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Article ; Online: Jiao-Tai-Wan Ameliorates Depressive-Like Behavior through the A

Xiang, Lina / Feng, Yuan / Hu, Qianqian / Zhu, Jiahui / Ye, Ren / Yuan, Zhengzhong

2020 Volume 2020, Page(s) 1507561

Abstract: Objective: This study was aimed at observing the effect Jiao-Tai-Wan in menopausal depression ...

Abstract	Objective: This study was aimed at observing the effect Jiao-Tai-Wan in menopausal depression. Methods: In this paper, we used ovariectomized mice subjected to chronic unpredictable stress as a menopausal depression model. After the chronic stress, mice were administrated with JTW (3.3 and 6.6mg/kg) and imipramine (10 mg/kg) for 14 days. On the 14th day, mice were subjected to the behavior test like the forced swim test, tail suspension test, and locomotor activity or were sacrificed to assess the protein changes in different brain regions. Results: The administration of JTW at doses of 3.3 and 6.6mg/kg (p.o.) significantly shortened the duration of immobility in forced swim and tail suspension tests. There was no obvious difference in locomotor activity among all the groups. The western blot analysis data indicated that treatment with JTW (3.3 and 6.6 mg/kg, p.o.) prominently increased the A Conclusion: Our findings suggest that JTW plays a vital role in ameliorating menopausal depression symptoms in the A
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Depression/drug therapy ; Depression/metabolism ; Depressive Disorder/drug therapy ; Depressive Disorder/metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Female ; Hindlimb Suspension/physiology ; Hippocampus/drug effects ; Hippocampus/metabolism ; Imipramine/pharmacology ; Locomotion/drug effects ; MAP Kinase Signaling System/drug effects ; Mice ; Mice, Inbred ICR ; Ovariectomy/methods ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; Stress, Psychological/drug therapy ; Stress, Psychological/metabolism ; Swimming/physiology
Chemical Substances	Drugs, Chinese Herbal ; jiao tai wan ; Imipramine (OGG85SX4E4)
Language	English
Publishing date	2020-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2020/1507561
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Digestive promoting effect and mechanism of Jiao Sanxian in rats.

Liu, Ying / Liao, Wenting / Liu, Xingran / Hu, Yunwei / Zhu, Xiaoxia / Ju, Longtao / Feng, Feng / Qu, Wei / Liu, Wenyuan / Xu, Jian

Journal of ethnopharmacology

2021 Volume 278, Page(s) 114334

Abstract: Ethnopharmacological relevance: Jiao Sanxian, a customary term for the three ... This prescription is called "Jiao Sanxian" in China because people believe that it is a miracle medicine ... for enhancing digestion and improving stagnation of digestive system. Even though Jiao Sanxian is widely used ...

Abstract	Ethnopharmacological relevance: Jiao Sanxian, a customary term for the three Traditional Chinese Medicines of charred hawthorn (Crataegi Fructus), charred malt (Hordei Fructus Germinatus) and Liu Shenqu (Massa Medicata Fermentata), is a classic prescription for the treatment of functional dyspepsia (FD). This prescription is called "Jiao Sanxian" in China because people believe that it is a miracle medicine for enhancing digestion and improving stagnation of digestive system. Even though Jiao Sanxian is widely used in clinical treatment, the underlying mechanism has not been clarified to date. Aim of the study: The present study is aimed to explore the efficacy and mechanism of Jiao Sanxian in improving the symptoms of FD in rats by using multiple pharmacological methods. Materials and methods: The Sprague Dawley (SD) rats were divided into control, model, Jiao Sanxian decoction low-dosage (JSXD LD), Jiao Sanxian decoction medium-dosage (JSXD MD), and Jiao Sanxian decoction high-dosage (JSXD HD) group at random. A FD model was established with reserpine, and animals were given intragastric administration. During this period, weight and food intake of animals were recorded. Samples of rat gastric antrum, spleen, and duodenum were collected for pathological staining and immunohistochemical determination of Ghrelin protein expression after 19 days of treatment. Enzyme-linked immunosorbent assay (ELISA) was used to determine the concentration of related brain gut peptides in serum. Moreover, 16S rRNA sequencing was used to valuate the influence of intestinal flora structure of the cecal contents of experimental rats. And plasma metabolomics by Ultra Performance Liquid Chromatography coupled with Quadrupole-Time-of-Flight mass spectrometry (UPLC-Q/TOF-MS) were performed to further reveal the mechanism of action. Results: Jiao Sanxian decoction (JSXD) group with different dosage could increase body weight and food intake, improve histopathological changes, and alter disordered brain gut peptides in FD rats. 16S rRNA sequencing results described that JSXD improved the disorder of structural composition, biodiversity and function of gut microbiota in FD rats. Metabolomics illustrated 26 metabolites with JSXD treatment underwent continuous changes, which revealed JSXD might exert digestive effect by ameliorating abnormal metabolic pathways. The most relevant metabolic pathways were arachidonic acid metabolism, pyruvate metabolism, glycerophospholipid metabolism, alanine, aspartate and glutamate metabolism. Conclusions: JSXD can improve functional dyspepsia in rats and the mechanism is related to regulate secretion of brain gut peptides, significantly improve the disorder of intestinal flora and ameliorated multi-metabolic pathways.
MeSH term(s)	Animals ; Body Weight/drug effects ; Drugs, Chinese Herbal/pharmacology ; Dyspepsia/drug therapy ; Feeding Behavior/drug effects ; Gastrointestinal Microbiome/drug effects ; Gene Expression Regulation/drug effects ; Male ; Metabolomics ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Stomach/drug effects
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2021-06-12
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114334
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Article ; Online: Serum from Jiao-Tai-Wan treated rats increases glucose consumption by 3T3-L1 adipocytes through AMPK pathway signaling.

Yuan, Lin / Tang, Peng / Li, Hui-Jiao / Hu, Na / Zhong, Xiao-Yu / Lin, Min / Sun, Yin-Qiang / Lu, Min / Lu, Xiong

Bioscience reports

2019 Volume 39, Issue 4

Abstract: Type 2 diabetes (T2DM) is characterized by hyperglycemia resulting from insulin resistance. Jiao ...

Abstract	Type 2 diabetes (T2DM) is characterized by hyperglycemia resulting from insulin resistance. Jiao-Tai-Wan (JTW), a traditional Chinese medicine consisting of a 10:1 formulation of
MeSH term(s)	3T3 Cells ; AMP-Activated Protein Kinases/antagonists & inhibitors ; AMP-Activated Protein Kinases/metabolism ; Adipocytes/metabolism ; Animals ; Cell Line ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/pathology ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Glucose/metabolism ; Glucose Transporter Type 4/metabolism ; Hyperglycemia/drug therapy ; Hyperglycemia/pathology ; Hypoglycemic Agents/pharmacology ; Insulin Resistance/physiology ; Male ; Mice ; Rats ; Serum/chemistry
Chemical Substances	Drugs, Chinese Herbal ; Glucose Transporter Type 4 ; Hypoglycemic Agents ; Slc2a4 protein, mouse ; jiao tai wan ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2019-04-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	764946-0
ISSN	1573-4935 ; 0144-8463
ISSN (online)	1573-4935
ISSN	0144-8463
DOI	10.1042/BSR20181286
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Zs.A 1676: Show issues

Location:
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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Digestive promoting effect and mechanism of Jiao Sanxian in rats

Liu, Ying / Liao, Wenting / Liu, Xingran / Hu, Yunwei / Zhu, Xiaoxia / Ju, Longtao / Feng, Feng / Qu, Wei / Liu, Wenyuan / Xu, Jian

Journal of ethnopharmacology. 2021 Oct. 05, v. 278

2021

Abstract: Jiao Sanxian, a customary term for the three Traditional Chinese Medicines of charred hawthorn ... a classic prescription for the treatment of functional dyspepsia (FD). This prescription is called “Jiao ... improving stagnation of digestive system. Even though Jiao Sanxian is widely used in clinical treatment ...

Abstract	Jiao Sanxian, a customary term for the three Traditional Chinese Medicines of charred hawthorn (Crataegi Fructus), charred malt (Hordei Fructus Germinatus) and Liu Shenqu (Massa Medicata Fermentata), is a classic prescription for the treatment of functional dyspepsia (FD). This prescription is called “Jiao Sanxian” in China because people believe that it is a miracle medicine for enhancing digestion and improving stagnation of digestive system. Even though Jiao Sanxian is widely used in clinical treatment, the underlying mechanism has not been clarified to date.The present study is aimed to explore the efficacy and mechanism of Jiao Sanxian in improving the symptoms of FD in rats by using multiple pharmacological methods.The Sprague Dawley (SD) rats were divided into control, model, Jiao Sanxian decoction low-dosage (JSXD LD), Jiao Sanxian decoction medium-dosage (JSXD MD), and Jiao Sanxian decoction high-dosage (JSXD HD) group at random. A FD model was established with reserpine, and animals were given intragastric administration. During this period, weight and food intake of animals were recorded. Samples of rat gastric antrum, spleen, and duodenum were collected for pathological staining and immunohistochemical determination of Ghrelin protein expression after 19 days of treatment. Enzyme-linked immunosorbent assay (ELISA) was used to determine the concentration of related brain gut peptides in serum. Moreover, 16S rRNA sequencing was used to valuate the influence of intestinal flora structure of the cecal contents of experimental rats. And plasma metabolomics by Ultra Performance Liquid Chromatography coupled with Quadrupole-Time-of-Flight mass spectrometry (UPLC-Q/TOF-MS) were performed to further reveal the mechanism of action.Jiao Sanxian decoction (JSXD) group with different dosage could increase body weight and food intake, improve histopathological changes, and alter disordered brain gut peptides in FD rats. 16S rRNA sequencing results described that JSXD improved the disorder of structural composition, biodiversity and function of gut microbiota in FD rats. Metabolomics illustrated 26 metabolites with JSXD treatment underwent continuous changes, which revealed JSXD might exert digestive effect by ameliorating abnormal metabolic pathways. The most relevant metabolic pathways were arachidonic acid metabolism, pyruvate metabolism, glycerophospholipid metabolism, alanine, aspartate and glutamate metabolism.JSXD can improve functional dyspepsia in rats and the mechanism is related to regulate secretion of brain gut peptides, significantly improve the disorder of intestinal flora and ameliorated multi-metabolic pathways.
Keywords	Crataegus ; alanine ; arachidonic acid ; aspartic acid ; biodiversity ; blood serum ; body weight ; brain ; digestion ; duodenum ; enzyme-linked immunosorbent assay ; food intake ; ghrelin ; glutamic acid ; glycerophospholipids ; histopathology ; immunohistochemistry ; indigestion ; intestinal microorganisms ; intragastric administration ; malt ; mass spectrometry ; metabolites ; metabolomics ; models ; people ; protein synthesis ; pyruvic acid ; rats ; reserpine ; secretion ; spleen ; ultra-performance liquid chromatography ; China
Language	English
Dates of publication	2021-1005
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114334
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Jiao-tai-wan for insomnia symptoms caused by the disharmony of the heart and kidney

Congcong Zeng / Xi Liu / Lufeng Hu / Yuan Feng / Nengzhi Xia / Haihuan Zeng / Lin Luo / Ren Ye / Zhengzhong Yuan

Trials, Vol 21, Iss 1, Pp 1-

a study protocol for a randomized, double-blind, placebo-controlled trial

2020 Volume 9

Abstract: ... treatment strategies are scarce. The purpose of this study is to explore the efficacy and safety of Jiao-tai ...

Abstract	Abstract Background Insomnia seriously affects people’s normal lives and work. However, effective treatment strategies are scarce. The purpose of this study is to explore the efficacy and safety of Jiao-tai-wan (JTW) for ameliorating insomnia symptoms caused by disharmony of the heart and kidney. Design This is a randomized, double-blind, placebo-controlled pilot clinical trial. A total of 124 participants suffering from insomnia symptoms will be randomly assigned to the JTW or placebo group in an equal ratio. The participants will be asked to take JTW or placebo granules twice a day for 1 week. All data will be gathered at baseline and at the end of the drug intervention. The primary outcome measures will be the mean change in the Pittsburgh Sleep Quality Index (PSQI) from baseline to the end of the drug intervention. Secondary outcome measures will include the altered sleep parameters in polysomnography, 1H-magnetic resonance spectroscopy (1H-MRS) evaluation, the Disharmony of Heart and Kidney Scoring System score, and blood tests, including the levels of serum adenosine and melatonin. A laboratory test will be taken before and after treatment to assess the safety of JTW. Discussion The outcomes of this study will confirm the efficacy of JTW for the treatment of insomnia symptoms and will also be used to monitor the safety of JTW. Trial registration Chinese Clinical Trial Registry, ChiCTR1 800019239 . Registered on 1st November 2018.
Keywords	Jiao-tai-wan ; Insomnia ; Traditional herbal medicine ; Randomized controlled trial ; Study protocol ; Pattern identification ; Medicine (General) ; R5-920
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Jiao-tai-wan for insomnia symptoms caused by the disharmony of the heart and kidney: a study protocol for a randomized, double-blind, placebo-controlled trial.

Zeng, Congcong / Liu, Xi / Hu, Lufeng / Feng, Yuan / Xia, Nengzhi / Zeng, Haihuan / Luo, Lin / Ye, Ren / Yuan, Zhengzhong

Trials

2020 Volume 21, Issue 1, Page(s) 408

Abstract: ... treatment strategies are scarce. The purpose of this study is to explore the efficacy and safety of Jiao-tai ...

Abstract	Background: Insomnia seriously affects people's normal lives and work. However, effective treatment strategies are scarce. The purpose of this study is to explore the efficacy and safety of Jiao-tai-wan (JTW) for ameliorating insomnia symptoms caused by disharmony of the heart and kidney. Design: This is a randomized, double-blind, placebo-controlled pilot clinical trial. A total of 124 participants suffering from insomnia symptoms will be randomly assigned to the JTW or placebo group in an equal ratio. The participants will be asked to take JTW or placebo granules twice a day for 1 week. All data will be gathered at baseline and at the end of the drug intervention. The primary outcome measures will be the mean change in the Pittsburgh Sleep Quality Index (PSQI) from baseline to the end of the drug intervention. Secondary outcome measures will include the altered sleep parameters in polysomnography, Discussion: The outcomes of this study will confirm the efficacy of JTW for the treatment of insomnia symptoms and will also be used to monitor the safety of JTW. Trial registration: Chinese Clinical Trial Registry, ChiCTR1800019239. Registered on 1st November 2018.
MeSH term(s)	Adolescent ; Adult ; Double-Blind Method ; Drugs, Chinese Herbal/adverse effects ; Female ; Heart Diseases/complications ; Humans ; Kidney Diseases/complications ; Male ; Middle Aged ; Phytotherapy/methods ; Polysomnography ; Randomized Controlled Trials as Topic ; Sleep/drug effects ; Sleep Initiation and Maintenance Disorders/etiology ; Sleep Initiation and Maintenance Disorders/therapy ; Treatment Outcome ; Young Adult
Chemical Substances	Drugs, Chinese Herbal ; jiao tai wan
Language	English
Publishing date	2020-05-15
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1468-6708
ISSN (online)	1745-6215 ; 1468-6694
ISSN	1468-6708
DOI	10.1186/s13063-020-04299-x
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Article ; Online: Jiao-Tai-Wan Ameliorates Depressive-Like Behavior through the A1R Pathway in Ovariectomized Mice after Unpredictable Chronic Stress

Lina Xiang / Yuan Feng / Qianqian Hu / Jiahui Zhu / Ren Ye / Zhengzhong Yuan

BioMed Research International, Vol

2020 Volume 2020

Abstract: Objective. This study was aimed at observing the effect Jiao-Tai-Wan in menopausal depression ...

Abstract	Objective. This study was aimed at observing the effect Jiao-Tai-Wan in menopausal depression. Methods. In this paper, we used ovariectomized mice subjected to chronic unpredictable stress as a menopausal depression model. After the chronic stress, mice were administrated with JTW (3.3 and 6.6mg/kg) and imipramine (10 mg/kg) for 14 days. On the 14th day, mice were subjected to the behavior test like the forced swim test, tail suspension test, and locomotor activity or were sacrificed to assess the protein changes in different brain regions. Results. The administration of JTW at doses of 3.3 and 6.6mg/kg (p.o.) significantly shortened the duration of immobility in forced swim and tail suspension tests. There was no obvious difference in locomotor activity among all the groups. The western blot analysis data indicated that treatment with JTW (3.3 and 6.6 mg/kg, p.o.) prominently increased the A1R protein and the downstream protein ERK1/2 levels in the prefrontal cortex and hippocampus. However, the administration of JTW did not influence c-Fos protein in either the prefrontal cortex or hippocampus. Conclusion. Our findings suggest that JTW plays a vital role in ameliorating menopausal depression symptoms in the A1R-ERK1/2 pathway in the prefrontal cortex and hippocampus.
Keywords	Medicine ; R
Subject code	150
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction: Zhang, G.; Cheng, G.; Jia, P.; Jiao, S.; Feng, C.; Hu, T.; Liu, H.; Du, Y. The Positive Correlation of the Enhanced Immune Response to PCV2 Subunit Vaccine by Conjugation of Chitosan Oligosaccharide with the Deacetylation Degree. Marine Drugs 2017, 15, 236.

Zhang, Guiqiang / Cheng, Gong / Jia, Peiyuan / Jiao, Siming / Feng, Cui / Hu, Tao / Liu, Hongtao / Du, Yuguang

Marine drugs

2017 Volume 15, Issue 9

Abstract: The authors wish to correct Figure 1 in this paper [1] to be as follows:[ ... ]. ...

Abstract	The authors wish to correct Figure 1 in this paper [1] to be as follows:[...].
Language	English
Publishing date	2017-09-20
Publishing country	Switzerland
Document type	Journal Article ; Published Erratum
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md15090292
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Book: Wan qing shi qi de wai jiao ren wu he wai jiao si xiang

Hu, Daicong

2012

Author's details	Hu dai cong zhu
Keywords	Diplomats ; China
Language	Chinese
Size	11, 229 p, ill., ports, 21 cm
Edition	Di 1 ban
Publisher	Shi jie zhi shi chu ban she
Publishing place	Bei jing
Document type	Book
Note	Includes bibliographical references
ISBN	7501242429 ; 9787501242429
Database	Former special subject collection: coastal and deep sea fishing

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Book: Zhong ji han yu ting shuo jiao cheng

Hu, Xiaoqing

2008

Author's details	Hu Xiaoqing
Language	Chinese ; English
Publisher	Beijing da xue chu ban she
Publishing place	Beijing
Document type	Book
Database	Former special subject collection: coastal and deep sea fishing

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