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Abstract: SARS-CoV-2 infection alters cellular RNA content. Cellular RNAs are chemically modified and eventually degraded, depositing modified nucleosides into extracellular fluids such as serum and urine. Here we searched for COVID-19-specific changes in modified ...

Abstract	SARS-CoV-2 infection alters cellular RNA content. Cellular RNAs are chemically modified and eventually degraded, depositing modified nucleosides into extracellular fluids such as serum and urine. Here we searched for COVID-19-specific changes in modified nucleoside levels contained in serum and urine of 308 COVID-19 patients using liquid chromatography-mass spectrometry (LC-MS). We found that two modified nucleosides,
MeSH term(s)	Adenosine/analogs & derivatives ; Biomarkers ; COVID-19/diagnosis ; Humans ; Nucleosides/chemistry ; RNA ; SARS-CoV-2 ; Threonine/analogs & derivatives
Chemical Substances	2-methylthio-N6-threonylcarbamoyladenosine ; Biomarkers ; Nucleosides ; N(6)-(N-threonylcarbonyl)adenosine (24719-82-2) ; Threonine (2ZD004190S) ; RNA (63231-63-0) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2022-09-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom12091233
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Article ; Online: Efficacy of Native T

Tsunamoto, Hiroshi / Yamamoto, Hiroyuki / Masumoto, Akiko / Taniguchi, Yasuyo / Takahashi, Nobuyuki / Onishi, Tetsuari / Takaya, Tomofumi / Kawai, Hiroya / Hirata, Ken-Ichi / Tanaka, Hidekazu

Circulation journal : official journal of the Japanese Circulation Society

2024 Volume 88, Issue 4, Page(s) 519–527

Abstract: Background: We investigated the efficacy of left ventricular (LV) myocardial damage by native T ... Conclusions: Assessment of baseline LV myocardial damage based on native T ...

Abstract	Background: We investigated the efficacy of left ventricular (LV) myocardial damage by native T Conclusions: Assessment of baseline LV myocardial damage based on native T
MeSH term(s)	Humans ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/surgery ; Heart Ventricles ; Heart ; Contrast Media ; Heart Failure ; Cardiomyopathies/diagnostic imaging ; Treatment Outcome ; Heart Valve Prosthesis Implantation
Chemical Substances	Contrast Media
Language	English
Publishing date	2024-02-15
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.CJ-23-0777
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Ui IV Zs.74: Show issues

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Article ; Online: Tissue resident memory T-cells in lichen planus on a surgical scar.

Yamamoto, Toshiyuki

Clinical and experimental dermatology

2024

Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1093/ced/llae125
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Zs.A 1278: Show issues

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Article ; Online: Extranodal natural killer/T-cell lymphoma coexisting with peripheral T-cell lymphoma, not otherwise specified.

Hayashino, Kenta / Yoshida, Chikamasa / Ayata, Yoshiyuki / Yukawa, Ryouya / Komura, Aya / Nakamura, Makoto / Meguri, Yusuke / Yamamoto, Kazuhiko / Oda, Wakako / Imajo, Kenji

Journal of clinical and experimental hematopathology : JCEH

2024 Volume 64, Issue 1, Page(s) 52–58

Abstract: ... and CD8-positive cells were mixed in almost equal numbers. He was diagnosed with peripheral T-cell ... Therefore, the patient was diagnosed with extranodal natural killer/T-cell lymphoma (ENKTL) with bone marrow involvement ...

Abstract	We report the case of a 52-year-old male who presented to our hospital with cervical lymphadenopathy. Lymph node biopsy revealed small atypical lymphoid cells positive for CD3 and CD5 and negative for CD56 and Epstein-Barr virus (EBV)-encoded small RNA (EBER) by in situ hybridization. CD4-positive cells and CD8-positive cells were mixed in almost equal numbers. He was diagnosed with peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). The patient received one cycle of chemotherapy, resulting in severe sepsis. While undergoing treatment in the intensive care unit with an antimicrobial agent and prednisone, ascitic fluid appeared. Abdominal aspiration revealed neutrophil-predominant ascites and microbiological studies revealed Candida albicans. However, ascites did not improve when treated with micafungin for Candida peritonitis. Abdominal aspiration was re-performed, and atypical lymphoid cells that were positive for CD3 and CD56 were detected. EBV-DNA levels in whole blood were significantly elevated. Atypical lymphoid cells were positive for EBER by in situ hybridization and Southern blot analysis showed EBV terminal repeat monoclonal patterns. Bone marrow examination revealed the same atypical lymphoid cells. Therefore, the patient was diagnosed with extranodal natural killer/T-cell lymphoma (ENKTL) with bone marrow involvement 3 months after the diagnosis of PTCL-NOS. Complications associated with PTCL-NOS and ENKTL are rare. PTCL-NOS, chemotherapy, sepsis, and prednisone might have led to immunodeficiency and reactivation of EBV, which might be one of the pathophysiologies for developing ENKTL. Our case indicates that measuring EBV-DNA in the blood is a simple and prompt examination to detect complications of EBV-associated lymphoma.
MeSH term(s)	Male ; Humans ; Middle Aged ; Epstein-Barr Virus Infections/complications ; Herpesvirus 4, Human ; Lymphoma, T-Cell, Peripheral/complications ; Lymphoma, T-Cell, Peripheral/diagnosis ; Lymphoma, T-Cell, Peripheral/drug therapy ; Prednisone ; Lymphoma, Extranodal NK-T-Cell/complications ; Lymphoma, Extranodal NK-T-Cell/diagnosis ; Ascites/complications ; Ascites/pathology ; Killer Cells, Natural/pathology ; DNA
Chemical Substances	Prednisone (VB0R961HZT) ; DNA (9007-49-2)
Language	English
Publishing date	2024-03-27
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2395568-5
ISSN	1880-9952 ; 1880-9952
ISSN (online)	1880-9952
ISSN	1880-9952
DOI	10.3960/jslrt.23049
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Article ; Online: Reprogramming of pyrimidine nucleotide metabolism supports vigorous cell proliferation of normal and malignant T cells.

Watanabe, Tatsuro / Yamamoto, Yuta / Kurahashi, Yuki / Kawasoe, Kazunori / Kidoguchi, Keisuke / Ureshino, Hiroshi / Kamachi, Kazuharu / Yoshida-Sakai, Nao / Fukuda-Kurahashi, Yuki / Nakamura, Hideaki / Okada, Seiji / Sueoka, Eisaburo / Kimura, Shinya

Blood advances

2024 Volume 8, Issue 6, Page(s) 1345–1358

Abstract: Abstract: Adult T-cell leukemia/lymphoma (ATL) is triggered by infection with human T-cell ... T cells and ATL cells through regulation of uridine-cytidine kinase 2 (UCK2), which supports vigorous ... biosynthesis and drug metabolism. We found that UCK2 was overexpressed aberrantly in HTLV-1-infected T ...

Abstract	Abstract: Adult T-cell leukemia/lymphoma (ATL) is triggered by infection with human T-cell lymphotropic virus-1 (HTLV-1). Here, we describe the reprogramming of pyrimidine biosynthesis in both normal T cells and ATL cells through regulation of uridine-cytidine kinase 2 (UCK2), which supports vigorous proliferation. UCK2 catalyzes the monophosphorylation of cytidine/uridine and their analogues during pyrimidine biosynthesis and drug metabolism. We found that UCK2 was overexpressed aberrantly in HTLV-1-infected T cells but not in normal T cells. T-cell activation via T-cell receptor (TCR) signaling induced expression of UCK2 in normal T cells. Somatic alterations and epigenetic modifications in ATL cells activate TCR signaling. Therefore, we believe that expression of UCK2 in HTLV-1-infected cells is induced by dysregulated TCR signaling. Recently, we established azacitidine-resistant (AZA-R) cells showing absent expression of UCK2. AZA-R cells proliferated normally in vitro, whereas UCK2 knockdown inhibited ATL cell growth. Although uridine and cytidine accumulated in AZA-R cells, possibly because of dysfunction of pyrimidine salvage biosynthesis induced by loss of UCK2 expression, the amount of UTP and CTP was almost the same as in parental cells. Furthermore, AZA-R cells were more susceptible to an inhibitor of dihydroorotic acid dehydrogenase, which performs the rate-limiting enzyme of de novo pyrimidine nucleotide biosynthesis, and more resistant to dipyridamole, an inhibitor of pyrimidine salvage biosynthesis, suggesting that AZA-R cells adapt to UCK2 loss by increasing de novo pyrimidine nucleotide biosynthesis. Taken together, the data suggest that fine-tuning pyrimidine biosynthesis supports vigorous cell proliferation of both normal T cells and ATL cells.
MeSH term(s)	Adult ; Humans ; Pyrimidines ; Uridine/metabolism ; Cell Proliferation ; Cytidine ; Human T-lymphotropic virus 1 ; Pyrimidine Nucleotides ; Receptors, Antigen, T-Cell ; T-Lymphocytes/metabolism
Chemical Substances	Pyrimidines ; Uridine (WHI7HQ7H85) ; Cytidine (5CSZ8459RP) ; Pyrimidine Nucleotides ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2023011131
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Zs.A 7153: Show issues

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Article: IMiD/CELMoD-induced growth suppression of adult T-cell leukemia/lymphoma cells

Wang, Yu / Shimosaki, Shunsuke / Ikebe, Emi / Iha, Hidekatsu / Yamamoto, Jun-Ichi / Fife, Nichole / Ichikawa, Tomonaga / Hori, Mitsuo / Ogata, Masao / Tsukamoto, Yoshiyuki / Hijiya, Naoki / Moriyama, Masatsugu / Hagiwara, Shotaro / Kusano, Shuichi / Saito, Masumichi / Ahmed, Kamruddin / Nishizono, Akira / Handa, Hiroshi / Morishita, Kazuhiro

Frontiers in oncology

2024 Volume 13, Page(s) 1272528

Abstract: Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasia associated with human T-cell ...

Abstract	Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasia associated with human T-cell leukemia virus type 1 (HTLV-1) infection and has an extremely poor prognosis. Lenalidomide (LEN; a second-generation immunomodulatory drug [IMiD]) has been employed as an additional therapeutic option for ATL since 2017, but its mechanism of action has not been fully proven, and recent studies reported emerging concerns about the development of second primary malignancies in patients treated with long-term IMiD therapy. Our purpose in this study was to elucidate the IMiD-mediated anti-ATL mechanisms. Thirteen ATL-related cell lines were divided into LEN-sensitive or LEN-resistant groups.
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1272528
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Article ; Online: The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer.

Haruna, Miya / Ueyama, Azumi / Yamamoto, Yoko / Hirata, Michinari / Goto, Kumiko / Yoshida, Hiroshi / Higuchi, Naoko / Yoshida, Tetsuya / Kidani, Yujiro / Nakamura, Yamami / Nagira, Morio / Kawashima, Atsunari / Iwahori, Kota / Shintani, Yasushi / Ohkura, Naganari / Wada, Hisashi

Scientific reports

2022 Volume 12, Issue 1, Page(s) 5377

Abstract: Regulatory T cells (Tregs) suppress the host immune response and maintain immune homeostasis. Tregs ... their immune suppressive function, especially the influence on cytotoxic T lymphocyte cell function. The Cancer Genome ... Atlas analysis revealed that CD8 T cell activities were suppressed in high CCR8-expressing tumors ...

Abstract	Regulatory T cells (Tregs) suppress the host immune response and maintain immune homeostasis. Tregs also promote cancer progression and are involved in resistance to immune checkpoint inhibitor treatments. Recent studies identified selective CCR8 expression on tumor-infiltrating Tregs; CCR8+ Tregs have been indicated as a possible new target of cancer immunotherapy. Here, we investigated the features of CCR8+ Tregs in lung cancer patients. CCR8+ Tregs were highly activated and infiltration of CCR8+ Tregs in tumors was associated with poor prognosis in lung cancer patients. We also investigated their immune suppressive function, especially the influence on cytotoxic T lymphocyte cell function. The Cancer Genome Atlas analysis revealed that CD8 T cell activities were suppressed in high CCR8-expressing tumors. Additionally, depletion of CCR8+ cells enhanced CD8 T cell function in an ex vivo culture of lung tumor-infiltrating cells. Moreover, CCR8+ Tregs, but not CCR8- Tregs, induced from human PBMCs markedly suppressed CD8 T cell cytotoxicity. Finally, we demonstrated the therapeutic effect of targeting CCR8 in a murine model of lung cancer. These findings reveal the significance of CCR8+ Tregs for immunosuppression in lung cancer, especially via cytotoxic T lymphocyte cell suppression, and suggest the potential value of CCR8-targeted therapy for cancer treatment.
MeSH term(s)	Animals ; Humans ; Immune Tolerance ; Immunotherapy ; Lung Neoplasms/pathology ; Mice ; Receptors, CCR8/metabolism ; T-Lymphocytes, Cytotoxic ; T-Lymphocytes, Regulatory
Chemical Substances	CCR8 protein, human ; Ccr8 protein, mouse ; Receptors, CCR8
Language	English
Publishing date	2022-03-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-09458-5
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Article ; Online: Insect bite-like reaction in a patient with T-cell lymphoma.

Mori, Tatsuhiko / Irie, Kinuko / Yamamoto, Toshiyuki

Anais brasileiros de dermatologia

2022 Volume 97, Issue 6, Page(s) 829–832

MeSH term(s)	Diagnosis, Differential ; Humans ; Insect Bites and Stings/complications ; Lymphoma, T-Cell
Language	English
Publishing date	2022-09-08
Publishing country	Spain
Document type	Journal Article
ZDB-ID	433655-0
ISSN	1806-4841 ; 0365-0596
ISSN (online)	1806-4841
ISSN	0365-0596
DOI	10.1016/j.abd.2020.12.021
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Zs.A 359: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 344: Show issues

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Article: An Investigation Into the Effect of Different Static Magnetic Fields of 1.5-T and 3.0-T MRI on the Measurement of Tumor Diameters in Breast Cancer.

Yamamoto, Shinji / Okada, Yukinori / Yoshida, Nobukiyo / Takeshita, Koji / Sakurai, Noriko / Ichikawa, Atsushi / Takimoto, Manabu

Cureus

2024 Volume 16, Issue 1, Page(s) e52838

Abstract: Objective This study aimed to determine whether differences in the static field strength of 1.5-T ... and 3.0-T MRI systems affect the diagnostic results of tumor size measurement in breast cancer and ... In this study, the maximum diameters of the tumor obtained by DWI and Gd-T1WI on 1.5-T and 3.0-T MRI systems ...

Abstract	Objective This study aimed to determine whether differences in the static field strength of 1.5-T and 3.0-T MRI systems affect the diagnostic results of tumor size measurement in breast cancer and to compare them with the results of tumor size in surgical pathology diagnosis. Methods We adopted a retrospective and case-control study design. We included patients with a suspected or confirmed diagnosis of breast cancer who underwent breast MRI at our hospital between January 2017 and March 2023. Diffusion-weighted imaging (DWI), gadolinium-enhanced T1-weighted (Gd-T1WI) MRI, and tumor size from surgical pathology were compared via a significance difference test and correlation analysis between the two groups. In this study, the maximum diameters of the tumor obtained by DWI and Gd-T1WI on 1.5-T and 3.0-T MRI systems were divided by the maximum diameter from surgical pathology diagnosis to arrive at the tumor ratio index. Results A total of 36 patients met the selection criteria: 15 for the 1.5-T system and 21 for the 3.0-T system; all of them were female. The mean ratio of pathological tumor length to diameter measured by MRI for each system showed no significant difference between the groups (p=0.653). For the 1.5-T MRI system, the ratio of tumor length diameter by DWI to that by pathology was 1.042 ±0.361, and the ratio of tumor length diameter by Gd-T1WI to that by pathology was 1.107 ±0.314, with no significant difference observed between ratios (p=0.345). The correlation coefficient between them was r=0.730 (p=0.002). For the 3.0-T MRI system, the ratio of tumor length diameter by DWI to that by pathology was 0.893 ±0.197, while the ratio of tumor length diameter by Gd-T1WI to that by pathology was 1.062 ±0.177, with a significant difference between the two (p<0.001). The correlation coefficient between the two groups was 0.695 (p<0.001). Conclusions While there was no significant difference in the ratios of tumor length diameter measured by 1.5-T Gd-T1WI and DWI compared to pathology, there was a significant difference in the ratios of tumor length diameter measured by 3.0-T DWI and Gd-T1WI compared to pathology. Hence, only 3.0-T DWI can lead to a potential underestimation of tumor length.
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52838
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Article: [A Case of Extranodal NK/T-Cell Lymphoma with Perforation of the Small Intestine].

Nakagawa, Masataka / Yamamoto, Yuji / Yamamoto, Rie / Nishisaka, Takashi / Shiozaki, Shohei / Nishikawa, Saki / Hamaoka, Michinori / Misumi, Toshihiro / Miguchi, Masashi / Ikeda, Satoshi / Matsugu, Yasuhiro / Nakahara, Hideki / Itamoto, Toshiyuki

Gan to kagaku ryoho. Cancer & chemotherapy

2022 Volume 48, Issue 13, Page(s) 1825–1827

Abstract: A rare case of extranodal NK/T-cell lymphoma(ENKL)with small intestinal perforation is reported ...

Abstract	A rare case of extranodal NK/T-cell lymphoma(ENKL)with small intestinal perforation is reported. A 92-year-old man was admitted for a loss of consciousness. Computed tomography(CT)scan revealed the presence of an intraperitoneal abscess that was drained. Two days later, the drained fluid changed to intestinal juice, and intestinal perforation was suspected. The patient underwent surgery which revealed a 1 cm perforation site in the ileum. A high fever continued after surgery, and malignant lymphoma was diagnosed from pathological findings; however, further treatment could not be performed. He died 24 days after the operation. Pathological dissection revealed metastasis of ENKL at the systemic lymph nodes.
MeSH term(s)	Aged, 80 and over ; Humans ; Intestinal Perforation/etiology ; Intestinal Perforation/surgery ; Intestine, Small/surgery ; Lymph Nodes ; Lymphoma, Extranodal NK-T-Cell/complications ; Lymphoma, Extranodal NK-T-Cell/surgery ; Male ; Tomography, X-Ray Computed
Language	Japanese
Publishing date	2022-01-19
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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