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  1. Article: Variations in the plasticity of functional traits indicate the differential impacts of abiotic and biotic factors on the structure and growth of trees in tropical dry forest fragments.

    Chaturvedi, Ravi Kant / Pandey, Santosh Kumar / Tripathi, Anshuman / Goparaju, Laxmi / Raghubanshi, Akhilesh Singh / Singh, J S

    Frontiers in plant science

    2024  Volume 14, Page(s) 1181293

    Abstract: Abiotic and biotic factors have considerable impact on the plasticity of plant functional traits, which influences forest structure and productivity; however, their inter-relationships have not been quantified for fragmented tropical dry forest (TDF) ... ...

    Abstract Abiotic and biotic factors have considerable impact on the plasticity of plant functional traits, which influences forest structure and productivity; however, their inter-relationships have not been quantified for fragmented tropical dry forest (TDF) ecosystems. We asked the following questions: (1) what are the variations in the plasticity of functional traits due to soil moisture availability in TDF fragments? (2) what are the roles of soil nutrients and forest disturbances in influencing variations in the plasticity of functional traits in the TDF fragments? and (3) how do the variations in the plasticity of functional traits influence the structure and productivity of TDF fragments? Based on linear mixed-effects results, we observed significant variations among tree species for soil moisture content (SMC) under the canopy and selected functional traits across forest fragments. We categorized tree species across fragments by principal component analysis (PCA) and hierarchical clustering on principal components (HCPC) analyses into three functional types,
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1181293
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  2. Article: Mental capacity including testamentary capacity.

    Dalal, Pronob Kumar / Tripathi, Adarsh / Kar, Sujita Kumar / Narayan, Choudhary Laxmi / Matkar, Abhay

    Indian journal of psychiatry

    2022  Volume 64, Issue Suppl 1, Page(s) S25–S34

    Language English
    Publishing date 2022-03-22
    Publishing country India
    Document type Journal Article
    ZDB-ID 221523-8
    ISSN 0019-5545
    ISSN 0019-5545
    DOI 10.4103/indianjpsychiatry.indianjpsychiatry_696_21
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  3. Article ; Online: Computational Study and Synthesis of a New Class of Anticonvulsants with 6 Hz Psychomotor Seizure Test Activity: 2-(1,3-benzodioxol-5-yloxy)- N'-[substituted]-acetohydrazides.

    Kumar, Praveen / Tripathi, Laxmi

    Medicinal chemistry (Shariqah (United Arab Emirates))

    2020  Volume 17, Issue 10, Page(s) 1175–1193

    Abstract: Background: About 50 million epileptic cases worldwide and 12 million in India are reported. Currently, available drugs yield adequate control of seizure in 60-70% of patients and show many toxic effects. These actualities provoked the search for novel, ...

    Abstract Background: About 50 million epileptic cases worldwide and 12 million in India are reported. Currently, available drugs yield adequate control of seizure in 60-70% of patients and show many toxic effects. These actualities provoked the search for novel, more efficacious and safer anticonvulsants.
    Objective: The concatenation of 2-(1,3-benzodioxol-5-yloxy)-N'-[substituted]-acetohydrazides SA 1- 10 was designed by molecular hybridization, optimized by computational study and synthesized with the objective of obtaining a prototype of potent anticonvulsant molecules especially active against partial seizures.
    Methods: Computational study was performed to calculate the pharmacophoric design, projection of the pharmacokinetic parameters and docking scores of the titled compounds with molecular targets of epilepsy. The anticonvulsant activity was ascertained by 6 Hz psychomotor seizure test. Minimal motor impairment showing neurotoxicity was assessed using the Rotarod test.
    Results: Titled compounds possessed the indispensable elements of pharmacophore and displayed good binding affinity with molecular targets of epilepsy, such as GABA (A) alpha-1 & delta receptor, glutamate receptor, Na+/H+ exchanger and GABA- aminotransferase in docking studies. The most potent compound of the concatenation was 2-(1,3-benzodioxol-5-yloxy)-N'-[4-(4- chlorophenoxy)benzylidene]-acetohydrazide SA 4, showing 100% protection at four different time points with ED
    Conclusion: The protection shown in 6 Hz test is implicated as the compound's ability to control partial seizures. Thus, the titled compounds can be considered as potential prototype candidates for antiepileptic therapy against partial seizures.
    MeSH term(s) Animals ; Anticonvulsants/therapeutic use ; Anticonvulsants/toxicity ; Dose-Response Relationship, Drug ; Electroshock ; Epilepsy/drug therapy ; Humans ; Hydrazines ; Mice ; Pentylenetetrazole/therapeutic use ; Seizures/chemically induced ; Seizures/drug therapy
    Chemical Substances Anticonvulsants ; Hydrazines ; acetylhydrazine (SK0DPC9098) ; Pentylenetetrazole (WM5Z385K7T)
    Language English
    Publishing date 2020-12-08
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1875-6638
    ISSN (online) 1875-6638
    DOI 10.2174/1573406416666201106111110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Shape and Phase-Controlled One-Pot Synthesis of Air Stable Cationic AgCdS Nanocrystals, Optoelectronic and Electrochemical Hydrogen Evolution Studies.

    Chaturvedi, Jyotsna / Munthasir, Akkarakkaran Thayyil Muhammed / Nayak, Arpan Kumar / Tripathi, Laxmi Narayan / Thilagar, Pakkirisamy / Jagirdar, Balaji R

    Small methods

    2023  Volume 8, Issue 1, Page(s) e2300907

    Abstract: CdS-based materials are extensively studied for photocatalytic water splitting. By incorporating ... ...

    Abstract CdS-based materials are extensively studied for photocatalytic water splitting. By incorporating Ag
    Language English
    Publishing date 2023-10-17
    Publishing country Germany
    Document type Journal Article
    ISSN 2366-9608
    ISSN (online) 2366-9608
    DOI 10.1002/smtd.202300907
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  5. Article ; Online: Nanoantenna enhanced terahertz interaction of biomolecules.

    Adak, Subham / Tripathi, Laxmi Narayan

    The Analyst

    2019  Volume 144, Issue 21, Page(s) 6172–6192

    Abstract: Terahertz time-domain spectroscopy (THz-TDS) is a non-invasive, non-contact and label-free technique for biological and chemical sensing as THz-spectra are less energetic and lie in the characteristic vibration frequency regime of proteins and DNA ... ...

    Abstract Terahertz time-domain spectroscopy (THz-TDS) is a non-invasive, non-contact and label-free technique for biological and chemical sensing as THz-spectra are less energetic and lie in the characteristic vibration frequency regime of proteins and DNA molecules. However, THz-TDS is less sensitive for the detection of micro-organisms of size equal to or less than λ/100 (where, λ is the wavelength of the incident THz wave), and molecules in extremely low concentration solutions (like, a few femtomolar). After successful high-throughput fabrication of nanostructures, nanoantennas were found to be indispensable in enhancing the sensitivity of conventional THz-TDS. These nanostructures lead to strong THz field enhancement when in resonance with the absorption spectrum of absorptive molecules, causing significant changes in the magnitude of the transmission spectrum, therefore, enhancing the sensitivity and allowing the detection of molecules and biomaterials in extremely low concentration solutions. Herein, we review the recent developments in ultra-sensitive and selective nanogap biosensors. We have also provided an in-depth review of various high-throughput nanofabrication techniques. We also discussed the physics behind the field enhancements in the sub-skin depth as well as sub-nanometer sized nanogaps. We introduce finite-difference time-domain (FDTD) and molecular dynamics (MD) simulation tools to study THz biomolecular interactions. Finally, we provide a comprehensive account of nanoantenna enhanced sensing of viruses (like, H1N1) and biomolecules such as artificial sweeteners which are addictive and carcinogenic.
    MeSH term(s) Aspartame/analysis ; Influenza A virus/isolation & purification ; Molecular Dynamics Simulation ; Nanostructures/chemistry ; Proteins/chemistry ; Sweetening Agents/analysis ; Terahertz Spectroscopy/methods ; Thiazines/analysis
    Chemical Substances Proteins ; Sweetening Agents ; Thiazines ; acetosulfame (MA3UYZ6K1H) ; Aspartame (Z0H242BBR1)
    Language English
    Publishing date 2019-10-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/c9an00798a
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    Zs.A 2423: Show issues Location:
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  6. Book ; Online: Deterministic coupling of a quantum emitter to surface plasmon polaritons, Purcell enhanced generation of indistinguishable single photons and quantum information processing

    Sharma, Lakshminarayan / Tripathi, Laxmi Narayan

    2021  

    Abstract: Integrated photonic circuits are an integral part of all-optical and on-chip quantum information processing and quantum computer. Deterministically integrated single-photon sources in nanoplasmonic circuits lead to densely packed scalable quantum logic ... ...

    Abstract Integrated photonic circuits are an integral part of all-optical and on-chip quantum information processing and quantum computer. Deterministically integrated single-photon sources in nanoplasmonic circuits lead to densely packed scalable quantum logic circuits operating beyond the diffraction limit. Here, we report the coupling efficiency of single-photon sources to the plasmonic waveguide, characteristic transmission spectrum, propagation length, decay length, and plasmonic Purcell factor. We simulated the transmission spectrum to find the appropriate wavelength for various width of the dielectric in the metal-dielectric-metal waveguide. We find the maximum propagation length of 3.98 $\mu$m for Al$_{2}$O$_{3}$ dielectric-width equal to 140 nm and coupling efficiency to be greater than 82 \%. The plasmonic Purcell factor was found to be inversely proportional to dielectric-width (w), reaching as high as 31974 for w equal to 1 nm. We also calculated quantum properties of the photons like indistinguishability and found that it can be enhanced by plasmonic-nanocavity if single-photon sources are deterministically coupled. We further, propose a scalable metal-dielectric-metal waveguide based quantum logic circuits using the plasmonic circuit and Mach-Zehnder interferometer.

    Comment: Published in optics communications
    Keywords Physics - Optics ; Condensed Matter - Mesoscale and Nanoscale Physics ; Condensed Matter - Materials Science ; Quantum Physics
    Subject code 535
    Publishing date 2021-08-25
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Neuroprotective validation of pectin in T2DM-induced allodynia and hyperalgesia in diabetic peripheral neuropathic pain.

    Srivastava, Rajnish / Tripathi, Laxmi / Swain, Sudhansu Ranjan / Singh, Jagan

    Archives of physiology and biochemistry

    2021  Volume 129, Issue 4, Page(s) 901–912

    Abstract: Aim: To validate neuroprotective effect of pectin against neuropathic pain in diabetic rodents.: Material and method: Pectin was isolated and characterised from different sources to validate its neuroprotective effect against T2DM associated ... ...

    Abstract Aim: To validate neuroprotective effect of pectin against neuropathic pain in diabetic rodents.
    Material and method: Pectin was isolated and characterised from different sources to validate its neuroprotective effect against T2DM associated neuropathic pain. The antioxidant activity of pectins was done by the DPPH method. Type-2 diabetes mellitus (T2DM) was induced in Wistar albino rats by high-fat diet and high-fat emulsion feeding for 2 weeks followed by a single i.p. of Sterptozotocin in 3rd week. The animals were grouped as positive control and Citrus sinensis (L.) Osbeck peel pectin (CSL-OP) as test group and treated for the next 4 weeks. Body weight and blood glucose were measured up to 8 weeks; however, behavioural assessment was done at the end of 5th to 8th week.
    Result: CSL-OP restored the reduced body weight and elevated blood glucose with increased pain threshold and improved walking performance.
    Conclusion: CSL-OP prevented progression of early diabetic neuropathy with anti-oxidant activity.
    MeSH term(s) Rats ; Animals ; Hyperalgesia/drug therapy ; Hyperalgesia/etiology ; Diabetic Neuropathies/drug therapy ; Diabetic Neuropathies/prevention & control ; Diabetic Neuropathies/chemically induced ; Pectins/adverse effects ; Blood Glucose ; Neuroprotective Agents ; Diabetes Mellitus, Experimental/chemically induced ; Rats, Wistar ; Diabetes Mellitus, Type 2/complications ; Antioxidants/adverse effects ; Neuralgia/drug therapy ; Neuralgia/prevention & control ; Body Weight
    Chemical Substances Pectins (89NA02M4RX) ; Blood Glucose ; Neuroprotective Agents ; Antioxidants
    Language English
    Publishing date 2021-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1238320-x
    ISSN 1744-4160 ; 1381-3455
    ISSN (online) 1744-4160
    ISSN 1381-3455
    DOI 10.1080/13813455.2021.1884725
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    Uc I Zs.99: Show issues Location:
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  8. Article ; Online: Design, Synthesis, Anticonvulsant Activity, Preclinical Study and Pharmacokinetic Performance of N-{[3-(4-chlorophenyl)-4-oxo-3, 4-dihydroquinazolin- 2-yl] methyl}, 2-[(2-isopropyl-5-methyl) 1-cyclo Hexylidene] Hydrazinecarboxamide.

    Yadav, Meena K / Tripathi, Laxmi

    Central nervous system agents in medicinal chemistry

    2018  Volume 19, Issue 1, Page(s) 31–45

    Abstract: Background: N-{[3-(4-chlorophenyl)-4-oxo-3, 4-dihydroquinazolin-2-yl] methyl}, 2-[(2- isopropyl-5-methyl) 1-cyclohexylidene] hydrazinecarboxamide QS11 was designed by computational study. It possessed essential pharmacophoric features for anticonvulsant ...

    Abstract Background: N-{[3-(4-chlorophenyl)-4-oxo-3, 4-dihydroquinazolin-2-yl] methyl}, 2-[(2- isopropyl-5-methyl) 1-cyclohexylidene] hydrazinecarboxamide QS11 was designed by computational study. It possessed essential pharmacophoric features for anticonvulsant activity and showed good docking with iGluRs (Kainate) glutamate receptor.
    Methods: QSAR and ADMET screening results suggested that QS11 would possess good potency for anticonvulsant activity. QS11 was synthesised and evaluated for its anticonvulsant activity and neurotoxicity. QS11 showed protection in strychnine, thiosemicarbazide, 4-aminopyridine and scPTZ induced seizure models and MES seizure model. QS11 showed higher ED50, TD50 and PI values as compared to the standard drugs in both MES and scPTZ screen. A high safety profile (HD50/ED50 values) was noted and hypnosis, analgesia, and anaesthesia were only observed at higher doses. No considerable increase or decrease in the concentration of liver enzymes was observed. Optimized QS11 was subjected to preclinical (in-vivo) studies and the pharmacokinetic performance of the sample was investigated. The result revealed that the pharmacokinetic performance of QS11 achieved maximum plasma concentrations (Cmax) of 0.315 ± 0.011 µg/mL at Tmax of 2.0 ± 0.13 h, area under the curve (AUC0-∞) value 4.591 ± 0.163 µg/ml x h, elimination half-life (T1/2) 6.28 ± 0.71 h and elimination rate constant was found 0.110 ± 0.013 h-1 .
    Results and conclusion: Above evidences indicate that QS11 could serve as a lead for development of new antiepileptic drugs.
    MeSH term(s) Animals ; Anticonvulsants/chemical synthesis ; Anticonvulsants/pharmacokinetics ; Anticonvulsants/therapeutic use ; Drug Design ; Drug Evaluation, Preclinical/methods ; Male ; Mice ; Purines/chemical synthesis ; Purines/pharmacokinetics ; Purines/therapeutic use ; Quantitative Structure-Activity Relationship ; Seizures/drug therapy ; Seizures/metabolism
    Chemical Substances Anticonvulsants ; Purines ; QS11 compound
    Language English
    Publishing date 2018-11-22
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2227560-5
    ISSN 1875-6166 ; 1871-5249
    ISSN (online) 1875-6166
    ISSN 1871-5249
    DOI 10.2174/1871524919666181122124012
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    Zs.A 5594: Show issues Location:
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  9. Article ; Online: Hydroxytriazenes incorporating sulphonamide derivatives: evaluation of antidiabetic, antioxidant, anti-inflammatory activities, and computational study.

    Chauhan, Laxmi K / Chopra, Jaishri / Vanangamudi, Murugesan / Tripathi, Indra P / Bhargava, Amit / Goswami, Ajay K / Baroliya, Prabhat K

    Molecular diversity

    2022  Volume 27, Issue 1, Page(s) 223–237

    Abstract: The existent investigation deals with synthesis, characterization, computational analysis, and biological activities of some hydroxytriazene derivatives containing sulphonamide moiety. The compounds were screened for antidiabetic, antioxidant, and anti- ... ...

    Abstract The existent investigation deals with synthesis, characterization, computational analysis, and biological activities of some hydroxytriazene derivatives containing sulphonamide moiety. The compounds were screened for antidiabetic, antioxidant, and anti-inflammatory activities. The antidiabetic activity was assessed using α-glucosidase and α-amylase inhibition assays with IC
    MeSH term(s) Humans ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/chemistry ; Molecular Docking Simulation ; Anti-Inflammatory Agents/pharmacology ; Carrageenan
    Chemical Substances Antioxidants ; Hypoglycemic Agents ; Anti-Inflammatory Agents ; Carrageenan (9000-07-1)
    Language English
    Publishing date 2022-04-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1376507-3
    ISSN 1573-501X ; 1381-1991
    ISSN (online) 1573-501X
    ISSN 1381-1991
    DOI 10.1007/s11030-022-10420-w
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    Zs.A 4946: Show issues Location:
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  10. Article: Separation and Enrichment of Platelets from Whole Blood Using a PDMS-Based Passive Microdevice

    Laxmi, Vijai / Tripathi, Siddhartha / Joshi, Suhas S / Agrawal, Amit

    Industrial & engineering chemistry process design and development. 2020 Feb. 06, v. 59, no. 10

    2020  

    Abstract: Separation and enrichment of platelets in blood plasma play a major role in monitoring the human health condition and transfusion purposes. Although centrifugation is frequently employed to achieve platelet separation, recent advancements in the field of ...

    Abstract Separation and enrichment of platelets in blood plasma play a major role in monitoring the human health condition and transfusion purposes. Although centrifugation is frequently employed to achieve platelet separation, recent advancements in the field of cell separation place microfluidic platforms in advantageous positions over the conventional ones. In this work, we report the development of a PDMS-based passive microfluidics device to separate and enrich platelets in blood plasma. The devices were tested with whole blood in a practically relevant flow rate range of 0.2–0.6 mL/min. One of our proposed devices, comprising gradual constriction–expansion, is able to separate and enrich platelets with 8.7-fold enrichment factor, 25.5% purity, and with minimum activation at a flow rate of 0.4 mL/min using whole human blood. The amount of enrichment and purity is found to be sensitive to the ratio of RBCs and WBCs to platelets in the incoming sample. The ability of the microdevice to handle whole blood at a high flow rate, and enrich platelets in plasma with minimal activation, makes the microdevice unique. These results also demonstrate the strong effect of the RBCs and WBCs to platelet ratio on the amount of enrichment and purity that can be obtained from passive microdevices.
    Keywords blood plasma ; blood platelets ; centrifugation ; erythrocytes ; humans ; leukocytes ; microfluidic technology
    Language English
    Dates of publication 2020-0206
    Size p. 4792-4801.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 1484436-9
    ISSN 1520-5045 ; 0888-5885
    ISSN (online) 1520-5045
    ISSN 0888-5885
    DOI 10.1021/acs.iecr.0c00502
    Database NAL-Catalogue (AGRICOLA)

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