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  1. Book ; Online: HIV and Cancer Immunotherapy: Similar Challenges and Converging Approaches

    Paiardini, Mirko / Ahmed, Rafi / Grant Deeks, Steven / Dhodapkar, Kavita M.

    2020  

    Keywords Medicine ; Immunology ; HIV ; cancer ; ART ; immunotherapy ; immune surveillance ; immune checkpoint blockade ; inflammation ; CAR T cells
    Size 1 electronic resource (157 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231291
    ISBN 9782889637164 ; 2889637166
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Role of B cells in immune-related adverse events following checkpoint blockade.

    Dhodapkar, Kavita M / Duffy, Alyssa / Dhodapkar, Madhav V

    Immunological reviews

    2023  Volume 318, Issue 1, Page(s) 89–95

    Abstract: Blockade of immune checkpoints has transformed the therapy of several cancers. However, immune-related adverse events (irAEs) have emerged as a major challenge limiting the clinical application of this approach. B cells are recognized as major players in ...

    Abstract Blockade of immune checkpoints has transformed the therapy of several cancers. However, immune-related adverse events (irAEs) have emerged as a major challenge limiting the clinical application of this approach. B cells are recognized as major players in the pathogenesis of human autoimmunity and have been successfully targeted to treat these disorders. While T cells have been extensively studied as therapeutic targets of immune checkpoint blockade (ICB), these checkpoints also impact B cell tolerance. Blockade of immune checkpoints in the clinic is associated with distinct changes in the B cell compartment that correlate with the development of irAEs. In this review, we focus on the possible role of humoral immunity, specifically human B cell subsets and autoantibodies in the pathogenesis of ICB-induced irAEs. There remains an unmet need to better understand the T:B cell cross talk underlying the activation of pathogenic B cells and the development of ICB-induced irAEs. Such studies may identify new targets or approaches to prevent or treat irAEs and improve the application of ICB therapy in cancer.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; B-Lymphocytes/pathology ; Autoimmunity ; Immune Checkpoint Inhibitors/adverse effects ; Autoantibodies ; Immunotherapy/adverse effects
    Chemical Substances Immune Checkpoint Inhibitors ; Autoantibodies
    Language English
    Publishing date 2023-07-08
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Role of B cells in immune‐related adverse events following checkpoint blockade

    Dhodapkar, Kavita M. / Duffy, Alyssa / Dhodapkar, Madhav V.

    Immunological Reviews. 2023 Sept., v. 318, no. 1 p.89-95

    2023  

    Abstract: Blockade of immune checkpoints has transformed the therapy of several cancers. However, immune‐related adverse events (irAEs) have emerged as a major challenge limiting the clinical application of this approach. B cells are recognized as major players in ...

    Abstract Blockade of immune checkpoints has transformed the therapy of several cancers. However, immune‐related adverse events (irAEs) have emerged as a major challenge limiting the clinical application of this approach. B cells are recognized as major players in the pathogenesis of human autoimmunity and have been successfully targeted to treat these disorders. While T cells have been extensively studied as therapeutic targets of immune checkpoint blockade (ICB), these checkpoints also impact B cell tolerance. Blockade of immune checkpoints in the clinic is associated with distinct changes in the B cell compartment that correlate with the development of irAEs. In this review, we focus on the possible role of humoral immunity, specifically human B cell subsets and autoantibodies in the pathogenesis of ICB‐induced irAEs. There remains an unmet need to better understand the T:B cell cross talk underlying the activation of pathogenic B cells and the development of ICB‐induced irAEs. Such studies may identify new targets or approaches to prevent or treat irAEs and improve the application of ICB therapy in cancer.
    Keywords B-lymphocytes ; autoantibodies ; autoimmunity ; humans ; humoral immunity ; pathogenesis ; therapeutics
    Language English
    Dates of publication 2023-09
    Size p. 89-95.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note REVIEW
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13238
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Tissue-resident memory-like T cells in tumor immunity: Clinical implications.

    Dhodapkar, Madhav V / Dhodapkar, Kavita M

    Seminars in immunology

    2020  Volume 49, Page(s) 101415

    Abstract: Tissue-resident memory ( ... ...

    Abstract Tissue-resident memory (T
    MeSH term(s) Animals ; Cancer Vaccines/immunology ; Combined Modality Therapy ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Immunologic Memory ; Immunotherapy, Adoptive ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/therapy ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Tumor Microenvironment/immunology
    Chemical Substances Cancer Vaccines ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2020-09-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2020.101415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2843: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Autoimmune complications of cancer immunotherapy.

    Dhodapkar, Kavita M

    Current opinion in immunology

    2019  Volume 61, Page(s) 54–59

    Abstract: Immunotherapy of cancer with blockade of inhibitory immune checkpoints and adoptive cell therapies have led to impressive clinical responses in several cancers. However, with increasing utilization of these therapies, immune-related adverse events have ... ...

    Abstract Immunotherapy of cancer with blockade of inhibitory immune checkpoints and adoptive cell therapies have led to impressive clinical responses in several cancers. However, with increasing utilization of these therapies, immune-related adverse events have emerged as a major obstacle. Herein I discuss recent insights into the immunobiology of these toxicities. Deeper understanding of the underlying pathogenic mechanisms, cellular and molecular pathways involved, similarities and differences with spontaneous autoimmunity, and identification of clinically relevant predictive biomarkers is needed to develop optimal approaches to prevent and treat these toxicities, without compromising the therapeutic benefit from these immune therapies. These events may also provide a unique window into mechanisms underlying spontaneous autoimmunity.
    MeSH term(s) Animals ; Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Agents, Immunological/therapeutic use ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/etiology ; Autoimmune Diseases/prevention & control ; Autoimmune Diseases/therapy ; Autoimmunity ; Biomarkers, Tumor ; Disease Models, Animal ; Disease Susceptibility/immunology ; Humans ; Immunotherapy, Adoptive/adverse effects ; Immunotherapy, Adoptive/methods ; Molecular Targeted Therapy/adverse effects ; Molecular Targeted Therapy/methods ; Neoplasms/complications ; Neoplasms/immunology ; Neoplasms/therapy ; Risk Factors
    Chemical Substances Antineoplastic Agents, Immunological ; Biomarkers, Tumor
    Language English
    Publishing date 2019-09-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2019.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2773: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 13: Show issues

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  6. Article: Role of Tissue-Resident Memory in Intra-Tumor Heterogeneity and Response to Immune Checkpoint Blockade.

    Dhodapkar, Kavita M

    Frontiers in immunology

    2018  Volume 9, Page(s) 1655

    Abstract: Tissue-resident memory T ( ... ...

    Abstract Tissue-resident memory T (T
    Language English
    Publishing date 2018
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.01655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Moving Immunoprevention Beyond Virally Mediated Malignancies: Do We Need to Link It to Early Detection?

    Dhodapkar, Madhav V / Dhodapkar, Kavita M

    Frontiers in immunology

    2019  Volume 10, Page(s) 2385

    Abstract: Vaccines can successfully prevent viral infections and have emerged as an effective strategy for preventing some virally mediated malignancies. They also represent our major hope for cost-effective reduction of the cancer burden. The concept that the ... ...

    Abstract Vaccines can successfully prevent viral infections and have emerged as an effective strategy for preventing some virally mediated malignancies. They also represent our major hope for cost-effective reduction of the cancer burden. The concept that the immune system mediates surveillance and editing roles against tumors is now well-established in murine models. However, harnessing the immune system to prevent human cancers that do not have a known viral etiology has not yet been realized. Most human cancers originate in a premalignant phase that is more common than the cancer itself. Many of the genetic changes that underlie carcinogenesis originate at this stage when the malignant phenotype is not manifest. Studies evaluating host response in human premalignancy have documented that these lesions are immunogenic, setting the stage for immune-based approaches for targeted prevention of human cancer. However, recent studies suggest that the hierarchy of T cell exhaustion and immune-suppressive factors have already begun to emerge in many preneoplastic states. These considerations underscore the need to link immune prevention to earlier detection of such lesions and to personalize such approaches based on the status of the pre-existing immune response.
    MeSH term(s) Animals ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/immunology ; Cancer Vaccines/administration & dosage ; Cancer Vaccines/immunology ; Cell Transformation, Viral ; Chronic Disease ; Clinical Trials as Topic ; Disease Models, Animal ; Disease Susceptibility ; Early Detection of Cancer ; Humans ; Immunologic Surveillance ; Immunotherapy ; Mutation ; Neoplasms/diagnosis ; Neoplasms/etiology ; Neoplasms/prevention & control ; Precancerous Conditions/diagnosis ; Precancerous Conditions/etiology ; Precancerous Conditions/prevention & control ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Treatment Outcome ; Virus Diseases/complications ; Virus Diseases/virology
    Chemical Substances Antigens, Neoplasm ; Cancer Vaccines
    Language English
    Publishing date 2019-10-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.02385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Viral Immunity and Vaccines in Hematologic Malignancies: Implications for COVID-19.

    Dhodapkar, Madhav V / Dhodapkar, Kavita M / Ahmed, Rafi

    Cancer discovery

    2020  Volume 2, Issue 1, Page(s) 9–12

    Abstract: Patients with hematologic malignancies have increased susceptibility to viral infections and suboptimal immunologic responses to current vaccines due to both disease-associated and therapy-related immune dysfunction. These considerations may impact the ... ...

    Abstract Patients with hematologic malignancies have increased susceptibility to viral infections and suboptimal immunologic responses to current vaccines due to both disease-associated and therapy-related immune dysfunction. These considerations may impact the efficacy of emerging COVID-19 vaccines in this patient population as well and warrant the need to systematically study natural and vaccine-induced virus-specific immunity in these patients.
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2643-3230.BCD-20-0177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6916: Show issues Location:
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  9. Article ; Online: Viral Immunity and Vaccines in Hematologic Malignancies: Implications for COVID-19.

    Dhodapkar, Madhav V / Dhodapkar, Kavita M / Ahmed, Rafi

    Blood cancer discovery

    2020  Volume 2, Issue 1, Page(s) 9–12

    Abstract: Patients with hematologic malignancies have increased susceptibility to viral infections and suboptimal immunologic responses to current vaccines due to both disease-associated and therapy-related immune dysfunction. These considerations may impact the ... ...

    Abstract Patients with hematologic malignancies have increased susceptibility to viral infections and suboptimal immunologic responses to current vaccines due to both disease-associated and therapy-related immune dysfunction. These considerations may impact the efficacy of emerging COVID-19 vaccines in this patient population as well and warrant the need to systematically study natural and vaccine-induced virus-specific immunity in these patients.
    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Hematologic Neoplasms ; Humans ; SARS-CoV-2 ; Virus Diseases/prevention & control
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3028898-8
    ISSN 2643-3249 ; 2643-3230
    ISSN (online) 2643-3249
    ISSN 2643-3230
    DOI 10.1158/2643-3230.bcd-20-0177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Co-evolution of Immune Response in Multiple Myeloma: Implications for Immune Prevention.

    McCachren, Samuel S / Dhodapkar, Kavita M / Dhodapkar, Madhav V

    Frontiers in immunology

    2021  Volume 12, Page(s) 632564

    Abstract: Multiple myeloma (MM), a malignant neoplasm of plasma cells that reside in the bone marrow (BM), is universally preceded by a precursor state termed monoclonal gammopathy of undetermined significance (MGUS). Many individuals with MGUS never progress to ... ...

    Abstract Multiple myeloma (MM), a malignant neoplasm of plasma cells that reside in the bone marrow (BM), is universally preceded by a precursor state termed monoclonal gammopathy of undetermined significance (MGUS). Many individuals with MGUS never progress to MM or progress over many years. Therefore, MGUS provides a unique opportunity to surveil changes in the BM tumor microenvironment throughout disease progression. It is increasingly appreciated that MGUS cells carry many of the genetic changes found in MM. Prior studies have also shown that MGUS cells can be recognized by the immune system, leading to early changes in the BM immune environment compared to that of healthy individuals, including alterations in both innate and adaptive immunity. Progression to clinical MM is associated with attrition of T cells with stem memory-like features and instead accumulation of T cells with more terminally differentiated features. Recent clinical studies have suggested that early application of immune-modulatory drugs, which are known to activate both innate and adaptive immunity, can delay the progression to clinical MM. Understanding the biology of how the immune response and tumors coevolve over time is needed to develop novel immune-based approaches to achieve durable and effective prevention of clinical malignancy.
    MeSH term(s) Adaptive Immunity ; Bone Marrow/immunology ; Humans ; Immune Checkpoint Proteins/immunology ; Immunity, Innate ; Immunologic Surveillance ; Immunomodulation ; Monoclonal Gammopathy of Undetermined Significance/genetics ; Monoclonal Gammopathy of Undetermined Significance/immunology ; Multiple Myeloma/genetics ; Multiple Myeloma/immunology ; Multiple Myeloma/prevention & control ; Tumor Microenvironment
    Chemical Substances Immune Checkpoint Proteins
    Language English
    Publishing date 2021-02-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.632564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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