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  1. Article ; Online: Perspectives of mitochondria-lysosome-related organelle in hepatocyte dedifferentiation and implications in chronic liver disease.

    Ma, Xiaowen / Ni, Hong-Min / Ding, Wen-Xing

    eGastroenterology

    2024  Volume 2, Issue 1

    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ISSN 2976-7296
    ISSN (online) 2976-7296
    DOI 10.1136/egastro-2023-100046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reply: Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation.

    Ma, Xiaowen / Ding, Wen-Xing

    Hepatology (Baltimore, Md.)

    2023  Volume 78, Issue 4, Page(s) E82–E83

    MeSH term(s) Humans ; Hepatitis, Alcoholic ; Mitochondrial Swelling ; Mitochondria ; Mitochondrial Dynamics
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Caveats to link in vitro mechanistic mitophagy studies to the pathogenesis of non-alcoholic steatohepatitis.

    Zhang, Chen / Ding, Wen-Xing

    Journal of hepatology

    2023  Volume 79, Issue 4, Page(s) e162–e163

    MeSH term(s) Humans ; Mitophagy ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/pathology
    Language English
    Publishing date 2023-05-06
    Publishing country Netherlands
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2023.04.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Matrix Gla Protein, a New Target Fighting Against Fibrosis of Nonalcoholic Steatohepatitis?

    Hinz, Kaitlyn / Ding, Wen-Xing

    Cellular and molecular gastroenterology and hepatology

    2023  Volume 16, Issue 6, Page(s) 1034–1035

    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease ; Calcium-Binding Proteins ; Extracellular Matrix Proteins ; Fibrosis ; Matrix Gla Protein
    Chemical Substances Calcium-Binding Proteins ; Extracellular Matrix Proteins
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2023.09.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The pre-mRNA alternative splicing regulated by SRPK2: A new player in alcohol-associated liver disease?

    Yang, Zhihong / Ding, Wen-Xing

    Hepatology (Baltimore, Md.)

    2023  Volume 78, Issue 5, Page(s) 1329–1331

    MeSH term(s) Humans ; Alternative Splicing/genetics ; Liver Diseases/genetics ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; RNA Precursors/genetics ; RNA Splicing ; Liver Diseases, Alcoholic/genetics ; Liver Diseases, Alcoholic/metabolism
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1) ; RNA Precursors ; SRPK2 protein, human (EC 2.7.11.1)
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: SQSTM1/p62 and Hepatic Mallory-Denk Body Formation in Alcohol-Associated Liver Disease.

    Qian, Hui / Ding, Wen-Xing

    The American journal of pathology

    2023  Volume 193, Issue 10, Page(s) 1415–1426

    Abstract: Sequestosome 1 (SQSTM1/p62; hereafter p62) is an autophagy receptor protein for selective autophagy primarily due to its direct interaction with the microtubule light chain 3 protein that specifically localizes on autophagosome membranes. As a result, ... ...

    Abstract Sequestosome 1 (SQSTM1/p62; hereafter p62) is an autophagy receptor protein for selective autophagy primarily due to its direct interaction with the microtubule light chain 3 protein that specifically localizes on autophagosome membranes. As a result, impaired autophagy leads to the accumulation of p62. p62 is also a common component of many human liver disease-related cellular inclusion bodies, such as Mallory-Denk bodies, intracytoplasmic hyaline bodies, α
    MeSH term(s) Humans ; Sequestosome-1 Protein/metabolism ; Signal Transduction ; Liver Neoplasms/pathology ; NF-kappa B/metabolism ; Liver Diseases, Alcoholic ; Autophagy/physiology
    Chemical Substances Sequestosome-1 Protein ; NF-kappa B ; SQSTM1 protein, human
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2023.02.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.76: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Methods for Monitoring Mitochondrial Biogenesis and Turnover in Cultured Hepatocytes and Mouse Liver Using MitoTimer Reporter Assay.

    Ma, Xiaowen / Ding, Wen-Xing

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2675, Page(s) 97–107

    Abstract: Mitochondrial biogenesis and turnover rate are critical to maintain homeostasis of the intracellular mitochondrial pool. Altered mitochondrial biogenesis and mitophagy are closely related to many chronic diseases, highlighting the importance of ... ...

    Abstract Mitochondrial biogenesis and turnover rate are critical to maintain homeostasis of the intracellular mitochondrial pool. Altered mitochondrial biogenesis and mitophagy are closely related to many chronic diseases, highlighting the importance of mitochondrial stasis in various pathological conditions including liver diseases. We describe a detailed protocol for monitoring mitochondrial lifecycle in primary cultured mouse hepatocytes and mouse liver using the dual color fluorescence-based imaging of MitoTimer. Three types of mitochondria were visualized in mouse hepatocytes: green-only mitochondria (newly synthesized mitochondria), red-only mitochondria (old/aging mitochondria), as well as the majority of yellow mitochondria (representing an intermediate stage of mitochondria). The ratio of red/green fluorescence in each cell will be used to track mitochondrial aging. Super-resolution microscopy analysis revealed that majority of mitochondria were spatially heterogeneous with proteins from simultaneous new synthesis, maturation, and turnover in hepatocytes. MitoTimer reporter assay can specifically target to mitochondria and be used to monitor mitochondrial biogenesis and maturation as well as turnover in vitro and in vivo.
    MeSH term(s) Mice ; Animals ; Organelle Biogenesis ; Mitochondria/metabolism ; Mitophagy ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Liver/metabolism ; Hepatocytes/metabolism
    Chemical Substances Luminescent Proteins
    Language English
    Publishing date 2023-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3247-5_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Editorial of special column on Drug targets and drug development for Alzheimer's disease.

    Ding, Wen-Xing / Swerdlow, Russell H

    Acta pharmaceutica Sinica. B

    2022  Volume 12, Issue 4, Page(s) 1686–1687

    Language English
    Publishing date 2022-04-22
    Publishing country Netherlands
    Document type Editorial
    ISSN 2211-3835
    ISSN 2211-3835
    DOI 10.1016/j.apsb.2022.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online ; E-Book: Cellular injury in liver diseases

    Ding, Wen Xing / Yin, Xiao-Ming

    (Cell death in biology and diseases)

    2017  

    Author's details Wen-Xing Ding, Xiao-Ming Yin editors
    Series title Cell death in biology and diseases
    Language English
    Size 1 Online-Ressource (xiii, 263 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019410243
    ISBN 978-3-319-53774-0 ; 9783319537733 ; 3-319-53774-1 ; 3319537733
    DOI 10.1007/978-3-319-53774-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Article ; Online: Linking of Senescence to Autophagy Deficiency in Chronic Liver Disease.

    Ma, Xiaowen / Williams, Sha Neisha / Ding, Wen-Xing

    Cellular and molecular gastroenterology and hepatology

    2022  Volume 14, Issue 2, Page(s) 405–406

    MeSH term(s) Autophagy ; Cellular Senescence ; Humans ; Liver Diseases
    Language English
    Publishing date 2022-05-20
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2022.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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