts of heat stress. Mindfulness, stress management techniques, and therapy are suggested as effective means for individuals to manage psychological distress. Conclusion: Implementing preventive measures are essential steps in promoting mental wellness in high temperatures. Proactive strategies by addressing the physiological and psychological effects of heat and considering the specific needs of vulnerable populations can help individuals and communities navigate the challenges posed by rising temperatures and promote resilience and preserve their mental well-being.
Language	English
Publishing date	2023-12-04
Publishing country	United States
Document type	Journal Article
ISSN	2398-8835
ISSN (online)	2398-8835
DOI	10.1002/hsr2.1729
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Article ; Online: The association between work-life imbalance, employees' unhappiness, work's impact on family, and family impacts on work among nurses

Moustaq Karim Khan Rony / Sharker Md. Numan / Hasnat M. Alamgir

Informatics in Medicine Unlocked, Vol 38, Iss , Pp 101226- (2023)

A Cross-sectional Study

2023

Abstract: Background: Work-life imbalance has been a growing issue globally particularly among healthcare workers including nurses as they must maintain a healthy work-life balance to deliver quality patient care-the primary objective of all healthcare ... ...

Abstract	Background: Work-life imbalance has been a growing issue globally particularly among healthcare workers including nurses as they must maintain a healthy work-life balance to deliver quality patient care-the primary objective of all healthcare organizations. Factors contributing to nurses' work-life imbalance have not been investigated well particularly in the Low-and-middle-income countries (LMIC) including Bangladesh. Aims: This study investigated the interrelationship of work-life imbalance, employee dissatisfaction, the impact of work on the family as well as the influence of family on work. Methods: This cross-sectional study was conducted among 656 nurses employed in various healthcare settings in Dhaka, Bangladesh using a convenient sampling technique. Face-to-face interviews were conducted between June 2 and December 15, 2022. Data were analyzed for descriptive and inferential statistics using STATA. This study adhered to Enhancing the Quality and Transparency of Health Research (EQUATOR) criteria. The probability of an event occurring and the correlations between predictive and outcome variables were determined using multivariate logistic regression. Results: Multinomial logistic regression revealed the highly influential parameters to work-life imbalance levels. The Pearson correlation showed the positive association between employees' unhappiness, family's negative impact on career, work's negative impact on family, and work-life imbalance. Conclusions: Maintaining nurses' work-life balance is critical in improving healthcare organizations' productivity, delivery of quality patient care and ensuring positive clinical outcomes.
Keywords	Work-life balance ; Work-life imbalance ; Work-family conflict ; Employee happiness ; Nurses ; Healthcare ; Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	300 ; 360
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Hollow Mesoporous Silica Nanoparticles for Dual Chemo-starvation Therapy of Hepatocellular Carcinoma.

Ullah, Aftab / Khan, Marina / Yibang, Zhang / Raza, Faisal / Hasnat, Muhammad / Cao, Jin / Qi, Xueyong / Hussain, Abid / Liu, Daojun

Pharmaceutical research

2023 Volume 40, Issue 9, Page(s) 2215–2228

Abstract: Purpose: This study aims at chemotherapy and starvation therapy of HCC via starvation and apoptosis.: Methods: Hollow mesoporous organosilica nanoparticles (HMONs) with the thioether-hybrid structure were developed using an organic/inorganic co- ... ...

Abstract	Purpose: This study aims at chemotherapy and starvation therapy of HCC via starvation and apoptosis. Methods: Hollow mesoporous organosilica nanoparticles (HMONs) with the thioether-hybrid structure were developed using an organic/inorganic co-templating assembly approach. Hydrofluoric acid was used to remove the internal MSN core for yielding large radial mesopores for loading drug cargos. The morphology and structure of NPs were determined using TEM and SEM. HMONs were stepwise surface modified with glucose oxidase (GOx), oxygen (O Results: The prepared NPs were spherical, hollow and mesoporous with excellent surface area and pore size distribution. The GOx-modified NPs exhibited excellent catalytic activity. The TSBRs showed better cytotoxicity and reduce the tumor size and weight. The NPs showed long-term safety in vivo. Conclusion: TSBRs destroyed cancer cells by starvation and chemotherapy in both in-vitro and in-vivo settings which demonstrates its anti-cancer potential.
MeSH term(s)	Mice ; Animals ; Carcinoma, Hepatocellular/drug therapy ; Drug Delivery Systems ; Silicon Dioxide/chemistry ; Hydrogen Peroxide ; Liver Neoplasms/drug therapy ; Nanoparticles/chemistry ; Doxorubicin/chemistry ; Porosity
Chemical Substances	Silicon Dioxide (7631-86-9) ; Hydrogen Peroxide (BBX060AN9V) ; Doxorubicin (80168379AG)
Language	English
Publishing date	2023-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	843063-9
ISSN	1573-904X ; 0724-8741 ; 0739-0742
ISSN (online)	1573-904X
ISSN	0724-8741 ; 0739-0742
DOI	10.1007/s11095-023-03599-6
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Article ; Online: Crosstalk between Sirtuins and Nrf2: SIRT1 activators as emerging treatment for diabetic neuropathy.

Patel, Shivangi / Khan, Hasnat / Majumdar, Anuradha

Metabolic brain disease

2022 Volume 37, Issue 7, Page(s) 2181–2195

Abstract: About 50% of the diabetic patients worldwide suffer from Diabetic peripheral neuropathy (DPN) which is characterized by chronic pain and loss of sensation, frequent foot ulcerations, and risk for amputation. Numerous factors like hyperglycemia, oxidative ...

Abstract	About 50% of the diabetic patients worldwide suffer from Diabetic peripheral neuropathy (DPN) which is characterized by chronic pain and loss of sensation, frequent foot ulcerations, and risk for amputation. Numerous factors like hyperglycemia, oxidative stress (OS), impaired glucose signaling, inflammatory responses, neuronal cell death are known to be the various mechanisms underlying DACD and DPN. Development of tolerance, insufficient and inadequate relief and potential toxicity of classical antinociceptives still remains a challenge in the clinical setting. Therefore, there is an emerging need for novel treatments which are both without any potential side effects as well as which focus more on the pathophysiological mechanisms underlying the disease. Also, sirtuins are known to deacetylate Nrf2 and contribute to its action of reducing ROS by generation of anti-oxidant enzymes. Therefore, targeting sirtuins could be a favourable therapeutic strategy to treat diabetic neuropathy by reducing ROS and thereby alleviating OS in DPN. In the present review, we outline the potential use of SIRT1 activators as therapeutic alternatives in treating DPN. We have tried to highlight how sirtuins are interlinked with Nrf2 and NF-κB and put forth how SIRT activators could serve as potential therapy for DPN.
MeSH term(s)	Humans ; Diabetic Neuropathies/drug therapy ; Diabetic Neuropathies/metabolism ; NF-E2-Related Factor 2/metabolism ; Sirtuin 1 ; NF-kappa B ; Antioxidants/therapeutic use ; Sirtuins/therapeutic use ; NAD/therapeutic use ; Reactive Oxygen Species ; Glucose ; Diabetes Mellitus
Chemical Substances	NF-E2-Related Factor 2 ; Sirtuin 1 (EC 3.5.1.-) ; NF-kappa B ; Antioxidants ; Sirtuins (EC 3.5.1.-) ; NAD (0U46U6E8UK) ; Reactive Oxygen Species ; Glucose (IY9XDZ35W2) ; SIRT1 protein, human (EC 3.5.1.-)
Language	English
Publishing date	2022-05-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	632824-6
ISSN	1573-7365 ; 0885-7490
ISSN (online)	1573-7365
ISSN	0885-7490
DOI	10.1007/s11011-022-00956-z
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Article: Inferior Vena Cava Thrombosis and Pulmonary Embolism in a Patient With Behcet Disease: A Rare Presentation.

Mushtaq, Muhammad Hamza / Ali Khan, Osama / Khan, Hasnat / Ikram, Muhammad Tabish / Tariq, Muhammad Danyal

Cureus

2023 Volume 15, Issue 8, Page(s) e44184

Abstract: Behcet syndrome is a systemic vasculitic syndrome. Vascular involvement in Behcet syndrome affects both arterial and venous vascular systems, contributing to significant morbidity and mortality. However, diagnosing vascular lesions can be challenging due ...

Abstract	Behcet syndrome is a systemic vasculitic syndrome. Vascular involvement in Behcet syndrome affects both arterial and venous vascular systems, contributing to significant morbidity and mortality. However, diagnosing vascular lesions can be challenging due to their resemblance to common vascular diseases, leading to potential misdiagnoses. This case report emphasizes the importance of recognizing atypical manifestations of this disease to ensure a prompt and accurate diagnosis. This case report describes a unique presentation of Behcet syndrome in a 23-year-old male patient who presented with per rectal bleeding, abdominal distension, right quadrant abdominal pain, pleuritic chest pain, and fever. The patient also reported a history of recurrent oral and genital ulcers, skin lesions, and a previous episode of dural venous sinus thrombosis. Extensive investigations revealed the involvement of the inferior vena cava and right hepatic vein, representing an atypical vascular manifestation of Behcet syndrome. Prompt diagnosis by a multidisciplinary team led to appropriate treatment with cyclophosphamide and steroids, resulting in the resolution of vascular thrombosis. In this particular case, the patient presented with involvement of the inferior vena cava and right hepatic vein, a rare and unusual manifestation of the disease. This case highlights the diverse nature of vascular complications in Behcet syndrome and underscores the importance of considering this diagnosis in patients with unexplained vascular abnormalities. Overall, this case report highlights the importance of considering Behcet syndrome in the differential diagnosis of patients with unexplained vascular manifestations. It also emphasizes the need for a comprehensive clinical evaluation and collaborative approach to ensure timely and effective management.
Language	English
Publishing date	2023-08-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.44184
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Article ; Online: Coping strategies that motivated frontline nurses while caring for the COVID-19 patients during the pandemic: A scoping review.

Rony, Moustaq Karim Khan / Islam, Kanika / Alamgir, Hasnat M

Journal of nursing management

2022 Volume 30, Issue 6, Page(s) 1881–1891

Abstract: Background: The world faced a great health crisis during the COVID-19 pandemic. Consequently, the health care providers struggled and faced tremendous difficulties in treating high-load critical patients. This was particularly true in low- and middle- ... ...

Abstract	Background: The world faced a great health crisis during the COVID-19 pandemic. Consequently, the health care providers struggled and faced tremendous difficulties in treating high-load critical patients. This was particularly true in low- and middle-income countries where the work and patient loads are always higher and nurses at the forefront must deal with emergencies while being at high risk of exposure. However, little is known about the survival strategies of frontline nurses as dealt with the pandemic. Objectives: This study catalogued the coping strategies of frontline nurses to deal with caring for the COVID-19 patients during the pandemic. Methods: The Arksey O'Malley framework was followed to conduct a scoping review. A systematic literature search was conducted using three databases: Google Scholar, Scopus and PubMed; and out of the 192 studies, 12 met the inclusion criteria set for this review study. Results: A total of 44 strategies were identified that motivated nurses to deal with the COVID-19 situation, and these strategies could be categorized into five main themes: nurses' self-strategies, nurses' strategies at the ethical level, employers' strategies, nursing leaders' strategies and supplementary strategies. Conclusions: The findings of this study will provide guidance for health care workers, employers, policymakers, regulators and other stakeholders to adopt and promote different strategies in managing difficult emergency situations in future. Implications for nursing management: This study emphasizes the importance of learning how to deal with adversity by health care workers and organizations in an emergency.
MeSH term(s)	Adaptation, Psychological ; COVID-19/epidemiology ; Health Personnel ; Humans ; Income ; Pandemics
Language	English
Publishing date	2022-05-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1162321-4
ISSN	1365-2834 ; 0966-0429
ISSN (online)	1365-2834
ISSN	0966-0429
DOI	10.1111/jonm.13644
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Article ; Online: Altitude-Related Venous Thrombosis With Heart Disease: An Updated Review.

Chaudhry, Waqar Arif Rasool / Ahmad, Binish Ayub / Waqas, Muhammad Saad / Khan, Junaid Raza / Khan, Malik Hasnat Ul Hassan / Khiyam, Umer / Malik, Jahanzeb

Current problems in cardiology

2023 Volume 49, Issue 1 Pt A, Page(s) 102018

Abstract: Altitude-related venous thrombosis (ARVT) is a condition of growing concern among individuals engaged in high-altitude travel and activities. This updated review explores the epidemiology, pathophysiological mechanisms, clinical presentations, and ... ...

Abstract	Altitude-related venous thrombosis (ARVT) is a condition of growing concern among individuals engaged in high-altitude travel and activities. This updated review explores the epidemiology, pathophysiological mechanisms, clinical presentations, and management of ARVT based on a thematic analysis and synthesis of the existing literature. ARVT's multifactorial etiology involves the interplay of hypobaric hypoxia and endothelial dysfunction, creating a procoagulant state and increasing the risk of thrombosis. Common clinical manifestations include pain, swelling, and redness in the extremities, necessitating accurate and timely diagnosis, particularly in remote settings. Thromboprophylaxis during high-altitude travel and activities plays a crucial role in reducing the risk of ARVT, while anticoagulation remains the mainstay of management. Further research is needed to optimize preventive and treatment strategies, enhancing patient outcomes and safety in high-altitude environments.
MeSH term(s)	Humans ; Altitude ; Anticoagulants/therapeutic use ; Risk Factors ; Venous Thromboembolism/etiology ; Venous Thrombosis/epidemiology ; Venous Thrombosis/etiology ; Venous Thrombosis/prevention & control ; Heart Diseases
Chemical Substances	Anticoagulants
Language	English
Publishing date	2023-08-05
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	441230-8
ISSN	1535-6280 ; 0146-2806
ISSN (online)	1535-6280
ISSN	0146-2806
DOI	10.1016/j.cpcardiol.2023.102018
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