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Book ; Online ; E-Book: Protocol handbook for cancer biology

Misra, Gauri / Rajawat, Jyotika

2021

Author's details	edited by Gauri Misra, Jyotika Rajawat
Keywords	Electronic books
Language	English
Size	1 Online-Ressource (xvii, 201 Seiten), Illustrationen, Diagramme
Publisher	Elsevier Academic Press
Publishing place	London
Publishing country	Great Britain
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020867140
ISBN	978-0-323-89817-1 ; 9780323900065 ; 0-323-89817-3 ; 0323900062
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: PARP inhibitor olaparib induced differential protein expression in cervical cancer cells.

Rajawat, Jyotika / Awasthi, Poorwa / Banerjee, Monisha

Journal of proteomics

2023 Volume 275, Page(s) 104823

Abstract: PARP inhibitors are a potential class of chemotherapeutic drugs but PARP inhibitor response has not been explored systematically. We lack a specific understanding of the subset of the proteome preferentially modified in various cancers by PARP inhibitors. ...

Abstract	PARP inhibitors are a potential class of chemotherapeutic drugs but PARP inhibitor response has not been explored systematically. We lack a specific understanding of the subset of the proteome preferentially modified in various cancers by PARP inhibitors. Implications of PARP inhibitor and PARP1 in cervical cancer treatment and resistance are not fully elucidated. We conducted a mass spectrometry-based proteomic analysis of cervical cancer Hela cells treated with olaparib. We aimed to identify the alteration in the protein signaling pathway induced by PARP inhibitors beyond the DNA damage response pathway. Our data demonstrate a significant reduction in PARP activity and enhanced cell death after olaparib treatment. We further observed articulated proteomic changes with a significant enrichment of proteins in diverse cellular processes. The differentially expressed proteins were predominantly associated with RNA metabolism, mRNA splicing, processing, and RNA binding. Our data also identified proteins that could probably contribute to survival mechanisms resulting in resistance to PARP inhibitors. Hence, we put forth the overview of proteomic changes induced by PARP inhibitor olaparib in cervical cancer cells. This study highlights the significant proteins modified during PARP inhibition and thus could be a probable target for combination therapies with PARP inhibitors in cervical cancer. SIGNIFICANCE.
MeSH term(s)	Female ; Humans ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Uterine Cervical Neoplasms/drug therapy ; HeLa Cells ; Proteomics ; Cell Line, Tumor ; Antineoplastic Agents/pharmacology ; RNA
Chemical Substances	Poly(ADP-ribose) Polymerase Inhibitors ; olaparib (WOH1JD9AR8) ; Antineoplastic Agents ; RNA (63231-63-0)
Language	English
Publishing date	2023-01-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2400835-7
ISSN	1876-7737 ; 1874-3919
ISSN (online)	1876-7737
ISSN	1874-3919
DOI	10.1016/j.jprot.2023.104823
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Article ; Online: WITHDRAWN: Therapeutic Targeted Approaches for Covid-19 Treatment

Rajawat, Jyotika / Misra, Gauri / Anvikar, Anup K / Era, Benedetta

Current pharmaceutical biotechnology

2022

Language	English
Publishing date	2022-03-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2132197-8
ISSN	1873-4316 ; 1389-2010
ISSN (online)	1873-4316
ISSN	1389-2010
DOI	10.2174/1389201023666220304163903
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Article ; Online: Skeletal Aging and Osteoporosis: Mechanisms and Therapeutics.

Chandra, Abhishek / Rajawat, Jyotika

International journal of molecular sciences

2021 Volume 22, Issue 7

Abstract: Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone homeostasis, which is maintained by an intricate balance between bone formation and bone resorption, undergoes deregulation. Oxidative stress-induced DNA damage, ... ...

Abstract	Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone homeostasis, which is maintained by an intricate balance between bone formation and bone resorption, undergoes deregulation. Oxidative stress-induced DNA damage, cellular apoptosis, and cellular senescence are all responsible for this tissue dysfunction and the imbalance in the bone homeostasis. These cellular mechanisms have become a target for therapeutics to treat age-related osteoporosis. Genetic mouse models have shown the importance of senescent cell clearance in alleviating age-related osteoporosis. Furthermore, we and others have shown that targeting cellular senescence pharmacologically was an effective tool to alleviate age- and radiation-induced osteoporosis. Senescent cells also have an altered secretome known as the senescence associated secretory phenotype (SASP), which may have autocrine, paracrine, or endocrine function. The current review discusses the current and potential pathways which lead to a senescence profile in an aged skeleton and how bone homeostasis is affected during age-related osteoporosis. The review has also discussed existing therapeutics for the treatment of osteoporosis and rationalizes for novel therapeutic options based on cellular senescence and the SASP as an underlying pathogenesis of an aging bone.
MeSH term(s)	Aging/physiology ; Animals ; Bone and Bones/physiology ; Bone and Bones/physiopathology ; Cellular Senescence ; DNA Damage ; Epigenesis, Genetic ; Genomic Instability ; Humans ; Mitochondria/genetics ; Mitochondria/metabolism ; Osteoporosis/drug therapy ; Osteoporosis/etiology ; Osteoporosis/physiopathology ; Parathyroid Hormone/metabolism ; Poly (ADP-Ribose) Polymerase-1/physiology ; Telomere/physiology
Chemical Substances	Parathyroid Hormone ; Poly (ADP-Ribose) Polymerase-1 (EC 2.4.2.30)
Language	English
Publishing date	2021-03-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22073553
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Article ; Online: Role of Poly(ADP-ribose) Polymerase (PARP1) in Viral Infection and its Implication in SARS-CoV-2 Pathogenesis.

Rajawat, Jyotika / Chandra, Abhishek

Current drug targets

2021 Volume 22, Issue 13, Page(s) 1477–1484

Abstract: Background: Activation of Poly (ADP-ribose) polymerase 1 (PARP1), a post-translational modifying enzyme, has been shown to be involved with several inflammatory and viral diseases.: Objectives: The goal of this review is to highlight the mechanisms ... ...

Abstract	Background: Activation of Poly (ADP-ribose) polymerase 1 (PARP1), a post-translational modifying enzyme, has been shown to be involved with several inflammatory and viral diseases. Objectives: The goal of this review is to highlight the mechanisms underlying PARP1 activation during viral or infectious pathogenesis and to assess potential possibilities of using PARP1 inhibitors as a therapeutic countering of SARS-CoV-2 virus. Methods: An extensive bibliographic search was done using Pubmed, Mendeley and google scholar with key words. Pre-prints are reported with potential caveats and studies without experimental data were excluded. Results: Covid-19, a global pandemic; is associated with systemic surge of inflammatory cytokines resulting in severe inflammation of the lung, heart dysfunction, ischemia, and stroke. PARP1 regulates expression of NFkB and downstream cytokine production and its inhibition is known to attenuate the expression of inflammatory cytokines. PARP1 and other PARP family members regulate viral infection, replication, and virulence. The literature clearly suggests that PARP1 plays an important role in host-pathogen interactions and pathogenesis, with pre-clinical and in vitro studies supporting the idea that PARP1 inhibition may negatively affect viability of several viruses including the replication of the SARS-CoV and SARS-CoV-2 virus. Conclusion: The current review discusses mechanisms of PARP1 activation during viral infection, inflammatory diseases, cytokine expression and possibility of PARP1 in regulating cytokine storm and hyper-inflammation seen with Covid-19. Additionally, in vitro studies showing the negative regulation of SARS-CoV-2 virus replication by PARP inhibitors indicates a potential therapeutic role of PARP inhibitors for Covid-19 or its variants.
MeSH term(s)	Animals ; COVID-19/drug therapy ; COVID-19/virology ; Cardiovascular Diseases/metabolism ; Humans ; Inflammation/drug therapy ; Inflammation/enzymology ; Lung Diseases/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Poly(ADP-ribose) Polymerases/immunology ; Poly(ADP-ribose) Polymerases/metabolism ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology ; SARS-CoV-2/metabolism
Chemical Substances	Poly(ADP-ribose) Polymerase Inhibitors ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30)
Language	English
Publishing date	2021-01-25
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2064859-5
ISSN	1873-5592 ; 1389-4501
ISSN (online)	1873-5592
ISSN	1389-4501
DOI	10.2174/1389450122666210120142746
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Article ; Online: Skeletal Aging and Osteoporosis

Abhishek Chandra / Jyotika Rajawat

International Journal of Molecular Sciences, Vol 22, Iss 3553, p

Mechanisms and Therapeutics

2021 Volume 3553

Abstract	Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone homeostasis, which is maintained by an intricate balance between bone formation and bone resorption, undergoes deregulation. Oxidative stress-induced DNA damage, cellular apoptosis, and cellular senescence are all responsible for this tissue dysfunction and the imbalance in the bone homeostasis. These cellular mechanisms have become a target for therapeutics to treat age-related osteoporosis. Genetic mouse models have shown the importance of senescent cell clearance in alleviating age-related osteoporosis. Furthermore, we and others have shown that targeting cellular senescence pharmacologically was an effective tool to alleviate age- and radiation-induced osteoporosis. Senescent cells also have an altered secretome known as the senescence associated secretory phenotype (SASP), which may have autocrine, paracrine, or endocrine function. The current review discusses the current and potential pathways which lead to a senescence profile in an aged skeleton and how bone homeostasis is affected during age-related osteoporosis. The review has also discussed existing therapeutics for the treatment of osteoporosis and rationalizes for novel therapeutic options based on cellular senescence and the SASP as an underlying pathogenesis of an aging bone.
Keywords	osteoporosis ; senescence ; SASP ; aging ; radiation ; senotherapeutic ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Present and future of artificial intelligence in dentistry.

Tandon, Divya / Rajawat, Jyotika

Journal of oral biology and craniofacial research

2020 Volume 10, Issue 4, Page(s) 391–396

Abstract: The last decennary has marked as the breakthrough in the advancement of technology with evolution of artificial intelligence, which is rapidly gaining the attention of researchers across the globe. Every field opted artificial intelligence with huge ... ...

Abstract	The last decennary has marked as the breakthrough in the advancement of technology with evolution of artificial intelligence, which is rapidly gaining the attention of researchers across the globe. Every field opted artificial intelligence with huge enthusiasm and so the field of dental science is no exception. With huge increases in patient documented information and data this is the need of the hour to use intelligent software to compile and save this data. From the basic step of taking a patient's history to data processing and then to extract the information from the data for diagnosis, artificial intelligence has many applications in dental and medical science. While in no case artificial intelligence can replace the role of a dental surgeon but it is important to be acquainted with the scope to amalgamate this advancement of technology in future for betterment of dental practice.
Language	English
Publishing date	2020-07-24
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2212-4268
ISSN	2212-4268
DOI	10.1016/j.jobcr.2020.07.015
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Article ; Online: Targeted inhibition of MASTL kinase activity induces apoptosis in breast cancer.

Misra, Gauri / Rajawat, Jyotika / Pal, Rajesh / Smith, Jeremy C / Kumar, Amit

Life sciences

2023 Volume 334, Page(s) 122250

Abstract: Microtubule-associated serine/threonine kinase-like (MASTL) (or Greatwall kinase (GWL)) is an important cell cycle regulating kinase that regulates the G2-M transition. Uncontrolled MASTL activity is implicated in breast cancer progression. To date, very ...

Abstract	Microtubule-associated serine/threonine kinase-like (MASTL) (or Greatwall kinase (GWL)) is an important cell cycle regulating kinase that regulates the G2-M transition. Uncontrolled MASTL activity is implicated in breast cancer progression. To date, very few inhibitors have been reported against this protein. Here, structure-based computational modeling indicates that the natural product flavopiridol (FLV) binds strongly to MASTL and these results are validated using molecular dynamics simulation studies. An in vitro kinase assay reveals an EC
MeSH term(s)	Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Microtubule-Associated Proteins/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Molecular Dynamics Simulation ; Apoptosis ; Cell Line, Tumor
Chemical Substances	Microtubule-Associated Proteins ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; MASTL protein, human (EC 2.7.11.1)
Language	English
Publishing date	2023-11-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2023.122250
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Article ; Online: Enhanced therapeutic efficacy of Piperlongumine for cancer treatment using nano-liposomes mediated delivery.

Parveen, Shama / Kumar, Saurabh / Pal, Sarita / Yadav, Narayan Prasad / Rajawat, Jyotika / Banerjee, Monisha

International journal of pharmaceutics

2023 Volume 643, Page(s) 123212

Abstract: Piperlongumine (PL) is a well-known bioactive alkaloid that has been reported as a potent anticancer molecule but has failed to provide potential activity in translational and clinical applications due to some drawbacks like low bioavailability, ... ...

Abstract	Piperlongumine (PL) is a well-known bioactive alkaloid that has been reported as a potent anticancer molecule but has failed to provide potential activity in translational and clinical applications due to some drawbacks like low bioavailability, hydrophobicity, and rapid degradation. However, nano-formulation is a good choice to increase the bioavailability and enhance cellular uptake of PL. In this study, PL loaded nano-liposomes (NPL) were formulated using the thin-film hydration method and analyzed by Response Surface Methodology (RSM) in order to treat cervical cancer. The NPL were thoroughly characterized using particle size, PDI, zeta potential, drug loading capacity, encapsulation efficiency, SEM, AFM and FTIR. Different assays viz. MTT, AO/PI, DAPI, MMP, cell migration, DCFDA and apoptotic assay using Annexin V-FITC/PI were performed for anticancer potential of NPL in human cervical carcinoma cells (SiHa and HeLa). NPL showed enhanced cytotoxicity, diminished cell proliferation, reduced cell viability, enhanced nuclear condensation, reduction in mitochondrial membrane potential, inhibited cell migration, increased ROS level and promoted more apoptosis in both human cervical cancer cell lines. These findings demonstrated that NPL may be a potential therapeutic option for cervical cancer.
MeSH term(s)	Female ; Humans ; Liposomes/pharmacology ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/pathology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Dioxolanes/pharmacology ; Apoptosis ; Cell Line, Tumor
Chemical Substances	Liposomes ; piperlongumine (SGD66V4SVJ) ; Antineoplastic Agents ; Dioxolanes
Language	English
Publishing date	2023-07-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2023.123212
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Article ; Online: Therapeutic natural compounds Enzastaurin and Palbociclib inhibit MASTL kinase activity preventing breast cancer cell proliferation.

Polisety, Aneesha / Misra, Gauri / Rajawat, Jyotika / Katiyar, Amit / Singh, Harpreet / Bhatt, Anant Narayan

Medical oncology (Northwood, London, England)

2022 Volume 39, Issue 5, Page(s) 100

Abstract: Microtubule-associated serine/threonine kinase-like (MASTL) regulates mitotic progression and is an attractive target for the development of new anticancer drugs. In this study, novel inhibitory molecules were screened against MASTL kinase, a protein ... ...

Abstract	Microtubule-associated serine/threonine kinase-like (MASTL) regulates mitotic progression and is an attractive target for the development of new anticancer drugs. In this study, novel inhibitory molecules were screened against MASTL kinase, a protein involved in cell proliferation in breast cancer. Natural source-derived drugs Enzastaurin and Palbociclib were selected to identify their role as MASTL kinase inhibitors. Cytotoxic activity, kinase activity, and other cell-based assays of Enzastaurin and Palbociclib were evaluated on human breast cancer (MCF-7) cells. The potential natural compounds caused cytotoxicity in MCF-7 cells in a dose- and time-dependent manner. Further analysis by Annexin V and PI staining indicated that both drugs are potent inducers of apoptosis. Enzastaurin induced G2/M phase arrest, while Palbociclib caused G1 arrest. MASTL kinase activity was significantly abrogated with both the compounds showing EC
MeSH term(s)	Apoptosis ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Cell Proliferation ; Female ; Humans ; Indoles ; Microtubule-Associated Proteins/metabolism ; Microtubule-Associated Proteins/therapeutic use ; Piperazines ; Protein Serine-Threonine Kinases ; Pyridines
Chemical Substances	Indoles ; Microtubule-Associated Proteins ; Piperazines ; Pyridines ; MASTL protein, human (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; palbociclib (G9ZF61LE7G) ; enzastaurin (UC96G28EQF)
Language	English
Publishing date	2022-05-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-022-01701-3
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