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  1. Book: Xian dai Zhong yao jian ding shou ce

    Shen, Bao'an

    (Xian dai shi yong Zhong yao xi lie cong shu)

    2006  

    Author's details Shen Bao'an, Liu Ronglu zhu bian
    Series title Xian dai shi yong Zhong yao xi lie cong shu
    MeSH term(s) Materia Medica ; Medicine, Chinese Traditional
    Language Chinese
    Size 8, 551 p., [4] p. of plates :, ill. (some col.) ;, 27 cm.
    Edition Di 1 ban.
    Publisher Zhongguo Zhong yi yao chu ban she
    Publishing place Beijing Shi
    Document type Book
    ISBN 9787801569868 ; 7801569865
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Book: Zhong yao jian ding xue

    Ren, Ren'an

    gong Zhong yao zhuan ye yong

    (Gao deng yi yao yuan xiao jiao cai)

    1986  

    Title translation Assay of traditional Chinese drugs.
    Author's details zhu bian Ren Ren'an
    Series title Gao deng yi yao yuan xiao jiao cai
    MeSH term(s) Drugs, Chinese Herbal/analysis ; Materia Medica
    Language Chinese
    Size 5, 661 p. :, ill.
    Edition Di 1 ban.
    Publisher Shanghai ke xue ji shu chu ban she
    Publishing place Shanghai
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Article ; Online: Syntaxin17 Restores Lysosomal Function and Inhibits Pyroptosis Caused by Acinetobacter baumannii.

    An, Zhiyuan / Ding, Wenyi

    Journal of microbiology (Seoul, Korea)

    2024  

    Abstract: Acinetobacter baumannii (A. baumannii) causes autophagy flux disorder by degrading STX17, resulting in a serious inflammatory response. It remains unclear whether STX17 can alter the inflammatory response process by controlling autolysosome function. ... ...

    Abstract Acinetobacter baumannii (A. baumannii) causes autophagy flux disorder by degrading STX17, resulting in a serious inflammatory response. It remains unclear whether STX17 can alter the inflammatory response process by controlling autolysosome function. This study aimed to explore the role of STX17 in the regulation of pyroptosis induced by A. baumannii. Our findings indicate that overexpression of STX17 enhances autophagosome degradation, increases LAMP1 expression, reduces Cathepsin B release, and improves lysosomal function. Conversely, knockdown of STX17 suppresses autophagosome degradation, reduces LAMP1 expression, augments Cathepsin B release, and accelerates lysosomal dysfunction. In instances of A. baumannii infection, overexpression of STX17 was found to improve lysosomal function and reduce the expression of mature of GSDMD and IL-1β, along with the release of LDH, thus inhibiting pyroptosis caused by A. baumannii. Conversely, knockdown of STX17 led to increased lysosomal dysfunction and further enhanced the expression of mature of GSDMD and IL-1β, and increased the release of LDH, exacerbating pyroptosis induced by A. baumannii. These findings suggest that STX17 regulates pyroptosis induced by A. baumannii by modulating lysosomal function.
    Language English
    Publishing date 2024-03-07
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2012399-1
    ISSN 1976-3794 ; 1225-8873
    ISSN (online) 1976-3794
    ISSN 1225-8873
    DOI 10.1007/s12275-024-00109-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Clarification of issues brought up by '

    Ding, Lin / Ding, Shuang / He, Chunmei / Zhang, Qifa / An, Jingjing

    Gland surgery

    2022  Volume 11, Issue 8, Page(s) 1445–1446

    Language English
    Publishing date 2022-08-30
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 3016969-0
    ISSN 2227-8575 ; 2227-684X
    ISSN (online) 2227-8575
    ISSN 2227-684X
    DOI 10.21037/gs-2022-06
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Role of the CD40-CD40L expression level pathway in the diagnosis of unexplained recurrent pregnancy loss.

    Ding, Hui / An, Guoqian

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

    2023  Volume 43, Issue 2, Page(s) 2280840

    Abstract: Background: Unexplained recurrent spontaneous pregnancy loss (URPL) lacks effective treatment and reliable early diagnosis and prediction. Immunologic dysfunction can be an underlying cause of recurrent pregnancy loss (RPL). Considering the regulatory ... ...

    Abstract Background: Unexplained recurrent spontaneous pregnancy loss (URPL) lacks effective treatment and reliable early diagnosis and prediction. Immunologic dysfunction can be an underlying cause of recurrent pregnancy loss (RPL). Considering the regulatory role of CD40-CD40L in immune responses, we explored its clinical significance in URPL.
    Methods: The 108 women with URPL who were treated in Hebei Yanda Hospital from January 2020 to December 2022 were selected as study subjects, and another 108 healthy women who were not pregnant and matched with the age and body mass index of the study group were selected as the control group. CD40 and CD4 + CD25 + Treg cells in peripheral blood mononuclear cells (PBMCs) and CD40L in peripheral blood platelets were measured by flow cytometry. The predictive value of CD40-CD40L in URPL for the risk of RPL was determined by receiver operating characteristic (ROC) curves. The correlations of CD40-CD40L with CD4 + CD25 + Treg cells and serum pro-inflammatory factors were assessed by Pearson's analysis.
    Results: CD40 on the surface of PBMCs and CD40L on the surface of platelets were up-regulated in URPL patients. CD40 in combination with CD40L had high predictive value for the risk of RPL in URPL patients. Peripheral blood CD40-CD40L was positively linked to IL-17 and IL-23, and negatively to CD4 + CD25 + Treg cells and IL-10 in URPL patients.
    Conclusions: The CD40-CD40L pathway expression in peripheral blood can help predict the risk of RPL in URPL patients.
    MeSH term(s) Humans ; Pregnancy ; Female ; CD40 Ligand ; Leukocytes, Mononuclear ; Abortion, Habitual
    Chemical Substances CD40 Ligand (147205-72-9)
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 604639-3
    ISSN 1364-6893 ; 0144-3615
    ISSN (online) 1364-6893
    ISSN 0144-3615
    DOI 10.1080/01443615.2023.2280840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Robust Multi-Agent Communication With Graph Information Bottleneck Optimization.

    Ding, Shifei / Du, Wei / Ding, Ling / Zhang, Jian / Guo, Lili / An, Bo

    IEEE transactions on pattern analysis and machine intelligence

    2024  Volume 46, Issue 5, Page(s) 3096–3107

    Abstract: Recent research on multi-agent reinforcement learning (MARL) has shown that action coordination of multi-agents can be significantly enhanced by introducing communication learning mechanisms. Meanwhile, graph neural network (GNN) provides a promising ... ...

    Abstract Recent research on multi-agent reinforcement learning (MARL) has shown that action coordination of multi-agents can be significantly enhanced by introducing communication learning mechanisms. Meanwhile, graph neural network (GNN) provides a promising paradigm for communication learning of MARL. Under this paradigm, agents and communication channels can be regarded as nodes and edges in the graph, and agents can aggregate information from neighboring agents through GNN. However, this GNN-based communication paradigm is susceptible to adversarial attacks and noise perturbations, and how to achieve robust communication learning under perturbations has been largely neglected. To this end, this paper explores this problem and introduces a robust communication learning mechanism with graph information bottleneck optimization, which can optimally realize the robustness and effectiveness of communication learning. We introduce two information-theoretic regularizers to learn the minimal sufficient message representation for multi-agent communication. The regularizers aim at maximizing the mutual information (MI) between the message representation and action selection while minimizing the MI between the agent feature and message representation. Besides, we present a MARL framework that can integrate the proposed communication mechanism with existing value decomposition methods. Experimental results demonstrate that the proposed method is more robust and efficient than state-of-the-art GNN-based MARL methods.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 1939-3539
    ISSN (online) 1939-3539
    DOI 10.1109/TPAMI.2023.3337534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: ChatGPT: tackle the growing carbon footprint of generative AI.

    An, Jiafu / Ding, Wenzhi / Lin, Chen

    Nature

    2023  Volume 615, Issue 7953, Page(s) 586

    MeSH term(s) Artificial Intelligence/trends ; Carbon Footprint ; Sustainable Development/trends
    Language English
    Publishing date 2023-03-31
    Publishing country England
    Document type Letter
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-023-00843-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 244: Show issues

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  8. Article: Study of active components and mechanisms mediating the hypolipidemic effect of

    Ding, Guanwen / Guo, Xiao / Li, Xiao / An, Liping / Shi, Huawen

    Food science & nutrition

    2024  Volume 12, Issue 4, Page(s) 2833–2845

    Abstract: Hyperlipidemia is a multifaceted metabolic disease, which is the major risk factor for atherosclerosis and cardiovascular diseases. Traditional Chinese medicine provides valuable therapeutic strategies in the treatment of hyperlipidemia. ...

    Abstract Hyperlipidemia is a multifaceted metabolic disease, which is the major risk factor for atherosclerosis and cardiovascular diseases. Traditional Chinese medicine provides valuable therapeutic strategies in the treatment of hyperlipidemia.
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703010-6
    ISSN 2048-7177
    ISSN 2048-7177
    DOI 10.1002/fsn3.3964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Oxytocin and vaginal dinoprostone in labor induction: A systematic review and meta-analysis.

    Chang, Ting-An / Li, Yi-Rong / Ding, Dah-Ching

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2024  

    Abstract: Background: The comparison between prostaglandin E2 (PGE2) and oxytocin and for induction of labor (IOL) remains controversial.: Objective: The present study aimed to determine the safety and efficacy of these two agents in IOL.: Search strategy: ... ...

    Abstract Background: The comparison between prostaglandin E2 (PGE2) and oxytocin and for induction of labor (IOL) remains controversial.
    Objective: The present study aimed to determine the safety and efficacy of these two agents in IOL.
    Search strategy: PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov. from the establishment of the database to April 23, 2023.
    Selection criteria: A search was conducted with keywords "labor, induction, prostaglandin E2/PGE2/dinoprostone, and oxytocin". Only randomized clinical trials comparing oxytocin and vaginal dinoprostone in women who were at least late preterm (gestational age [GA] ≥34 weeks), singleton pregnant, and had intact membranes were enrolled for further meta-analysis.
    Data collection and analysis: We conducted both a descriptive analysis and a meta-analysis. In the meta-analysis, we utilized the Mantel-Haenszel random effects model to analyze dichotomous data, employing the relative risk (RR) as the effect measure along with 95% confidence intervals (CIs). The study quality was evaluated using Cochrane Collaboration's risk of bias assessment tool (RoB 2). A random-effects model was applied for the meta-analysis.
    Main results: After screening 3303 articles from five databases, a total of nine randomized controlled studies composed of 1071 patients were included. Our analysis included 534 patients in the PGE2 group and 537 patients in the oxytocin group. The pooled estimate of vaginal deliveries following PGE2 induction stood at 84.2%, while after oxytocin induction, it was 79.8%. The meta-analysis showed no statistical difference between the two groups in terms of the rate of vaginal delivery (pooled RR, 1.05; 95% CI: 0.95-1.16; P value for Q, 0.001; I
    Conclusions: When amalgamating the available literature, it implies that oxytocin was found to have similar effects as PGE2 on delivery outcomes and safety concerns in pregnant women with GA ≥36 weeks. Although the uterine cervix was unfavorable, both low and high doses of oxytocin were feasible for IOL.
    Language English
    Publishing date 2024-02-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.15443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 355: Show issues Location:
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    Zs.MO 183: Show issues

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  10. Article ; Online: Effects of a single dose of rocuronium in patients with different body fat percentages: A randomised controlled trial.

    An, Guanghui / Qiu, Yan / Zhou, Zheliang / Ding, Xueying / Li, Cheng

    Clinical and experimental pharmacology & physiology

    2024  Volume 51, Issue 3, Page(s) e13836

    Abstract: The pharmacodynamics in patients with high body fat percentage might be similar to those in obese patients. This randomised controlled clinical trial observed the effects of rocuronium in patients with different percent body fats (PBFs). Fifty-four ... ...

    Abstract The pharmacodynamics in patients with high body fat percentage might be similar to those in obese patients. This randomised controlled clinical trial observed the effects of rocuronium in patients with different percent body fats (PBFs). Fifty-four patients who underwent elective urological or pelvic surgery under general anaesthesia at Shanghai General Hospital were included in the present study; 51 patients were included for data analysis. Patients with normal PBF (<25%) were given a single dose of rocuronium calculated based on total body weight (N-TBW, control group). Patients with a higher PBF (≥25%) were given a single dose of rocuronium calculated based on total body weight (H-TBW). Patients with higher PBF and rocuronium were dosed based on fat-free mass (H-FFM). A train of four (TOF)-Watch acceleromyography monitor was used to measure the effects of the rocuronium. H-TBW (91.9 ± 28.8 s) had significantly shorter onset time than N-TBW and H-FFM (p = 0.003). H-TBW had significantly longer clinical duration time and pharmacological duration time than the other groups (p = 0.000 and 0.000, respectively); the TOF ratio
    MeSH term(s) Humans ; Rocuronium ; Neuromuscular Nondepolarizing Agents/pharmacology ; Androstanols/pharmacology ; China ; Obesity ; Adipose Tissue
    Chemical Substances Rocuronium (WRE554RFEZ) ; Neuromuscular Nondepolarizing Agents ; Androstanols
    Language English
    Publishing date 2024-01-30
    Publishing country Australia
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 189277-0
    ISSN 1440-1681 ; 0305-1870 ; 0143-9294
    ISSN (online) 1440-1681
    ISSN 0305-1870 ; 0143-9294
    DOI 10.1111/1440-1681.13836
    Database MEDical Literature Analysis and Retrieval System OnLINE

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