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  1. Article: Clinical research, the pharmaceutical industry and biomedical research teaching.

    Gamba, Gerardo

    Gaceta medica de Mexico

    2023  Volume 159, Issue 4, Page(s) 352–353

    Title translation Investigación clínica, industria farmacéutica y la enseñanza de la investigación biomédica.
    MeSH term(s) Humans ; Drug Industry ; Medicine
    Language English
    Publishing date 2023-09-11
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 425456-9
    ISSN 0016-3813
    ISSN 0016-3813
    DOI 10.24875/GMM.M23000789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Thirty years of the NaCl cotransporter: from cloning to physiology and structure.

    Gamba, Gerardo

    American journal of physiology. Renal physiology

    2023  Volume 325, Issue 4, Page(s) F479–F490

    Abstract: The primary structure of the thiazide-sensitive NaCl cotransporter (NCC) was resolved 30 years ago by the molecular identification of the cDNA encoding this cotransporter, from the winter's flounder urinary bladder, following a functional expression ... ...

    Abstract The primary structure of the thiazide-sensitive NaCl cotransporter (NCC) was resolved 30 years ago by the molecular identification of the cDNA encoding this cotransporter, from the winter's flounder urinary bladder, following a functional expression strategy. This review outlines some aspects of how the knowledge about thiazide diuretics and NCC evolved, the history of the cloning process, and the expansion of the SLC12 family of electroneutral cotransporters. The diseases associated with activation or inactivation of NCC are discussed, as well as the molecular model by which the activity of NCC is regulated. The controversies in the field are discussed as well as recent publication of the three-dimensional model of NCC obtained by cryo-electron microscopy, revealing not only the amino acid residues critical for Na
    MeSH term(s) Solute Carrier Family 12, Member 3/genetics ; Solute Carrier Family 12, Member 3/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Sodium Chloride/metabolism ; Cryoelectron Microscopy ; Sodium Chloride Symporter Inhibitors ; Cloning, Molecular
    Chemical Substances Solute Carrier Family 12, Member 3 ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Sodium Chloride (451W47IQ8X) ; Sodium Chloride Symporter Inhibitors
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00114.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: From Fish Physiology to Human Disease: The Discovery of the NCC, NKCC2, and the Cation-Coupled Chloride Cotransporters.

    Gamba, Gerardo

    Kidney360

    2023  Volume 5, Issue 1, Page(s) 133–141

    Abstract: The renal Na-K-2Cl and Na-Cl cotransporters are the major salt reabsorption pathways in the thick ascending limb of Henle loop and the distal convoluted tubule, respectively. These transporters are the target of the loop and thiazide type diuretics ... ...

    Abstract The renal Na-K-2Cl and Na-Cl cotransporters are the major salt reabsorption pathways in the thick ascending limb of Henle loop and the distal convoluted tubule, respectively. These transporters are the target of the loop and thiazide type diuretics extensively used in the world for the treatment of edematous states and arterial hypertension. The diuretics appeared in the market many years before the salt transport systems were discovered. The evolving of the knowledge and the cloning of the genes encoding the Na-K-2Cl and Na-Cl cotransporters were possible thanks to the study of marine species. This work presents the history of how we came to know the mechanisms for the loop and thiazide type diuretics actions, the use of marine species in the cloning process of these cotransporters and therefore in the whole solute carrier cotransproters 12 (SLC12) family of electroneutral cation chloride cotransporters, and the disease associated with each member of the family.
    MeSH term(s) Animals ; Humans ; Cations/metabolism ; Chlorides/metabolism ; Diuretics/metabolism ; Kidney Tubules, Distal/metabolism ; Sodium/metabolism ; Sodium Chloride/metabolism ; Sodium-Potassium-Chloride Symporters/genetics ; Sodium-Potassium-Chloride Symporters/metabolism ; Solute Carrier Family 12, Member 3/metabolism ; Thiazides/metabolism ; Solute Carrier Family 12, Member 1
    Chemical Substances Cations ; Chlorides ; Diuretics ; Sodium (9NEZ333N27) ; Sodium Chloride (451W47IQ8X) ; Sodium-Potassium-Chloride Symporters ; Solute Carrier Family 12, Member 3 ; Thiazides ; SLC12A3 protein, human ; SLC12A1 protein, human ; Solute Carrier Family 12, Member 1
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Arterial Blood Pressure, Neuronal Excitability, Mineral Metabolism and Cell Volume Regulation Mechanisms Revealed by

    Gamba, Gerardo

    Membranes

    2022  Volume 12, Issue 10

    Abstract: ... Xenopus ... ...

    Abstract Xenopus laevis
    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes12100911
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  5. Article: MY TIME AS THE EDITOR-IN-CHIEF OF THE REVISTA DE INVESTIGACIÓN CLÍNICA.

    Gamba, Gerardo

    Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

    2021  Volume 73, Issue 5, Page(s) 280–285

    Abstract: I was the Editor-in-Chief of the Revista de Investigación Clínica (RIC) from December 1999-May 2014. In this article, I present a review about how I initiated my experience in the RIC as an author, how I became the Editor-in-Chief, the philosophy of the ... ...

    Abstract I was the Editor-in-Chief of the Revista de Investigación Clínica (RIC) from December 1999-May 2014. In this article, I present a review about how I initiated my experience in the RIC as an author, how I became the Editor-in-Chief, the philosophy of the RIC during my time, the type of publications we had and the citations these papers have received today, the special issues and consensus we published and how the RIC became the official publication of the Mexican Institutes of Health.
    MeSH term(s) Humans ; Mexico ; Periodicals as Topic
    Language English
    Publishing date 2021-11-24
    Publishing country Mexico
    Document type Journal Article ; Personal Narrative ; Review
    ZDB-ID 138348-6
    ISSN 0034-8376
    ISSN 0034-8376
    DOI 10.24875/RIC.21000299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The serine-threonine protein phosphatases that regulate the thiazide-sensitive NaCl cotransporter.

    Carbajal-Contreras, Héctor / Gamba, Gerardo / Castañeda-Bueno, María

    Frontiers in physiology

    2023  Volume 14, Page(s) 1100522

    Abstract: The activity of the ... ...

    Abstract The activity of the Na
    Language English
    Publishing date 2023-02-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1100522
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  7. Article ; Online: Letter to the editor: Remembering Steve Hebert (1946-2008).

    Gamba, Gerardo

    American journal of physiology. Cell physiology

    2018  Volume 315, Issue 1, Page(s) C122–C123

    MeSH term(s) Humans ; Medical Laboratory Personnel ; Membrane Proteins/metabolism ; Sodium-Potassium-Chloride Symporters/metabolism
    Chemical Substances Membrane Proteins ; Sodium-Potassium-Chloride Symporters
    Language English
    Publishing date 2018-07-10
    Publishing country United States
    Document type Letter
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00178.2018
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  8. Article: Editorial: 30th anniversary of the molecular cloning and identification of the Na-Cl cotransporter, NCC.

    de Los Heros, Paola / Ellison, David H / Gamba, Gerardo

    Frontiers in physiology

    2023  Volume 14, Page(s) 1221806

    Language English
    Publishing date 2023-06-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1221806
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  9. Article ; Online: Regulation of the WNK4-SPAK-NCC pathway by the calcium-sensing receptor.

    Chávez-Canales, María / García, Janeth Alejandra / Gamba, Gerardo

    Current opinion in nephrology and hypertension

    2023  Volume 32, Issue 5, Page(s) 451–457

    Abstract: Purpose of review: Regulation of the sodium chloride cotransporter (NCC) in the distal convoluted tubule (DCT) plays a crucial role in renal salt handling. The calcium-sensing receptor (CaSR) has been shown to activate NCC through the WNK4-SPAK pathway, ...

    Abstract Purpose of review: Regulation of the sodium chloride cotransporter (NCC) in the distal convoluted tubule (DCT) plays a crucial role in renal salt handling. The calcium-sensing receptor (CaSR) has been shown to activate NCC through the WNK4-SPAK pathway, which is independent of the Renin-Angiotensin-Aldosterone system. In this review, we examine new information about the mechanism of how the CaSR regulates NCC through the WNK4-SPAK pathway and its physiological and therapeutic implications.
    Recent findings: The activation of CaSR in TALH cells during hypercalcemia inhibits NKCC2 and ROMK activity, reducing paracellular Ca2+ reabsorption but decreasing salt reabsorption. This pathway enables NaCl reabsorption in the DCT while promoting Ca2+ excretion. CaSR activation in the apical DCT stimulates a signaling pathway involving PKC, WNK4, and SPAK, which increases NCC activation to recover the NaCl not reabsorbed in TAHL. Glucose or fructose acting as calcimimetics enhance apical CaSR sensitivity, increasing NCC activity, which contribute to the mechanism of hypertension prevalence in diabetic patients or in those with high fructose consumption.
    Summary: These findings reveal the importance of the CaSR-mediated activation of the WNK4-SPAK pathway in regulating salt and calcium homeostasis and its potential as a therapeutic target for hypertension and related diseases.
    MeSH term(s) Humans ; Protein Serine-Threonine Kinases/metabolism ; Receptors, Calcium-Sensing/metabolism ; Phosphorylation ; Sodium Chloride/metabolism ; Calcium/metabolism ; Kidney Tubules, Distal/metabolism ; Hypertension/metabolism ; Sodium Chloride, Dietary/metabolism ; Solute Carrier Family 12, Member 3/metabolism
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Receptors, Calcium-Sensing ; Sodium Chloride (451W47IQ8X) ; Calcium (SY7Q814VUP) ; Sodium Chloride, Dietary ; Solute Carrier Family 12, Member 3 ; WNK4 protein, human (EC 2.7.11.1)
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3686: Show issues Location:
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  10. Article ; Online: (Pro)renin Receptor Deletion in Distal Convoluted Tubule 1 Produces Salt-Sensitive Hypertension.

    Chavez-Canales, María / Gamba, Gerardo

    Hypertension (Dallas, Tex. : 1979)

    2021  Volume 78, Issue 4, Page(s) 1039–1041

    MeSH term(s) Humans ; Hypertension/genetics ; Kidney Tubules, Distal ; Renin/genetics ; Sodium Chloride, Dietary/adverse effects
    Chemical Substances Sodium Chloride, Dietary ; Renin (EC 3.4.23.15)
    Language English
    Publishing date 2021-09-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.121.17815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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