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Article ; Online: Transcriptional and epigenetic regulation in thymic epithelial cells.

Martinez-Ruíz, Gustavo Ulises / Morales-Sánchez, Abigail / Bhandoola, Avinash

2021 Volume 305, Issue 1, Page(s) 43–58

Abstract: The thymus is required for the development of both adaptive and innate-like T cell subsets. There is keen interest in manipulating thymic function for therapeutic purposes in circumstances of autoimmunity, immunodeficiency, and for purposes of ... ...

Abstract	The thymus is required for the development of both adaptive and innate-like T cell subsets. There is keen interest in manipulating thymic function for therapeutic purposes in circumstances of autoimmunity, immunodeficiency, and for purposes of immunotherapy. Within the thymus, thymic epithelial cells play essential roles in directing T cell development. Several transcription factors are known to be essential for thymic epithelial cell development and function, and a few transcription factors have been studied in considerable detail. However, the role of many other transcription factors is less well understood. Further, it is likely that roles exist for other transcription factors not yet known to be important in thymic epithelial cells. Recent progress in understanding of thymic epithelial cell heterogeneity has provided some new insight into transcriptional requirements in subtypes of thymic epithelial cells. However, it is unknown whether progenitors of thymic epithelial cells exist in the adult thymus, and consequently, developmental relationships linking putative precursors with differentiated cell types are poorly understood. While we do not presently possess a clear understanding of stage-specific requirements for transcription factors in thymic epithelial cells, new single-cell transcriptomic and epigenomic technologies should enable rapid progress in this field. Here, we review our current knowledge of transcription factors involved in the development, maintenance, and function of thymic epithelial cells, and the mechanisms by which they act.
MeSH term(s)	Cell Differentiation ; Epigenesis, Genetic ; Epithelial Cells/physiology ; Humans ; T-Lymphocyte Subsets/metabolism ; Thymus Gland ; Transcription Factors/genetics
Chemical Substances	Transcription Factors
Language	English
Publishing date	2021-11-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	391796-4
ISSN	1600-065X ; 0105-2896
ISSN (online)	1600-065X
ISSN	0105-2896
DOI	10.1111/imr.13034
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Book ; Online: Compilado de proyectos de investigación científica empresarial : semana de la ciencia, la tecnología, la innovación y el emprendimiento

Mendoza Sánchez, Bernardo / Linero Meléndez, Carlos Manuel / Cárdenas Cantillo, Ingrid / Silva Tapias, Leonel / Ruiz Sánchez, Edier Alejandro / Villamil Villadiego, Graciela Esther / Guzman, Kedyn / Callejas Porto, Marcela / Calabria López, Marlon Antonio / Molina, William / Martínez Espeleta, Gustavo Rafael / Martínez T, Juan Carlos / Martínez Torres, Diana Carolina / Redondo Ochoa, Wendy / Towers, Walter / Galiano, Jossi / Martínez Juvene, Johanna / Betancourt Rodríguez, Libnazaret / Cortés Bracho, Oriana /

Martínez Torres, Juan Carlos / Martínez Torres, Juan Carlos

2023

Keywords	YQV ; Marketing ; Research ; Technological innovations ; Social entrepreneurship ; Rural development projects ; Industrial project management ; Small and medium-sized companies
Language	Spanish
Size	1 electronic resource (21 pages pages)
Publisher	Corporación Universitaria Americana
Publishing place	Barranquilla
Document type	Book ; Online
Note	Spanish
HBZ-ID	HT030380835
ISBN	9789585169531 ; 9585169533
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Roles Played by YY1 in Embryonic, Adult and Cancer Stem Cells.

Martinez-Ruiz, Gustavo Ulises / Morales-Sanchez, Abigail / Pacheco-Hernandez, Angel Francisco

Stem cell reviews and reports

2021 Volume 17, Issue 5, Page(s) 1590–1606

Abstract: Accumulating evidence strongly indicates that the presence of cancer stem cells (CSCs) leads to the emergence of worse clinical scenarios, such as chemo- and radiotherapy resistance, metastasis, and cancer recurrence. CSCs are a highly tumorigenic ... ...

Abstract	Accumulating evidence strongly indicates that the presence of cancer stem cells (CSCs) leads to the emergence of worse clinical scenarios, such as chemo- and radiotherapy resistance, metastasis, and cancer recurrence. CSCs are a highly tumorigenic population characterized by self-renewal capacity and differentiation potential. Thus, CSCs establish a hierarchical intratumor organization that enables tumor adaptation to evade the immune response and resist anticancer therapy. YY1 functions as a transcription factor, RNA-binding protein, and 3D chromatin regulator. Thus, YY1 has multiple effects and regulates several molecular processes. Emerging evidence indicates that the development of lethal YY1-mediated cancer phenotypes is associated with the presence of or enrichment in cancer stem-like cells. Therefore, it is necessary to investigate whether and to what extent YY1 regulates the CSC phenotype. Since CSCs mirror the phenotypic behavior of stem cells, we initially describe the roles played by YY1 in embryonic and adult stem cells. Next, we scrutinize evidence supporting the contributions of YY1 in CSCs from a number of various cancer types. Finally, we identify new areas for further investigation into the YY1-CSCs axis, including the participation of YY1 in the CSC niche.
MeSH term(s)	Carcinogenesis/pathology ; Humans ; Neoplasm Recurrence, Local/pathology ; Neoplastic Stem Cells/metabolism ; Transcription Factors/metabolism ; YY1 Transcription Factor/genetics ; YY1 Transcription Factor/metabolism
Chemical Substances	Transcription Factors ; YY1 Transcription Factor ; YY1 protein, human
Language	English
Publishing date	2021-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2495577-2
ISSN	2629-3277 ; 1558-6804 ; 1550-8943
ISSN (online)	2629-3277 ; 1558-6804
ISSN	1550-8943
DOI	10.1007/s12015-021-10151-9
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Article ; Online: Interposition Arthroplasty in Untreated Chronic Dislocation of the Elbow.

Tafoya-Arreguín, Gustavo Armando / Castillo-González, José Rene / Pellegrini-Verduzco, Irydia-Guadalupe / Martínez-Ruíz, José de Jesús / Esqueda-Godoy, Rubén Daniel / Arce-Rosas, Jorge Iván

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews

2022 Volume 6, Issue 5

Abstract: Objective: To describe the clinical outcomes of interposition arthroplasty with transposition of the medial epicondyle to the coronoid process and articulated external fixation in patients with untreated chronic dislocation of the elbow.: Methods: ... ...

Abstract	Objective: To describe the clinical outcomes of interposition arthroplasty with transposition of the medial epicondyle to the coronoid process and articulated external fixation in patients with untreated chronic dislocation of the elbow. Methods: Fourteen consecutive patients diagnosed with untreated chronic elbow dislocation performed a complete radiological and physical examination. The same surgeon treated all patients with a same technique. Passive mobilization started immediately in addition to the vigorous care of the surgical wound and surrounding skin. Results: A total of 14 patients were treated, with a mean age of 31 years, with the nondominant side being the most affected (65%). In the immediate postoperative period, the initial Mayo Elbow Performance Score was 60 pts. In all cases, the distraction from the articulated fixator was removed, and there was an average of 16 pts improvement at the time of removal. A hinged elbow orthosis was placed for 4 weeks starting strengthening and obtained radiographic integration of the neocoronoids; ranges of motion of flexion 122°, extension -6°, and pronosupination 70°, without data of any direction instability. Conclusion: Considering that this is one of the longest series with a follow-up of more than 60 months of evolution in our patients, the result is completely satisfactory, achieving the objective of a minimum range of motion of 100° in addition to elbow stability.
MeSH term(s)	Adult ; Arthroplasty/methods ; Elbow/surgery ; Elbow Joint/diagnostic imaging ; Elbow Joint/surgery ; External Fixators ; Humans ; Joint Dislocations/diagnostic imaging ; Joint Dislocations/surgery ; Treatment Outcome
Language	English
Publishing date	2022-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2898328-2
ISSN	2474-7661 ; 1067-151X
ISSN (online)	2474-7661
ISSN	1067-151X
DOI	10.5435/JAAOSGlobal-D-21-00034
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Article ; Online: Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut.

Das, Arundhoti / Martinez-Ruiz, Gustavo Ulises / Bouladoux, Nicolas / Stacy, Apollo / Moraly, Josquin / Vega-Sendino, Maria / Zhao, Yongge / Lavaert, Marieke / Ding, Yi / Morales-Sanchez, Abigail / Harly, Christelle / Seedhom, Mina O / Chari, Raj / Awasthi, Parirokh / Ikeuchi, Tomoko / Wang, Yueqiang / Zhu, Jinfang / Moutsopoulos, Niki M / Chen, WanJun /

Yewdell, Jonathan W / Shapiro, Virginia Smith / Ruiz, Sergio / Taylor, Naomi / Belkaid, Yasmine / Bhandoola, Avinash

Immunity

2024

Abstract: Group 3 innate lymphoid cells (ILC3) are the major subset of gut-resident ILC with essential roles in infections and tissue repair, but how they adapt to the gut environment to maintain tissue residency is unclear. We report that Tox2 is critical for gut ...

Abstract	Group 3 innate lymphoid cells (ILC3) are the major subset of gut-resident ILC with essential roles in infections and tissue repair, but how they adapt to the gut environment to maintain tissue residency is unclear. We report that Tox2 is critical for gut ILC3 maintenance and function. Gut ILC3 highly expressed Tox2, and depletion of Tox2 markedly decreased ILC3 in gut but not at central sites, resulting in defective control of Citrobacter rodentium infection. Single-cell transcriptional profiling revealed decreased expression of Hexokinase-2 in Tox2-deficient gut ILC3. Consistent with the requirement for hexokinases in glycolysis, Tox2
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2024.04.001
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Automatic discovery of 100-miRNA signature for cancer classification using ensemble feature selection.

Lopez-Rincon, Alejandro / Martinez-Archundia, Marlet / Martinez-Ruiz, Gustavo U / Schoenhuth, Alexander / Tonda, Alberto

BMC bioinformatics

2019 Volume 20, Issue 1, Page(s) 480

Abstract: Background: MicroRNAs (miRNAs) are noncoding RNA molecules heavily involved in human tumors, in which few of them circulating the human body. Finding a tumor-associated signature of miRNA, that is, the minimum miRNA entities to be measured for ... ...

Abstract	Background: MicroRNAs (miRNAs) are noncoding RNA molecules heavily involved in human tumors, in which few of them circulating the human body. Finding a tumor-associated signature of miRNA, that is, the minimum miRNA entities to be measured for discriminating both different types of cancer and normal tissues, is of utmost importance. Feature selection techniques applied in machine learning can help however they often provide naive or biased results. Results: An ensemble feature selection strategy for miRNA signatures is proposed. miRNAs are chosen based on consensus on feature relevance from high-accuracy classifiers of different typologies. This methodology aims to identify signatures that are considerably more robust and reliable when used in clinically relevant prediction tasks. Using the proposed method, a 100-miRNA signature is identified in a dataset of 8023 samples, extracted from TCGA. When running eight-state-of-the-art classifiers along with the 100-miRNA signature against the original 1046 features, it could be detected that global accuracy differs only by 1.4%. Importantly, this 100-miRNA signature is sufficient to distinguish between tumor and normal tissues. The approach is then compared against other feature selection methods, such as UFS, RFE, EN, LASSO, Genetic Algorithms, and EFS-CLA. The proposed approach provides better accuracy when tested on a 10-fold cross-validation with different classifiers and it is applied to several GEO datasets across different platforms with some classifiers showing more than 90% classification accuracy, which proves its cross-platform applicability. Conclusions: The 100-miRNA signature is sufficiently stable to provide almost the same classification accuracy as the complete TCGA dataset, and it is further validated on several GEO datasets, across different types of cancer and platforms. Furthermore, a bibliographic analysis confirms that 77 out of the 100 miRNAs in the signature appear in lists of circulating miRNAs used in cancer studies, in stem-loop or mature-sequence form. The remaining 23 miRNAs offer potentially promising avenues for future research.
MeSH term(s)	Humans ; Machine Learning/trends ; MicroRNAs/genetics ; Neoplasms/classification
Chemical Substances	MicroRNAs
Language	English
Publishing date	2019-09-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2041484-5
ISSN	1471-2105 ; 1471-2105
ISSN (online)	1471-2105
ISSN	1471-2105
DOI	10.1186/s12859-019-3050-8
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Article ; Online: The fatal contribution of serine protease-related genetic variants to COVID-19 outcomes.

Martínez-Gómez, Laura Edith / Martinez-Armenta, Carlos / Tusie-Luna, Teresa / Vázquez-Cárdenas, Paola / Vidal-Vázquez, Rosa P / Ramírez-Hinojosa, Juan P / Gómez-Martín, Diana / Vargas-Alarcón, Gilberto / Posadas-Sánchez, Rosalinda / Fragoso, José Manuel / de la Peña, Aurora / Rodríguez-Pérez, José Manuel / Mata-Miranda, Mónica M / Vázquez-Zapién, Gustavo J / Martínez-Cuazitl, Adriana / Martínez-Ruiz, Felipe de J / Zayago-Angeles, Dulce M / Ramos-Tavera, Luis / Méndez-Aguilera, Alberto /

Camacho-Rea, María Del C / Ordoñez-Sánchez, María L / Segura-Kato, Yayoi / Suarez-Ahedo, Carlos / Olea-Torres, Jessel / Herrera-López, Brígida / Pineda, Carlos / Martínez-Nava, Gabriela A / López-Reyes, Alberto

Frontiers in immunology

2024 Volume 15, Page(s) 1335963

Abstract: Introduction: Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 (: Methods: To evaluate the genetic variants of the genes previously associated with COVID-19 outcomes, we ... ...

Abstract	Introduction: Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 ( Methods: To evaluate the genetic variants of the genes previously associated with COVID-19 outcomes, we performed a cross-sectional study in which 1536 SARS-CoV-2-positive participants were enrolled. Results: According to our codominant model, the GA genotype of rs2227667 (OR=0.55; 95% CI = 0.36-0.84; Discussion: Our data suggest that the rs75603675
MeSH term(s)	Humans ; COVID-19/genetics ; Serine Proteases ; SARS-CoV-2 ; Diabetes Mellitus, Type 2 ; Cross-Sectional Studies
Chemical Substances	Serine Proteases (EC 3.4.-)
Language	English
Publishing date	2024-03-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1335963
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Article ; Online: Advances in novel activation methods to perform green organic synthesis using recyclable heteropolyacid catalysis

Ruiz Diego M. / Pasquale Gustavo A. / Martínez José J. / Romanelli Gustavo P.

Green Processing and Synthesis, Vol 11, Iss 1, Pp 766-

2022 Volume 809

Abstract: Highly functionalized, high value added bioactive molecules are generally obtained by synthetic procedures that are highly selective, economical, with high atom economy, and environmentally friendly. Following these guidelines, the use of recoverable ... ...

Abstract	Highly functionalized, high value added bioactive molecules are generally obtained by synthetic procedures that are highly selective, economical, with high atom economy, and environmentally friendly. Following these guidelines, the use of recoverable solid catalysts, nonpolluting substrates, or toxic organic solvent contributes greatly to these demands. In the last three decades, heteropolyacids (HPAs) and its derivatives have received great attention as recyclable solid catalysts, due to their strong Brönsted acidity, excellent oxidizing capacity under mild conditions, and various reuse cycles without appreciable loss of their catalytic activity. However, new activation methods should be investigated to improve the sustainability of a process using HPAs. In this review, we report the latest advances associated with the synthesis of potentially bioactive molecules using more energy efficient alternatives such as microwaves, ultrasound, mechanochemistry, and photochemistry to minimize the energy consumption associated with organic synthesis. The transformations studied include construction reaction, heterocycle synthesis, selective oxidation, and biomass recovery.
Keywords	green chemistry ; novel chemical activation methods ; heteropolyacids ; organic transformations ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bacillus cabrialesii

de Los Santos-Villalobos, Sergio / Valenzuela-Ruiz, Valeria / Montoya-Martínez, Amelia C / Parra-Cota, Fannie I / Santoyo, Gustavo / Larsen, John

International journal of systematic and evolutionary microbiology

2023 Volume 73, Issue 4

MeSH term(s)	Bacillus ; Triticum/microbiology ; Biological Control Agents ; Mexico ; Sequence Analysis, DNA ; Phylogeny ; DNA, Bacterial/genetics ; RNA, Ribosomal, 16S/genetics ; Bacterial Typing Techniques ; Base Composition ; Fatty Acids/chemistry ; Bacteria
Chemical Substances	Biological Control Agents ; DNA, Bacterial ; RNA, Ribosomal, 16S ; Fatty Acids
Language	English
Publishing date	2023-07-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijsem.0.005779
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Zs.A 409: Show issues

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Article ; Online: Transcriptional Regulation of Yin-Yang 1 Expression through the Hypoxia Inducible Factor-1 in Pediatric Acute Lymphoblastic Leukemia.

Antonio-Andres, Gabriela / Martinez-Ruiz, Gustavo U / Morales-Martinez, Mario / Jiménez-Hernandez, Elva / Martinez-Torres, Estefany / Lopez-Perez, Tania V / Estrada-Abreo, Laura A / Patino-Lopez, Genaro / Juarez-Mendez, Sergio / Davila-Borja, Víctor M / Huerta-Yepez, Sara

International journal of molecular sciences

2022 Volume 23, Issue 3

Abstract: Yin-Yang transcription factor 1 (YY1) is involved in tumor progression, metastasis and has been shown to be elevated in different cancers, including leukemia. The regulatory mechanism underlying YY1 expression in leukemia is still not understood. ... ...

Abstract	Yin-Yang transcription factor 1 (YY1) is involved in tumor progression, metastasis and has been shown to be elevated in different cancers, including leukemia. The regulatory mechanism underlying YY1 expression in leukemia is still not understood. Bioinformatics analysis reveal three Hypoxia-inducible factor 1-alpha (HIF-1α) putative binding sites in the YY1 promoter region. The regulation of YY1 by HIF-1α in leukemia was analyzed. Mutation of the putative YY1 binding sites in a reporter system containing the HIF-1α promoter region and CHIP analysis confirmed that these sites are important for YY1 regulation. Leukemia cell lines showed that both proteins HIF-1α and YY1 are co-expressed under hypoxia. In addition, the expression of mRNA of YY1 was increased after 3 h of hypoxia conditions and affect several target genes expression. In contrast, chemical inhibition of HIF-1α induces downregulation of YY1 and sensitizes cells to chemotherapeutic drugs. The clinical implications of HIF-1α in the regulation of YY1 were investigated by evaluation of expression of HIF-1α and YY1 in 108 peripheral blood samples and by RT-PCR in 46 bone marrow samples of patients with pediatric acute lymphoblastic leukemia (ALL). We found that the expression of HIF-1α positively correlates with YY1 expression in those patients. This is consistent with bioinformatic analyses of several databases. Our findings demonstrate for the first time that YY1 can be transcriptionally regulated by HIF-1α, and a correlation between HIF-1α expression and YY1 was found in ALL clinical samples. Hence, HIF-1α and YY1 may be possible therapeutic target and/or biomarkers of ALL.
MeSH term(s)	Adolescent ; Cell Line, Tumor ; Child ; Child, Preschool ; Gene Expression Regulation, Neoplastic ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Infant ; Infant, Newborn ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; YY1 Transcription Factor/metabolism
Chemical Substances	HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; YY1 Transcription Factor ; YY1 protein, human
Language	English
Publishing date	2022-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23031728
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