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  1. Article: Tea intake and total body bone mineral density of all ages: a Mendelian randomization analysis.

    Xing, Chen / Tan, Yanrong / Ni, Wentao

    Frontiers in nutrition

    2024  Volume 11, Page(s) 1289730

    Abstract: Background: There is increasing evidence indicating that tea intake affects bone mineral density levels; however, the causality between tea intake and bone mineral density is inconclusive. This study aimed to assess the causal relationship between tea ... ...

    Abstract Background: There is increasing evidence indicating that tea intake affects bone mineral density levels; however, the causality between tea intake and bone mineral density is inconclusive. This study aimed to assess the causal relationship between tea intake and total body bone mineral density (TB-BMD) through two-sample Mendelian randomization (MR) analysis.
    Methods: We conducted a two-sample MR approach to estimate the potential causal effects of tea intake on TB-BMD at all ages in a European population. The analyses were performed using summary statistics obtained for single-nucleotide polymorphisms (SNPs), identified from a genome-wide association meta-analysis of tea intake (
    Results: The MR analysis revealed that genetically determined tea intake exerts a causal impact on TB-BMD, with an odds ratio (OR) of 1.204 (95% CI: 1.062-1.366,
    Conclusion: The findings of this study support the evidence that tea consumption increases bone density and reduces the risk of osteoporosis in the age group of 45-60 years within the European population.
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2024.1289730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Attention-Guided Partial Domain Adaptation for Automated Pneumonia Diagnosis From Chest X-Ray Images.

    Liu, Wentao / Ni, Zhiwei / Chen, Qian / Ni, Liping

    IEEE journal of biomedical and health informatics

    2023  Volume 27, Issue 12, Page(s) 5848–5859

    Abstract: Deep neural networks (DNN) supported by multicenter large-scale Chest X-Ray (CXR) datasets can efficiently perform tasks such as disease identification, lesion segmentation, and report generation. However, the non-ignorable inter-domain heterogeneity ... ...

    Abstract Deep neural networks (DNN) supported by multicenter large-scale Chest X-Ray (CXR) datasets can efficiently perform tasks such as disease identification, lesion segmentation, and report generation. However, the non-ignorable inter-domain heterogeneity caused by different equipment, ethnic groups, and scanning protocols may lead to dramatic degradation in model performance. Unsupervised domain adaptation (UDA) methods help alleviate the cross-domain discrepancy for subsequent analysis. Nevertheless, they may be prone to: 1) spatial negative transfer: misaligning non-transferable regions which have inadequate knowledge, and 2) semantic negative transfer: failing to extend to scenarios where the label spaces of the source and target domain are partially shared. In this work, we propose a classification-based framework named attention-guided partial domain adaptation (AGPDA) network for overcoming these two negative transfer challenges. AGPDA is composed of two key modules: 1) a region attention discrimination block (RADB) to generate fine-grained attention value via lightweight region-wise multi-adversarial networks. 2) a residual feature recalibration block (RFRB) trained with class-weighted maximum mean discrepancy (MMD) loss for down-weighing the irrelevant source samples. Extensive experiments on two publicly available CXR datasets containing a total of 8598 pneumonia (viral, bacterial, and COVID-19) cases, 7163 non-pneumonia or healthy cases, demonstrate the superior performance of our AGPDA. Especially on three partial transfer tasks, AGPDA significantly increases the accuracy, sensitivity, and F1 score by 4.35%, 4.05%, and 1.78% compared to recently strong baselines.
    MeSH term(s) Humans ; X-Rays ; Pneumonia/diagnostic imaging ; COVID-19/diagnostic imaging ; Thorax ; Health Status ; COVID-19 Testing
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2695320-1
    ISSN 2168-2208 ; 2168-2194
    ISSN (online) 2168-2208
    ISSN 2168-2194
    DOI 10.1109/JBHI.2023.3313886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5483: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: PEEP-Induced Lung Recruitment Maneuver Combined with Prone Position for ARDS: A Single-Center, Prospective, Randomized Clinical Trial.

    Lan, Lan / Ni, Yuenan / Zhou, Yubei / Fu, Linxi / Wu, Wentao / Li, Ping / Yu, He / Liang, Guopeng / Luo, Fengming

    Journal of clinical medicine

    2024  Volume 13, Issue 3

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Cefiderocol for the Treatment of Multidrug-Resistant Gram-Negative Bacteria: A Systematic Review of Currently Available Evidence.

    Wang, Chuanhai / Yang, Deqing / Wang, Yifan / Ni, Wentao

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 896971

    Abstract: Cefiderocol is a novel synthetic siderophore-conjugated antibiotic that hijacks the bacterial iron transport systems facilitating drug entry into cells, achieving high periplasmic concentrations. This systematic review analyzed the currently available ... ...

    Abstract Cefiderocol is a novel synthetic siderophore-conjugated antibiotic that hijacks the bacterial iron transport systems facilitating drug entry into cells, achieving high periplasmic concentrations. This systematic review analyzed the currently available literature on cefiderocol. It summarized
    Language English
    Publishing date 2022-04-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.896971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Vertically Integrated Monolithic Neuromorphic Nanowire Device for Physiological Information Processing.

    Liu, Junchi / Jiang, Chengpeng / Wei, Huanhuan / Wang, Zixian / Sun, Lin / Zhang, Song / Ni, Yao / Qu, Shangda / Yang, Lu / Xu, Wentao

    Nano letters

    2024  Volume 24, Issue 15, Page(s) 4336–4345

    Abstract: This study demonstrates the conceptual design and fabrication of a vertically integrated monolithic (VIM) neuromorphic device. The device comprises an n-type ... ...

    Abstract This study demonstrates the conceptual design and fabrication of a vertically integrated monolithic (VIM) neuromorphic device. The device comprises an n-type SnO
    MeSH term(s) Nanowires ; Synapses
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c04391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Low expression of RACK1 is associated with metastasis and worse prognosis in cholangiocarcinoma.

    Gao, Zhihui / Sun, Wentao / Ni, Xiaojian / Wan, Wenze / Suo, Tao / Ni, Xiaoling / Liu, Han / Li, Na / Sheng Shen / Liu, Houbao

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27366

    Abstract: Background: Cholangiocarcinoma is a poorly prognostic malignant tumor, and the metastatic stage of cancer is not an early stage when diagnosed. Lymph node metastasis is common in the early stage. Ribosomal receptor for activated C-kinase 1 (RACK1) has ... ...

    Abstract Background: Cholangiocarcinoma is a poorly prognostic malignant tumor, and the metastatic stage of cancer is not an early stage when diagnosed. Lymph node metastasis is common in the early stage. Ribosomal receptor for activated C-kinase 1 (RACK1) has found involved in the oncogenesis of various tumors and in the epithelial-mesenchymal transition (EMT). Nevertheless, its role in cholangiocarcinoma remains unknown.
    Material and methods: The possible correlation between RACK1 and tumor prognosis was analyzed in cholangiocarcinoma patients. The GEO and TCGA databases were used to evaluate the level of
    Results: The Kaplan-Meier analysis indicated that low expression of RACK1 was associated with poor prognosis and RACK1 was negatively related to lymph node metastasis, which were verified in databases TCGA and GEO; downregulation of RACK1 via RNA interference correlated with changes in the expression of EMT biomarkers and promoted the migration of cholangiocarcinoma cell lines.
    Conclusion: The protein expression of RACK1 is significantly higher in cholangiocarcinoma tissues than in peritumoral tissues, however, the high RACK1 expression indicates better overall survival and less risk for lymph node metastasis.
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Advanced NASICON-Type Na

    Gao, Jinqiang / Mei, Yu / Ni, Lianshan / Wang, Haoji / Song, Bai / Deng, Wentao / Zou, Guoqiang / Hou, Hongshuai / Ji, Xiaobo

    Inorganic chemistry

    2023  Volume 62, Issue 23, Page(s) 9099–9110

    Abstract: ... ...

    Abstract Na
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c00948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Aluminum ion chemistry of Na

    Gao, Jinqiang / Zeng, Jingyao / Jian, Weishun / Mei, Yu / Ni, Lianshan / Wang, Haoji / Wang, Kai / Hu, Xinyu / Deng, Wentao / Zou, Guoqiang / Hou, Hongshuai / Ji, Xiaobo

    Science bulletin

    2024  Volume 69, Issue 6, Page(s) 772–783

    Abstract: ... ...

    Abstract Na
    Language English
    Publishing date 2024-01-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2024.01.026
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  9. Article ; Online: A High-Strength Neuromuscular System That Implements Reflexes as Controlled by a Multiquadrant Artificial Efferent Nerve.

    Ni, Yao / Liu, Lu / Liu, Jiaqi / Xu, Wentao

    ACS nano

    2022  Volume 16, Issue 12, Page(s) 20294–20304

    Abstract: We demonstrate an artificial efferent nerve that distinguishes environment-responsive conditioned and unconditioned reflexes, i.e., hand-retraction reflex and muscle memory, respectively. These reflex modes are immediately switchable by altering the ... ...

    Abstract We demonstrate an artificial efferent nerve that distinguishes environment-responsive conditioned and unconditioned reflexes, i.e., hand-retraction reflex and muscle memory, respectively. These reflex modes are immediately switchable by altering the polarity of charge carriers in a parallel-channeled artificial synapse; this ability emulates multiplexed neurotransmission of different neurotransmitters to form glutamine-induced short-term plasticity and acetylcholine-induced long-term plasticity. This is the successful control of high-strength artificial muscle fibers by using an artificial efferent nerve to form a neuromuscular system that can realize curvature and force simultaneously and in which all these aspects far surpass currently available neuromuscular systems. Furthermore, the special four-quadrant information-processing mechanism of our artificial efferent nerve allows complex application extensions, i.e., relative-position tracking of sound sources, immediate switchable learning modes between fast information processing and long-term memory, and high-accuracy pattern cognition. This work is a step toward development of human-compatible artificial neuromuscular systems.
    MeSH term(s) Humans ; Reflex/physiology ; Muscle, Skeletal ; Synaptic Transmission
    Language English
    Publishing date 2022-11-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.2c06122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Discovery of Fibrinogen γ-chain as a potential urinary biomarker for renal interstitial fibrosis in IgA nephropathy.

    Guan, Jie / Wang, Meiling / Zhao, Man / Ni, Wentao / Zhang, Man

    BMC nephrology

    2023  Volume 24, Issue 1, Page(s) 60

    Abstract: Background: IgA nephropathy (IgAN) is a major cause of chronic kidney disease (CKD). Renal interstitial fibrosis is a hallmark of CKD progression. Non-invasive biomarkers are needed to dynamically evaluate renal fibrosis. Data independent acquisition ( ... ...

    Abstract Background: IgA nephropathy (IgAN) is a major cause of chronic kidney disease (CKD). Renal interstitial fibrosis is a hallmark of CKD progression. Non-invasive biomarkers are needed to dynamically evaluate renal fibrosis. Data independent acquisition (DIA)-based liquid chromatography-mass spectrometry (DIA-MS) was used to identify candidate urinary biomarkers in IgAN patients with different renal interstitial fibrosis degrees.
    Methods: Eighteen biopsy-proven IgAN patients and six healthy controls were recruited in a discovery cohort. Interstitial fibrosis changes were evaluated according to Oxford MEST-C scores. Urinary samples were analyzed with DIA-MS to identify hub proteins. Hub proteins were then confirmed by enzyme-linked immunosorbent assay (ELISA) in a validation cohort and the associated gene mRNA expression was analyzed using public gene expression omnibus (GEO) datasets.
    Results: Complement and coagulation cascades pathway was the main KEGG pathway related to the over-expressed proteins. Fibrinogen γ-Chain (FGG) was selected as the potential urinary marker for further validation. Urinary FGG to creatinine ratio (uFGG/Cr) levels were higher in both disease controls and IgAN group than in healthy controls, but were not significantly different between IgAN and disease groups. uFGG/Cr was confirmed to be increased with the extent of renal fibrosis and presented moderate correlations with T score (r = 0.614, p < 0.01) and eGFR (r = -0.682, p < 0.01), and a mild correlation with UTP (r = 0.497, p < 0.01) in IgAN group. In disease control group, uFGG/Cr was higher in patients with T1 + 2 compared to those with T0. uFGG/Cr had a good discriminatory power to distinguish different fibrosis stages in IgAN: interstitial fibrosis ≤ 5% (minimal fibrosis) vs. interstitial fibrosis (mild fibrosis) > 5%, AUC 0.743; T0 vs. T1 + 2, AUC 0.839; T0 + 1 vs. T2, AUC 0.854. In disease control group, uFGG/Cr showed better performance of AUC than UTP between minimal and mild fibrosis (p = 0.038 for Delong's test). Moreover, GSE104954 dataset showed that FGG mRNA expression was up-regulated (fold change 1.20, p = 0.009) in tubulointerstitium of IgAN patients when compared to healthy living kidney donors.
    Conclusion: Urinary FGG is associated with renal interstitial fibrosis and could be used as a noninvasive biomarker for renal fibrosis in IgAN.
    MeSH term(s) Humans ; Glomerulonephritis, IGA/complications ; Kidney/pathology ; Uridine Triphosphate ; Renal Insufficiency, Chronic/complications ; Biomarkers/urine ; Fibrosis ; RNA, Messenger
    Chemical Substances Uridine Triphosphate (UT0S826Z60) ; Biomarkers ; RNA, Messenger
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-023-03103-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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