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  1. Book: Obesity

    Jensen, Michael D.

    (Endocrinology and metabolism clinics of North America ; volume 49, number 2 (June 2020))

    2020  

    Author's details editor Michael D. Jensen
    Series title Endocrinology and metabolism clinics of North America ; volume 49, number 2 (June 2020)
    Collection
    Language English
    Size xiv Seiten, Seite 216-346, Illustrationen, Diagramme
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT020518223
    ISBN 978-0-323-71306-1 ; 0-323-71306-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 148 -49,2- verfügbar in Königswinter Königswinter

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  2. Book: Synthetic metabolic pathways

    Krogh Jensen, Michael / Keasling, Jay D.

    methods and protocols

    (Methods in molecular biology ; 1671 ; Springer protocols ; Biomedicine)

    2018  

    Author's details edited by Michael Krogh Jensen (The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark), Jay D. Keasling (Joint BioEnergy Institute, Emeryville, CA, USA)
    Series title Methods in molecular biology ; 1671
    Springer protocols
    Biomedicine
    Collection
    Keywords cell factory ; Genome-scale ; metabolism ; prototyping ; Prokaryote
    Subject code 610
    Language English
    Size xii, 354 Seiten, Illustrationen, Diagramme, 25.4 cm x 17.8 cm
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT019404657
    ISBN 978-1-4939-7294-4 ; 1-4939-7294-4 ; 9781493972951 ; 1493972952
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 7042 -1671- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Insulin regulation of regional lipolysis in upper-body obese and lean humans.

    Nielsen, Søren / Jensen, Michael D

    JCI insight

    2024  

    Abstract: Background: Upper body obesity (UBO) results in insulin resistance with regards to free fatty acid (FFA) release; how this differs by fat depot and sex between UBO and lean adults is unknown. We tested the hypothesis that insulin suppression of FFA ... ...

    Abstract Background: Upper body obesity (UBO) results in insulin resistance with regards to free fatty acid (FFA) release; how this differs by fat depot and sex between UBO and lean adults is unknown. We tested the hypothesis that insulin suppression of FFA release from the splanchnic bed, leg fat and upper body non-splanchnic (UBNS) adipose tissue would be impaired in UBO.
    Methods: Fourteen UBO (7 men, 7 women) and 14 healthy, normal weight (7 men, 7 women) volunteers participated in studies that included femoral artery, femoral vein and hepatic vein catheterization. We then measured leg and splanchnic plasma flow as well as FFA kinetics (using isotopic tracers) under overnight fasting, low- and high-dose insulin infusion using the insulin clamp technique.
    Results: We found the expected insulin resistance in UBO; the most quantitatively important difference between UBO and lean adults was greater FFA release from UBNS adipose tissue when plasma insulin concentrations are in the post-prandial, physiological range. There were obesity, but not sex differences in the regulation of splanchnic FFA release and sex differences in the regulation of leg FFA release.
    Conclusion: Reversing the defects in insulin-regulated UBNS adipose tissue FFA release would have the greatest impact on systemic FFA abnormalities in UBO.
    Trial registration: (not applicable)Funding: These studies were supported by grants DK45343 and DK40484 from the U.S. Public Health Service, and the Novo Nordic Foundation (grant numbers NNF18OC0031804 and NNF16OC0021406) and the Independent Research Fund Denmark (grant number 8020-00420B).
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.175629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: RNA-mediated

    Jensen, Emil D / Jensen, Michael K

    Bio-protocol

    2022  Volume 12, Issue 5, Page(s) e4346

    Abstract: Directed evolution is a powerful approach to obtain genetically-encoded sought-for traits. Compared to the prolonged adaptation regimes to mutations occurring under natural selection, directed evolution unlocks rapid screening and selection of mutants ... ...

    Abstract Directed evolution is a powerful approach to obtain genetically-encoded sought-for traits. Compared to the prolonged adaptation regimes to mutations occurring under natural selection, directed evolution unlocks rapid screening and selection of mutants with improved traits from vast mutated sequence spaces. Many systems have been developed to search variant landscapes based on
    Language English
    Publishing date 2022-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Obesity 2020: From Basic Mechanisms to Clinical Pearls.

    Jensen, Michael D

    Endocrinology and metabolism clinics of North America

    2020  Volume 49, Issue 2, Page(s) xiii–xiv

    MeSH term(s) Humans ; Obesity/therapy
    Language English
    Publishing date 2020-04-16
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/j.ecl.2020.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Characteristics of Normal Weight Insulin-Resistant Adults with Unfavorable Health Outcomes.

    Zhang, Lili / Vella, Adrian / Nair, K Sreekumaran / Jensen, Michael D

    Metabolic syndrome and related disorders

    2024  

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2151220-6
    ISSN 1557-8518 ; 1540-4196
    ISSN (online) 1557-8518
    ISSN 1540-4196
    DOI 10.1089/met.2023.0154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Visceral Fat: Culprit or Canary?

    Jensen, Michael D

    Endocrinology and metabolism clinics of North America

    2020  Volume 49, Issue 2, Page(s) 229–237

    Abstract: Although visceral fat is strongly correlated with the metabolic complications of obesity, the existing data indicate it is not the cause of these complications. Excess release of free fatty acids (FFA) from adipose tissue lipolysis can account for a ... ...

    Abstract Although visceral fat is strongly correlated with the metabolic complications of obesity, the existing data indicate it is not the cause of these complications. Excess release of free fatty acids (FFA) from adipose tissue lipolysis can account for a sizable portion of the metabolic complications of obesity. In humans, upper-body subcutaneous adipose tissue accounts for most systemic FFA, whereas visceral fat contributes a modest portion of the excess amount to which the liver is exposed. This pattern is maintained in upper-body/visceral obesity, except that greater amounts of visceral fat expose the liver to more FFA from visceral adipose tissue lipolysis.
    MeSH term(s) Adipogenesis/physiology ; Fatty Acids, Nonesterified/metabolism ; Humans ; Insulin Resistance/physiology ; Intra-Abdominal Fat/metabolism ; Intra-Abdominal Fat/pathology ; Intra-Abdominal Fat/physiopathology ; Metabolic Diseases/metabolism ; Metabolic Diseases/pathology ; Metabolic Diseases/physiopathology
    Chemical Substances Fatty Acids, Nonesterified
    Language English
    Publishing date 2020-04-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/j.ecl.2020.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Coronary artery calcium to guide treatment in primary prevention-can we afford not to?

    Jensen, Joseph C / Miedema, Michael D

    European journal of preventive cardiology

    2022  Volume 29, Issue 13, Page(s) 1800–1801

    MeSH term(s) Humans ; Coronary Vessels ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/prevention & control ; Calcium ; Primary Prevention ; Risk Factors ; Registries ; Denmark
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwac142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Metabolic changes in aging humans: current evidence and therapeutic strategies.

    Palmer, Allyson K / Jensen, Michael D

    The Journal of clinical investigation

    2022  Volume 132, Issue 16

    Abstract: Aging and metabolism are inextricably linked, and many age-related changes in body composition, including increased central adiposity and sarcopenia, have underpinnings in fundamental aging processes. These age-related changes are further exacerbated by ... ...

    Abstract Aging and metabolism are inextricably linked, and many age-related changes in body composition, including increased central adiposity and sarcopenia, have underpinnings in fundamental aging processes. These age-related changes are further exacerbated by a sedentary lifestyle and can be in part prevented by maintenance of activity with aging. Here we explore the age-related changes seen in individual metabolic tissues - adipose, muscle, and liver - as well as globally in older adults. We also discuss the available evidence for therapeutic interventions such as caloric restriction, resistance training, and senolytic and senomorphic drugs to maintain healthy metabolism with aging, focusing on data from human studies.
    MeSH term(s) Adipose Tissue ; Aged ; Aging/metabolism ; Caloric Restriction ; Humans ; Obesity ; Sarcopenia/therapy
    Language English
    Publishing date 2022-08-20
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI158451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Diabesity and heart failure with preserved ejection fraction: the picture is getting clearer.

    Omar, Massar / Jensen, Michael D / Borlaug, Barry A

    European journal of heart failure

    2022  Volume 24, Issue 3, Page(s) 510–512

    MeSH term(s) Heart Failure ; Hospitalization ; Humans ; Stroke Volume
    Language English
    Publishing date 2022-02-14
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2440
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