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  1. Article ; Online: Does the Term "Deflators" Reflect More Accurately the Beneficial Effects of Long-acting Bronchodilators in COPD?

    Kostikas, Konstantinos / Siafakas, Nikolaos M

    COPD

    2016  Volume 13, Issue 5, Page(s) 537–539

    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article
    ZDB-ID 2171107-0
    ISSN 1541-2563 ; 1541-2555
    ISSN (online) 1541-2563
    ISSN 1541-2555
    DOI 10.3109/15412555.2016.1153615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5990: Show issues Location:
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  2. Article ; Online: Preventing exacerbations of COPD--advice from Hippocrates.

    Siafakas, Nikolaos M

    The New England journal of medicine

    2011  Volume 365, Issue 8, Page(s) 753–754

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Azithromycin/therapeutic use ; Drug Resistance, Bacterial ; Humans ; Pulmonary Disease, Chronic Obstructive/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Azithromycin (83905-01-5)
    Language English
    Publishing date 2011-08-25
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1106979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
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  3. Article: Predominance of Recombinant Norovirus Strains in Greece, 2016-2018.

    Siafakas, Nikolaos / Anastassopoulou, Cleo / Lafazani, Maria / Chronopoulou, Genovefa / Rizos, Emmanouil / Pournaras, Spyridon / Tsakris, Athanasios

    Microorganisms

    2023  Volume 11, Issue 12

    Abstract: GII.4 noroviruses have caused the overwhelming majority of norovirus-related gastroenteritis cases during the past two decades. However, a trend towards the emergence of new genotypes and novel GII.4 variants provided the impetus to explore further the ... ...

    Abstract GII.4 noroviruses have caused the overwhelming majority of norovirus-related gastroenteritis cases during the past two decades. However, a trend towards the emergence of new genotypes and novel GII.4 variants provided the impetus to explore further the changing patterns in norovirus epidemiology during the present study. Genotyping of 60 norovirus strains detected during a period of 33 months (January 2016-October 2018) was performed on the basis of the capsid VP1-coding ORF2 gene sequence. All norovirus strains detected were classified into seven genotypes, six of which belonged to genogroup GII. GII.2 was the dominant genotype till February 2017, whereas GII.4 prevailed thereafter. Most of the GII.4 strains were of the Sydney_2012 variant, whereas five strains could not be classified. Further recombination analysis at the ORF1/ORF2 gene junction revealed that 23 out of 24 strains were recombinant, thereby showcasing the significant role of genetic recombination in norovirus evolution and epidemiology. Continuous genomic surveillance and molecular characterization are essential for tracking norovirus evolution, which could contribute to the elucidation of new aspects of virus-host interactions that potentially affect host morbidity and epidemiology.
    Language English
    Publishing date 2023-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11122885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Field Evaluation of the New Rapid NG-Test

    Avgoulea, Kalliopi / Beredaki, Maria-Ioanna / Vourli, Sophia / Siopi, Maria / Siafakas, Nikolaos / Pournaras, Spyros

    Frontiers in public health

    2022  Volume 10, Page(s) 840984

    Abstract: Background: As the COVID-19 pandemic resurges affecting large numbers of patients, rapid, and accurate diagnosis using point-of-care tests is very important.: Objectives: To evaluate the NG-Test: Methods: All adult ambulatory patients presenting ... ...

    Abstract Background: As the COVID-19 pandemic resurges affecting large numbers of patients, rapid, and accurate diagnosis using point-of-care tests is very important.
    Objectives: To evaluate the NG-Test
    Methods: All adult ambulatory patients presenting to the Emergencies of "Attikon" University hospital (Athens, Greece) within three consecutive hours per day between December 2020 and March 2021 and for whom SARS-CoV-2 PCR testing was requested were included. Two NP and one OP samples obtained from each participant were analyzed to determine the diagnostic performance [sensitivity, specificity, positive/negative predictive values (PPV/NPV)] of the NG-Test (NP/OP swabs) in comparison to the reference RT-PCR (NP swab).
    Results: Overall, 134/263 (51%) patients tested were RT-PCR positive, whereof 108 (overall sensitivity 81%, 95% CI 73-87%) were NP NG-Test positive (PPV 99%, NPV 83%) and 68 (overall sensitivity 51%, 95% CI 42-59%) were OP NG-Test positive (PPV 100%, NPV 66%). The test's specificity (95% CI) was 99% (95-100%) and 100% (96-100%) for NP and OP swabs, respectively. The assay's sensitivity (95% CI) for high viral load (C
    Conclusions: NG-Test using NP swabs detected almost all patients with high viral loads, showing satisfactory performance as a point-of-care test for NP samples obtained from patients with acute infection.
    MeSH term(s) Adult ; Antigens, Viral ; COVID-19/diagnosis ; Emergencies ; Emergency Service, Hospital ; Hospitals ; Humans ; Pandemics ; Referral and Consultation ; SARS-CoV-2 ; Sensitivity and Specificity
    Chemical Substances Antigens, Viral
    Language English
    Publishing date 2022-04-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.840984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Is the inflammatory response of the lungs in COPD abnormal?

    Siafakas, Nikolaos M / Tzortzaki, Eleni G

    Chest

    2011  Volume 140, Issue 2, Page(s) 561–562

    MeSH term(s) Airway Resistance/physiology ; Asthma/drug therapy ; Asthma/physiopathology ; Humans ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/physiopathology
    Language English
    Publishing date 2011-08
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.11-0224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  6. Article ; Online: Suicidality and COVID-19: Suicidal ideation, suicidal behaviors and completed suicides amidst the COVID-19 pandemic (Review).

    Efstathiou, Vasiliki / Stefanou, Maria-Ioanna / Siafakas, Nikolaos / Makris, Michael / Tsivgoulis, Georgios / Zoumpourlis, Vassilios / Spandidos, Demetrios A / Smyrnis, Nikolaos / Rizos, Emmanouil

    Experimental and therapeutic medicine

    2021  Volume 23, Issue 1, Page(s) 107

    Abstract: Since the outbreak of the coronavirus 2019 (COVID-19) pandemic, there has been widespread concern that social isolation, financial stress, depression, limited or variable access to health care services and other pandemic-related stressors may contribute ... ...

    Abstract Since the outbreak of the coronavirus 2019 (COVID-19) pandemic, there has been widespread concern that social isolation, financial stress, depression, limited or variable access to health care services and other pandemic-related stressors may contribute to an increase in suicidal behaviors. In patients who have recovered from COVID-19, an increased risk of developing suicidal behaviors may be noted, while post-COVID syndrome comprises another potential risk factor contributing to increased suicidal behaviors. Despite the initial alarming predictions for an increase in suicide rates due to the COVID-19 pandemic, the majority of published studies to date suggest that experienced difficulties and distress do not inevitably translate into an increased number of suicide-related deaths, at least not in the short-term. Nevertheless, the long-term mental health effects of the COVID-19 pandemic have yet to be unfolded and are likely to remain for a long period of time. Suicide prevention and measures aiming at promoting well-being and mitigating the effects of COVID-19 on mental health, particularly among vulnerable groups, should thus be a priority for healthcare professionals and policymakers amidst the evolving COVID-19 pandemic.
    Language English
    Publishing date 2021-12-02
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2021.11030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Pulmonary involvement and allergic disorders in inflammatory bowel disease.

    Tzanakis, Nikolaos E / Tsiligianni, Ioanna G / Siafakas, Nikolaos M

    World journal of gastroenterology

    2010  Volume 16, Issue 3, Page(s) 299–305

    Abstract: Inflammatory bowel disease (IBD) has been associated with either clinical or subclinical airway and parenchymal lung involvement and interstitial lung complications. Several studies have reported that atopy has a high prevalence in IBD patients. ... ...

    Abstract Inflammatory bowel disease (IBD) has been associated with either clinical or subclinical airway and parenchymal lung involvement and interstitial lung complications. Several studies have reported that atopy has a high prevalence in IBD patients. Overlapping allergic disorders seem to be present in both the respiratory and gastrointestinal systems. The purpose of this review is to update clinicians on recent available literature and to discuss the need for a highly suspicious approach by clinicians.
    MeSH term(s) Humans ; Hypersensitivity/epidemiology ; Hypersensitivity/physiopathology ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/physiopathology ; Lung/physiopathology ; Lung Diseases, Interstitial/epidemiology ; Lung Diseases, Interstitial/physiopathology ; Prevalence ; Risk Factors
    Language English
    Publishing date 2010-01-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v16.i3.299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
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  8. Article ; Online: Long COVID and neuropsychiatric manifestations (Review).

    Efstathiou, Vasiliki / Stefanou, Maria-Ioanna / Demetriou, Marina / Siafakas, Nikolaos / Makris, Michael / Tsivgoulis, Georgios / Zoumpourlis, Vassilios / Kympouropoulos, Stylianos P / Tsoporis, James N / Spandidos, Demetrios A / Smyrnis, Nikolaos / Rizos, Emmanouil

    Experimental and therapeutic medicine

    2022  Volume 23, Issue 5, Page(s) 363

    Abstract: There is accumulating evidence in the literature indicating that a number of patients with coronavirus disease 2019 (COVID-19) may experience a range of neuropsychiatric symptoms, persisting or even presenting following the resolution of acute COVID-19. ... ...

    Abstract There is accumulating evidence in the literature indicating that a number of patients with coronavirus disease 2019 (COVID-19) may experience a range of neuropsychiatric symptoms, persisting or even presenting following the resolution of acute COVID-19. Among the neuropsychiatric manifestations more frequently associated with 'long COVID' are depression, anxiety, post-traumatic stress disorder, sleep disturbances, fatigue and cognitive deficits, that can potentially be debilitating and negatively affect patients' wellbeing, albeit in the majority of cases symptoms tend to improve over time. Despite variations in results obtained from studies using different methodological approaches to define 'long COVID' syndrome, the most widely accepted factors associated with a higher risk of developing neuropsychiatric manifestations include the severity of foregoing COVID-19, the female sex, the presence of comorbidities, a history of mental health disease and an elevation in the levels of inflammatory markers, albeit further research is required to establish causal associations. To date, the pathophysiological mechanisms implicated in neuropsychiatric manifestations of 'long COVID' remain only partially elucidated, while the role of the indirect effects of the COVID-19 pandemic, such as social isolation and uncertainty concerning social, financial and health recovery post-COVID, have also been highlighted. Given the alarming effects of 'long-COVID', interdisciplinary cooperation for the early identification of patients who are at a high risk of persistent neuropsychiatric presentations, beyond COVID-19 recovery, is crucial to ensure that appropriate integrated physical and mental health support is provided, with the aim of mitigating the risks of long-term disability at a societal and individual level.
    Language English
    Publishing date 2022-04-01
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2022.11290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: New‑onset neuropsychiatric sequelae and 'long‑COVID' syndrome (Review).

    Efstathiou, Vasiliki / Stefanou, Maria-Ioanna / Demetriou, Marina / Siafakas, Nikolaos / Katsantoni, Eleni / Makris, Michael / Tsivgoulis, Georgios / Zoumpourlis, Vassilios / Kympouropoulos, Stylianos P / Tsoporis, James N / Spandidos, Demetrios A / Ferentinos, Panagiotis / Smyrnis, Nikolaos / Rizos, Emmanouil

    Experimental and therapeutic medicine

    2022  Volume 24, Issue 5, Page(s) 705

    Abstract: The ongoing coronavirus disease 2019 (COVID-19) pandemic has had a widespread impact on individuals' mental health through indirect psychological and social mechanisms, related to factors such as fear of infection or death, social isolation, lack of ... ...

    Abstract The ongoing coronavirus disease 2019 (COVID-19) pandemic has had a widespread impact on individuals' mental health through indirect psychological and social mechanisms, related to factors such as fear of infection or death, social isolation, lack of social support and financial instability. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has also been associated with the development or recurrence of neuropsychiatric symptoms, both during the acute phase, as well as during the post-acute 'long-COVID' phase. In addition to the COVID-19 survivors with a mental health history that are at a high risk of experiencing a range of neuropsychiatric symptoms following resolution of acute COVID-19, there is accumulating evidence that a diagnosis of COVID-19 may also be associated with new-onset neuropsychiatric morbidity among survivors without pre-existing mental health disorders. In particular, studies investigating the incidence of post-acute neuropsychiatric sequelae, based mostly on retrospective cohort study designs and data from national health registries, have reported the development of new-onset manifestations, including depression, anxiety, psychotic symptoms, sleep disturbances and fatigue. Nevertheless, when COVID-19 survivors were compared with SARS-CoV-2-negative controls and especially survivors of other disorders (such as influenza), the findings regarding the risk of incident neuropsychiatric manifestations varied among studies. While there is evidence of an association between SARS-CoV-2 infection and the subsequent occurrence of new-onset neuropsychiatric symptoms, especially among patients with increased disease severity, further research using methodological approaches less susceptible to confounding bias is required to establish causal relationships.
    Language English
    Publishing date 2022-10-04
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2022.11641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Asthma in the Elderly: Can We Distinguish It from COPD?

    Tzortzaki, Eleni G / Proklou, Athanasia / Siafakas, Nikolaos M

    Journal of allergy

    2011  Volume 2011, Page(s) 843543

    Abstract: Asthma in older adults affects quality of life and results in a higher hospitalization rate and mortality. In common clinical practice, asthma in the elderly is underdiagnosed and undertreated or overdiagnosed and mistreated. The age-related reduction in ...

    Abstract Asthma in older adults affects quality of life and results in a higher hospitalization rate and mortality. In common clinical practice, asthma in the elderly is underdiagnosed and undertreated or overdiagnosed and mistreated. The age-related reduction in perception of shortness of breath and the high incidence of comorbidities make the diagnosis and management more difficult and challenging for the physicians. Chronic obstructive pulmonary disease (COPD) is usually easy to distinguish from asthma, but sometimes the distinction from late-onset asthma in older patients, particularly in cigarette smokers, is difficult and may be impossible. Both diseases are characterized by the presence of airflow obstruction but have distinct pathogenesis, inflammatory pattern, and prognosis. The distinction between Asthma and COPD based simply on spirometric parameters is difficult especially in the elderly asthmatics. The combination of lung function testing, bronchial hyperresponsiveness (BHR) and atopy status, HRCT scans, and the newly developed biological techniques, allowing the assessment of biomarker profiles, could facilitate the distinction between these diseases.
    Language English
    Publishing date 2011-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2571416-8
    ISSN 1687-9791 ; 1687-9783
    ISSN (online) 1687-9791
    ISSN 1687-9783
    DOI 10.1155/2011/843543
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