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  1. Article: Retrospective Study of T Cell Leukaemia (Large Granular Lymphocyte Variant) in Dogs Associated with Suspected Immune-Mediated Cytopaenia(s) in the Absence of Peripheral Lymphocytosis.

    Capasso, Angelo / Villers, Elizabeth / Elliott, James / Ilchyshyn, Nic / Hopkins, Ian / Sanchez, Ferran Valls / Verganti, Sara

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 3

    Abstract: Canine chronic large granular lymphocyte (LGL) leukaemia is commonly characterised by moderate to marked lymphocytosis but not neutropaenia. In humans, LGL leukaemia is often associated with autoimmune disorders, including immune-mediated cytopaenias ( ... ...

    Abstract Canine chronic large granular lymphocyte (LGL) leukaemia is commonly characterised by moderate to marked lymphocytosis but not neutropaenia. In humans, LGL leukaemia is often associated with autoimmune disorders, including immune-mediated cytopaenias (mainly neutropaenia). This presentation is rare in dogs. The aim of this retrospective study was to describe the clinical characteristics, treatments, and outcomes of dogs with chronic LGL leukaemia with suspected immune-mediated cytopaenia. Six dogs with a median age of 4.5 years (range 2-8 years) were included in the study. The most common presenting signs were pyrexia and lethargy. All dogs had severe neutropaenia (median neutrophil count 0.07 × 10
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13030357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Retrospective Study of T Cell Leukaemia (Large Granular Lymphocyte Variant) in Dogs Associated with Suspected Immune-Mediated Cytopaenia(s) in the Absence of Peripheral Lymphocytosis

    Capasso, Angelo / Villers, Elizabeth / Elliott, James / Ilchyshyn, Nic / Hopkins, Ian / Sanchez, Ferran Valls / Verganti, Sara

    Animals. 2023 Jan. 20, v. 13, no. 3

    2023  

    Abstract: ... cytology revealed infiltration of granular T lymphocytes; PARR analysis confirmed clonality in four, and ...

    Abstract Canine chronic large granular lymphocyte (LGL) leukaemia is commonly characterised by moderate to marked lymphocytosis but not neutropaenia. In humans, LGL leukaemia is often associated with autoimmune disorders, including immune-mediated cytopaenias (mainly neutropaenia). This presentation is rare in dogs. The aim of this retrospective study was to describe the clinical characteristics, treatments, and outcomes of dogs with chronic LGL leukaemia with suspected immune-mediated cytopaenia. Six dogs with a median age of 4.5 years (range 2–8 years) were included in the study. The most common presenting signs were pyrexia and lethargy. All dogs had severe neutropaenia (median neutrophil count 0.07 × 10⁹/L), three had thrombocytopaenia (median platelet count 66 × 10⁹/L), and one had anaemia (HCT 0.32 L/L). In all dogs, bone marrow cytology revealed infiltration of granular T lymphocytes; PARR analysis confirmed clonality in four, and bone marrow flow cytometry identified CD3+ CD8+ neoplastic cells in two cases. All patients received systemic chemotherapy, and the cytopaenias resolved after 1–19 weeks. Two dogs were euthanised 133 and 322 days after diagnosis, two were lost to follow-up after 224 and 357 days, and two were alive at 546 and 721 days. A subset of LGL leukaemia in dogs is associated with immune-mediated cytopaenia and has a unique clinical presentation.
    Keywords T-lymphocytes ; anemia ; blood platelet count ; bone marrow ; dogs ; drug therapy ; fever ; flow cytometry ; leukemia ; neutropenia ; neutrophils ; retrospective studies ; thrombocytopenia
    Language English
    Dates of publication 2023-0120
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13030357
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Retrospective Study of T Cell Leukaemia (Large Granular Lymphocyte Variant) in Dogs Associated with Suspected Immune-Mediated Cytopaenia(s) in the Absence of Peripheral Lymphocytosis

    Angelo Capasso / Elizabeth Villers / James Elliott / Nic Ilchyshyn / Ian Hopkins / Ferran Valls Sanchez / Sara Verganti

    Animals, Vol 13, Iss 357, p

    2023  Volume 357

    Abstract: ... cytology revealed infiltration of granular T lymphocytes; PARR analysis confirmed clonality in four, and ...

    Abstract Canine chronic large granular lymphocyte (LGL) leukaemia is commonly characterised by moderate to marked lymphocytosis but not neutropaenia. In humans, LGL leukaemia is often associated with autoimmune disorders, including immune-mediated cytopaenias (mainly neutropaenia). This presentation is rare in dogs. The aim of this retrospective study was to describe the clinical characteristics, treatments, and outcomes of dogs with chronic LGL leukaemia with suspected immune-mediated cytopaenia. Six dogs with a median age of 4.5 years (range 2–8 years) were included in the study. The most common presenting signs were pyrexia and lethargy. All dogs had severe neutropaenia (median neutrophil count 0.07 × 10 9 /L), three had thrombocytopaenia (median platelet count 66 × 10 9 /L), and one had anaemia (HCT 0.32 L/L). In all dogs, bone marrow cytology revealed infiltration of granular T lymphocytes; PARR analysis confirmed clonality in four, and bone marrow flow cytometry identified CD3+ CD8+ neoplastic cells in two cases. All patients received systemic chemotherapy, and the cytopaenias resolved after 1–19 weeks. Two dogs were euthanised 133 and 322 days after diagnosis, two were lost to follow-up after 224 and 357 days, and two were alive at 546 and 721 days. A subset of LGL leukaemia in dogs is associated with immune-mediated cytopaenia and has a unique clinical presentation.
    Keywords large granular lymphocyte leukaemia ; immune-mediated neutropaenia ; cytopaenias ; dog ; chronic lymphocytic leukaemia ; bone marrow ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
    Subject code 630
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Search for flavor-changing neutral currents in top-quark decays t → Zq in pp collisions at sqrt[s] = 8 TeV.

    Chatrchyan, S / Khachatryan, V / Sirunyan, A M / Tumasyan, A / Adam, W / Bergauer, T / Dragicevic, M / Erö, J / Fabjan, C / Friedl, M / Frühwirth, R / Ghete, V M / Hartl, C / Hörmann, N / Hrubec, J / Jeitler, M / Kiesenhofer, W / Knünz, V / Krammer, M /
    Krätschmer, I / Liko, D / Mikulec, I / Rabady, D / Rahbaran, B / Rohringer, H / Schöfbeck, R / Strauss, J / Taurok, A / Treberer-Treberspurg, W / Waltenberger, W / Wulz, C-E / Mossolov, V / Shumeiko, N / Suarez Gonzalez, J / Alderweireldt, S / Bansal, M / Bansal, S / Cornelis, T / De Wolf, E A / Janssen, X / Knutsson, A / Luyckx, S / Mucibello, L / Ochesanu, S / Roland, B / Rougny, R / Van Haevermaet, H / Van Mechelen, P / Van Remortel, N / Van Spilbeeck, A / Blekman, F / Blyweert, S / D'Hondt, J / Heracleous, N / Kalogeropoulos, A / Keaveney, J / Kim, T J / Lowette, S / Maes, M / Olbrechts, A / Strom, D / Tavernier, S / Van Doninck, W / Van Mulders, P / Van Onsem, G P / Villella, I / Caillol, C / Clerbaux, B / De Lentdecker, G / Favart, L / Gay, A P R / Hreus, T / Léonard, A / Marage, P E / Mohammadi, A / Perniè, L / Reis, T / Seva, T / Thomas, L / Vander Velde, C / Vanlaer, P / Wang, J / Adler, V / Beernaert, K / Benucci, L / Cimmino, A / Costantini, S / Dildick, S / Garcia, G / Klein, B / Lellouch, J / Mccartin, J / Ocampo Rios, A A / Ryckbosch, D / Sigamani, M / Strobbe, N / Thyssen, F / Tytgat, M / Walsh, S / Yazgan, E / Zaganidis, N / Basegmez, S / Beluffi, C / Bruno, G / Castello, R / Caudron, A / Ceard, L / Da Silveira, G G / Delaere, C / du Pree, T / Favart, D / Forthomme, L / Giammanco, A / Hollar, J / Jez, P / Komm, M / Lemaitre, V / Liao, J / Militaru, O / Nuttens, C / Pagano, D / Pin, A / Piotrzkowski, K / Popov, A / Quertenmont, L / Selvaggi, M / Vidal Marono, M / Vizan Garcia, J M / Beliy, N / Caebergs, T / Daubie, E / Hammad, G H / Alves, G A / Correa Martins Junior, M / Martins, T / Pol, M E / Souza, M H G / Aldá Júnior, W L / Carvalho, W / Chinellato, J / Custódio, A / Da Costa, E M / De Jesus Damiao, D / De Oliveira Martins, C / Fonseca De Souza, S / Malbouisson, H / Malek, M / Matos Figueiredo, D / Mundim, L / Nogima, H / Prado Da Silva, W L / Santaolalla, J / Santoro, A / Sznajder, A / Tonelli Manganote, E J / Vilela Pereira, A / Bernardes, C A / Dias, F A / Tomei, T R Fernandez Perez / Gregores, E M / Lagana, C / Mercadante, P G / Novaes, S F / Padula, Sandra S / Genchev, V / Iaydjiev, P / Marinov, A / Piperov, S / Rodozov, M / Sultanov, G / Vutova, M / Dimitrov, A / Hadjiiska, R / Litov, L / Pavlov, B / Petkov, P / Bian, J G / Chen, G M / Chen, H S / Chen, M / Du, R / Jiang, C H / Liang, D / Liang, S / Meng, X / Plestina, R / Tao, J / Wang, X / Wang, Z / Asawatangtrakuldee, C / Ban, Y / Guo, Y / Li, Q / Li, W / Liu, S / Mao, Y / Qian, S J / Wang, D / Zhang, L / Zou, W / Avila, C / Carrillo Montoya, C A / Chaparro Sierra, L F / Florez, C / Gomez, J P / Gomez Moreno, B / Sanabria, J C / Godinovic, N / Lelas, D / Polic, D / Puljak, I / Antunovic, Z / Kovac, M / Brigljevic, V / Kadija, K / Luetic, J / Mekterovic, D / Morovic, S / Tikvica, L / Attikis, A / Mavromanolakis, G / Mousa, J / Nicolaou, C / Ptochos, F / Razis, P A / Finger, M / Abdelalim, A A / Assran, Y / Elgammal, S / Ellithi Kamel, A / Mahmoud, M A / Radi, A / Kadastik, M / Müntel, M / Murumaa, M / Raidal, M / Rebane, L / Tiko, A / Eerola, P / Fedi, G / Voutilainen, M / Härkönen, J / Karimäki, V / Kinnunen, R / Kortelainen, M J / Lampén, T / Lassila-Perini, K / Lehti, S / Lindén, T / Luukka, P / Mäenpää, T / Peltola, T / Tuominen, E / Tuominiemi, J / Tuovinen, E / Wendland, L / Tuuva, T / Besancon, M / Couderc, F / Dejardin, M / Denegri, D / Fabbro, B / Faure, J L / Ferri, F / Ganjour, S / Givernaud, A / Gras, P / Hamel de Monchenault, G / Jarry, P / Locci, E / Malcles, J / Nayak, A / Rander, J / Rosowsky, A / Titov, M / Baffioni, S / Beaudette, F / Busson, P / Charlot, C / Daci, N / Dahms, T / Dalchenko, M / Dobrzynski, L / Florent, A / Granier de Cassagnac, R / Haguenauer, M / Miné, P / Mironov, C / Naranjo, I N / Nguyen, M / Ochando, C / Paganini, P / Sabes, D / Salerno, R / Sirois, Y / Veelken, C / Yilmaz, Y / Zabi, A / Agram, J-L / Andrea, J / Bloch, D / Brom, J-M / Chabert, E C / Collard, C / Conte, E / Drouhin, F / Fontaine, J-C / Gelé, D / Goerlach, U / Goetzmann, C / Juillot, P / Le Bihan, A-C / Van Hove, P / Gadrat, S / Beauceron, S / Beaupere, N / Boudoul, G / Brochet, S / Chasserat, J / Chierici, R / Contardo, D / Depasse, P / El Mamouni, H / Fan, J / Fay, J / Gascon, S / Gouzevitch, M / Ille, B / Kurca, T / Lethuillier, M / Mirabito, L / Perries, S / Ruiz Alvarez, J D / Sgandurra, L / Sordini, V / Vander Donckt, M / Verdier, P / Viret, S / Xiao, H / Tsamalaidze, Z / Autermann, C / Beranek, S / Bontenackels, M / Calpas, B / Edelhoff, M / Feld, L / Hindrichs, O / Klein, K / Ostapchuk, A / Perieanu, A / Raupach, F / Sammet, J / Schael, S / Sprenger, D / Weber, H / Wittmer, B / Zhukov, V / Ata, M / Caudron, J / Dietz-Laursonn, E / Duchardt, D / Erdmann, M / Fischer, R / Güth, A / Hebbeker, T / Heidemann, C / Hoepfner, K / Klingebiel, D / Knutzen, S / Kreuzer, P / Merschmeyer, M / Meyer, A / Olschewski, M / Padeken, K / Papacz, P / Reithler, H / Schmitz, S A / Sonnenschein, L / Teyssier, D / Thüer, S / Weber, M / Cherepanov, V / Erdogan, Y / Flügge, G / Geenen, H / Geisler, M / Haj Ahmad, W / Hoehle, F / Kargoll, B / Kress, T / Kuessel, Y / Lingemann, J / Nowack, A / Nugent, I M / Perchalla, L / Pooth, O / Stahl, A / Asin, I / Bartosik, N / Behr, J / Behrenhoff, W / Behrens, U / Bell, A J / Bergholz, M / Bethani, A / Borras, K / Burgmeier, A / Cakir, A / Calligaris, L / Campbell, A / Choudhury, S / Costanza, F / Diez Pardos, C / Dooling, S / Dorland, T / Eckerlin, G / Eckstein, D / Eichhorn, T / Flucke, G / Geiser, A / Grebenyuk, A / Gunnellini, P / Habib, S / Hauk, J / Hellwig, G / Hempel, M / Horton, D / Jung, H / Kasemann, M / Katsas, P / Kleinwort, C / Krämer, M / Krücker, D / Lange, W / Leonard, J / Lipka, K / Lohmann, W / Lutz, B / Mankel, R / Marfin, I / Melzer-Pellmann, I-A / Meyer, A B / Mnich, J / Mussgiller, A / Naumann-Emme, S / Novgorodova, O / Nowak, F / Perrey, H / Petrukhin, A / Pitzl, D / Placakyte, R / Raspereza, A / Ribeiro Cipriano, P M / Riedl, C / Ron, E / Sahin, M Ö / Salfeld-Nebgen, J / Schmidt, R / Schoerner-Sadenius, T / Schröder, M / Stein, M / Vargas Trevino, A D R / Walsh, R / Wissing, C / Aldaya Martin, M / Blobel, V / Enderle, H / Erfle, J / Garutti, E / Görner, M / Gosselink, M / Haller, J / Heine, K / Höing, R S / Kirschenmann, H / Klanner, R / Kogler, R / Lange, J / Marchesini, I / Ott, J / Peiffer, T / Pietsch, N / Rathjens, D / Sander, C / Schettler, H / Schleper, P / Schlieckau, E / Schmidt, A / Seidel, M / Sibille, J / Sola, V / Stadie, H / Steinbrück, G / Troendle, D / Usai, E / Vanelderen, L / Barth, C / Baus, C / Berger, J / Böser, C / Butz, E / Chwalek, T / De Boer, W / Descroix, A / Dierlamm, A / Feindt, M / Guthoff, M / Hartmann, F / Hauth, T / Held, H / Hoffmann, K H / Husemann, U / Katkov, I / Kornmayer, A / Kuznetsova, E / Lobelle Pardo, P / Martschei, D / Mozer, M U / Müller, Th / Niegel, M / Nürnberg, A / Oberst, O / Quast, G / Rabbertz, K / Ratnikov, F / Röcker, S / Schilling, F-P / Schott, G / Simonis, H J / Stober, F M / Ulrich, R / Wagner-Kuhr, J / Wayand, S / Weiler, T / Wolf, R / Zeise, M / Anagnostou, G / Daskalakis, G / Geralis, T / Kesisoglou, S / Kyriakis, A / Loukas, D / Markou, A / Markou, C / Ntomari, E / Topsis-Giotis, I / Gouskos, L / Panagiotou, A / Saoulidou, N / Stiliaris, E / Aslanoglou, X / Evangelou, I / Flouris, G / Foudas, C / Kokkas, P / Manthos, N / Papadopoulos, I / Paradas, E / Bencze, G / Hajdu, C / Hidas, P / Horvath, D / Sikler, F / Veszpremi, V / Vesztergombi, G / Zsigmond, A J / Beni, N / Czellar, S / Molnar, J / Palinkas, J / Szillasi, Z / Karancsi, J / Raics, P / Trocsanyi, Z L / Ujvari, B / Swain, S K / Beri, S B / Bhatnagar, V / Dhingra, N / Gupta, R / Kaur, M / Mehta, M Z / Mittal, M / Nishu, N / Sharma, A / Singh, J B / Kumar, Ashok / Kumar, Arun / Ahuja, S / Bhardwaj, A / Choudhary, B C / Kumar, A / Malhotra, S / Naimuddin, M / Ranjan, K / Saxena, P / Sharma, V / Shivpuri, R K / Banerjee, S / Bhattacharya, S / Chatterjee, K / Dutta, S / Gomber, B / Jain, Sa / Jain, Sh / Khurana, R / Modak, A / Mukherjee, S / Roy, D / Sarkar, S / Sharan, M / Singh, A P / Abdulsalam, A / Dutta, D / Kailas, S / Kumar, V / Mohanty, A K / Pant, L M / Shukla, P / Topkar, A / Aziz, T / Chatterjee, R M / Ganguly, S / Ghosh, S / Guchait, M / Gurtu, A / Kole, G / Kumar, S / Maity, M / Majumder, G / Mazumdar, K / Mohanty, G B / Parida, B / Sudhakar, K / Wickramage, N / Dugad, S / Arfaei, H / Bakhshiansohi, H / Behnamian, H / Etesami, S M / Fahim, A / Jafari, A / Khakzad, M / Mohammadi Najafabadi, M / Naseri, M / Paktinat Mehdiabadi, S / Safarzadeh, B / Zeinali, M / Grunewald, M / Abbrescia, M / Barbone, L / Calabria, C / Chhibra, S S / Colaleo, A / Creanza, D / De Filippis, N / De Palma, M / Fiore, L / Iaselli, G / Maggi, G / Maggi, M / Marangelli, B / My, S / Nuzzo, S / Pacifico, N / Pompili, A / Pugliese, G / Radogna, R / Selvaggi, G / Silvestris, L / Singh, G / Venditti, R / Verwilligen, P / Zito, G / Abbiendi, G / Benvenuti, A C / Bonacorsi, D / Braibant-Giacomelli, S / Brigliadori, L / Campanini, R / Capiluppi, P / Castro, A / Cavallo, F R / Codispoti, G / Cuffiani, M / Dallavalle, G M / Fabbri, F / Fanfani, A / Fasanella, D / Giacomelli, P / Grandi, C / Guiducci, L / Marcellini, S / Masetti, G / Meneghelli, M / Montanari, A / Navarria, F L / Odorici, F / Perrotta, A / Primavera, F / Rossi, A M / Rovelli, T / Siroli, G P / Tosi, N / Travaglini, R / Albergo, S / Cappello, G / Chiorboli, M / Costa, S / Giordano, F / Potenza, R / Tricomi, A / Tuve, C / Barbagli, G / Ciulli, V / Civinini, C / D'Alessandro, R / Focardi, E / Gallo, E / Gonzi, S / Gori, V / Lenzi, P / Meschini, M / Paoletti, S / Sguazzoni, G / Tropiano, A / Benussi, L / Bianco, S / Piccolo, D / Fabbricatore, P / Ferretti, R / Ferro, F / Lo Vetere, M / Musenich, R / Robutti, E / Tosi, S / Benaglia, A / Dinardo, M E / Fiorendi, S / Gennai, S / Ghezzi, A / Govoni, P / Lucchini, M T / Malvezzi, S / Manzoni, R A / Martelli, A / Menasce, D / Moroni, L / Paganoni, M / Pedrini, D / Ragazzi, S / Redaelli, N / Tabarelli de Fatis, T / Buontempo, S / Cavallo, N / Fabozzi, F / Iorio, A O M / Lista, L / Meola, S / Merola, M / Paolucci, P / Azzi, P / Bacchetta, N / Bisello, D / Branca, A / Carlin, R / Checchia, P / Dorigo, T / Fanzago, F / Galanti, M / Gasparini, F / Gasparini, U / Giubilato, P / Gonella, F / Gozzelino, A / Kanishchev, K / Lacaprara, S / Lazzizzera, I / Margoni, M / Meneguzzo, A T / Montecassiano, F / Pazzini, J / Pozzobon, N / Ronchese, P / Simonetto, F / Torassa, E / Tosi, M / Vanini, S / Zotto, P / Zucchetta, A / Zumerle, G / Gabusi, M / Ratti, S P / Riccardi, C / Vitulo, P / Biasini, M / Bilei, G M / Fanò, L / Lariccia, P / Mantovani, G / Menichelli, M / Nappi, A / Romeo, F / Saha, A / Santocchia, A / Spiezia, A / Androsov, K / Azzurri, P / Bagliesi, G / Bernardini, J / Boccali, T / Broccolo, G / Castaldi, R / Ciocci, M A / Dell'Orso, R / Fiori, F / Foà, L / Giassi, A / Grippo, M T / Kraan, A / Ligabue, F / Lomtadze, T / Martini, L / Messineo, A / Moon, C S / Palla, F / Rizzi, A / Savoy-Navarro, A / Serban, A T / Spagnolo, P / Squillacioti, P / Tenchini, R / Tonelli, G / Venturi, A / Verdini, P G / Vernieri, C / Barone, L / Cavallari, F / Del Re, D / Diemoz, M / Grassi, M / Jorda, C / Longo, E / Margaroli, F / Meridiani, P / Micheli, F / Nourbakhsh, S / Organtini, G / Paramatti, R / Rahatlou, S / Rovelli, C / Soffi, L / Traczyk, P / Amapane, N / Arcidiacono, R / Argiro, S / Arneodo, M / Bellan, R / Biino, C / Cartiglia, N / Casasso, S / Costa, M / Degano, A / Demaria, N / Mariotti, C / Maselli, S / Migliore, E / Monaco, V / Musich, M / Obertino, M M / Ortona, G / Pacher, L / Pastrone, N / Pelliccioni, M / Potenza, A / Romero, A / Ruspa, M / Sacchi, R / Solano, A / Staiano, A / Tamponi, U / Belforte, S / Candelise, V / Casarsa, M / Cossutti, F / Della Ricca, G / Gobbo, B / La Licata, C / Marone, M / Montanino, D / Penzo, A / Schizzi, A / Umer, T / Zanetti, A / Chang, S / Kim, T Y / Nam, S K / Kim, D H / Kim, G N / Kim, J E / Kong, D J / Lee, 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    Physical review letters

    2014  Volume 112, Issue 17, Page(s) 171802

    Abstract: A search for flavor-changing neutral currents in top-quark decays t → Zq is performed in events ... A combination with a previous search at 7 TeV excludes a t → Zq branching fraction greater than 0.05% at the 95 ...

    Abstract A search for flavor-changing neutral currents in top-quark decays t → Zq is performed in events produced from the decay chain tt → Zq+Wb, where both vector bosons decay leptonically, producing a final state with three leptons (electrons or muons). A data set collected with the CMS detector at the LHC is used, corresponding to an integrated luminosity of 19.7 fb(-1) of proton-proton collisions at a center-of-mass energy of 8 TeV. No excess is seen in the observed number of events relative to the standard model prediction; thus, no evidence for flavor-changing neutral currents in top-quark decays is found. A combination with a previous search at 7 TeV excludes a t → Zq branching fraction greater than 0.05% at the 95% confidence level.
    MeSH term(s) Models, Theoretical ; Neutrons ; Nuclear Physics/methods ; Thermodynamics
    Language English
    Publishing date 2014-05-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.112.171802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: What If Your Husband Doesn’t Feel the Pressure? An Exploration of Women’s Involvement in WaSH Decision Making in Nyanchwa, Kenya

    Thelma Zulfawu Abu / Elijah Bisung / Susan J. Elliott

    International Journal of Environmental Research and Public Health, Vol 16, Iss 10, p

    2019  Volume 1763

    Abstract: ... and implementation processes. This research sought to explore women’s experiences in participating ... literacy rates also emerged. The paper concludes with a call for collaboration among women’s groups ...

    Abstract Access to water, sanitation and hygiene (WaSH) is a major challenge in sub-Saharan Africa (SSA). Women and girls suffer the main burden of a lack of access to WaSH because they are primarily responsible for collecting water for their homes. However, they are often excluded from WaSH decision-making and implementation processes. This research sought to explore women’s experiences in participating in WaSH decision-making through a case study in Nyanchwa, Kenya. Twelve (12) key informant interviews were conducted with community leaders and members regarding challenges and possible measures for enhancing women and girls’ participation in WaSH decision-making. From this research, it is evident that economic challenges and cultural factors such as male dominance, greatly inhibit women and girls’ participation in WaSH decision-making and implementation processes. Other factors such as time constraints and low literacy rates also emerged. The paper concludes with a call for collaboration among women’s groups to enhance collective action for improved access to WaSH. This will undoubtedly lead to enhanced community health and wellbeing (Sustainable Development Goal 3, SDG3) through the empowerment of women (Sustainable Development Goal 5, SDG5).
    Keywords women and girls ; WaSH ; participation ; finance ; Kenya ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Measurement of the t-channel single top quark production cross section in pp collisions at √s=7  TeV.

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    Physical review letters

    2011  Volume 107, Issue 9, Page(s) 91802

    Abstract: ... luminosity of 36  pb⁻¹. With an event selection optimized for t-channel production, two complementary ...

    Abstract Electroweak production of the top quark is measured for the first time in pp collisions at √=7  TeV, using a data set collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 36  pb⁻¹. With an event selection optimized for t-channel production, two complementary analyses are performed. The first one exploits the special angular properties of the signal, together with background estimates from the data. The second approach uses a multivariate analysis technique to probe the compatibility with signal topology expected from electroweak top-quark production. The combined measurement of the cross section is 83.6±29.8(stat+syst)±3.3(lumi)  pb, consistent with the standard model expectation.
    Language English
    Publishing date 2011-08-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.107.091802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Human T cell lymphotropic virus type 1 infection among U.S. thalassemia patients.

    Switzer, William M / Shankar, Anupama / Trimble, Sean R / Thompson, Alexis A / Giardina, Patricia J / Cohen, Alan R / Coates, Thomas D / Vichinsky, Elliott / Neufeld, Ellis J / Boudreaux, Jeanne M / Heneine, Walid

    AIDS research and human retroviruses

    2013  Volume 29, Issue 7, Page(s) 1006–1009

    Abstract: ... including human T cell lymphotropic viruses (HTLV) that are transmitted by transfusion of cellular blood ... products. Here, we examined the prevalence of HTLV among 234 U.S. thalassemia patients using sera collected ... before HTLV blood screening was implemented in 1988. We identified a substantial HTLV-1 seroprevalence in U.S ...

    Abstract Thalassemia is an inherited genetic disorder requiring multiple transfusions to treat anemia caused by low hemoglobin levels. Thus, thalassemia patients are at risk for infection with blood-borne pathogens, including human T cell lymphotropic viruses (HTLV) that are transmitted by transfusion of cellular blood products. Here, we examined the prevalence of HTLV among 234 U.S. thalassemia patients using sera collected in 2008. Sera were tested for antibodies to HTLV-1/2 using enzyme immunoassay (EIA) and a confirmatory western blot (WB) that differentiates between HTLV-1 and HTLV-2. Demographic information and clinical information were collected at study enrollment, including HIV and hepatitis C virus (HCV) status. Three patients (1.3%) were WB positive; two were HTLV-1 and one could not be serotyped as HTLV-1/2. All three HTLV-positive persons were HIV-1 negative and one was HCV seropositive. The HTLV seroprevalence was higher than that of HIV-1 (0.85%) and lower than HCV (18.8%) in this population. All three patients (ages 26-46 years) were diagnosed with β-thalassemia shortly after birth and have since been receiving multiple transfusions annually. Two of the HTLV-positive patients confirmed receiving transfusions before HTLV blood screening was implemented in 1988. We identified a substantial HTLV-1 seroprevalence in U.S. thalassemia patients that is much greater than that seen in blood donors. Our findings highlight the importance of HTLV testing of patients with thalassemia and other diseases requiring multiple transfusions, especially in recipients of unscreened transfusions. In addition, appropriate counseling and follow-up of HTLV-infected patients are warranted.
    MeSH term(s) Adult ; Female ; HTLV-I Antibodies/blood ; HTLV-I Infections/complications ; HTLV-I Infections/epidemiology ; HTLV-I Infections/transmission ; HTLV-II Infections/complications ; Hepatitis C/complications ; Humans ; Male ; Middle Aged ; Prevalence ; Risk Factors ; Transfusion Reaction ; United States/epidemiology ; alpha-Thalassemia/complications ; beta-Thalassemia/complications
    Chemical Substances HTLV-I Antibodies
    Language English
    Publishing date 2013-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/AID.2012.0382
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  8. Article ; Online: Hypervalency in amorphous chalcogenides.

    Lee, T H / Elliott, S R

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 1458

    Abstract: ... extended to include interactions with cation s ...

    Abstract The concept of hypervalency emerged as a notion for chemical bonding in molecules to explain the atomic coordination in hypervalent molecules that violates the electron-octet rule. Despite its significance, however, hypervalency in condensed phases, such as amorphous solids, remains largely unexplored. Using ab initio molecular-dynamics simulations, we report here the underlying principles of hypervalency in amorphous chalcogenide materials, in terms of the behaviour of hypervalent structural units, and its implicit relationship with material properties. The origin of a material-dependent tendency towards hypervalency is made evident with the multi-centre hyperbonding model, from which its relationship to abnormally large Born effective charges is also unambiguously revealed. The hyperbonding model is here extended to include interactions with cation s
    Language English
    Publishing date 2022-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-29054-5
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  9. Book: The making of T. S. Eliot's plays

    Browne, Elliott Martin

    1970  

    Author's details E. Martin Browne
    Language English
    Size XV, 357 S
    Edition Repr
    Publisher Cambridge Univ. Press
    Publishing place London
    Document type Book
    ISBN 0521073723 ; 9780521073721
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article ; Online: Multiple quantum filtered nuclear magnetic resonance of 23Na+ in uniformly stretched and compressed hydrogels.

    Elliott, S J / Eykyn, T R / Kuchel, P W

    The Journal of chemical physics

    2023  Volume 159, Issue 3

    Abstract: Stretching or compressing hydrogels creates anisotropic environments that lead to motionally averaged alignment of embedded guest quadrupolar nuclear spins such as 23Na+. These distorted hydrogels can elicit a residual quadrupolar coupling that gives an ... ...

    Abstract Stretching or compressing hydrogels creates anisotropic environments that lead to motionally averaged alignment of embedded guest quadrupolar nuclear spins such as 23Na+. These distorted hydrogels can elicit a residual quadrupolar coupling that gives an oscillation in the trajectories of single quantum coherences (SQCs) as a function of the evolution time during a spin-echo experiment. We present solutions to equations of motion derived with a Liouvillian superoperator approach, which encompass the coherent quadrupolar interaction in conjunction with relaxation, to give a full analytical description of the evolution trajectories of rank-1 (T^1±1), rank-2 (T^2±1), and rank-3 (T^3±1) SQCs. We performed simultaneous numerical fitting of the experimental 23Na nuclear magnetic resonance (NMR) spectra and rank-2 (T^2±1) and rank-3 (T^3±1) SQC evolution trajectories measured in double and triple quantum filtered experiments, respectively. We estimated values of the quadrupolar coupling constant CQ, rotational correlation time τC, and 3 × 3 Saupe order matrix. We performed simultaneous fitting of the analytical expressions to the experimental data to estimate values of the quadrupolar coupling frequency ωQ/2π, residual quadrupolar coupling ωQ/2π, and corresponding spherical order parameter S0*, which showed a linear dependence on the extent of uniform hydrogel stretching and compression. The analytical expressions were completely concordant with the numerical approach. The insights gained here can be extended to more complicated (biological) systems such as 23Na+ bound to proteins or located inside and outside living cells in high-field NMR experiments and, by extension, to the anisotropic environments found in vivo with 23Na magnetic resonance imaging.
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0158608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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