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  1. Book: The EACVI handbook of cardiovascular CT

    Gaemperli, Oliver / Maurovich-Horvat, Pál / Nieman, Koen / Pontone, Gianluca / Pugliese, Francesca

    2023  

    Title variant Cardiovascular CT ; Handbook of cardiovascular CT
    Institution European Society of Cardiology
    Author's details editors Oliver Gaemperli, Pál Maurovich-Horvat, Koen Nieman, Gianluca Pontone, Francesca Pugliese
    Keywords Cardiovascular Diseases / diagnostic imaging ; Radiography ; Tomography, X-Ray Computed / methods ; Cardiovascular system/Diseases/Tomography
    Subject code 616.120757
    Language English
    Size xviii, 365 Seiten, Illustrationen, Diagramme, 20 cm
    Edition First edition
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT021700818
    ISBN 978-0-19-288445-9 ; 978019288447 ; 0-19-288445-X ; 9780192884473 ; 0192884476
    DOI 10.1093/med/9780192884459.001.0001
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2023 A 210 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Congenital ventricular diverticulum of right ventricle: a clinical case.

    Tassetti, Luigi / Rellini, Carlotta / Pontone, Gianluca

    European heart journal. Cardiovascular Imaging

    2024  

    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeae091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5614: Show issues Location:
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  3. Article ; Online: TAVI: What Happens Behind the Stage?

    Pontone, Gianluca / Maragna, Riccardo

    JACC. Cardiovascular imaging

    2023  Volume 17, Issue 4, Page(s) 408–410

    MeSH term(s) Humans ; Predictive Value of Tests ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Transcatheter Aortic Valve Replacement/adverse effects ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2023.09.012
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  4. Article: Clinical implications of cardiac magnetic resonance imaging fibrosis.

    Guglielmo, Marco / Pontone, Gianluca

    European heart journal supplements : journal of the European Society of Cardiology

    2022  Volume 24, Issue Suppl I, Page(s) I123–I126

    Abstract: Cardiac magnetic resonance (CMR) is a non-invasive imaging method that allows to characterize myocardial tissue. In particular, using the late gadolinium enhancement technique, it is possible to identify areas of focal fibrosis. Specific distribution ... ...

    Abstract Cardiac magnetic resonance (CMR) is a non-invasive imaging method that allows to characterize myocardial tissue. In particular, using the late gadolinium enhancement technique, it is possible to identify areas of focal fibrosis. Specific distribution patterns of this fibrosis allow us to distinguish ischaemic cardiomyopathy (iCMP) from non-ischaemic cardiomyopathy (nCMP) and sometimes to identify the aetiology of the latter. Diffuse fibrosis can also be identified using the parametric T1 mapping sequences. For this purpose, the native T1 of the tissue is measured before the administration of the contrast agent (c.a.) or the extracellular volume is calculated after c.a. Both focal and diffuse fibrosis evaluated with CMR appear to be strong prognostic predictors for the identification of threatening ventricular arrhythmias and sudden cardiac death. These evidence open the doors to a possible role of CMR in the selection of the patient to be sent to a defibrillator implant in primary prevention. In this review, we will briefly review the techniques used in CMR for the evaluation of fibrosis. We will then focus on the clinical role of myocardial tissue fibrosis detection in iCMP and nCMP.
    Language English
    Publishing date 2022-11-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartjsupp/suac085
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  5. Article ; Online: Should we choose CT angiography first instead of SPECT/PET first for the diagnosis and management of coronary artery disease?

    Pontone, Gianluca / Rossi, Alexia / Gimelli, Alessia / Neglia, Danilo

    Atherosclerosis

    2023  Volume 385, Page(s) 117315

    Abstract: In patients presenting with chest pain, current guidelines recommend the use of coronary computed tomography angiography and single-photon emission tomography/positron emission tomography, both with equal class 1 indication and level of evidence A. There ...

    Abstract In patients presenting with chest pain, current guidelines recommend the use of coronary computed tomography angiography and single-photon emission tomography/positron emission tomography, both with equal class 1 indication and level of evidence A. There is no clear recommendation on which test should be used as a first-line test. The choice of the test should be based on individualized clinical risk assessment, patient characteristics, local expertise/availability, and patient preferences. In this context, it is fair to ask which non-invasive imaging test to choose. The debate reproduced in this article answers this question by summarizing the considerations in selecting present state-of-the-art criteria of the right test for the right patient to ensure efficient resource utilization, minimize unnecessary testing, and maximize diagnostic accuracy and therapeutic efficacy.
    MeSH term(s) Humans ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Computed Tomography Angiography ; Coronary Angiography ; Tomography, Emission-Computed, Single-Photon ; Positron-Emission Tomography ; Myocardial Perfusion Imaging
    Language English
    Publishing date 2023-10-05
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2023.117315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 226: Show issues Location:
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  6. Article ; Online: Stress-only dynamic computed tomography perfusion protocol (CTP) alone without computed tomography coronary angiography (CCTA) has limited specificity to diagnose ischemia: A retrospective two-center study.

    Sliwicka, Olga / Baggiano, Andrea / Sechopoulos, Ioannis / Pontone, Gianluca

    European journal of radiology

    2023  Volume 169, Page(s) 111152

    Abstract: Purpose: To investigate diagnostic performance of stress-only dynamic myocardial computed tomography perfusion (CTP) without computed tomography coronary angiography (CCTA) to diagnose ischemia with invasive fractional flow reserve (FFR) as a reference ... ...

    Abstract Purpose: To investigate diagnostic performance of stress-only dynamic myocardial computed tomography perfusion (CTP) without computed tomography coronary angiography (CCTA) to diagnose ischemia with invasive fractional flow reserve (FFR) as a reference standard.
    Method: 135 datasets (68 positive for ischemia with invasive FFR < 0.8) acquired with a 256-slice CT system (Revolution, GE Healthcare, Chicago, IL, USA) were retrieved, postprocessed with a deep learning-based algorithm (Advanced intelligent Clear-IQ Engine (AiCE), Canon Medical Systems, Otawara, Japan) (FC03/cardiac kernel, 8 mm slice thickness), analyzed using a dedicated workstation (Vitrea research 7.11.0. Vital Images, Minnetonka, MN, USA), and loaded into a clinical workstation (CardIQ, GE Healthcare, Chicago, IL, USA) for review. Ten observers with various experience from two research sites evaluated the post-processed images, perfusion slices and maps to indicate presence vs absence of perfusion defect and its probability (five-point Likert scale). Binary decisions and probability scores were used to calculate sensitivity and specificity for each reader, and to create receiver operating characteristics (ROC) curves, respectively. Furthermore, the correlation coefficient (ICC) was computed. ROC AUC of a purely quantitative analysis was obtained thanks to a color-coded map with a fixed scale superimposed on myocardial walls displaying myocardial blood flow (MBF) values.
    Results: The overall case-based sensitivity and specificity for the detection of perfusion deficit were 0.79 and 0.30, respectively. No significant differences were detected in the AUC across readers (p value = 0.66). The AUC values were 0.50, 0.58, 0.63, 0.59, 0.45, 0.60, 0.56, 0.61, 0.52, 0.61. Absolute reader agreement ICC was 0.60 (good agreement) for an average case.
    Conclusion: Dynamic CTP alone has good sensitivity, but low specificity when analyzed without CCTA. These findings reinforce the need to guide the interpretation functional test with the knowledge of coronary artery anatomy.
    MeSH term(s) Humans ; Coronary Artery Disease/diagnostic imaging ; Coronary Angiography/methods ; Retrospective Studies ; Fractional Flow Reserve, Myocardial/physiology ; Myocardial Perfusion Imaging/methods ; Tomography, X-Ray Computed/methods ; Computed Tomography Angiography/methods ; Ischemia ; Perfusion ; Coronary Stenosis ; Predictive Value of Tests
    Language English
    Publishing date 2023-10-19
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 138815-0
    ISSN 1872-7727 ; 0720-048X
    ISSN (online) 1872-7727
    ISSN 0720-048X
    DOI 10.1016/j.ejrad.2023.111152
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    Zs.A 1630: Show issues Location:
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  7. Article ; Online: Anatomy and physiology in ischaemic heart disease: a second honeymoon?

    Pontone, Gianluca

    European heart journal

    2016  Volume 37, Issue 15, Page(s) 1228–1231

    MeSH term(s) Coronary Artery Disease ; Humans ; Myocardial Ischemia
    Language English
    Publishing date 2016-04-14
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehv748
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    Zs.MO 640: Show issues

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  8. Article: Risk stratification in cardiomyopathies (dilated, hypertrophic, and arrhythmogenic cardiomyopathy) by cardiac magnetic resonance imaging.

    Guglielmo, Marco / Pontone, Gianluca

    European heart journal supplements : journal of the European Society of Cardiology

    2021  Volume 23, Issue Suppl E, Page(s) E118–E122

    Abstract: Cardiac magnetic resonance imaging (CMR) is a non-invasive, multiplanar, and high spatial resolution imaging technique, which represents the current gold standard for the evaluation of biventricular volumes and function. Furthermore, unlike other methods, ...

    Abstract Cardiac magnetic resonance imaging (CMR) is a non-invasive, multiplanar, and high spatial resolution imaging technique, which represents the current gold standard for the evaluation of biventricular volumes and function. Furthermore, unlike other methods, it has the great advantage of characterizing the myocardial tissue by identifying the presence of alterations, such as oedema and focal and diffuse fibrosis. In particular, the late gadolinium enhancement technique makes it possible to identify areas of focal fibrosis that often constitute the substrate for the triggering of threatening ventricular arrhythmias at the basis of sudden cardiac death. For this reason, the use of CMR in the study of cardiomyopathies has become of primary importance, both for the differential diagnosis and for patient risk stratification. In this brief review, the ability of CMR in prognostic stratification of patients with dilated, hypertrophic, and arrhythmogenic cardiomyopathy will be analysed. In particular, the role of CMR in the prediction of arrhythmic risk and in the decision-making process for the implantation of a cardiac defibrillator will be examined.
    Language English
    Publishing date 2021-10-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartj/suab105
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  9. Article ; Online: Aortic valve neocuspidization and bioprosthetic valves: Evaluating turbulence haemodynamics.

    Manchester, Emily Louise / Pirola, Selene / Pirola, Sergio / Mastroiacovo, Giorgio / Polvani, Gianluca / Pontone, Gianluca / Xu, Xiao Yun

    Computers in biology and medicine

    2024  Volume 171, Page(s) 108123

    Abstract: Aortic valve disease is often treated with bioprosthetic valves. An alternative treatment is aortic valve neocuspidization which is a relatively new reparative procedure whereby the three aortic cusps are replaced with patient pericardium or bovine ... ...

    Abstract Aortic valve disease is often treated with bioprosthetic valves. An alternative treatment is aortic valve neocuspidization which is a relatively new reparative procedure whereby the three aortic cusps are replaced with patient pericardium or bovine tissues. Recent research indicates that aortic blood flow is disturbed, and turbulence effects have yet to be evaluated in either bioprosthetic or aortic valve neocuspidization valve types in patient-specific settings. The aim of this study is to better understand turbulence production in the aorta and evaluate its effects on laminar and turbulent wall shear stress. Four patients with aortic valve disease were treated with either bioprosthetic valves (n=2) or aortic valve neocuspidization valvular repair (n=2). Aortic geometries were segmented from magnetic resonance images (MRI), and 4D flow MRI was used to derive physiological inlet and outlet boundary conditions. Pulsatile large-eddy simulations were performed to capture the full range of laminar, transitional and turbulence characteristics in the aorta. Turbulence was produced in all aortas with highest levels occurring during systolic deceleration. In the ascending aorta, turbulence production is attributed to a combination of valvular skew, valvular eccentricity, and ascending aortic dilation. In the proximal descending thoracic aorta, turbulence production is dependent on the type of arch-descending aorta connection (e.g., a narrowing or sharp bend) which induces flow separation. Laminar and turbulent wall shear stresses are of similar magnitude throughout late systolic deceleration and diastole, although turbulent wall shear stress magnitudes exceed laminar wall shear stresses between 27.3% and 61.1% of the cardiac cycle. This emphasises the significance of including turbulent wall shear stress to improve our comprehension of progressive arterial wall diseases. The findings of this study recommend that aortic valve treatments should prioritise minimising valvular eccentricity and skew in order to mitigate turbulence generation.
    MeSH term(s) Humans ; Animals ; Cattle ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Blood Flow Velocity/physiology ; Hemodynamics/physiology ; Aorta ; Aortic Valve Disease ; Stress, Mechanical
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2024.108123
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    Zs.A 653: Show issues Location:
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  10. Article ; Online: Cardiac magnetic resonance mapping for the diagnosis of reverse ventricular Takotsubo cardiomyopathy.

    Marcon, Lorenzo / Baggiano, Andrea / Pontone, Gianluca

    European heart journal. Cardiovascular Imaging

    2022  Volume 23, Issue 5, Page(s) e243

    MeSH term(s) Heart Ventricles ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Pericardium ; Takotsubo Cardiomyopathy/diagnostic imaging
    Language English
    Publishing date 2022-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeac016
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