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Article ; Online: Current availability and distribution of Congo Basin’s freshwater resources

Mohammad J. Tourian / Fabrice Papa / Omid Elmi / Nico Sneeuw / Benjamin Kitambo / Raphael M. Tshimanga / Adrien Paris / Stéphane Calmant

Communications Earth & Environment, Vol 4, Iss 1, Pp 1-

2023 Volume 13

Abstract: ... that currently the Congo Basin’s Total Drainable Water Storage lies within a range of 476 km3 to 502 km3 ...

Abstract	Abstract The Congo Basin is of global significance for biodiversity and the water and carbon cycles. However, its freshwater availability and distribution remain relatively unknown. Using satellite data, here we show that currently the Congo Basin’s Total Drainable Water Storage lies within a range of 476 km3 to 502 km3, unevenly distributed throughout the region, with 63% being stored in the southernmost sub-basins, Kasaï (220–228 km3) and Lualaba (109–169 km3), while the northern sub-basins contribute only 173 ± 8 km3. We further estimate the hydraulic time constant for draining its entire water storage to be 4.3 ± 0.1 months, but, regionally, permanent wetlands and large lakes act as resistors resulting in greater time constants of up to 105 ± 3 months. Our estimate provides a robust basis to address the challenges of water demand for 120 million inhabitants, a population expected to double in a few decades.
Keywords	Geology ; QE1-996.5 ; Environmental sciences ; GE1-350
Subject code	550
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Alzheimer’s Disease from the Amyloidogenic Theory to the Puzzling Crossroads between Vascular, Metabolic and Energetic Maladaptive Plasticity

Michele Cerasuolo / Michele Papa / Anna Maria Colangelo / Maria Rosaria Rizzo

Biomedicines, Vol 11, Iss 861, p

2023 Volume 861

Abstract: Alzheimer’s disease (AD) is a progressive and degenerative disease producing the most common type ...

Abstract	Alzheimer’s disease (AD) is a progressive and degenerative disease producing the most common type of dementia worldwide. The main pathogenetic hypothesis in recent decades has been the well-known amyloidogenic hypothesis based on the involvement of two proteins in AD pathogenesis: amyloid β (Aβ) and tau. Amyloid deposition reported in all AD patients is nowadays considered an independent risk factor for cognitive decline. Vascular damage and blood–brain barrier (BBB) failure in AD is considered a pivotal mechanism for brain injury, with increased deposition of both immunoglobulins and fibrin. Furthermore, BBB dysfunction could be an early sign of cognitive decline and the early stages of clinical AD. Vascular damage generates hypoperfusion and relative hypoxia in areas with high energy demand. Long-term hypoxia and the accumulation within the brain parenchyma of neurotoxic molecules could be seeds of a self-sustaining pathological progression. Cellular dysfunction comprises all the elements of the neurovascular unit (NVU) and neuronal loss, which could be the result of energy failure and mitochondrial impairment. Brain glucose metabolism is compromised, showing a specific region distribution. This energy deficit worsens throughout aging. Mild cognitive impairment has been reported to be associated with a glucose deficit in the entorhinal cortex and in the parietal lobes. The current aim is to understand the complex interactions between amyloid β (Aβ) and tau and elements of the BBB and NVU in the brain. This new approach aimed at the study of metabolic mechanisms and energy insufficiency due to mitochondrial impairment would allow us to define therapies aimed at predicting and slowing down the progression of AD.
Keywords	Alzheimer’s disease ; neurovascular unit ; blood–brain barrier ; glia ; reactive oxygen species (ROS) ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Outcomes of cystoid macular edema following Descemet’s membrane endothelial keratoplasty in a referral center for keratoplasty in Spain

Nuno Moura-Coelho / Renato Papa-Vettorazzi / Imalvet Santiesteban-García / Arnaldo Dias-Santos / Felicidad Manero / João Paulo Cunha / José Güell

Scientific Reports, Vol 13, Iss 1, Pp 1-

retrospective study

2023 Volume 9

Abstract: Abstract The aim of this study was to analyze the outcomes of eyes with visually significant cystoid macular œdema (vs-CMO) after Descemet membrane endothelial keratoplasty (DMEK) in a referral center for keratoplasty in Spain. We conducted a ... ...

Abstract	Abstract The aim of this study was to analyze the outcomes of eyes with visually significant cystoid macular œdema (vs-CMO) after Descemet membrane endothelial keratoplasty (DMEK) in a referral center for keratoplasty in Spain. We conducted a retrospective, single-surgeon case series of eyes that developed post-DMEK vs-CMO performed between January 2011 and December 2020. Data collected included: indication for DMEK; biometric data; ocular comorbidities; past medical history; time to detection of vs-CMO after DMEK (T, weeks); best-corrected visual acuity (BCVA, logMAR) and central retinal thickness (CRT, µm) at diagnosis of vs-CMO, after resolution of CMO, and at last follow-up; and management strategy. Main outcomes analyzed were incidence of vs-CMO, improvement in BCVA and CRT after treatment of vs-CMO. Of 291 consecutive DMEK surgeries, 14 eyes of 13 patients (4.8%) developed vs-CMO. Five patients (38.5%) had history of CMO, and 28.6% of eyes had ophthalmic comorbidities. Median (P25-P75) T was 4 (3–10) weeks. Treatment success was observed in 12/13 eyes (92.3%), two of which required second-line treatment. In successful cases (median time-to-resolution 3.0 (2.0–3.5) months), median BCVA improved from 0.60 (0.40–0.80) logMAR to 0.30 (0.15–0.40) logMAR (p = 0.002) after treatment, and median CRT improved from 582.5 (400.0–655.0) µm to 278.0 (258.0–294.0) µm (p = 0.005). In our study, we found a 4.8% rate of post-DMEK vs-CMO, with most cases occurring in the first 3 months after surgery. Good functional and anatomical outcomes are expected in most eyes, without treatment-related complications or implications in graft outcomes. Additional studies are encouraged to determine a standardized protocol for post-DMEK vs-CMO.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Book ; Online: Mathematical Modeling of Biological Systems : Geometry, Symmetry and Conservation Laws

Papa, Federico / Sinisgalli, Carmela

2022

Keywords	Information technology industries ; COVID-19 seasonality ; S.I.R. models ; mathematical modeling ; forced seasonality ; confounding variables ; uncertainty ; Atangana-Baleanu ; Caputo ; eco-epidemiology ; Rosenzweig-MacArthur ; epidemic ODE model ; COVID-19 spread in Italy ; system control and identification ; blood microcirculation ; ultrafiltration process ; vasomotion ; Fårhæus-Lindquist effect ; type-1 diabetes mellitus ; global analysis ; β cells ; regulatory system ; dynamical systems ; network optimization ; stability analysis ; global attractor ; relative entropy ; information geometry ; Voronoi diagram ; diffusion process ; bivariate probability density function ; diameter ; polygon area ; stand density ; predictive microbiology ; lactic acid bacteria ; batch fermentation ; primary mathematical model ; bacterial growth ; bounded noises ; kinetic theory ; active particles ; statistical mechanics ; population dynamics ; Fokker-Planck equation ; mathematical oncology ; ecology ; noise induced transitions ; systems biology ; enzymatic reactions ; quadratization ; ODE integration
Size	1 electronic resource (218 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021291348
ISBN	9783036527642 ; 3036527648
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: 360° Ab-Interno Schlemm’s Canal Viscodilation with OMNI Viscosurgical Systems for Open-Angle Glaucoma—Midterm Results

Giacomo Toneatto / Marco Zeppieri / Veronica Papa / Laura Rizzi / Carlo Salati / Andrea Gabai / Paolo Brusini

Journal of Clinical Medicine, Vol 11, Iss 259, p

2022 Volume 259

Abstract: ... of Schlemm’s canal (SC) performed with OMNI viscosurgical system in open angle glaucoma (OAG) together or not ...

Abstract	Purpose: To evaluate the effectiveness of ab-interno microcatheterization and 360° viscodilation of Schlemm’s canal (SC) performed with OMNI viscosurgical system in open angle glaucoma (OAG) together or not with phacoemulsification. Setting: Two surgical sites. Design: Retrospective, observational. Methods: Eighty eyes from 73 patients with mild to moderate OAG underwent ab- interno SC viscodilation performed with OMNI system. Fifty eyes (Group 1) underwent only SC viscodilation, while 30 eyes (Group 2) underwent glaucoma surgery + cataract extraction. Primary success endpoint at 12 months was an intraocular pressure (IOP) reduction higher than 25% from baseline with an absolute value of 18 mmHg or lower, either on the same number or fewer ocular hypotensive medications, without further interventions. Secondary effectiveness endpoints included mean IOP, number of medications and comparison of outcomes between groups. Safety endpoints consisted of best-corrected visual acuity (BCVA), adverse events (AEs), and subsequent surgical procedures. Results: Primary success was achieved in 40.0% and 67.9% in Groups 1 and 2, respectively. Mean IOP at 12-month follow-up showed a significant reduction in both groups (from 23.0 to 15.6 mmHg, p < 0.001, and from 21.5 to 14.1, p < 0.001, in Groups 1 and 2, respectively). Mean medication number decreased in both groups (from 3.0 to 2.0, p < 0.001 and from 3.4 to 1.9, p < 0.001, in Groups 1 and 2, respectively). AEs included hyphema (2 eyes), mild hypotony (4 eyes), IOP spikes one month after surgery (1 eye). Twelve eyes (15.0%) required subsequent surgical procedures. No BCVA reduction was observed. Conclusions: Viscodilation of SC using OMNI viscosurgical systems is safe and relatively effective in reducing IOP in adult patients with OAG.
Keywords	open angle glaucoma (OAG) ; Schlemm’s canal viscodilation ; OMNI viscosurgical system ; minimally invasive glaucoma surgeries (MIGS) ; trabeculotomy ; cataract extraction ; Medicine ; R
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Endoscopic prediction of submucosal invasion in Barrett’s cancer with the use of artificial intelligence: a pilot study

Endoscopy

2020 Volume 53, Issue 09, Page(s) 878–883

Abstract: Background: The accurate differentiation between T1a and T1b Barrett’s-related cancer has ... between T1a and T1b Barrett’s cancer on white-light images.: Methods: Endoscopic images from three ... in endoscopic diagnosis and treatment of Barrett’s cancer.: Results: The sensitivity, specificity, F1 score ...

Abstract	Background: The accurate differentiation between T1a and T1b Barrett’s-related cancer has both therapeutic and prognostic implications but is challenging even for experienced physicians. We trained an artificial intelligence (AI) system on the basis of deep artificial neural networks (deep learning) to differentiate between T1a and T1b Barrett’s cancer on white-light images. Methods: Endoscopic images from three tertiary care centers in Germany were collected retrospectively. A deep learning system was trained and tested using the principles of cross validation. A total of 230 white-light endoscopic images (108 T1a and 122 T1b) were evaluated using the AI system. For comparison, the images were also classified by experts specialized in endoscopic diagnosis and treatment of Barrett’s cancer. Results: The sensitivity, specificity, F1 score, and accuracy of the AI system in the differentiation between T1a and T1b cancer lesions was 0.77, 0.64, 0.74, and 0.71, respectively. There was no statistically significant difference between the performance of the AI system and that of experts, who showed sensitivity, specificity, F1, and accuracy of 0.63, 0.78, 0.67, and 0.70, respectively. Conclusion: This pilot study demonstrates the first multicenter application of an AI-based system in the prediction of submucosal invasion in endoscopic images of Barrett’s cancer. AI scored equally to international experts in the field, but more work is necessary to improve the system and apply it to video sequences and real-life settings. Nevertheless, the correct prediction of submucosal invasion in Barrett’s cancer remains challenging for both experts and AI.
Language	English
Publishing date	2020-11-16
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-1311-8570
Database	Thieme publisher's database

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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: COVID-19 infection in Crohn’s disease under treatment with adalimumab

Tursi, Antonio / Angarano, Gioacchino / Monno, Laura / Saracino, Annalisa / Signorile, Fabio / Ricciardi, Aurelia / Papa, Alfredo

Gut

2020 Volume 69, Issue 7, Page(s) 1364–1365

Keywords	Gastroenterology ; covid19
Language	English
Publisher	BMJ
Publishing country	uk
Document type	Article ; Online
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2020-321240
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Article ; Online: Prevalence of Staphylococcus aureus and of methicillin-resistant S. aureus (MRSA) along the production chain of dairy products in north-western Greece.

Papadopoulos, Panagiotis / Papadopoulos, Theofilos / Angelidis, Apostolos S / Boukouvala, Evridiki / Zdragas, Antonios / Papa, Anna / Hadjichristodoulou, Christos / Sergelidis, Daniel

Food microbiology

2018 Volume 69, Page(s) 43–50

Abstract: ... 19 dairy products, 72 human, 185 animal, 55 equipment), 212 (57.8%) were found positive for S. aureus ... circulation through the dairy production chain. The presence of MDR S. aureus, and especially MRSA, in animals ...

Abstract	The objective of this study was to estimate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in the production chain of dairy products. Of 367 tested samples (36 bulk tank milk (BTM), 19 dairy products, 72 human, 185 animal, 55 equipment), 212 (57.8%) were found positive for S. aureus. Almost all isolates (99.6%) were resistant to at least one antimicrobial and 13.3% were multi-drug resistant (MDR), exhibiting resistance to three or more antibiotic classes. Eleven samples (3%) were found contaminated by MRSA carrying the mecA gene. None of the MRSA isolates carried the mecC or the Pandon-Valentine leucocidin (PVL) genes. Four spa types were identified among the MRSA isolates: t127, t3586, t1773, t4038, with t127 being the most prevalent (7 out of 11). Two of them, t3586 and t1773, were isolated for the first time in Greece. Furthermore, Pulse-Field Gel Electrophoresis (PFGE) analysis indicated clonal circulation through the dairy production chain. The presence of MDR S. aureus, and especially MRSA, in animals and dairy products represents a potential threat for the spread of this pathogen in the community. The results indicated that human, animal and environmental sources could be involved in the contamination of dairy products along their production chain and therefore further investigation of contamination sources is needed to control the dispersion of MRSA in the community.
MeSH term(s)	Animals ; Cattle ; Dairy Products/microbiology ; Food Contamination/analysis ; Food Contamination/statistics & numerical data ; Greece ; Humans ; Methicillin Resistance ; Methicillin-Resistant Staphylococcus aureus/classification ; Methicillin-Resistant Staphylococcus aureus/genetics ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Milk/microbiology ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/classification ; Staphylococcus aureus/genetics ; Staphylococcus aureus/isolation & purification
Language	English
Publishing date	2018-02
Publishing country	England
Document type	Journal Article
ZDB-ID	50892-5
ISSN	1095-9998 ; 0740-0020
ISSN (online)	1095-9998
ISSN	0740-0020
DOI	10.1016/j.fm.2017.07.016
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nou realisme(s). Breu investigació teòrica

Ernesto Sferrazza Papa

Tiempo Devorado, Vol 4, Iss 3, Pp 460-

2017 Volume 477

Abstract: Entre les diferents tendències de la filosofia contemporània, l'anomenat "nou realisme" és probablement un dels més interessants. El "Nou Realisme" no és simplement un "retorn" a la realitat, un reconeixement banal i trivial de l'existència del món ... ...

Abstract	Entre les diferents tendències de la filosofia contemporània, l'anomenat "nou realisme" és probablement un dels més interessants. El "Nou Realisme" no és simplement un "retorn" a la realitat, un reconeixement banal i trivial de l'existència del món extern. Més aviat, és un moviment filosòfic polèmic (i per tant polític) contra el monopoli teòric, especialment en la filosofia continental, governada pel discurs filosòfic postmodern. Per tant, el Nou Realisme és una espècie d'antagonista filosòfic de la postmodernitat. No obstant això, no podem reduir el Nou Realisme a la simple crítica de la postmodernitat. De fet, el Nou Realisme és un moviment filosòfic multifacètic i estratificat. Hi ha molts Realismes Nous diferents. Aquests Nous Realismes inclouen diferents autors, línies i camins d'investigació, units per la crítica de la postmodernitat, però distingits de moltes maneres. L'objectiu d'aquesta contribució és doble. En primer lloc, es rastrejarà breument la història teòrica del Nou Realisme. En segon lloc, es posarà l'accent en les temàtiques més importants del nou realisme i, al mateix temps, en les diferents teories filosòfiques (Ferraris, Meillassoux, Gabriel, Boghossian, Harman, Gratton) desenvolupades sota la denominació de "Nou Realisme"
Keywords	Realismo ; postmodernidad ; realidad ; verdad ; objeto ; History (General) and history of Europe ; D ; 1789- ; D299-475
Language	Catalan
Publishing date	2017-12-01T00:00:00Z
Publisher	Universitat Autonoma de Barcelona
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nou realisme(s). Breu investigació teòrica

Ernesto Sferrazza Papa

Tiempo Devorado, Vol 4, Iss

2017 Volume 3

Abstract	Entre les diferents tendències de la filosofia contemporània, l'anomenat "nou realisme" és probablement un dels més interessants. El "Nou Realisme" no és simplement un "retorn" a la realitat, un reconeixement banal i trivial de l'existència del món extern. Més aviat, és un moviment filosòfic polèmic (i per tant polític) contra el monopoli teòric, especialment en la filosofia continental, governada pel discurs filosòfic postmodern. Per tant, el Nou Realisme és una espècie d'antagonista filosòfic de la postmodernitat. No obstant això, no podem reduir el Nou Realisme a la simple crítica de la postmodernitat. De fet, el Nou Realisme és un moviment filosòfic multifacètic i estratificat. Hi ha molts Realismes Nous diferents. Aquests Nous Realismes inclouen diferents autors, línies i camins d'investigació, units per la crítica de la postmodernitat, però distingits de moltes maneres. L'objectiu d'aquesta contribució és doble. En primer lloc, es rastrejarà breument la història teòrica del Nou Realisme. En segon lloc, es posarà l'accent en les temàtiques més importants del nou realisme i, al mateix temps, en les diferents teories filosòfiques (Ferraris, Meillassoux, Gabriel, Boghossian, Harman, Gratton) desenvolupades sota la denominació de "Nou Realisme"
Keywords	Realismo ; postmodernidad ; realidad ; verdad ; objeto ; History (General) and history of Europe ; D ; 1789- ; D299-475
Language	Catalan
Publishing date	2017-12-01T00:00:00Z
Publisher	Universitat Autonoma de Barcelona
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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