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  1. Article ; Online: Endoscopic and Radiologic Central Compartment Disease as Predictors of Perennial Inhalant Allergen Sensitization in Chronic Rhinosinusitis.

    Lau, Linus / Low, Terese / Ong, Yew Kwang / Xinni, Xu

    American journal of rhinology & allergy

    2024  Volume 38, Issue 3, Page(s) 178–184

    Abstract: Background: Central compartment atopic disease (CCAD) is a recently described variant of chronic rhinosinusitis (CRS) strongly associated with atopy. The association between central compartment disease (CCD) and inhalant allergy is not well established ... ...

    Abstract Background: Central compartment atopic disease (CCAD) is a recently described variant of chronic rhinosinusitis (CRS) strongly associated with atopy. The association between central compartment disease (CCD) and inhalant allergy is not well established in South-East Asia, where perennial allergic rhinitis is common.
    Objectives: The primary objective was to evaluate endoscopic and radiologic CCD as predictors of perennial allergen sensitization in primary CRS. The secondary objective was to compare clinical characteristics of CCAD with other CRS subtypes (CRSwNP and CRSsNP).
    Methods: A retrospective study of consecutive patients with primary CRS who underwent endoscopic sinus surgery at our institution was performed. Allergen sensitization was confirmed by skin or serum testing. Endoscopy records and computed tomography scans of paranasal sinuses were reviewed for CCD. The diagnostic accuracy of endoscopic and radiologic CCD in predicting atopy was calculated.
    Results: There were 104 patients (43 CCAD, 30 CRSwNP and 31 CRSsNP). Endoscopic CCD was significantly associated with aeroallergen sensitization (odds ratio (OR) 3.99, 95% confidence interval (CI) 1.65-9.67,
    Conclusions: Endoscopic CCD was a better predictor of inhalant allergy than radiologic CCD in primary CRS, in a locale of perennial allergic rhinitis.
    MeSH term(s) Humans ; Allergens ; Rhinitis/diagnosis ; Rhinitis/epidemiology ; Rhinitis/surgery ; Retrospective Studies ; Rhinosinusitis ; Sinusitis/surgery ; Hypersensitivity, Immediate ; Endoscopy ; Rhinitis, Allergic/epidemiology ; Chronic Disease ; Nasal Polyps/surgery
    Chemical Substances Allergens
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2482804-X
    ISSN 1945-8932 ; 1945-8924
    ISSN (online) 1945-8932
    ISSN 1945-8924
    DOI 10.1177/19458924241237915
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    Zs.A 2542: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Conference proceedings: Anatomic Study of Novel Endoscopic Surgical Approaches to the Parapharyngeal Internal Carotid Artery

    Tang, Anthony / Dang, Sophia / Xu, Xinni / Affolter, Kyle / Gardner, Paul / Snyderman, Carl

    Journal of Neurological Surgery Part B: Skull Base

    2024  Volume 85, Issue S 01

    Event/congress 33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
    Language English
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0044-1780353
    Database Thieme publisher's database

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    Zs.A 3425: Show issues Location:
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  3. Article ; Online: A context-dependent perspective to understand the relation between parent-child physiological synchrony and child socioemotional adjustment.

    Xu, Jianjie / Zhang, Yutong / Wang, Hui / Peng, Mengting / Zhu, Yuhao / Wang, Xinni / Yi, Zhennan / Chen, Lu / Han, Zhuo Rachel

    Developmental science

    2024  , Page(s) e13506

    Abstract: Physiological synchrony is an important biological process during which parent-child interaction plays a significant role in shaping child socioemotional adjustment. The present study held a context-dependent perspective to examine the conditional ... ...

    Abstract Physiological synchrony is an important biological process during which parent-child interaction plays a significant role in shaping child socioemotional adjustment. The present study held a context-dependent perspective to examine the conditional association between parent-child physiological synchrony and child socioemotional adjustment (i.e., relationship quality with parents and child emotion regulation) under different (i.e., from highly unsupportive to highly supportive) emotional contexts. One hundred and fifty school-age Chinese children (M
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2023952-X
    ISSN 1467-7687 ; 1363-755X
    ISSN (online) 1467-7687
    ISSN 1363-755X
    DOI 10.1111/desc.13506
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  4. Article ; Online: Radiopathologic predictors of 1- and 2-year frontal sinusotomy outcomes in a southeast Asian chronic rhinosinusitis population.

    Chee, Jeremy / Ong, Yew Kwang / Seet, Ju Ee / Xu, Xinni

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2023  Volume 280, Issue 11, Page(s) 4915–4921

    Abstract: Background: The frontal sinus and its drainage pathway are difficult spaces to navigate surgically. The complexity of the frontal recess anatomy as well as inflammatory factors may influence outcomes of endoscopic frontal sinusotomy. It is not clear ... ...

    Abstract Background: The frontal sinus and its drainage pathway are difficult spaces to navigate surgically. The complexity of the frontal recess anatomy as well as inflammatory factors may influence outcomes of endoscopic frontal sinusotomy. It is not clear which factors are more important in determining post-operative frontal ostium patency.
    Objective: The objective is to investigate whether the distribution of fronto-ethmoidal cells, frontal recess dimensions and sinonasal inflammation predict frontal ostium patency at 1- and 2-years after endoscopic frontal sinusotomy.
    Methods: A retrospective review of 94 chronic rhinosinusitis patients (185 sides) who had undergone endoscopic frontal sinusotomies between 2015 and 2019 was conducted. Computed tomography was used to evaluate the type of fronto-ethmoidal cells present and determine the dimensions of the frontal recess. The International Classification of the Radiological Complexity of frontal recess and frontal sinus was used to grade the complexity of frontal recess anatomy. Mucosal inflammation was graded according to a structured histopathology report. Frontal ostium patency at 1- and 2-years post-operatively was recorded.
    Results: The frontal ostium patency rates were 80.9% and 73.4% at 1- and 2-years respectively. Eosinophilic predominance (adjusted OR 3.5, 95% CI 1.6-8.0, p = 0.003) and mucosal ulceration on histology (adjusted OR 4.5, 95% CI 1.1-17.9, p = 0.033) predicted ostial stenosis at 1 year. Smoking (adjusted OR 7.6, 95% CI 2.4-24.7, p = 0.001), aspirin exacerbated respiratory disease (AERD) (adjusted OR 7.6, 95% CI 1.9-30.1, p = 0.004) and histological findings of severe inflammation (adjusted OR 8.9, 95% CI 1.9-41.2, p = 0.005) were independent predictors of ostial stenosis at 2 years. Frontal cell patterns, frontal recess dimensions and frontal recess complexity did not predict frontal ostium stenosis at both 1- and 2-years post-operatively.
    Conclusion: Post-operative control of sinonasal inflammation is important in maintaining frontal ostium patency, regardless of frontal cell patterns or frontal recess dimensions.
    MeSH term(s) Humans ; Frontal Sinus/diagnostic imaging ; Frontal Sinus/surgery ; Frontal Sinus/pathology ; Constriction, Pathologic/diagnostic imaging ; Constriction, Pathologic/etiology ; Constriction, Pathologic/surgery ; Southeast Asian People ; Sinusitis/diagnostic imaging ; Sinusitis/surgery ; Sinusitis/pathology ; Endoscopy/methods ; Inflammation/pathology ; Chronic Disease
    Language English
    Publishing date 2023-05-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-023-08048-z
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    Ul II Zs.50: Show issues Location:
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  5. Article ; Online: An endoscopic anatomical study of the levator veli palatini and its relationship to the parapharyngeal internal carotid artery.

    Xu, Xinni / Ong, Yew Kwang

    Head & neck

    2020  Volume 42, Issue 8, Page(s) 1829–1836

    Abstract: Background: The objectives of this study are to describe the levator veli palatini (LVP) as a landmark for the parapharyngeal internal carotid artery (pICA) and the endoscopic course of the pICA.: Methods: Cadaver dissection and illustrative case ... ...

    Abstract Background: The objectives of this study are to describe the levator veli palatini (LVP) as a landmark for the parapharyngeal internal carotid artery (pICA) and the endoscopic course of the pICA.
    Methods: Cadaver dissection and illustrative case study.
    Results: Seven cadaveric heads (12 sides) were dissected. In all 12 sides, the LVP was consistently located between the Eustachian tube and the pICA near the skull base, making the LVP just anterior to and the closest structure to the pICA. The distance between the pICA and the nares ranged from 9.0 to 12.7 cm. The distance between the pICA and the midpoint of the nasopharynx ranged from 1.9 to 3.7 cm. The case study illustrated the applicability of these findings.
    Conclusion: The LVP is a reliable and precise landmark for the pICA. A safe working distance to the pICA is 1.9 cm from the midpoint of the nasopharynx and 9.0 cm from the nares.
    MeSH term(s) Cadaver ; Carotid Artery, Internal ; Endoscopy ; Eustachian Tube ; Humans ; Palatal Muscles ; Skull Base
    Language English
    Publishing date 2020-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.26101
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    Zs.A 1493: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: Dual Function of Par3 in Tumorigenesis.

    Lv, Tao / Xu, Jiashun / Yuan, Hemei / Wang, Jianling / Jiang, Xinni

    Frontiers in oncology

    2022  Volume 12, Page(s) 915957

    Abstract: Cell maintenance and the establishment of cell polarity involve complicated interactions among multiple protein complexes as well as the regulation of different signaling pathways. As an important cell polarity protein, Par3 is evolutionarily conserved ... ...

    Abstract Cell maintenance and the establishment of cell polarity involve complicated interactions among multiple protein complexes as well as the regulation of different signaling pathways. As an important cell polarity protein, Par3 is evolutionarily conserved and involved in tight junction formation as well as tumorigenesis. In this review, we aimed to explore the function of Par3 in tumorigenesis. Research has shown that Par3 exhibits dual functions in human cancers, both tumor-promoting and tumor-suppressive. Here, we focus on the activities of Par3 in different stages and types of tumors, aiming to offer a new perspective on the molecular mechanisms that regulate the functions of Par3 in tumor development. Tumor origin, tumor microenvironment, tumor type, cell density, cell-cell contact, and the synergistic effect of Par3 and other tumor-associated signaling pathways may be important reasons for the dual function of Par3. The important role of Par3 in mammalian tumorigenesis and potential signaling pathways is context dependent.
    Language English
    Publishing date 2022-07-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.915957
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  7. Article ; Online: Updates in biologic therapy for chronic rhinosinusitis with nasal polyps and NSAID-exacerbated respiratory disease.

    Xu, Xinni / Reitsma, Sietze / Wang, De Yun / Fokkens, Wytske J

    Allergy

    2022  Volume 77, Issue 12, Page(s) 3593–3605

    Abstract: Chronic rhinosinusitis with nasal polyps (CRSwNP) associated with type 2 inflammation and non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD) can be difficult to control with standard medical therapy and sinus surgery. In ...

    Abstract Chronic rhinosinusitis with nasal polyps (CRSwNP) associated with type 2 inflammation and non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD) can be difficult to control with standard medical therapy and sinus surgery. In this group, biologicals are potentially promising treatment options. The phase III clinical trials for omalizumab, dupilumab, mepolizumab and benralizumab in CRSwNP have demonstrated favourable outcomes. Moving forward, direct comparisons among biologicals, refining patient selection criteria for specific biologicals, determining optimal treatment duration and monitoring long-term outcomes are areas of emerging interest. This review summarizes the clinical evidence from the recent 2 years on the role of biologicals in severe CRSwNP and N-ERD, and proposes an approach towards decision-making in their use.
    MeSH term(s) Humans ; Nasal Polyps/drug therapy ; Nasal Polyps/complications ; Rhinitis/drug therapy ; Rhinitis/complications ; Sinusitis/drug therapy ; Sinusitis/complications ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Chronic Disease ; Biological Therapy ; Respiration Disorders/therapy ; Biological Products/therapeutic use
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Biological Products
    Language English
    Publishing date 2022-09-15
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15507
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    Uh III Zs.150: Show issues Location:
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    Zs.MO 125: Show issues

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  8. Article: Warming Menstruation and Analgesic Soup Inhibits PD-1/PD-L1 Pathway in Rats with Endometriosis.

    Feng, Dan / Wang, Xinni / Huang, Yanhui / Chen, Xi / Xu, Ruyi / Qu, Zhun / Chou, Dan

    Alternative therapies in health and medicine

    2023  Volume 29, Issue 4, Page(s) 152–157

    Abstract: Aim: To observe the effect of warming menstruation and analgesic herbal soup (WMAS) on the pathway of programmed cell death protein 1 and its ligand 1 PD-1/PD-L1 in rats with endometriosis model.: Methods: A total of 90 mature female Wistar rats were ...

    Abstract Aim: To observe the effect of warming menstruation and analgesic herbal soup (WMAS) on the pathway of programmed cell death protein 1 and its ligand 1 PD-1/PD-L1 in rats with endometriosis model.
    Methods: A total of 90 mature female Wistar rats were randomly divided into 6 groups of 15 rats each. Of these, 5 groups were randomly selected for endometriosis molding and given high (HW group), medium (MW group) and low (LW group) doses of WMAS, western medicine (progesterone capsules, PC group) and saline gavage (SG group) respectively. The other group was a normal group (NM group), which was given saline gavage. The protein expression of PD-1 and PD-L1 on rat in eutopic and ectopic endothelium was detected by immunohistochemistry and the mRNA expression of PD-1 and PD-L1 in rats was detected by real-time fluorescence quantitative polymerase chain reaction (PCR).
    Results: The protein and mRNA expression of PD-1 and PD-L in the eutopic and ectopic endometrium of rats in the endometriosis group were higher than in the normal group (P <.05). The protein and mRNA expression of PD-1 and PD-L1 in the eutopic and ectopic endothelium of the HW, MW and PC groups were lower than in the SG group (P <.05).
    Conclusion: High expression of PD-1 and PD-L1 occurs in endometriosis, and WMAS can inhibit the immune signalling pathway PD-1/PD-L1, which may be available to inhibit the development of endometriosis.
    MeSH term(s) Humans ; Rats ; Female ; Animals ; Endometriosis/drug therapy ; Endometriosis/genetics ; Endometriosis/metabolism ; Menstruation ; B7-H1 Antigen/metabolism ; Programmed Cell Death 1 Receptor/metabolism ; Rats, Wistar ; RNA, Messenger ; Analgesics
    Chemical Substances B7-H1 Antigen ; Programmed Cell Death 1 Receptor ; RNA, Messenger ; Analgesics
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
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    Zs.A 4504: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: WIPF1 promotes gastric cancer progression by regulating PI3K/Akt signaling in a myocardin-dependent manner.

    Su, Fei / Xiao, Ruowen / Chen, Rui / Yang, Tianning / Wang, Danwen / Xu, Xinni / Hou, Xiaoming / Guan, Quanlin / Feng, Maohui

    iScience

    2023  Volume 26, Issue 11, Page(s) 108273

    Abstract: Wiskott-Aldrich syndrome protein-interacting protein family member 1 (WIPF1) is associated with malignant tumor progression. However, molecular links between WIPF1 and gastric cancer (GC) remain elusive. The expression of WIPF1 was detected in GC tissues ...

    Abstract Wiskott-Aldrich syndrome protein-interacting protein family member 1 (WIPF1) is associated with malignant tumor progression. However, molecular links between WIPF1 and gastric cancer (GC) remain elusive. The expression of WIPF1 was detected in GC tissues and cells. WIPF1 was overexpressed in GC tissues and cells and high expression of WIPF1 was an independent risk factor for a poor prognosis in patients with GC. Further experiments indicated that WIPF1 promoted the proliferation, invasion, and migration of GC cells
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108273
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  10. Article: Precision Medicine in Chronic Rhinosinusitis: Where Does Allergy Fit In?

    Xu, Xinni / Ong, Yew Kwang / Wang, De Yun

    Handbook of experimental pharmacology

    2021  Volume 268, Page(s) 151–170

    Abstract: Chronic rhinosinusitis (CRS) is a clinical syndrome stemming from persistent inflammation of the sinonasal mucosa. Phenotypically, it is traditionally and widely described according to the presence or absence of polyps. While this distinction is simple ... ...

    Abstract Chronic rhinosinusitis (CRS) is a clinical syndrome stemming from persistent inflammation of the sinonasal mucosa. Phenotypically, it is traditionally and widely described according to the presence or absence of polyps. While this distinction is simple to use, it has little bearing on prognosis and treatment, for CRS is essentially an inflammatory disease resulting from dysregulated interaction between a multitude of host and environmental factors. Allergy is merely one of them and, like many of the proposed aetiologies, has been subject to much debate which will be discussed here. As our understanding of CRS continues to evolve, previous so-called conventional wisdom about phenotypes (e.g. CRS with nasal polyps is associated with Type 2 inflammation) is being challenged, and new phenotypes are also emerging. In addition, there is growing interest in defining the endotypes of CRS to deliver precise and personalised treatment, especially pertaining to the development of biologics for the group of severe, difficult-to-treat CRS patients. A proposed model of precision medicine tailored to management of CRS will also be introduced to readers, which can be continually modified to adapt to new discoveries about this exciting condition.
    MeSH term(s) Chronic Disease ; Humans ; Hypersensitivity ; Nasal Polyps/drug therapy ; Precision Medicine ; Rhinitis/diagnosis ; Rhinitis/drug therapy ; Rhinitis/etiology ; Sinusitis/diagnosis ; Sinusitis/drug therapy ; Sinusitis/etiology
    Language English
    Publishing date 2021-05-18
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2021_489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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