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Article ; Online: Modulation of PM

Collazo, Soledad / Ordóñez, Carlos / García-Herrera, Ricardo

2024 Volume 915, Page(s) 170132

Abstract: In the Amazon basin, biomass burning has been identified as a major cause of poor regional air quality and the dominant source of particulate matter (PM). In this study, we analyse the impact of the upper-level jet on ... ...

Abstract	In the Amazon basin, biomass burning has been identified as a major cause of poor regional air quality and the dominant source of particulate matter (PM). In this study, we analyse the impact of the upper-level jet on PM
Language	English
Publishing date	2024-01-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.170132
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Article ; Online: Online hemodiafiltration without calcium replacement using citrate as an anticoagulant and dialysis fluid with 3.5 mEq of post dilutional calcium in patients with heparin-induced thrombocytopenia: Report of 2 cases.

Ramos, Lucas / Luxardo, Rosario / Crucelegui, María Soledad / Satera, Nadia / Jordán Ordoñez, Yuliana / Rosa-Diez, Guillermo

Nefrologia

2024

Language	English
Publishing date	2024-03-27
Publishing country	Spain
Document type	Letter
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefroe.2024.03.001
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Article: Importance of

Radomska, Katarzyna A / Wösten, Marc M S M / Ordoñez, Soledad R / Wagenaar, Jaap A / van Putten, Jos P M

Frontiers in microbiology

2017 Volume 8, Page(s) 1060

Abstract: Flagella-driven motility enables bacteria to reach their favorable niche within the host. The human foodborne ... ...

Abstract	Flagella-driven motility enables bacteria to reach their favorable niche within the host. The human foodborne pathogen
Language	English
Publishing date	2017-06-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2017.01060
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Article: Role of Soluble Innate Effector Molecules in Pulmonary Defense against Fungal Pathogens.

Ordonez, Soledad R / Veldhuizen, Edwin J A / van Eijk, Martin / Haagsman, Henk P

Frontiers in microbiology

2017 Volume 8, Page(s) 2098

Abstract: Fungal infections of the lung are life-threatening but rarely occur in healthy, immunocompetent individuals, indicating efficient clearance by pulmonary defense mechanisms. Upon inhalation, fungi will first encounter the airway surface liquid which ... ...

Abstract	Fungal infections of the lung are life-threatening but rarely occur in healthy, immunocompetent individuals, indicating efficient clearance by pulmonary defense mechanisms. Upon inhalation, fungi will first encounter the airway surface liquid which contains several soluble effector molecules that form the first barrier of defense against fungal infections. These include host defense peptides, like LL-37 and defensins that can neutralize fungi by direct killing of the pathogen, and collectins, such as surfactant protein A and D, that can aggregate fungi and stimulate phagocytosis. In addition, these molecules have immunomodulatory activities which can aid in fungal clearance from the lung. However, existing observations are based on
Language	English
Publishing date	2017-10-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2017.02098
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Article: Antifungal activities of surfactant protein D in an environment closely mimicking the lung lining

Ordonez, Soledad R / Edwin J.A. Veldhuizen / Hans de Cock / Henk P. Haagsman / Martin van Eijk / Natalia Escobar Salazar

Molecular immunology. 2019 Jan., v. 105

2019

Abstract: At the lung lining innate defenses protect our lungs against inhaled fungal cells that could pose a threat to our health. These defenses are comprised of mucociliary clearance, soluble effector molecules and roaming phagocytic cells, such as macrophages ... ...

Abstract	At the lung lining innate defenses protect our lungs against inhaled fungal cells that could pose a threat to our health. These defenses are comprised of mucociliary clearance, soluble effector molecules and roaming phagocytic cells, such as macrophages and neutrophils. How important each of these defenses is during fungal clearance depends on the specific fungal pathogen in question and on the stage of infection. In this study the localization and antifungal activity of the lung surfactant protein D (SP-D) was studied in an environment mimicking the lung lining. To this end Calu-3 cells were grown on an air-liquid interface allowing them to polarize and to produce mucus at their apical surface. Additionally, neutrophils were added to study their role in fungal clearance. Two fungal pathogens were used for these experiments: Candida albicans and Aspergillus fumigatus, both of clinical relevance. During fungal infection SP-D localized strongly to both fungal surfaces and stayed bound through the different stages of infection. Furthermore, SP-D decreased fungal adhesion to the epithelium and increased fungal clearance by neutrophils from the epithelial surface. These findings suggest that SP-D plays an important role at the different stages of pulmonary defense against fungal intruders.
Keywords	adhesion ; antifungal properties ; Aspergillus fumigatus ; Candida albicans ; epithelium ; fungi ; liquid-air interface ; lungs ; macrophages ; mucus ; neutrophils ; pathogens ; proteins ; surfactants
Language	English
Dates of publication	2019-01
Size	p. 260-269.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	424427-8
ISSN	1872-9142 ; 0161-5890
ISSN (online)	1872-9142
ISSN	0161-5890
DOI	10.1016/j.molimm.2018.12.003
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 166: Show issues

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Article ; Online: Antifungal activities of surfactant protein D in an environment closely mimicking the lung lining.

Ordonez, Soledad R / van Eijk, Martin / Escobar Salazar, Natalia / de Cock, Hans / Veldhuizen, Edwin J A / Haagsman, Henk P

Molecular immunology

2018 Volume 105, Page(s) 260–269

Abstract	At the lung lining innate defenses protect our lungs against inhaled fungal cells that could pose a threat to our health. These defenses are comprised of mucociliary clearance, soluble effector molecules and roaming phagocytic cells, such as macrophages and neutrophils. How important each of these defenses is during fungal clearance depends on the specific fungal pathogen in question and on the stage of infection. In this study the localization and antifungal activity of the lung surfactant protein D (SP-D) was studied in an environment mimicking the lung lining. To this end Calu-3 cells were grown on an air-liquid interface allowing them to polarize and to produce mucus at their apical surface. Additionally, neutrophils were added to study their role in fungal clearance. Two fungal pathogens were used for these experiments: Candida albicans and Aspergillus fumigatus, both of clinical relevance. During fungal infection SP-D localized strongly to both fungal surfaces and stayed bound through the different stages of infection. Furthermore, SP-D decreased fungal adhesion to the epithelium and increased fungal clearance by neutrophils from the epithelial surface. These findings suggest that SP-D plays an important role at the different stages of pulmonary defense against fungal intruders.
MeSH term(s)	Antifungal Agents/chemistry ; Antifungal Agents/immunology ; Aspergillosis/immunology ; Aspergillosis/pathology ; Aspergillus fumigatus/immunology ; Candida albicans/immunology ; Candidiasis/immunology ; Candidiasis/pathology ; Cell Line ; Humans ; Lung/immunology ; Lung/microbiology ; Pulmonary Surfactant-Associated Protein D/chemistry ; Pulmonary Surfactant-Associated Protein D/immunology ; Respiratory Mucosa/immunology ; Respiratory Mucosa/microbiology
Chemical Substances	Antifungal Agents ; Pulmonary Surfactant-Associated Protein D
Language	English
Publishing date	2018-12-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424427-8
ISSN	1872-9142 ; 0161-5890
ISSN (online)	1872-9142
ISSN	0161-5890
DOI	10.1016/j.molimm.2018.12.003
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Zs.A 166: Show issues

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Article ; Online: Feedback control of Campylobacter jejuni flagellin levels through reciprocal binding of FliW to flagellin and the global regulator CsrA.

Radomska, Katarzyna A / Ordoñez, Soledad R / Wösten, Marc M S M / Wagenaar, Jaap A / van Putten, Jos P M

Molecular microbiology

2016 Volume 102, Issue 2, Page(s) 207–220

Abstract: Bacterial flagella assembly is tightly regulated to ensure a timely and sequential production of the various flagellum constituents. In the pathogen Campylobacter jejuni the hierarchy in flagella biosynthesis is largely determined at the transcriptional ... ...

Abstract	Bacterial flagella assembly is tightly regulated to ensure a timely and sequential production of the various flagellum constituents. In the pathogen Campylobacter jejuni the hierarchy in flagella biosynthesis is largely determined at the transcriptional level through the activity of the alternative sigma factors sigma
MeSH term(s)	Bacterial Proteins/metabolism ; Campylobacter jejuni/genetics ; Campylobacter jejuni/metabolism ; Feedback, Physiological ; Flagella/metabolism ; Flagellin/biosynthesis ; Flagellin/metabolism ; Gene Expression Regulation, Bacterial/genetics ; RNA-Binding Proteins/metabolism ; Repressor Proteins/metabolism ; Sigma Factor/metabolism
Chemical Substances	Bacterial Proteins ; RNA-Binding Proteins ; Repressor Proteins ; Sigma Factor ; Flagellin (12777-81-0) ; flaB flagellin (140470-87-7)
Language	English
Publishing date	2016-10
Publishing country	England
Document type	Journal Article
ZDB-ID	619315-8
ISSN	1365-2958 ; 0950-382X
ISSN (online)	1365-2958
ISSN	0950-382X
DOI	10.1111/mmi.13455
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Zs.A 2502: Show issues

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Article ; Online: Expression profile analysis reveals that Aspergillus fumigatus but not Aspergillus niger makes type II epithelial lung cells less immunological alert.

Escobar, Natalia / Valdes, Ivan D / Keizer, Esther M / Ordonez, Soledad R / Ohm, Robin A / Wösten, Han A B / de Cock, Hans

BMC genomics

2018 Volume 19, Issue 1, Page(s) 534

Abstract: Background: Aspergillus fumigatus is the main causative agent of aspergillosis. Infections rarely occur in immunocompetent individuals, indicating efficient clearance of conidia by pulmonary defense mechanisms. Other aspergilli like Aspergillus niger ... ...

Abstract	Background: Aspergillus fumigatus is the main causative agent of aspergillosis. Infections rarely occur in immunocompetent individuals, indicating efficient clearance of conidia by pulmonary defense mechanisms. Other aspergilli like Aspergillus niger also cause infections but to a much lesser extent. Our previous studies showed that A. fumigatus and A. niger have different behavior in the presence of type II alveolar A549 epithelial cells. A. fumigatus conidia are more efficiently internalized by these cells and germination is delayed when compared to A. niger. In addition, hyphae that have escaped the epithelial cells grow parallel to the epithelium, while A. niger grows away from this cell layer. Results: Here it is shown that global gene expression of A. fumigatus and A. niger is markedly different upon contact with A549 cells. A total of 545 and 473 genes of A. fumigatus and A. niger, respectively, were differentially expressed when compared to growth in the absence of A549 cells. Notably, only 53 genes (approximately 10%) were shared in these gene sets. The different response was also illustrated by the fact that only 4 out of 75 GO terms were shared that were enriched in the differentially expressed gene sets. The orthologues of A. fumigatus genes involved in hypoxia regulation and heat shock were also up-regulated in A. niger, whereas thioredoxin reductase and allergen genes were found up-regulated in A. fumigatus but down-regulated in A. niger. Infection with A. fumigatus resulted in only 62 up and 47 down-regulated genes in A549. These numbers were 17 and 34 in the case of A. niger. GO terms related with immune response were down-regulated upon exposure to A. fumigatus but not in the case of A. niger. This indicates that A. fumigatus reprograms A549 to be less immunologically alert. Conclusions: Our dual transcriptomic analysis supports earlier observations of a marked difference in life style between A. fumigatus and A. niger when grown in the presence of type II epithelial cells. The results indicate important differences in gene expression, amongst others down regulation of immune response genes in lung epithelial cells by A. fumigatus but not by A niger.
MeSH term(s)	A549 Cells ; Aspergillus fumigatus/pathogenicity ; Aspergillus niger/pathogenicity ; Down-Regulation ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Epithelial Cells/microbiology ; Gene Expression Profiling ; Host-Pathogen Interactions/genetics ; Humans ; Interleukin-8/genetics ; Interleukin-8/metabolism ; RNA/chemistry ; RNA/isolation & purification ; RNA/metabolism ; Sequence Analysis, RNA ; Up-Regulation
Chemical Substances	Interleukin-8 ; RNA (63231-63-0)
Language	English
Publishing date	2018-07-13
Publishing country	England
Document type	Journal Article
ISSN	1471-2164
ISSN (online)	1471-2164
DOI	10.1186/s12864-018-4895-3
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Article ; Online: Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action.

Scheenstra, Maaike R / van den Belt, Matthias / Tjeerdsma-van Bokhoven, Johanna L M / Schneider, Viktoria A F / Ordonez, Soledad R / van Dijk, Albert / Veldhuizen, Edwin J A / Haagsman, Henk P

Scientific reports

2019 Volume 9, Issue 1, Page(s) 4780

Abstract: Host defense peptides (HDPs) play a pivotal role in innate immunity and have, in addition to antimicrobial activity, also important immunomodulatory functions. Bacteria are less likely to develop resistance against HDPs because these peptides target and ... ...

Abstract	Host defense peptides (HDPs) play a pivotal role in innate immunity and have, in addition to antimicrobial activity, also important immunomodulatory functions. Bacteria are less likely to develop resistance against HDPs because these peptides target and kill bacteria in multiple ways, as well as modulate the immune system. Therefore, HDPs, and derivatives thereof, are promising alternatives to traditional antibiotics. Hardly anything is known about the immunomodulatory functions of porcine cathelicidin PMAP-36. In this study, we aimed to determine both antibacterial and immunomodulatory activities of PMAP-36 comparing the properties of PMAP-36 analogs with two well-studied peptides, human LL-37 and chicken CATH-2. Transmission electron microscopy revealed different killing mechanisms of E. coli for PMAP-36, CATH-2 and LL-37. LL-37 binds LPS very weakly in contrast to PMAP-36, but it inhibits LPS activation of macrophages the strongest. The first 11 amino acids of the N-terminal side of PMAP-36 are dispensable for E. coli killing, LPS-neutralization and binding. Deletion of four additional amino acids resulted in a strong decrease in activity. The activity of full length PMAP-36 was not affected by monomerization, whereas the shorter analogs require dimerization for proper immunomodulatory activity but not for their antibacterial activity.
MeSH term(s)	Animals ; Antimicrobial Cationic Peptides/metabolism ; Antimicrobial Cationic Peptides/pharmacology ; Cells, Cultured ; Chickens ; Escherichia coli/drug effects ; Hemolysis ; Humans ; Lipopolysaccharides/metabolism ; Mice ; Protein Binding ; Protein Multimerization ; RAW 264.7 Cells ; Swine
Chemical Substances	Antimicrobial Cationic Peptides ; CMAP27 protein, chicken ; Lipopolysaccharides ; PMAP-36 ; ropocamptide (3DD771JO2H)
Language	English
Publishing date	2019-03-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-41246-6
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Article ; Online: Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action

Maaike R. Scheenstra / Matthias van den Belt / Johanna L. M. Tjeerdsma-van Bokhoven / Viktoria A. F. Schneider / Soledad R. Ordonez / Albert van Dijk / Edwin J. A. Veldhuizen / Henk P. Haagsman

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 12

Abstract: Abstract Host defense peptides (HDPs) play a pivotal role in innate immunity and have, in addition to antimicrobial activity, also important immunomodulatory functions. Bacteria are less likely to develop resistance against HDPs because these peptides ... ...

Abstract	Abstract Host defense peptides (HDPs) play a pivotal role in innate immunity and have, in addition to antimicrobial activity, also important immunomodulatory functions. Bacteria are less likely to develop resistance against HDPs because these peptides target and kill bacteria in multiple ways, as well as modulate the immune system. Therefore, HDPs, and derivatives thereof, are promising alternatives to traditional antibiotics. Hardly anything is known about the immunomodulatory functions of porcine cathelicidin PMAP-36. In this study, we aimed to determine both antibacterial and immunomodulatory activities of PMAP-36 comparing the properties of PMAP-36 analogs with two well-studied peptides, human LL-37 and chicken CATH-2. Transmission electron microscopy revealed different killing mechanisms of E. coli for PMAP-36, CATH-2 and LL-37. LL-37 binds LPS very weakly in contrast to PMAP-36, but it inhibits LPS activation of macrophages the strongest. The first 11 amino acids of the N-terminal side of PMAP-36 are dispensable for E. coli killing, LPS-neutralization and binding. Deletion of four additional amino acids resulted in a strong decrease in activity. The activity of full length PMAP-36 was not affected by monomerization, whereas the shorter analogs require dimerization for proper immunomodulatory activity but not for their antibacterial activity.
Keywords	Medicine ; R ; Science ; Q
Subject code	540
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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