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Article ; Online: Assay of GTPγS Binding in Autoradiography.

Gabaglio, Marina / Prini, Pamela / Zamberletti, Erica / Rubino, Tiziana / Parolaro, Daniela

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2576, Page(s) 181–188

Abstract: Autoradiography of radiolabeled GTPγS ([ ...

Abstract	Autoradiography of radiolabeled GTPγS ([
MeSH term(s)	Autoradiography ; Brain/metabolism ; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Sulfur Radioisotopes/metabolism
Chemical Substances	Receptors, G-Protein-Coupled ; Sulfur Radioisotopes ; Guanosine 5'-O-(3-Thiotriphosphate) (37589-80-3)
Language	English
Publishing date	2022-09-24
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2728-0_14
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Therapeutic potential of cannabidivarin for epilepsy and autism spectrum disorder.

Zamberletti, Erica / Rubino, Tiziana / Parolaro, Daniela

Pharmacology & therapeutics

2021 Volume 226, Page(s) 107878

Abstract: Recent years have seen a renewed interest on the possible therapeutic exploitations of specific cannabinoids derived from the Cannabis sativa plant. Thus far, the most studied non-psychotomimetic cannabinoid is cannabidiol (CBD), which has shown ... ...

Abstract	Recent years have seen a renewed interest on the possible therapeutic exploitations of specific cannabinoids derived from the Cannabis sativa plant. Thus far, the most studied non-psychotomimetic cannabinoid is cannabidiol (CBD), which has shown promising therapeutic potential for relieving a variety of neurological diseases. However, also its propyl analogue, cannabidivarin (CBDV), has recently gained much attention as a potential therapeutic agent for the management of disabling neurological conditions. This review aims at providing a comprehensive and updated overview of the available animal and human data, which have investigated the possible therapeutic potential of CBDV for the management of epilepsy and autism spectrum disorder.
MeSH term(s)	Animals ; Autism Spectrum Disorder/drug therapy ; Cannabinoids/therapeutic use ; Epilepsy/drug therapy ; Humans
Chemical Substances	Cannabinoids ; cannabidivarin (I198VBV98I)
Language	English
Publishing date	2021-04-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	194735-7
ISSN	1879-016X ; 0163-7258
ISSN (online)	1879-016X
ISSN	0163-7258
DOI	10.1016/j.pharmthera.2021.107878
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Article ; Online: Long-Term Consequences of Adolescent Exposure to THC-Rich/CBD-Poor and CBD-Rich/THC-Poor Combinations: A Comparison with Pure THC Treatment in Female Rats.

Gabaglio, Marina / Zamberletti, Erica / Manenti, Cristina / Parolaro, Daniela / Rubino, Tiziana

International journal of molecular sciences

2021 Volume 22, Issue 16

Abstract: Cannabis is the most-used recreational drug worldwide, with a high prevalence of use among adolescents. In animal models, long-term adverse effects were reported following chronic adolescent exposure to the main psychotomimetic component of the plant, ... ...

Abstract	Cannabis is the most-used recreational drug worldwide, with a high prevalence of use among adolescents. In animal models, long-term adverse effects were reported following chronic adolescent exposure to the main psychotomimetic component of the plant, delta-9-tetrahydrocannabinol (THC). However, these studies investigated the effects of pure THC, without taking into account other cannabinoids present in the cannabis plant. Interestingly, cannabidiol (CBD) content seems to mitigate some of the side effects of THC, at least in adult animals. Thus, in female rats, we evaluated the long-term consequences of a co-administration of THC and CBD at a 3:1 ratio, chosen based on the analysis of recently confiscated illegal cannabis samples in Europe. CBD content is able to mitigate some of the long-term behavioral alterations induced by adolescent THC exposure as well as long-term changes in CB1 receptor and microglia activation in the prefrontal cortex (PFC). We also investigated, for the first time, possible long-term effects of chronic administration of a THC/CBD combination reminiscent of "light cannabis" (CBD:THC in a 33:1 ratio; total THC 0.3%). Repeated administration of this CBD:THC combination has long-term adverse effects on cognition and leads to anhedonia. Concomitantly, it boosts Glutamic Acid Decarboxylase-67 (GAD67) levels in the PFC, suggesting a possible lasting effect on GABAergic neurotransmission.
Language	English
Publishing date	2021-08-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22168899
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Article: Consumo de cánnabis de los adolescentes y esquizofrenia: evidencias epidemiológicas y experimentales.

Parolaro, Daniela

Adicciones

2010 Volume 22, Issue 3, Page(s) 185–189

Abstract: Marijuana is consistently the most widely used illicit drug among teenagers and most users first experiment it in adolescence. Adolescence is a critical period between childhood and adulthood, including not only reproductive maturation, but also ... ...

Title translation	Adolescent cannabis consumption and schizophrenia: epidemiological and experimental evidences.
Abstract	Marijuana is consistently the most widely used illicit drug among teenagers and most users first experiment it in adolescence. Adolescence is a critical period between childhood and adulthood, including not only reproductive maturation, but also cognitive, emotional and social maturation. In this period adolescent brain is still in transition differing anatomically and neurochemically from the adult's one. The endocannabinoid system is an important determinant for cerebral maturation, therefore its strong stimulation by the delta-9- tetrahydrocannabinol, that acts through the endocannabinoid system, might lead to subtle but lasting neurobiological changes that can affect adult brain functions and behaviour. We summarize the more recent researches investigating the relationships between adolescent exposure to cannabinoids and increased risk for psychotic disease such as schizophrenia, as highlighted by both human and animal studies. Epidemiological evidence suggests that cannabis use is a risk factor for schizophrenia, and an exacerbation of symptoms and worsening of the schizophrenic prognosis may occur in individuals with a predisposition for schizophrenia. The characteristic of adolescent brain probably makes it more vulnerable to cannabis effect producing psychotic like symptoms and possibly cause schizophrenia.
MeSH term(s)	Adolescent ; Animals ; Humans ; Marijuana Abuse/complications ; Schizophrenia/epidemiology ; Schizophrenia/etiology
Language	Spanish
Publishing date	2010
Publishing country	Spain
Document type	Editorial ; English Abstract
ZDB-ID	2018873-0
ISSN	0214-4840
ISSN	0214-4840
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Zs.A 5233: Show issues

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Article ; Online: Long-Term Consequences of Adolescent Exposure to THC-Rich/CBD-Poor and CBD-Rich/THC-Poor Combinations

Marina Gabaglio / Erica Zamberletti / Cristina Manenti / Daniela Parolaro / Tiziana Rubino

International Journal of Molecular Sciences, Vol 22, Iss 8899, p

A Comparison with Pure THC Treatment in Female Rats

2021 Volume 8899

Abstract	Cannabis is the most-used recreational drug worldwide, with a high prevalence of use among adolescents. In animal models, long-term adverse effects were reported following chronic adolescent exposure to the main psychotomimetic component of the plant, delta-9-tetrahydrocannabinol (THC). However, these studies investigated the effects of pure THC, without taking into account other cannabinoids present in the cannabis plant. Interestingly, cannabidiol (CBD) content seems to mitigate some of the side effects of THC, at least in adult animals. Thus, in female rats, we evaluated the long-term consequences of a co-administration of THC and CBD at a 3:1 ratio, chosen based on the analysis of recently confiscated illegal cannabis samples in Europe. CBD content is able to mitigate some of the long-term behavioral alterations induced by adolescent THC exposure as well as long-term changes in CB1 receptor and microglia activation in the prefrontal cortex (PFC). We also investigated, for the first time, possible long-term effects of chronic administration of a THC/CBD combination reminiscent of “light cannabis” (CBD:THC in a 33:1 ratio; total THC 0.3%). Repeated administration of this CBD:THC combination has long-term adverse effects on cognition and leads to anhedonia. Concomitantly, it boosts Glutamic Acid Decarboxylase-67 (GAD67) levels in the PFC, suggesting a possible lasting effect on GABAergic neurotransmission.
Keywords	delta-9-tetrahydrocannabinol ; cannabidiol ; adolescence ; females ; light cannabis ; behavior ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	333
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Impact of Exposure to Cannabinoids in Adolescence: Insights From Animal Models.

Rubino, Tiziana / Parolaro, Daniela

Biological psychiatry

2016 Volume 79, Issue 7, Page(s) 578–585

Abstract: The regular use of cannabis during adolescence is of particular concern because use by this age group seems to be associated with an increased likelihood of deleterious consequences, as reported by several epidemiologic studies. However, despite their ... ...

Abstract	The regular use of cannabis during adolescence is of particular concern because use by this age group seems to be associated with an increased likelihood of deleterious consequences, as reported by several epidemiologic studies. However, despite their unquestionable value, epidemiologic data are inconclusive. Modeling the adolescent phase in animals appears to be a useful approach to investigate the impact of cannabis use on the adolescent brain. In these models, adolescent cannabinoid exposure has been reported to cause long-term impairment in specific components of learning and memory and to have differential effects on anxiety, social behavior, and depressive-like signs. These findings suggest that it may represent, per se or in association with other hits, a risk factor for developing psychotic-like symptoms in adulthood. The neurobiological bases of this association include the induction of alterations in the maturational events of the endocannabinoid system occurring in the adolescent brain. Alterations in the endocannabinoid system may profoundly dysregulate developmental processes in some neurotransmitter systems, such as gamma-aminobutyric acid and glutamate, mainly in the cortex. The resulting picture strongly resembles the one present in schizophrenic patients, highlighting the translational value of this experimental approach.
MeSH term(s)	Adolescent ; Animals ; Brain/drug effects ; Brain/physiopathology ; Cannabinoids/adverse effects ; Cannabinoids/pharmacology ; Cognition/drug effects ; Disease Models, Animal ; Endocannabinoids/metabolism ; Humans ; Learning ; Marijuana Abuse/physiopathology ; Memory ; Mice ; Psychoses, Substance-Induced/physiopathology ; Rats ; gamma-Aminobutyric Acid/metabolism
Chemical Substances	Cannabinoids ; Endocannabinoids ; gamma-Aminobutyric Acid (56-12-2)
Language	English
Publishing date	2016-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/j.biopsych.2015.07.024
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Zs.A 720: Show issues

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Article: Sex-dependent vulnerability to cannabis abuse in adolescence.

Rubino, Tiziana / Parolaro, Daniela

Frontiers in psychiatry

2015 Volume 6, Page(s) 56

Abstract: The goal of this review is to summarize current evidence for sex differences in the response to cannabinoid compounds, focusing mainly on a specific age of exposure, i.e., adolescence. Preclinical as well as clinical studies are examined. Among the ... ...

Abstract	The goal of this review is to summarize current evidence for sex differences in the response to cannabinoid compounds, focusing mainly on a specific age of exposure, i.e., adolescence. Preclinical as well as clinical studies are examined. Among the different possible underlying mechanisms, the consistent dimorphism in the endocannabinoid system and delta9-tetrahydrocannabinol metabolism may play a part. All the collected data point to the need of including females in basic research as well as of analyzing results for sex differences in epidemiological studies.
Language	English
Publishing date	2015-04-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2015.00056
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Article ; Online: Neurobiological mechanisms underlying cannabis-induced memory impairment.

Prini, Pamela / Zamberletti, Erica / Manenti, Cristina / Gabaglio, Marina / Parolaro, Daniela / Rubino, Tiziana

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

2020 Volume 36, Page(s) 181–190

Abstract: A growing body of literature suggests that cannabis intake can induce memory loss in humans and animals. Besides the recreational use, daily cannabis users may also belong to the ever-increasing population of patients who are administered cannabis as a ... ...

Abstract	A growing body of literature suggests that cannabis intake can induce memory loss in humans and animals. Besides the recreational use, daily cannabis users may also belong to the ever-increasing population of patients who are administered cannabis as a medicine. As such, they also can experience impairments in memory as a negative side effect of their therapy. Comprehension of the neurobiological mechanisms responsible for such detrimental effects would be therefore of paramount relevance to public health. The investigation of neurobiological mechanisms in humans, despite the progress in the development of imaging technologies that allow the study of brain structure and function, still suffers substantial limitations. Animal models, instead, enable us to establish a causal relationship and thus to better elucidate the neurobiological mechanisms underlying the process under study. In this review, we will attempt to collect the insight coming from animal models about cannabis effects on memory, trying to depict a picture of the neurobiological mechanisms contributing to the development of cognitive deficits following cannabis use.
MeSH term(s)	Animals ; Brain/drug effects ; Brain/metabolism ; Dronabinol/administration & dosage ; Dronabinol/adverse effects ; Hallucinogens/administration & dosage ; Hallucinogens/adverse effects ; Humans ; Marijuana Use/adverse effects ; Marijuana Use/psychology ; Marijuana Use/trends ; Memory Disorders/chemically induced ; Memory Disorders/metabolism ; Memory Disorders/psychology ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/metabolism
Chemical Substances	Hallucinogens ; Receptor, Cannabinoid, CB1 ; Dronabinol (7J8897W37S)
Language	English
Publishing date	2020-03-02
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1082947-7
ISSN	1873-7862 ; 0924-977X
ISSN (online)	1873-7862
ISSN	0924-977X
DOI	10.1016/j.euroneuro.2020.02.002
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Zs.A 3288: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The Endocannabinoid System and Autism Spectrum Disorders: Insights from Animal Models.

Zamberletti, Erica / Gabaglio, Marina / Parolaro, Daniela

International journal of molecular sciences

2017 Volume 18, Issue 9

Abstract: Autism spectrum disorder (ASD) defines a group of neurodevelopmental disorders whose symptoms include impaired communication and social interaction with restricted or repetitive motor movements, frequently associated with general cognitive deficits. ... ...

Abstract	Autism spectrum disorder (ASD) defines a group of neurodevelopmental disorders whose symptoms include impaired communication and social interaction with restricted or repetitive motor movements, frequently associated with general cognitive deficits. Although it is among the most severe chronic childhood disorders in terms of prevalence, morbidity, and impact to the society, no effective treatment for ASD is yet available, possibly because its neurobiological basis is not clearly understood hence specific drugs have not yet been developed. The endocannabinoid (EC) system represents a major neuromodulatory system involved in the regulation of emotional responses, behavioral reactivity to context, and social interaction. Furthermore, the EC system is also affected in conditions often present in subsets of patients diagnosed with ASD, such as seizures, anxiety, intellectual disabilities, and sleep pattern disturbances. Despite the indirect evidence suggestive of an involvement of the EC system in ASD, only a few studies have specifically addressed the role of the EC system in the context of ASD. This review describes the available data on the investigation of the presence of alterations of the EC system as well as the effects of its pharmacological manipulations in animal models of ASD-like behaviors.
Language	English
Publishing date	2017-09-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms18091916
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Article ; Online: Cognitive dysfunction and impaired neuroplasticity following repeated exposure to the synthetic cannabinoid JWH-018 in male mice.

Bilel, Sabrine / Zamberletti, Erica / Caffino, Lucia / Tirri, Micaela / Mottarlini, Francesca / Arfè, Raffaella / Barbieri, Mario / Beggiato, Sarah / Boccuto, Federica / Bernardi, Tatiana / Casati, Sara / Brini, Anna T / Parolaro, Daniela / Rubino, Tiziana / Ferraro, Luca / Fumagalli, Fabio / Marti, Matteo

British journal of pharmacology

2023 Volume 180, Issue 21, Page(s) 2777–2801

Abstract: Background and purpose: Psychotic disorders have been reported in long-term users of synthetic cannabinoids. This study aims at investigating the long-lasting effects of repeated JWH-018 exposure.: Experimental approach: Male CD-1 mice were injected ... ...

Abstract	Background and purpose: Psychotic disorders have been reported in long-term users of synthetic cannabinoids. This study aims at investigating the long-lasting effects of repeated JWH-018 exposure. Experimental approach: Male CD-1 mice were injected with vehicle, JWH-018 (6 mg·kg Key results: The repeated treatment with JWH-018 induced psychomotor agitation while reducing social dominance, recognition memory and PPI in mice. JWH-018 disrupted hippocampal LTP and decreased BDNF expression, reduced the synaptic levels of NMDA receptor subunits and decreased the expression of PSD95. Repeated exposure to JWH-018, reduced hippocampal CB Conclusion and implications: Our findings suggest that repeated administration of a high dose of JWH-018 leads to the manifestation of psychotic-like symptoms accompanied by alterations in neuroplasticity and change in the endocannabinoid system.
MeSH term(s)	Mice ; Male ; Animals ; Endocannabinoids/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Receptors, N-Methyl-D-Aspartate ; Cannabinoids/pharmacology ; Neuronal Plasticity ; Cognitive Dysfunction ; Receptor, Cannabinoid, CB1/metabolism
Chemical Substances	Endocannabinoids ; 1-pentyl-3-(1-naphthoyl)indole (G391998J57) ; Brain-Derived Neurotrophic Factor ; Receptors, N-Methyl-D-Aspartate ; Cannabinoids ; Receptor, Cannabinoid, CB1
Language	English
Publishing date	2023-07-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.16164
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