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  1. Article ; Online: Biportal endoscopic-assisted cortical bone trajectory screw placement and lumbar interbody fusion.

    Zhu, Chengyue / Liang, Jiaming / Pan, Hao / Zhang, Wei

    Acta neurochirurgica

    2024  Volume 166, Issue 1, Page(s) 74

    Abstract: Background: Endoscopically assisted screw fixation with lumbar interbody fusion is rarely performed. We succeeded in implanting the cortical bone trajectory (CBT) screws under the guidance of unilateral biportal endoscopy (UBE).: Method: We attempted ...

    Abstract Background: Endoscopically assisted screw fixation with lumbar interbody fusion is rarely performed. We succeeded in implanting the cortical bone trajectory (CBT) screws under the guidance of unilateral biportal endoscopy (UBE).
    Method: We attempted endoscopically assisted screw fixation in a patient with degenerative spondylolisthesis. Through a third portal, ipsilateral CBT screws were implanted without complications.
    Conclusions: We successfully performed unilateral biportal endoscopic lumbar interbody fusion (ULIF) with CBT and reversed CBT screws. Compared with percutaneous pedicle screw (PPS) placement, this procedure is a minimally invasive, endoscopic alternative that allows precise screw placement.
    MeSH term(s) Humans ; Spondylolisthesis/diagnostic imaging ; Spondylolisthesis/surgery ; Endoscopy ; Cortical Bone/diagnostic imaging ; Cortical Bone/surgery ; Bone and Bones ; Pedicle Screws ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Spinal Fusion/methods ; Treatment Outcome
    Language English
    Publishing date 2024-02-08
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-024-05986-3
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  2. Article ; Online: Far lateral lumbar interbody fusion with unilateral pedicle screw fixation and double traversing cages using a biportal endoscopic technique.

    Zhu, Chengyue / Liang, Jiaming / Pan, Hao / Zhang, Wei

    Acta neurochirurgica

    2023  Volume 165, Issue 8, Page(s) 2165–2169

    Abstract: Background: Transforaminal lumbar interbody fusion (TLIF) with a single cage and bilateral pedicle screw fixation results in decreased stability or increased risk of cage displacement Wang and Guo (Comput Methods Biomech Biomed Eng, 24(3):308-319, 6). ... ...

    Abstract Background: Transforaminal lumbar interbody fusion (TLIF) with a single cage and bilateral pedicle screw fixation results in decreased stability or increased risk of cage displacement Wang and Guo (Comput Methods Biomech Biomed Eng, 24(3):308-319, 6). We succeeded in inserting double traversing cages with unilateral pedicle screw fixation (UPSF) during far lateral TLIF using unilateral biportal endoscopy (UBE).
    Method: We attempted far lateral UBE-TLIF through two small incisions for degenerative lumbar spondylolisthesis with unilateral stenosis. With the help of novel instruments, far lateral UBE-TLIF with double traversing cages and UPSF was performed under tracheal intubation anaesthesia.
    Conclusions: We successfully performed far lateral UBE-TLIF with double traversing cages and UPSF. This procedure may be an alternative minimally invasive method for treating lumbar instability.
    MeSH term(s) Humans ; Pedicle Screws ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Spinal Fusion/methods ; Spondylolisthesis/diagnostic imaging ; Spondylolisthesis/surgery ; Endoscopy
    Language English
    Publishing date 2023-07-13
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-023-05702-7
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  3. Article ; Online: Comparison of Outcomes between Unilateral Biportal Endoscopic and Percutaneous Posterior Endoscopic Cervical Keyhole Surgeries.

    Wang, Dong / Xu, Jinchao / Zhu, Chengyue / Zhang, Wei / Pan, Hao

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 3

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Humans ; Retrospective Studies ; Endoscopy ; Neck ; Spondylosis/complications ; Spondylosis/surgery ; Cervical Vertebrae/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59030437
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  4. Article ; Online: Contralateral translaminar endoscopic approach for highly down-migrated lumbar disc herniation using percutaneous biportal endoscopic surgery : Original research.

    Cheng, Wei / Gao, Wenshuo / Zhu, Chengyue / Shao, Rongxue / Wang, Dong / Pan, Hao / Zhang, Wei

    BMC surgery

    2024  Volume 24, Issue 1, Page(s) 58

    Abstract: Objective: Unilateral biportal endoscopy (UBE)is a minimally invasive spine surgery with reduced traumatization of the posterior lumbar ligament and muscular structures. This study reports contralateral translaminar approach with UBE for highly down- ... ...

    Abstract Objective: Unilateral biportal endoscopy (UBE)is a minimally invasive spine surgery with reduced traumatization of the posterior lumbar ligament and muscular structures. This study reports contralateral translaminar approach with UBE for highly down-migrated lumbar disc herniation (LDH).
    Methods: Data of 32 patients with highly down-migrated LDH treated using UBE at our center from January 2020 to July 2022 were retrospectively analyzed. The operation time and perioperative complications were recorded, and the visual analog scale (VAS) of pain was recorded to evaluate the degree of lower back and extremity pain. The Oswestry disability index (ODI) was used to evaluate lumbar spine function. The modified MacNab score was used to evaluate clinical efficacy.
    Results: All patients successfully underwent the operation, with a time range from 47 to 65 min and an average operation time of 56.09 ± 5.11 min. Overall, 17 and 15 were males and females, respectively, with ages ranging from 34 to 72 years and an average age of 56 ± 7.89 years. The postoperative follow-up period was 12-18 months, with an average of 14.9 ± 2.3 months. The postoperative lower back VAS pain score and ODI were statistically significant compared with preoperatively (P < 0.05). At the final follow-up, according to the modified Macnab criteria, 90.6% of cases were classified as good or excellent.
    Conclusion: UBE treatment of highly down-migrated LDH through the contralateral translaminar approach is safe and efficient. Therefore, this approach can be an efficient alternative for patients with highly downward-migrating LDH.
    MeSH term(s) Male ; Female ; Humans ; Middle Aged ; Intervertebral Disc Displacement/surgery ; Retrospective Studies ; Endoscopy ; Treatment Outcome ; Pain ; Lumbar Vertebrae/surgery
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050442-1
    ISSN 1471-2482 ; 1471-2482
    ISSN (online) 1471-2482
    ISSN 1471-2482
    DOI 10.1186/s12893-024-02348-9
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  5. Article ; Online: Lumbar interbody fusion with bilateral cages using a biportal endoscopic technique with a third portal.

    Zhu, Chengyue / Zhang, Liangping / Pan, Hao / Zhang, Wei

    Acta neurochirurgica

    2022  Volume 164, Issue 9, Page(s) 2343–2347

    Abstract: Background: Unilateral biportal endoscopic lumbar interbody fusion (ULIF) with one cage results in fewer definitive fusions (Park et al. in Neurosurg Rev 42(3):753-761, 2019). We succeeded in inserting bilateral cages during ULIF.: Method: We ... ...

    Abstract Background: Unilateral biportal endoscopic lumbar interbody fusion (ULIF) with one cage results in fewer definitive fusions (Park et al. in Neurosurg Rev 42(3):753-761, 2019). We succeeded in inserting bilateral cages during ULIF.
    Method: We attempted posterior ULIF for degenerative lumbar spondylolisthesis with bilateral recess stenosis. With the help of a third portal, ULIF with bilateral cage insertion was performed under general anaesthesia.
    Conclusions: We successfully performed ULIF with bilateral cages with the help of a third portal. This procedure may be an alternative for treating lumbar stenosis with instability.
    MeSH term(s) Constriction, Pathologic ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Lumbosacral Region ; Spinal Fusion/methods ; Spondylolisthesis/diagnostic imaging ; Spondylolisthesis/surgery
    Language English
    Publishing date 2022-07-31
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-022-05324-5
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  6. Article ; Online: Comparison of Outcomes between Unilateral Biportal Endoscopic and Percutaneous Posterior Endoscopic Cervical Keyhole Surgeries

    Dong Wang / Jinchao Xu / Chengyue Zhu / Wei Zhang / Hao Pan

    Medicina, Vol 59, Iss 437, p

    2023  Volume 437

    Abstract: Objective : The purpose of this study was to compare the clinical and radiological outcomes of unilateral biportal endoscopic (UBE) and percutaneous posterior endoscopic cervical discectomy (PE) keyhole surgeries. Methods : Patients diagnosed with ... ...

    Abstract Objective : The purpose of this study was to compare the clinical and radiological outcomes of unilateral biportal endoscopic (UBE) and percutaneous posterior endoscopic cervical discectomy (PE) keyhole surgeries. Methods : Patients diagnosed with cervical spondylotic radiculopathy (CSR) treated by UBE or PE keyhole surgery from May 2017 to April 2020 were retrospectively analyzed. The length of incision, fluoroscopic time, postoperative hospital stay, and total cost were compared. The clinical efficacy was assessed using a visual analog scale (VAS), neck disability index (NDI), and modified MacNab criteria. Moreover, the C2-7 Cobb’s angle, range of motion (ROM), intervertebral height, vertebral horizontal displacement, and angular displacement of the surgical segment were measured. Results : A total of 154 patients were enrolled, including 89 patients in the UBE group and 65 patients in the PE group, with a follow-up period of 24–32 months. Compared with PE surgery, UBE surgery required shorter fluoroscopic times (6.76 ± 1.09 vs. 8.31 ± 1.10 s) and operation times (77.48 ± 17.37 vs. 84.92 ± 21.97 min) but led to higher total hospitalization costs and longer incisions. No significant differences were observed in the postoperative hospital stay, bleeding volume, VAS score, NDI score, effective rate, or complication rate between the UBE and PE groups. Both the C2-7 Cobb’s angle and ROM increased significantly after surgery, with no significant differences between groups. There were no significant differences between intervertebral height, vertebral horizontal displacement, and angular displacement of the surgical segment at different times. Conclusions : Both UBE and PE surgeries in the treatment of CSR were effective and similar after 24 months. The fluoroscopic and operation times of UBE were shorter than those of PE.
    Keywords unilateral biportal endoscopy ; full endoscopy ; posterior cervical foraminotomy ; cervical spondylotic radiculopathy ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Unilateral biportal endoscopic laminectomy with lateral mass screw fixation for treating cervical spinal stenosis.

    Zhu, Chengyue / Deng, Xueqing / Pan, Hao / Zhang, Wei

    Acta neurochirurgica

    2022  Volume 164, Issue 6, Page(s) 1529–1533

    Abstract: Background: The unilateral biportal endoscopic (UBE) technique is less invasive and has a faster recovery time than open surgery. Compared with the uniportal technique, the biportal technique has a larger field of vision and a wider operation range.: ... ...

    Abstract Background: The unilateral biportal endoscopic (UBE) technique is less invasive and has a faster recovery time than open surgery. Compared with the uniportal technique, the biportal technique has a larger field of vision and a wider operation range.
    Method: We attempted the posterior UBE approach for cervical stenosis at the C4-C6 levels. UBE decompression of C4-C6 with unilateral lateral mass screw fixation at the C4-C5 levels was performed under general anesthesia.
    Conclusions: We successfully performed cord decompression at the C4-C6 levels using the UBE technique. This approach could be used as an alternative method to treat cervical stenosis with instability.
    MeSH term(s) Bone Screws ; Constriction, Pathologic/surgery ; Decompression, Surgical/methods ; Humans ; Laminectomy/methods ; Spinal Stenosis/diagnostic imaging ; Spinal Stenosis/surgery ; Treatment Outcome
    Language English
    Publishing date 2022-04-29
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-022-05212-y
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  8. Article: Inflammation aggravated the hepatotoxicity of triptolide by oxidative stress, lipid metabolism disorder, autophagy, and apoptosis in zebrafish.

    Li, Chenqinyao / Zhang, Changqing / Zhu, Chengyue / Zhang, Jie / Xia, Qing / Liu, Kechun / Zhang, Yun

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 949312

    Abstract: Triptolide is a major compound isolated from ... ...

    Abstract Triptolide is a major compound isolated from the
    Language English
    Publishing date 2022-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.949312
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  9. Article ; Online: Unilateral Biportal Endoscopic Laminectomy for Treating Cervical Stenosis: A Technical Note and Preliminary Results.

    Zhu, Chengyue / Zhou, Xizhuo / Ge, Guofen / Wang, Cuijuan / Zhuang, Xiaoshan / Cheng, Wei / Wang, Dong / Zhu, Hang / Pan, Hao / Zhang, Wei

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 2

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Male ; Female ; Humans ; Laminectomy/adverse effects ; Lordosis/etiology ; Lordosis/surgery ; Constriction, Pathologic/surgery ; Treatment Outcome ; Endoscopy/methods ; Retrospective Studies
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59020305
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  10. Article ; Online: The enhanced hepatotoxicity of isobavachalcone in depigmented zebrafish due to calcium signaling dysregulation and lipid metabolism disorder.

    Zhang, Huiwen / Zhu, Chengyue / Zhao, Jingcheng / Zheng, Ruifang / Xing, Jianguo / Li, Zhijian / Zhang, Yun / Xu, Qian

    Journal of applied toxicology : JAT

    2024  

    Abstract: Isobavachalcone (IBC) is a flavonoid component derived from Psoraleae Fructus that can increase skin pigmentation and treat vitiligo. However, IBC has been reported to be hepatotoxic. Current studies on IBC hepatotoxicity are mostly on normal organisms ... ...

    Abstract Isobavachalcone (IBC) is a flavonoid component derived from Psoraleae Fructus that can increase skin pigmentation and treat vitiligo. However, IBC has been reported to be hepatotoxic. Current studies on IBC hepatotoxicity are mostly on normal organisms but lack studies on hepatotoxicity in patients. This study established the depigmented zebrafish model by using phenylthiourea (PTU) and investigated the difference in hepatotoxicity between normal and depigmented zebrafish caused by IBC and the underlying mechanism. Morphological, histological, and ultrastructural examination and RT-qPCR verification were used to evaluate the effects of IBC on the livers of zebrafish larvae. IBC significantly decreased liver volume, altered lipid metabolism, and induced pathological and ultrastructural changes in the livers of zebrafish with depigmentation compared with normal zebrafish. The RNA-sequencing and RT-qPCR results showed that the difference in hepatotoxicity between normal and depigmented zebrafish caused by IBC was closely related to the calcium signaling pathway, lipid decomposition and metabolism, and oxidative stress. This work delved into the mechanism of the enhanced IBC-induced hepatotoxicity in depigmented zebrafish and provided a new insight into the hepatotoxicity of IBC.
    Language English
    Publishing date 2024-02-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 604625-3
    ISSN 1099-1263 ; 0260-437X
    ISSN (online) 1099-1263
    ISSN 0260-437X
    DOI 10.1002/jat.4593
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