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Article ; Online: Role of conservative treatment of cervical spine injuries.

Lauweryns, Philippe

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

2009 Volume 19 Suppl 1, Page(s) S23–6

Abstract: Conservative treatment still has an important role to play, despite the increasing possibilities of surgical treatment. Treatment starts at the site of trauma. Transportation and immobilisation in braces are discussed. Skeletal skull traction can be used ...

Abstract	Conservative treatment still has an important role to play, despite the increasing possibilities of surgical treatment. Treatment starts at the site of trauma. Transportation and immobilisation in braces are discussed. Skeletal skull traction can be used for realignment and reduction, and eventually used in halo-vest treatment. The advantages and disadvantages of these different treatment options are discussed.
MeSH term(s)	Braces/standards ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/injuries ; Cervical Vertebrae/pathology ; Emergency Medical Services/methods ; Emergency Medical Services/standards ; External Fixators/standards ; External Fixators/trends ; Humans ; Prosthesis Fitting/methods ; Prosthesis Fitting/standards ; Radiography ; Skull/anatomy & histology ; Spinal Fractures/diagnosis ; Spinal Fractures/physiopathology ; Spinal Fractures/therapy ; Spinal Injuries/diagnosis ; Spinal Injuries/physiopathology ; Spinal Injuries/therapy ; Traction/standards ; Traction/trends ; Transportation of Patients/methods ; Transportation of Patients/standards
Language	English
Publishing date	2009-08-08
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1115375-1
ISSN	1432-0932 ; 0940-6719
ISSN (online)	1432-0932
ISSN	0940-6719
DOI	10.1007/s00586-009-1116-4
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Article: Prospective analysis of a new bone graft in lumbar interbody fusion: results of a 2- year prospective clinical and radiological study.

Lauweryns, Philippe / Raskin, Yannic

International journal of spine surgery

2015 Volume 9

Abstract: Background: This study examined the efficacy and safety of bone graft material ABM/P-15 (iFACTOR) for use in posterior lumbar interbody fusion. ABM/P-15 has been used safely for more than a decade in dental applications.: Methods: Forty patients ... ...

Abstract	Background: This study examined the efficacy and safety of bone graft material ABM/P-15 (iFACTOR) for use in posterior lumbar interbody fusion. ABM/P-15 has been used safely for more than a decade in dental applications. Methods: Forty patients underwent PLIF surgery, with each patient as control. Assessments up to 24 months included radiographs, CT scan, VAS, and ODI. Primary success criteria were fusion and safety. Results: Intra-cage bridging bone occurred earlier with ABM/P-15 than autograft (97.73% vs. 59.09% at 6 months). On average pain decreased 29 points and function improved 43 points. Radio dense material outside the disk space occurred more frequently with ABM/P-15 than autograft, without clinical consequence. Conclusions: This study suggests that ABM/P-15 has equal or greater efficacy at 6 and 12 months. Pain improvements exceeded success criteria at all time points. Functional improvement exceeded success criteria at all time points. Clinical relevance: This study explores the safety and efficacy of an osteobiologic peptide enhanced bone graft material as a viable alternative to autograft and its attendant risks.
Language	English
Publishing date	2015-02-03
Publishing country	Netherlands
Document type	Journal Article
ISSN	2211-4599
ISSN	2211-4599
DOI	10.14444/2002
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Article: Randomized Controlled Trial of Posterior Lumbar Interbody Fusion With Ti- and CaP-Nanocoated Polyetheretherketone Cages: Comparative Study of the 1-Year Radiological and Clinical Outcome.

Willems, Karel / Lauweryns, Philippe / Verleye, Gino / VAN Goethem, Johan

International journal of spine surgery

2019 Volume 13, Issue 6, Page(s) 575–587

Abstract: Background: Polyetheretherketone (PEEK) is a popular material for posterior lumbar interbody fusion (PLIF) cages, although osseointegration remains limited. To optimize PEEK cage characteristics, titanium (Ti) and calcium phosphate (CaP) nanocoatings ... ...

Abstract	Background: Polyetheretherketone (PEEK) is a popular material for posterior lumbar interbody fusion (PLIF) cages, although osseointegration remains limited. To optimize PEEK cage characteristics, titanium (Ti) and calcium phosphate (CaP) nanocoatings have been developed with proven mechanical safety. This multicenter randomized controlled trial compared the clinical and radiological outcome parameters of nanocoated and uncoated PEEK cages, up to 1 year after surgery. Methods: Standard open PLIF surgery was performed on 127 patients, randomized in 3 groups: Ti-nanocoated (n = 44), CaP-nanocoated (n = 46), and uncoated PEEK cages (n = 37). Clinical assessments up to 1 year after surgery included visual analogue scales (VASs), Oswestry Disability Index (ODI), and 36-Item Short Form Survey (SF-36). Primary radiological outcome parameters were implant stability and fusion status, assessed by x-ray and computed tomography (CT) scans. Patients, surgeons, and postsurgery analysts were blinded. Results: PLIF surgery with all cage types resulted in significant improvements of clinical outcome parameters, exceeding the minimum clinically important differences. No significant differences in VAS, ODI, or SF-36 scores were found among the 3 groups. One year after the surgery, 65.6% of patients with uncoated PEEK cages achieved definite fusion. Significantly more patients with nanocoated PEEK cages achieved definite fusion: 93.9% for Ti nanocoating ( Conclusions: The similar clinical outcome improvements after 1 year suggest that nanocoated PEEK cages have the same safety and efficacy as the clinically accepted uncoated PEEK cages. Furthermore, nanocoated PEEK cages achieved a better fusion rate than uncoated PEEK cages at the 1-year follow-up. A 5-year follow-up study is warranted to revisit the findings. Clinical relevance: The safety, efficacy, and enhanced osseointegration of nanocoated PEEK cages were demonstrated. Osseointegration is a significant predictor of positive long-term clinical outcomes and improved implant longevity, implying a clinical added value of nanocoatings. Enhanced osseointegration becomes even more important in minimally invasive spine surgery and in patients at risk for incomplete fusion.
Language	English
Publishing date	2019-12-31
Publishing country	Netherlands
Document type	Journal Article
ISSN	2211-4599
ISSN	2211-4599
DOI	10.14444/6080
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Article ; Online: Atlantoaxial instability in monozygotic twin sisters: degenerative or congenital disease?

de Jong, Lars / Verfaillie, Michiel / Pans, Steven / Lauweryns, Philippe / Goffin, Jan / Depreitere, Bart

Journal of neurosurgery. Spine

2014 Volume 20, Issue 4, Page(s) 459–463

Abstract: The authors report on two 70-year-old monozygotic twin sisters who both suffered severe nontraumatic atlantoaxial instability. If either had been a solitary case, degenerative atlantoaxial instability would have been the most straightforward diagnosis. ... ...

Abstract	The authors report on two 70-year-old monozygotic twin sisters who both suffered severe nontraumatic atlantoaxial instability. If either had been a solitary case, degenerative atlantoaxial instability would have been the most straightforward diagnosis. In this case report the authors attempt to answer the question of whether an underlying congenital predisposition might be involved.
MeSH term(s)	Aged ; Atlanto-Axial Joint/diagnostic imaging ; Atlanto-Axial Joint/surgery ; Diseases in Twins/diagnostic imaging ; Diseases in Twins/genetics ; Diseases in Twins/surgery ; Female ; Humans ; Joint Instability/diagnostic imaging ; Joint Instability/genetics ; Joint Instability/surgery ; Laminectomy ; Radiography ; Spinal Fusion ; Treatment Outcome ; Twins, Monozygotic
Language	English
Publishing date	2014-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2158643-3
ISSN	1547-5646 ; 1547-5654
ISSN (online)	1547-5646
ISSN	1547-5654
DOI	10.3171/2013.12.SPINE13227
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Uk I Zs.135 -Spine-: Show issues

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Article: Early removal of a Maverick disc prosthesis: surgical findings and morphological changes.

François, Jens / Coessens, Ronald / Lauweryns, Philippe

Acta orthopaedica Belgica

2007 Volume 73, Issue 1, Page(s) 122–127

Abstract: We report the case of a patient who underwent explantation of a Maverick total disc prosthesis at the L5S1 level because of severe persisting pain one year after initial implantation. Dynamic radiographic imaging studies showed good position and size of ... ...

Abstract	We report the case of a patient who underwent explantation of a Maverick total disc prosthesis at the L5S1 level because of severe persisting pain one year after initial implantation. Dynamic radiographic imaging studies showed good position and size of the prosthesis and no evidence of loosening. Intraoperatively residual mobility at the proximal bone-prosthesis interface was detected, as well as gross metallosis around the articulation of the total disc prosthesis. A safe and straightforward technique for the extraction of a Maverick prosthesis using a hooked instrument to hook-on the keel of the device is reported. After removal of the device, an anterior lumbar interbody fusion with subsequent posterior pedicle screw fixation and posterior bone grafting with autologous iliac bone was performed (360 degrees fusion). During this posterior procedure, severe L5S1 facet joint arthrosis was observed. Early clinical and radiographic results were good with excellent patient satisfaction.
MeSH term(s)	Adult ; Device Removal ; Female ; Follow-Up Studies ; Humans ; Intervertebral Disc ; Joint Prosthesis ; Low Back Pain/surgery ; Lumbar Vertebrae/pathology ; Lumbar Vertebrae/surgery ; Pain, Postoperative/etiology ; Prosthesis Failure ; Reoperation ; Sacrum/pathology ; Sacrum/surgery ; Spinal Fusion
Language	English
Publishing date	2007-02
Publishing country	Belgium
Document type	Case Reports ; Journal Article
ZDB-ID	210367-9
ISSN	0001-6462 ; 1784-407X
ISSN	0001-6462 ; 1784-407X
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Zs.A 37: Show issues

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Article: Treatment of high-grade spondylolisthesis by posterior lumbosacral transfixation with transdiscal screws: surgical technique and preliminary results in four cases.

François, Jens / Lauweryns, Philippe / Fabry, Guy

Acta orthopaedica Belgica

2005 Volume 71, Issue 3, Page(s) 334–341

Abstract: In high-grade spondylolisthesis, the surgical treatment should be aimed at achieving good stability to allow solid fusion in the face of high biomechanical forces at the lumbosacral junction. A 360 degrees fusion seems to be able to provide this ... ...

Abstract	In high-grade spondylolisthesis, the surgical treatment should be aimed at achieving good stability to allow solid fusion in the face of high biomechanical forces at the lumbosacral junction. A 360 degrees fusion seems to be able to provide this stability. This is however extensive surgery and many problems and complications have been reported. In order to overcome these difficulties, various new procedures have been published. Most of these techniques aim for a good anterior column support, allowing primary stability and a large bony surface area for fusion. Transfixation of the lumbosacral disc space using a fibular strut graft was published decades ago. Several modifications have been reported since, including the use of threaded cages filled with bone graft. In contrast to the number of these surgical techniques, only few biomechanical test results and small-size clinical studies have been reported in the literature. An interesting technique of lumbosacral transfixation includes the use of transdiscal pedicle screws, described by Abdu et al in 1994. This allows for the use of standard instruments and implants, while biomechanical testing recently has shown improved stability equal to classic PLIF constructs by providing three-column support. Moreover, in high-grade slips this technique is easier to perform than other methods. We have treated four consecutive patients according to this technique with good clinical and radiographic results. The surgical technique is described in detail and a review of the literature is provided.
MeSH term(s)	Adult ; Aged ; Bone Screws ; Female ; Follow-Up Studies ; Humans ; Internal Fixators ; Lumbar Vertebrae ; Lumbosacral Region ; Male ; Pain Measurement ; Recovery of Function ; Sacrum ; Sampling Studies ; Severity of Illness Index ; Spinal Fusion/instrumentation ; Spinal Fusion/methods ; Spondylolisthesis/diagnostic imaging ; Spondylolisthesis/surgery ; Tomography, X-Ray Computed ; Treatment Outcome
Language	English
Publishing date	2005-06
Publishing country	Belgium
Document type	Comparative Study ; Journal Article
ZDB-ID	210367-9
ISSN	0001-6462 ; 1784-407X
ISSN	0001-6462 ; 1784-407X
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Article: Fine grained osseointegrative coating improves biocompatibility of PEEK in heterotopic sheep model.

Meers, Caroline M F / Verleye, Gino B M / Smeets, Dirk / Van Hauwermeiren, Hadewych Y R / Loeckx, Dirk / Willems, Karel / Siau, Vincent G M G G B / Lauweryns, Philippe J M E

International journal of spine surgery

2015 Volume 9, Page(s) 35

Abstract: Background and aim: Polyetheretherketone (PEEK) materials already have been used successfully in orthopedic and especially spine surgery. PEEK is radiolucent and comparable with bone regarding elasticity. However, PEEK is inert and the adhesion of PEEK ... ...

Abstract	Background and aim: Polyetheretherketone (PEEK) materials already have been used successfully in orthopedic and especially spine surgery. PEEK is radiolucent and comparable with bone regarding elasticity. However, PEEK is inert and the adhesion of PEEK implants to bone tissue proceeds slowly because of their relatively low biocompatibility. The aim of the study is to evaluate the effect of titanium and CaP coating on the adhesion of bone tissue. Material and methods: Six adult sheep (body weight 57.6 ± 3.9 kg) were included in this study. Three different types of cylindrical dowels (12 mm length x 8 mm diameter) were implanted in long bones (tibia and femur): PEEK dowels without coating (the control group), and PEEK dowels with a nanocoating of calcium phosphate (CaP group) or titanium (titanium group). Animals were sacrificed after 6, 12 and 26 weeks. Dowels were explanted for micro CT and histology. Results: Bone implant contact (BIC) ratio was significantly higher in the titanium versus control groups in the 6 to 12 weeks period (p = 0.03). The ratio between bone volume and tissue volume (BV/TV) was significantly higher in titanium versus control in the 6 to 12 weeks period (p = 0.02). A significant correlation between BIC and BV/TV was seen (r = 0.85, p < 0.05). Conclusion: Coating of PEEK dowels with a nanocoating of titanium has beneficial effects on adhesion of bone tissue.
Language	English
Publishing date	2015-07-17
Publishing country	Netherlands
Document type	Journal Article
ISSN	2211-4599
ISSN	2211-4599
DOI	10.14444/2035
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Article ; Online: Nucleus replacement with the DASCOR disc arthroplasty device: interim two-year efficacy and safety results from two prospective, non-randomized multicenter European studies.

Ahrens, Michael / Tsantrizos, Anthony / Donkersloot, Peter / Martens, Frederic / Lauweryns, Philippe / Le Huec, Jean Charles / Moszko, Slawomir / Fekete, Zsolt / Sherman, John / Yuan, Hansen A / Halm, Henry

Spine

2009 Volume 34, Issue 13, Page(s) 1376–1384

Abstract: Study design: A prospective, nonrandomized multicenter study of lumbar disc nucleus replacement using the DASCOR Disc Arthroplasty Device. An interim analysis of clinical results is presented, obtained from European patients enrolled in 2 studies.: ... ...

Abstract	Study design: A prospective, nonrandomized multicenter study of lumbar disc nucleus replacement using the DASCOR Disc Arthroplasty Device. An interim analysis of clinical results is presented, obtained from European patients enrolled in 2 studies. Objective: To determine the safety and efficacy of the DASCOR Device for the treatment of symptomatic single-level degenerative disc disease (DDD). Summary of background data: Patients suffering from DDD have been limited to a choice between nonoperative therapies or invasive surgical treatments such as total disc replacement or spinal fusion. The DASCOR Device was developed to provide an alternative treatment with a less invasive surgical intervention. Methods: A total of 85 patients from 11 European centers were enrolled in 1 of 2 studies between February 2003 and July 31, 2007. Data were collected before surgery and after surgery at 6 weeks and at 3, 6, 12, and 24 months. The clinical outcome measures were obtained from the Visual Analog Scale (VAS) for back pain, the Oswestry Disability Index (ODI), radiographic assessments, and records of analgesic medication use. Results: Mean VAS and ODI scores improved significantly after 6 weeks and throughout the 2 years. Radiographic results demonstrated, at a minimum, maintenance of disc height with no device expulsion and, despite Modic-Type 1 changes, no subsidence. Fourteen patients had serious adverse events including device explants in 7 patients (7 of 85), in which the main complication was resumed back pain after time. Patients' rate of analgesic medication decreased dramatically over time, with all patients experiencing significant improvements after 3 months and nearly no analgesic medication or narcotic drug use at 2 years. Conclusion: The interim outcomes showed significant improvements in mean ODI and VAS scores. The results of these European studies suggest that the DASCOR Device may be a safe and effective less-invasive surgical option for patients with DDD.
MeSH term(s)	Adult ; Back Pain/etiology ; Diskectomy/adverse effects ; Diskectomy/instrumentation ; Diskectomy/methods ; Equipment Design ; Europe ; Humans ; Intervertebral Disc/pathology ; Intervertebral Disc/physiopathology ; Intervertebral Disc/surgery ; Intervertebral Disc Displacement/pathology ; Intervertebral Disc Displacement/surgery ; Middle Aged ; Pain Measurement ; Postoperative Complications/etiology ; Prospective Studies ; Range of Motion, Articular ; Time Factors ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2009-06-01
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	752024-4
ISSN	1528-1159 ; 0362-2436
ISSN (online)	1528-1159
ISSN	0362-2436
DOI	10.1097/BRS.0b013e3181a3967f
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Zs.A 1305: Show issues

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Article ; Online: Different Patterns of Pulmonary Sequelae after Hyaline Membrane Disease: Heterogeneity of Bronchopulmonary Dysplasia?

Van Lierde, Stefaan / Cornelis, Ann / Devlieger, Hugo / Moerman, Philippe / Lauweryns, Joseph / Eggermont, Ephrem

Neonatology - Fetal and Neonatal Research

1991 Volume 60, Issue 3-4, Page(s) 152–162

Abstract: In an autopsy study of 37 infants who suffered from hyaline membrane disease (HMD), two distinct patterns of pulmonary lesions could be defined. One pattern, characterized by marked interstitial fibrosis in the absence of airway abnormalities, was ... ...

Abstract	In an autopsy study of 37 infants who suffered from hyaline membrane disease (HMD), two distinct patterns of pulmonary lesions could be defined. One pattern, characterized by marked interstitial fibrosis in the absence of airway abnormalities, was labelled Ê»interstitial-type’ histology. A second type, labelled Ê»bronchiolar-type’ histology, showed marked airway lesions and alveolar emphysema. Nine patients of each type were analysed. Nineteen other patients had a Ê»mixed-type’ histology and were not further studied. Retrospectively, the clinical and radiological characteristics of both series were analysed. No differences in birth weight, gestational age and initial radiological HMD grade could be demonstrated. The pulmonary function of the bronchiolar-type patients however was significantly worse at the onset, and these infants needed more oxygen and ventilatory support during the first 10 days of life. They all died from respiratory failure whereas 4 patients from the interstitial group had non-pulmonary fatalities. In the bronchiolar group chest X-rays showed atelectasis and pulmonary interstitial emphysema in the early stages, and hyperinflation with bullae and irregular streaky densities in the later. Patients in the interstitial group had no or minor emphysema with more homogeneously spread densities over both lungs. We conclude that both types of evolution represent two extremes of the bronchopulmonary dysplasia spectrum.
Keywords	Bronchopulmonary dysplasia ; Hyaline membrane disease ; Mechanical ventilation ; Oxygen toxicity
Language	English
Publisher	S. Karger AG
Publishing place	Basel
Publishing country	Switzerland
Document type	Article ; Online
ZDB-ID	2266911-5
ISSN	1661-7819 ; 1661-7800 ; 1661-7800
ISSN (online)	1661-7819
ISSN	1661-7800
DOI	10.1159/000243402
Database	Karger publisher's database

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